JP2009500037A - Haemophilusinfluenzae誘発性疾患のためのキメラワクチン - Google Patents

Haemophilusinfluenzae誘発性疾患のためのキメラワクチン Download PDF

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Publication number
JP2009500037A
JP2009500037A JP2008520357A JP2008520357A JP2009500037A JP 2009500037 A JP2009500037 A JP 2009500037A JP 2008520357 A JP2008520357 A JP 2008520357A JP 2008520357 A JP2008520357 A JP 2008520357A JP 2009500037 A JP2009500037 A JP 2009500037A
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seq
protein
nthi
chimeric protein
pila
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JP2009500037A5 (enExample
Inventor
ローレン オー. バカレッツ,
ロバート エス. ジュニア マンソン,
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ネイションワイド チルドレンズ ホスピタル, インコーポレイテッド
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Publication of JP2009500037A publication Critical patent/JP2009500037A/ja
Publication of JP2009500037A5 publication Critical patent/JP2009500037A5/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/102Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1242Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55572Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2008520357A 2005-07-08 2006-07-05 Haemophilusinfluenzae誘発性疾患のためのキメラワクチン Pending JP2009500037A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69764205P 2005-07-08 2005-07-08
US80183506P 2006-05-19 2006-05-19
PCT/US2006/026183 WO2007008527A2 (en) 2005-07-08 2006-07-05 Chimeric vaccine for haemophilus influenzae-induced disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009237768A Division JP2010172332A (ja) 2005-07-08 2009-10-14 Haemophilusinfluenzae誘発性疾患のためのキメラワクチン

Publications (2)

Publication Number Publication Date
JP2009500037A true JP2009500037A (ja) 2009-01-08
JP2009500037A5 JP2009500037A5 (enExample) 2010-01-14

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JP2008520357A Pending JP2009500037A (ja) 2005-07-08 2006-07-05 Haemophilusinfluenzae誘発性疾患のためのキメラワクチン
JP2009237768A Pending JP2010172332A (ja) 2005-07-08 2009-10-14 Haemophilusinfluenzae誘発性疾患のためのキメラワクチン

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JP2009237768A Pending JP2010172332A (ja) 2005-07-08 2009-10-14 Haemophilusinfluenzae誘発性疾患のためのキメラワクチン

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Country Link
US (3) US7811591B2 (enExample)
EP (2) EP1904519B1 (enExample)
JP (2) JP2009500037A (enExample)
AT (1) ATE488526T1 (enExample)
CA (1) CA2613970C (enExample)
DE (1) DE602006018308D1 (enExample)
WO (1) WO2007008527A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014512365A (ja) * 2011-04-13 2014-05-22 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム インフルエンザ菌タンパク質eおよびピリンaを含む融合タンパク質および組合せワクチン
JP2015536312A (ja) * 2012-10-17 2015-12-21 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 1種以上の肺炎球菌莢膜糖類コンジュゲートとインフルエンザ菌由来のタンパク質Eおよび/またはPilAを含むタンパク質成分とを含む免疫原性組成物

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9812613D0 (en) * 1998-06-11 1998-08-12 Smithkline Beecham Biolog Vaccine
ATE488526T1 (de) * 2005-07-08 2010-12-15 Nationwide Childrens Hospital Chimärer impfstoff für haemophilus influenzae- induzierte infektion
GB201218660D0 (en) 2012-10-17 2012-11-28 Glaxosmithkline Biolog Sa Immunogenic composition
AU2014225330B2 (en) 2013-03-08 2018-11-01 Lauren O. Bakaletz Transcutaneous dosage formulation
US11274144B2 (en) 2013-06-13 2022-03-15 Research Institute At Nationwide Children's Hospital Compositions and methods for the removal of biofilms
US11248040B2 (en) 2013-09-26 2022-02-15 Trellis Bioscience, Llc Binding moieties for biofilm remediation
US20180207067A1 (en) 2015-07-14 2018-07-26 Research Institute at Nationwide Children's Hospit al Novel formulation for the elimination of cariogenic and opportunistic pathogens within the oral cavity
HK1255383A1 (zh) 2015-07-31 2019-08-16 The Research Institute At Nationwide Children's Hospital 去除生物膜的肽及抗體
WO2017066719A2 (en) 2015-10-14 2017-04-20 Research Institute At Nationwide Children's Hospital Hu specific interfering agents
EP3565589A1 (en) 2017-01-04 2019-11-13 Research Institute at Nationwide Children's Hospital Dnabii vaccines and antibodies with enhanced activity
EP3860718A4 (en) 2018-10-05 2022-08-31 Research Institute at Nationwide Children's Hospital HMGB1 PROTEIN DERIVATIVES FOR BIOFILM REMOVAL
US12116614B2 (en) 2020-06-30 2024-10-15 Research Institute At Nationwide Children's Hospital Methods for determining antibiotic sensitivity
CN112961241B (zh) * 2020-06-30 2022-04-22 广州百暨基因科技有限公司 抗b7h3抗体及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843464A (en) * 1995-06-02 1998-12-01 The Ohio State University Synthetic chimeric fimbrin peptides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US19005A (en) 1857-12-29 de witt
US697642A (en) 1901-03-09 1902-04-15 Liberty Millet Process of strengthening clay hydraulic pipe, vases, crockery-ware, &c.
US801835A (en) 1905-02-25 1905-10-17 Rudolph H Apelt Ball-bearing.
US1900504A (en) 1930-11-25 1933-03-07 Ingersoll Rand Co Condensing apparatus
WO1994026304A1 (en) * 1993-05-18 1994-11-24 Ohio State Research Foundation Otitis media vaccine
DE4336530C1 (de) 1993-10-26 1995-04-13 Max Planck Gesellschaft Rekombinante PilC-Proteine, Verfahren zu ihrer Herstellung und ihre Verwendung
US6355450B1 (en) 1995-04-21 2002-03-12 Human Genome Sciences, Inc. Computer readable genomic sequence of Haemophilus influenzae Rd, fragments thereof, and uses thereof
GB9812613D0 (en) * 1998-06-11 1998-08-12 Smithkline Beecham Biolog Vaccine
ES2387215T3 (es) * 2003-12-23 2012-09-18 Nationwide Children's Hospital, Inc. Pili de tipo IV de la Haemophilus influenzae
ATE488526T1 (de) * 2005-07-08 2010-12-15 Nationwide Childrens Hospital Chimärer impfstoff für haemophilus influenzae- induzierte infektion

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843464A (en) * 1995-06-02 1998-12-01 The Ohio State University Synthetic chimeric fimbrin peptides

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014512365A (ja) * 2011-04-13 2014-05-22 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム インフルエンザ菌タンパク質eおよびピリンaを含む融合タンパク質および組合せワクチン
US11198707B2 (en) 2011-04-13 2021-12-14 Glaxosmithkline Biologicals Sa Fusion proteins and combination vaccines comprising Haemophilus influenzae Protein E and Pilin A
JP2015536312A (ja) * 2012-10-17 2015-12-21 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 1種以上の肺炎球菌莢膜糖類コンジュゲートとインフルエンザ菌由来のタンパク質Eおよび/またはPilAを含むタンパク質成分とを含む免疫原性組成物

Also Published As

Publication number Publication date
US20130064828A1 (en) 2013-03-14
EP1904519A2 (en) 2008-04-02
ATE488526T1 (de) 2010-12-15
JP2010172332A (ja) 2010-08-12
EP1904519B1 (en) 2010-11-17
DE602006018308D1 (de) 2010-12-30
US8741304B2 (en) 2014-06-03
WO2007008527A2 (en) 2007-01-18
CA2613970C (en) 2015-12-08
CA2613970A1 (en) 2007-01-18
EP2298794A2 (en) 2011-03-23
US8263363B2 (en) 2012-09-11
US7811591B2 (en) 2010-10-12
US20110081357A1 (en) 2011-04-07
US20080311110A1 (en) 2008-12-18
EP2298794A3 (en) 2011-04-06
WO2007008527A3 (en) 2007-03-15

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