JP2009233170A - Method for manufacturing sheet with high aspect ratio structure - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method for easily manufacturing a percutaneous absorption sheet having a high-aspect-ratio structure with shapely pointed tips, using pullulan. <P>SOLUTION: After a mold 10 having needle-like recesses 12 is filled with polymer solution 20 containing pullulan, the polymer solution is dried and solidified. A surfactant is added to the polymer solution 20. Thereby, the wettability of the polymer solution 20 is improved to easily manufacture the thin-film polymer sheet 22 having microneedles 24 with sharply pointed tips. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a method for producing a high aspect ratio structure sheet having a high aspect ratio structure formed on the surface thereof.

  In recent years, functional films having a high aspect ratio structure such as microneedles formed on the surface have been applied in various fields.

  For example, in the medical technology field, a percutaneous absorption system that efficiently administers a drug to a patient via the patient's skin surface or skin stratum corneum by using a functional membrane having a high aspect ratio structure containing the drug has attracted attention. Collecting. Such a functional membrane for a transdermal absorption system is generally referred to as a transdermal absorption sheet.

  The percutaneous absorption sheet is roughly classified into a non-biodegradable type that is not decomposed in vivo and a biodegradable type that is decomposed in vivo, and a manufacturing method suitable for each type has been proposed.

  Patent document 1 is disclosing the method of manufacturing the non-biodegradable type percutaneous absorption sheet which has the projection part coat | covered with the chemical | medical agent containing film. In this method, the metal plate is etched to produce a metal sheet having protrusions, and then immersed in a drug-containing solution, so that the surfaces of the protrusions are covered with the drug-containing film.

  However, in order to achieve higher dosing efficiency, a biodegradable type percutaneous absorption sheet that is decomposed in vivo together with a drug is preferred rather than a non-biodegradable type. Examples of methods for producing a biodegradable type percutaneous absorption sheet include the following methods.

  Patent Document 2 discloses a method of producing a biodegradable type percutaneous absorption sheet by extrusion molding using a molten saccharide material containing a drug.

  Patent Document 3 discloses a method for producing a biodegradable transdermal sheet by injection molding using a molten saccharide material containing a drug.

  However, in the methods of Patent Documents 2 and 3, since the saccharide material containing the drug is once heated and melted, the drugs that can be added to the material are limited to those whose efficacy is not deteriorated by heating. Therefore, the following method can be considered when using a drug that is susceptible to thermal degradation.

Patent Document 4 discloses a method for producing a biodegradable transdermal sheet by casting using a saccharide solution containing a saccharide material and a drug. In this method, a saccharide solution is poured into a mold having recesses, and then the saccharide solution is evaporated and solidified to produce a transdermal absorption sheet having projections.
Special table 2007-518468 gazette JP-T-2004-504120 JP 2003-238347 A JP 2007-87992 A

  As described above, for the production of a biodegradable type transdermal absorption sheet containing a drug that easily undergoes thermal degradation, it is preferable to use cast molding that does not require heating and melting of the material.

  As a material suitable for this cast molding, pullulan, which is a kind of natural polysaccharide, can be mentioned. Pullulan is highly soluble in water and has excellent film-forming properties, so it is suitable for cast molding, and also has good biocompatibility, which is a required characteristic of a transdermal absorption sheet.

  However, since the pullulan solution has low wettability and is difficult to spread on the mold, it is difficult to form a thin transdermal absorption sheet. In particular, when a mold having high liquid repellency such as a silicone resin is used, the pullulan solution becomes more difficult to spread and may not even be formed into a sheet.

  In addition, even if pullulan can be formed into a thin film sheet, pullulan solution is difficult to spread in the deepest part of the mold recess, so forming a high aspect ratio structure with a sharp pointed tip Have difficulty.

  On the other hand, with the advancement of medical technology in recent years, from the viewpoint of more efficient drug administration, there has been a strong demand for a transdermal absorption sheet having a high aspect ratio convex part with a sharp pointed tip. There is a growing need to solve the challenges.

  The present invention has been made in view of such circumstances, and relates to a method for easily producing a sheet having a high-aspect-ratio structure with a sharp tip using a pullulan.

  The invention described in claim 1 includes a step of applying a polymer solution containing pullulan and a surfactant to a mold in which a concave portion having a high aspect ratio structure is formed, and a convex portion having an inverted shape of the concave portion. A drying and solidifying step for drying and solidifying the polymer solution so as to form a polymer sheet, and a peeling step for peeling the polymer sheet formed in the drying and solidifying step from the mold. The present invention relates to a method for manufacturing a high aspect ratio structure sheet.

  According to the manufacturing method according to claim 1, since pullulan having excellent film forming property and high biocompatibility is used, a high aspect ratio and high aspect ratio structure sheet having excellent biocompatibility can be produced.

  Moreover, the wettability of a polymer solution can be improved by adding a surfactant to the polymer solution containing pullulan. Thereby, even if a mold having high liquid repellency is used, a thin high aspect ratio structure sheet can be easily produced. Furthermore, the addition of the surfactant makes it easy to fill the polymer solution in the recesses of the mold, and a high aspect ratio structure can be formed with high accuracy. For example, a microneedle having a height of 10 to 1000 μm, a width (diameter) of 10 to 500 μm, an aspect ratio of 1 or more, and a tip radius of curvature of 5 μm or less can be formed.

  The invention described in claim 2 further relates to a method for producing a high aspect ratio structure sheet according to claim 1, further comprising a filling promoting step for promoting filling of the polymer solution into the recess.

  According to the manufacturing method of the second aspect, since the polymer solution can be more reliably filled in the concave portion of the mold, an improvement in the formation accuracy of the structure having a high aspect ratio can be expected.

  Invention of Claim 3 is related with the manufacturing method of the high aspect ratio structure sheet | seat of Claim 1 or 2 characterized by the surface tension of the said polymer solution being 40 mN / m or less.

  According to the manufacturing method of the third aspect, since the polymer solution whose surface tension is adjusted to 40 mN / m or less by the surfactant is used, a thin high aspect ratio structure sheet can be easily manufactured.

  The invention described in claim 4 is the method for producing a high aspect ratio structure sheet according to any one of claims 1 to 3, wherein the surfactant is a nonionic surfactant. About.

  According to the production method of claim 4, by using a nonionic surfactant as the surfactant, the wettability of the polymer solution can be improved without affecting the human body.

  Examples of nonionic surfactants include fatty acid esters typified by sucrose stearate, polyoxyethylene castor oil, and the like.

  The invention described in claim 5 is the high aspect ratio structure according to any one of claims 1 to 4, wherein a film thickness of the polymer sheet formed in the drying step is 200 μm or less. The present invention relates to a sheet manufacturing method.

  The invention described in claim 6 relates to a method for producing a high aspect ratio structure sheet according to any one of claims 1 to 5, wherein the mold contains a silicone resin.

  Invention of Claim 7 is related with the manufacturing method of the high aspect ratio structure sheet | seat as described in any one of Claims 1-6 whose curvature radius of the front-end | tip of the said convex part is 5 micrometers or less. .

  According to the present invention, by adding a surfactant to a polymer solution containing pullulan to improve the wettability of the polymer solution, a sheet having a structure with a high aspect ratio with a sharp tip is easily obtained. Can be manufactured.

  Embodiments of the present invention will be described below with reference to the accompanying drawings. First, a method for manufacturing a high aspect ratio structure sheet according to an embodiment of the present invention will be described, and then a structural example of the high aspect ratio structure sheet manufactured by the method will be described.

  FIG. 1 is a diagram illustrating a state until a high aspect ratio structure sheet according to an embodiment of the present invention is manufactured.

  First, as shown to Fig.1 (a), the mold 10 which has the needle-shaped recessed part 12 is prepared. The needle-like recess 12 is a region that is recessed as compared with the flat surface 16 of the mold 10, and has a structure in which the width gradually decreases toward the deepest portion 14. The shape of the needle-shaped recess 12 is preferably determined in consideration of the effect of drying shrinkage of the polymer solution 20 so that a microneedle having a desired shape can be obtained. For example, from the viewpoint of forming a high-aspect-ratio microneedle with a sharp tip, it is preferable that the width (diameter) of the needle-like recess 12 is 10 to 500 μm and the curvature radius of the deepest portion 14 is 10 μm or less. Moreover, it is preferable that the depth of the needle-shaped recessed part 12 is 10-1000 micrometers, and it is more preferable that it is 100-1000 micrometers.

  Although the material of the mold 10 is not particularly limited, a resin having good releasability such as silicone rubber can be used from the viewpoint of preventing damage at the time of peeling the high aspect ratio structure sheet.

  Next, as shown in FIG. 1B, a polymer solution 20 is applied to the mold 10. At this time, for the purpose of facilitating casting into the mold 10, it is preferable to provide a frame around a region where the needle-like concave portions 12 of the mold 10 are arranged and to apply the polymer solution 20 into the frame. .

  Examples of the method for applying the polymer solution 20 include bar coating, spin coating, spray coating, and dropping using a dispenser. Especially, since the aspect which dripped the polymer solution 20 using a dispenser can control the dripping amount with high precision irrespective of the viscosity of the polymer solution 20, it is preferable.

  The polymer solution 20 is a solution in which a polymer is dispersed in a solvent such as water, alcohol, methyl ethyl ketone (MEK), and a surfactant is added for the purpose of improving wettability.

  The polymer of the polymer solution 20 is preferably a material that is easily degraded in the living body (biodegradable material) and pullulan that is a biocompatible material (biocompatible material). Since pullulan is a material that can be cast at a low temperature, when the chemical is added to the polymer solution 20, thermal degradation of the chemical during sheet molding can be prevented. In addition, pullulan has a low allergy risk and has a high dissolution rate in the patient's body, and therefore can be suitably used for producing a biodegradable transdermal absorption sheet. In addition to pullulan, for example, saccharides such as glucose and maltose, and biodegradable polymers such as gelatin, polylactic acid, and lactic acid / glycolic acid copolymer may be used.

  The pullulan concentration of the polymer solution 20 is preferably 5 to 30% by weight from the viewpoint of reducing the time required for solvent volatilization without impairing moldability. The viscosity of the polymer solution 20 is preferably 5 Pa · sec or less, and more preferably 2 Pa · sec or less, from the viewpoint of facilitating filling of the polymer solution 20 into the recess 12.

  The surfactant added to the polymer solution 20 is preferably a nonionic surfactant that has little influence on the human body. For example, fatty acid esters represented by sucrose stearate, polyoxyethylene castor oil, etc. Can be used. The addition amount of the surfactant varies depending on the type of the surfactant, but is preferably 5% by weight or less, and more preferably 1% by weight. In addition, it is preferable to adjust the surface tension of the polymer solution 20 after adding the surfactant to 40 mN / m or less from the viewpoint of easily producing a thin high aspect ratio structure sheet.

  The polymer solution 20 may contain various additives in addition to the surfactant. For example, a drug to be administered to a patient may be added to the polymer solution 20. Examples of drugs include diabetes drugs (insulin), cardiovascular dilators (nitroglycerin), vaccines, antibiotics, asthma drugs, analgesics and medical narcotics, local anesthetics, antianaphylaxis drugs, and skin disease drugs. Sleep-inducing drugs, vitamins, smoking cessation aids, etc. can be used. Moreover, you may add an adjuvant to the polymer solution 20 together with a chemical | medical agent from a viewpoint of penetrating a chemical | medical agent more efficiently in a patient's body.

  The application amount (film thickness) of the polymer solution 20 is preferably adjusted as appropriate in consideration of the polymer concentration of the polymer solution 20 so that a high aspect ratio structure sheet having a desired film thickness can be obtained. For example, the application amount (film thickness) of the polymer solution 20 can be adjusted in the range of 0.1 to 10 mm.

  Next, as shown in FIG.1 (c), the polymer solution 20 provided to the mold 10 is dried and solidified. Examples of the method for drying and solidifying the polymer solution 20 include a method for forcibly volatilizing the solvent of the polymer solution 20 by heating, air blowing, reduced pressure, etc., in addition to the method of naturally drying the polymer solution 20.

  Thereafter, by peeling from the mold 10, a polymer sheet 22 having microneedles 24 as shown in FIG. 1D is obtained.

  As an aspect of peeling of the polymer sheet 22, for example, a method in which a sheet having an adhesive layer on one side is attached to the back surface of the polymer sheet 22 and the whole sheet is peeled off, or a method in which a suction cup is adsorbed on the back side of the polymer sheet Etc.

  Next, the structure of the polymer sheet 22 manufactured by the above process will be described.

  FIG. 2 is a cross-sectional view showing a structural example of a polymer sheet manufactured by the method according to the present embodiment.

  The shape of the microneedle 24 may be, for example, a cone shape such as a cone or a pyramid. The microneedle 24 is preferably a high aspect ratio structure with a sharp pointed tip from the viewpoint of enabling more efficient drug administration. For example, the width (diameter) of the microneedle 24 is preferably 10 to 500 μm, and the radius of curvature of the tip of the microneedle 24 is preferably 5 μm or less. The height of the microneedle 24 is preferably 10 to 1000 μm, and more preferably 100 to 1000 μm. Further, the aspect ratio of the microneedle 24 is preferably 1 or more, and more preferably 2 or more. Here, the height of the microneedle 24 means the projection length H from the surface of the base portion 26, and the aspect ratio A of the microneedle 24 is the height (projection length) H and width (diameter) of the microneedle 24. ) D is defined by A = H / D.

  The number of microneedles 24 is not particularly limited, and may be one or plural. A plurality of microneedles 24 may be arranged two-dimensionally or three-dimensionally.

  The film thickness t of the base portion 26 is preferably 200 μm or less, and more preferably 100 μm or less, from the viewpoint of forming a flexible polymer sheet 22 that can be flexibly deformed in accordance with the shape of the patient's skin.

  Next, a method for producing the mold 10 used for producing the polymer sheet 22 will be described. As a method for producing the mold 10, a method of drilling the needle-like recess 12 in a metal plate such as nickel or copper by machining using a drill, a method of molding the original plate with a resin, or a reversal shape of the original plate by electroforming. The method of forming is mentioned.

  FIG. 3 is a diagram showing a mold manufacturing method by resin molding. After the resin solution is cast on the original plate 40 and solidified, it is peeled off from the original plate 40 to produce the mold 10. The original plate 40 used for the production of the mold 10 may be produced by machining a metal material, or produced by finely processing an inorganic material such as quartz, glass or silicon by electron beam lithography and etching. Also good. If the original 40 is produced using a highly durable material, it is possible to repeat the production of the mold 10 by repeatedly using one original 40.

  The mold 10 produced by the above method may be used alone, or a plurality of molds 10 may be used side by side. FIG. 4 is a view showing a large area mold including a plurality of molds.

  A large area mold 100 shown in FIG. 4 has a configuration in which a plurality of molds 10 are fixed to a substrate 44 through an adhesive layer 42. If the polymer sheet 22 is manufactured using the large area mold 100, the production efficiency is greatly improved.

  As described above, an example of the present invention has been described in detail. However, the present invention is not limited to this example, and various improvements and modifications may be made without departing from the scope of the present invention.

  For example, in the above-described embodiment, the example in which the polymer solution 20 is dried and solidified after the polymer solution 20 is applied to the mold 10 has been described. However, the polymer solution 20 is dissolved before the polymer solution 20 is dried and solidified. You may accelerate | stimulate filling to the needle-shaped recessed part 12 of the liquid 20. FIG. As a method of accelerating the filling of the polymer solution 20 into the needle-shaped recess 12, a method of pressurizing the polymer solution 20 after casting the polymer solution 20 into the mold 10, or a method of pressing the polymer solution 20 under reduced pressure in the mold 10. The method of returning to atmospheric pressure after casting is mentioned.

  FIG. 5 is a view showing a pressure filling device that promotes filling of the polymer solution into the needle-like concave portion.

  A pressure filling device 50 shown in FIG. 5 includes a pressure vessel 52 having an inlet 58 and a discharge port 60, a pedestal 54 provided inside the pressure vessel 52, and a compressor 56 that feeds pressurized fluid into the pressure vessel 52. including. Below, operation | movement of the pressurization filling apparatus 50 is demonstrated.

  In a state where the mold 10 into which the polymer solution 20 has been cast is placed on the pedestal 54, the pressurized fluid is fed into the pressure resistant container 52 through the inlet 58 by the compressor 56. The pressurization by the compressor 56 is performed, for example, under the condition that the pressure is in the range of 0.01 to 5 MPa and the pressurization time is 5 sec to 5000 sec. The casting of the polymer solution 20 may be performed in the pressure vessel 52.

  As the pressurized fluid, gas or liquid can be used. Examples of the gas that can be used as the pressurized fluid include air. From the viewpoint of preventing dissolution of the pressurized fluid in the polymer solution 20, a gas having a low dissolution rate in the polymer solution 20 should be selected. Is preferred. For example, when the solvent of the polymer solution 20 is water, nitrogen gas is preferably used as the pressurized fluid.

  From the viewpoint of preventing an increase in viscosity due to volatilization of the polymer solution 20, a liquid of the same type as the solvent of the polymer solution 20 is stored in the pressure vessel 52 in advance, and the inside of the pressure vessel 52 is saturated with the vapor of the liquid. It is preferable to be in a state.

  As described above, by facilitating the filling of the polymer solution 20 into the needle-like recess 12, the entire area of the needle-like recess 12 including the deepest portion 14 can be quickly filled with the polymer solution 20. This makes it possible to more reliably form the microneedle 24 having a sharp tip.

  By the method according to the above-described embodiment, a high aspect ratio structure sheet was produced as described below, and the microneedle moldability and sheet flexibility (flexibility) were evaluated.

[Example 1]
<Mold production>
First, a square pyramid shape with a base length of 160 μm and a height of 400 μm is formed at a pitch of 460 μm by cutting using a diamond tool in a central 10 mm × 10 mm region of a smooth copper plate of 40 mm × 40 mm, An original plate was prepared. Using this original plate, a transfer product of silicone rubber (manufactured by Shin-Etsu Chemical Co., Ltd., RTV rubber for Shin-Etsu silicone mold making) was produced, and a mold having a thickness of 5 mm and a size of 40 mm × 40 mm was obtained. A quadrangular pyramid-shaped recess having a depth of 400 μm and a width of 160 μm was formed in the central part 10 mm × 10 mm of the mold.

<Preparation of polymer solution>
Pullulan (manufactured by Hayashibara Co., Ltd., pullulan) was dissolved in warm water at 40 ° C. to prepare an aqueous solution having a pullulan concentration of 15% by weight. Further, 1% by weight of surfactant PEG-5 hydrogenated castor oil (Nikko Chemicals, NIKKOL HCO-5) was added, stirred at 40 ° C., and kept at 40 ° C. As a result, the aqueous pullulan solution had a surface tension of 32 mN / m and a viscosity of about 450 mPa · sec.

<Polymer solution casting>
An opening of 30 mm × 30 mm was provided in the central portion of a silicone sheet having a size of 40 mm × 40 mm and a thickness of 3 mm (manufactured by Shin-Etsu Finetech Co., Ltd., Shinetsu Silicon Sheet BA grade). The silicone sheet was laminated and bonded to the mold in a state in which the square pyramid hole pattern portion of the mold was positioned so as to be exposed from the opening of the silicone sheet. Then, 1 ml of polymer solution was dripped at the mold (silicone sheet opening) to which the silicone sheet was adhered using a dispenser.

<Pressure filling device>
An acrylic bottom plate having a thickness of 1 mm was welded to an acrylic pipe having an inner diameter of 150 mm, a length of 150 mm, and a thickness of 10 mm, and an acrylic flange having an O-ring groove engraved in the upper opening was attached. Then, the lid | cover which can be fixed with a volt | bolt was attached to the flange, and the pressure-resistant container was produced.

  The lid was provided with two through-holes (inlet and outlet), the inlet was connected to a compressor, and a valve was provided at the outlet. A pressure gauge was placed between the inlet and the compressor.

  An acrylic stage having a diameter of 100 mm supported by a leg having a height of 50 mm was installed inside the pressure vessel. Furthermore, the entire pressure vessel was covered with a heating jacket.

<Pressure filling of polymer solution>
In order to prevent volatilization of water which is a solvent of the polymer solution, hot water was stored up to a height of 40 mm at the bottom of the pressure vessel. The mold in which the polymer solution was cast was placed on the stage in the pressure vessel, an O-ring was sandwiched between the flange and the lid, and the pressure vessel was sealed with a bolt. After heating the inside of a pressure vessel to 40 degreeC with the heating jacket, compressed air was inject | poured in the pressure vessel from the compressor. Thereby, the pressure in the pressure vessel was held at 0.5 MPa for 5 minutes.

<Drying process>
The mold was taken out from the pressure vessel, put into an oven, and dried at 35 ° C. for 12 hours. By the drying treatment, the polymer solution was solidified to obtain a polymer sheet.

<Peeling process>
After the silicone sheet laminated and adhered to the mold was removed, an adhesive tape was attached to the back surface of the polymer sheet, and the entire adhesive tape was peeled off from the mold.

<Molded product>
The polymer sheet peeled from the mold had a three-dimensional array structure of quadrangular pyramid needles formed on the surface, and the film thickness of the base portion was 170 μm. The quadrangular pyramid needle had an average height of 400 μm, an average bottom length of 160 μm, and an average radius of curvature at the tip of 5 μm.

[Comparative Example 1]
By the method of Example 1, 3 ml of an aqueous pullulan solution was dropped with a dispenser. The polymer sheet finally obtained had a base film thickness of 500 μm.

[Comparative Example 2]
By the method of Example 1, a polymer sheet was prepared using a polymer solution containing no surfactant. The surface tension of the polymer solution was 67 mN / m. Further, the finally obtained polymer sheet had a base film thickness of 380 μm.

[Comparative Example 3]
In the method of Comparative Example 2, 3 ml of a polymer solution not containing a surfactant was dropped with a dispenser. The polymer sheet finally obtained had a base film thickness of 500 μm.

[Comparison study of Examples and Comparative Examples]
About the polymer sheet obtained by the above-mentioned Example 1 and Comparative Examples 1-3, the moldability of a microneedle and the flexibility of a polymer sheet were evaluated by the following methods.

<Microneedle moldability>
The height of the quadrangular pyramid needle formed on the surface of the polymer sheet was measured, the ratio of the quadrangular pyramid needle of 350 μm or more was calculated, and the needle moldability was evaluated based on the following evaluation criteria.

○: The ratio of needles with a height of 350 μm or more is 100%
Δ: Ratio of needles with a height of 350 μm or more is 50% or more and less than 100% ×: Ratio of needles with a height of 350 μm or more is less than 50% <Flexibility of polymer sheet>
The polymer sheet was cut into a size of 20 mm × 20 mm so that the pattern of the quadrangular pyramid needles was located at the center of the polymer sheet 10 mm × 10 mm. The back surface of this sheet was affixed and fixed to the center of a 30 mm × 30 mm medical tape to prepare an evaluation sample. And the sample for evaluation was bent so that two parallel sides of the medical tape were overlapped, and the flexibility of the polymer sheet was evaluated based on the following criteria.

○: Even if it is folded, it returns to the original sheet shape ×: By folding, the polymer sheet breaks or peels off from the tape

  From Table 1, it was found that in Comparative Examples 2 and 3, since the surface tension was high, the polymer solution did not spread sufficiently to the deepest part of the needle-like recess. Moreover, in Comparative Examples 1-3, since the sheet | seat film thickness was thick, it turned out that flexibility is not enough. In the case of Comparative Example 2, the reason why the flexibility was not sufficient was that the polymer solution could not spread on the mold surface and was solidified in the form of droplets. This is because the thickness is increased.

  On the other hand, when the surface tension is 40 mN / m or less and the film thickness of the polymer sheet is 200 μm or less (Example 1), it is confirmed that the moldability of the microneedle is good and the flexibility of the polymer sheet is also high. It was.

It is a figure which shows a mode until the high aspect ratio structure sheet | seat which concerns on one Embodiment of this invention is manufactured. It is sectional drawing which shows the structural example of the high aspect ratio structure sheet | seat manufactured by the method concerning this embodiment. It is a figure which shows the mold preparation method by resin mold taking. It is a figure which shows the large area mold containing a some mold. It is a figure which shows the pressure filling apparatus which accelerates | stimulates filling to the needle-shaped recessed part of a polymer solution.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 10 ... Mold, 12 ... Needle-shaped recessed part, 14 ... Deepest part, 16 ... Flat surface, 20 ... Polymer solution, 22 ... Polymer sheet, 24 ... Microneedle, 26 ... Base part, 40 ... Original plate, 42 ... Adhesive layer 44 ... Substrate, 100 ... Large area mold, 50 ... Pressure filling device, 52 ... Pressure vessel, 54 ... Base, 56 ... Compressor, 58 ... Inlet, 60 ... Discharge port

Claims (7)

An application step of applying a polymer solution containing pullulan and a surfactant to a mold in which a recess having a high aspect ratio structure is formed,
A drying and solidifying step of drying and solidifying the polymer solution so as to form a polymer sheet having a convex portion that is the inverted shape of the concave portion;
And a peeling step of peeling the polymer sheet formed in the drying and solidifying step from the mold.   The method for producing a high aspect ratio structure sheet according to claim 1, further comprising a filling promoting step of promoting filling of the polymer solution into the concave portion.   The method for producing a high aspect ratio structure sheet according to claim 1 or 2, wherein the polymer solution has a surface tension of 40 mN / m or less.   The said surfactant is a nonionic surfactant, The manufacturing method of the high aspect ratio structure sheet | seat as described in any one of Claims 1-3 characterized by the above-mentioned.   The method for producing a high aspect ratio structure sheet according to any one of claims 1 to 4, wherein a film thickness of the polymer sheet formed in the drying step is 200 µm or less.   The said mold contains a silicone resin, The manufacturing method of the high aspect ratio structure sheet | seat as described in any one of Claims 1-5 characterized by the above-mentioned.   The method of manufacturing a high aspect ratio structure sheet according to any one of claims 1 to 6, wherein a radius of curvature of the tip of the convex portion is 5 µm or less.

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