JP2009227672A5 - - Google Patents

Info

Publication number

JP2009227672A5

JP2009227672A5 JP2009051579A JP2009051579A JP2009227672A5 JP 2009227672 A5 JP2009227672 A5 JP 2009227672A5 JP 2009051579 A JP2009051579 A JP 2009051579A JP 2009051579 A JP2009051579 A JP 2009051579A JP 2009227672 A5 JP2009227672 A5 JP 2009227672A5

Authority

JP

Japan

Prior art keywords

composition

potassium

amine

containing compound

group

Prior art date

2009-03-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 claims description 51
• 230000000202 analgesic effect Effects 0.000 claims description 7
• 150000001412 amines Chemical class 0.000 claims 16
• 150000001875 compounds Chemical class 0.000 claims 16
• XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 9
• 229940122117 Potassium channel agonist Drugs 0.000 claims 7
• 230000001953 sensory effect Effects 0.000 claims 7
• NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims 6
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 4
• NSOXQYCFHDMMGV-UHFFFAOYSA-N Tetrakis(2-hydroxypropyl)ethylenediamine Chemical compound CC(O)CN(CC(C)O)CCN(CC(C)O)CC(C)O NSOXQYCFHDMMGV-UHFFFAOYSA-N 0.000 claims 4
• 239000007983 Tris buffer Substances 0.000 claims 4
• 230000005764 inhibitory process Effects 0.000 claims 4
• IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 claims 4
• BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 4
• KMUONIBRACKNSN-UHFFFAOYSA-N potassium dichromate Chemical compound [K+].[K+].[O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O KMUONIBRACKNSN-UHFFFAOYSA-N 0.000 claims 4
• -1 potassium fluorosilicate Chemical compound 0.000 claims 4
• FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims 4
• 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 3
• 229910052739 hydrogen Inorganic materials 0.000 claims 3
• 239000001257 hydrogen Substances 0.000 claims 3
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 3
• 229910001414 potassium ion Inorganic materials 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 238000006748 scratching Methods 0.000 claims 3
• 230000002393 scratching effect Effects 0.000 claims 3
• JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 claims 2
• QLOKJRIVRGCVIM-UHFFFAOYSA-N 1-[(4-methylsulfanylphenyl)methyl]piperazine Chemical compound C1=CC(SC)=CC=C1CN1CCNCC1 QLOKJRIVRGCVIM-UHFFFAOYSA-N 0.000 claims 2
• IVVNZDGDKPTYHK-JTQLQIEISA-N 1-cyano-2-[(2s)-3,3-dimethylbutan-2-yl]-3-pyridin-4-ylguanidine Chemical compound CC(C)(C)[C@H](C)N=C(NC#N)NC1=CC=NC=C1 IVVNZDGDKPTYHK-JTQLQIEISA-N 0.000 claims 2
• ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 claims 2
• 229960004042 diazoxide Drugs 0.000 claims 2
• 229960003632 minoxidil Drugs 0.000 claims 2
• LBHIOVVIQHSOQN-UHFFFAOYSA-N nicorandil Chemical compound [O-][N+](=O)OCCNC(=O)C1=CC=CN=C1 LBHIOVVIQHSOQN-UHFFFAOYSA-N 0.000 claims 2
• 229960002497 nicorandil Drugs 0.000 claims 2
• 229960002310 pinacidil Drugs 0.000 claims 2
• 229910000027 potassium carbonate Inorganic materials 0.000 claims 2
• VKJKEPKFPUWCAS-UHFFFAOYSA-M potassium chlorate Chemical compound [K+].[O-]Cl(=O)=O VKJKEPKFPUWCAS-UHFFFAOYSA-M 0.000 claims 2
• 239000001103 potassium chloride Substances 0.000 claims 2
• 235000011164 potassium chloride Nutrition 0.000 claims 2
• NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 claims 2
• 235000007715 potassium iodide Nutrition 0.000 claims 2
• PHZLMBHDXVLRIX-UHFFFAOYSA-M potassium lactate Chemical group [K+].CC(O)C([O-])=O PHZLMBHDXVLRIX-UHFFFAOYSA-M 0.000 claims 2
• 239000001521 potassium lactate Substances 0.000 claims 2
• 235000011085 potassium lactate Nutrition 0.000 claims 2
• 229960001304 potassium lactate Drugs 0.000 claims 2
• 235000010333 potassium nitrate Nutrition 0.000 claims 2
• 239000004323 potassium nitrate Substances 0.000 claims 2
• LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical compound [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 claims 2
• 229940074439 potassium sodium tartrate Drugs 0.000 claims 2
• OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims 2
• 229910052939 potassium sulfate Inorganic materials 0.000 claims 2
• 235000011151 potassium sulphates Nutrition 0.000 claims 2
• 235000011006 sodium potassium tartrate Nutrition 0.000 claims 2
• RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 claims 2
• 206010030113 Oedema Diseases 0.000 claims 1
• 229940127343 Potassium Channel Agonists Drugs 0.000 claims 1
• 159000000001 potassium salts Chemical class 0.000 claims 1
• 208000024891 symptom Diseases 0.000 description 4
• 208000002193 Pain Diseases 0.000 description 3
• 206010006784 Burning sensation Diseases 0.000 description 2
• 208000003251 Pruritus Diseases 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 230000005722 itchiness Effects 0.000 description 1
• 230000007803 itching Effects 0.000 description 1