JP2009191023A - Foamable solid preparation for oral cavity cleaning - Google Patents
Foamable solid preparation for oral cavity cleaning Download PDFInfo
- Publication number
- JP2009191023A JP2009191023A JP2008033773A JP2008033773A JP2009191023A JP 2009191023 A JP2009191023 A JP 2009191023A JP 2008033773 A JP2008033773 A JP 2008033773A JP 2008033773 A JP2008033773 A JP 2008033773A JP 2009191023 A JP2009191023 A JP 2009191023A
- Authority
- JP
- Japan
- Prior art keywords
- solid preparation
- tongue
- foamable
- oral cavity
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 41
- 239000007787 solid Substances 0.000 title claims abstract description 37
- 238000004140 cleaning Methods 0.000 title claims abstract description 27
- 210000000214 mouth Anatomy 0.000 title abstract description 20
- 239000000835 fiber Substances 0.000 claims abstract description 50
- 238000005187 foaming Methods 0.000 claims abstract description 43
- 241000196324 Embryophyta Species 0.000 claims description 47
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 241000207199 Citrus Species 0.000 claims description 7
- 240000001548 Camellia japonica Species 0.000 claims description 3
- 241000220222 Rosaceae Species 0.000 claims description 2
- 125000005587 carbonate group Chemical group 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 47
- 230000007774 longterm Effects 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
- 206010006326 Breath odour Diseases 0.000 description 35
- 239000011248 coating agent Substances 0.000 description 31
- 238000000576 coating method Methods 0.000 description 31
- 239000003826 tablet Substances 0.000 description 28
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 10
- 244000269722 Thea sinensis Species 0.000 description 10
- 235000013399 edible fruits Nutrition 0.000 description 10
- 241000951471 Citrus junos Species 0.000 description 8
- 102000004316 Oxidoreductases Human genes 0.000 description 8
- 108090000854 Oxidoreductases Proteins 0.000 description 8
- 239000002781 deodorant agent Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 7
- 235000006468 Thea sinensis Nutrition 0.000 description 6
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 5
- 208000032139 Halitosis Diseases 0.000 description 5
- JVOGSHDZLOJKKR-MXFMKSRJSA-I [Na+].[Na+].[Na+].[Mg++].CCc1c(C)c2cc3[n-]c(c(C)c3C=C)c(C)c3nc(C[C@H]3CCC([O-])=O)c(CC([O-])=O)c3[n-]c(cc1n2)c(C)c3C([O-])=O Chemical compound [Na+].[Na+].[Na+].[Mg++].CCc1c(C)c2cc3[n-]c(c(C)c3C=C)c(C)c3nc(C[C@H]3CCC([O-])=O)c(CC([O-])=O)c3[n-]c(cc1n2)c(C)c3C([O-])=O JVOGSHDZLOJKKR-MXFMKSRJSA-I 0.000 description 5
- 235000020971 citrus fruits Nutrition 0.000 description 5
- 229910052802 copper Inorganic materials 0.000 description 5
- 239000010949 copper Substances 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 description 5
- 102000035195 Peptidases Human genes 0.000 description 4
- 108091005804 Peptidases Proteins 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 230000037406 food intake Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000010992 reflux Methods 0.000 description 4
- 235000013616 tea Nutrition 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- 102000030523 Catechol oxidase Human genes 0.000 description 3
- 108010031396 Catechol oxidase Proteins 0.000 description 3
- 240000004307 Citrus medica Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 241000220225 Malus Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 244000235659 Rubus idaeus Species 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000001877 deodorizing effect Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 239000008247 solid mixture Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000002023 wood Substances 0.000 description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 244000183685 Citrus aurantium Species 0.000 description 2
- 235000007716 Citrus aurantium Nutrition 0.000 description 2
- 244000175448 Citrus madurensis Species 0.000 description 2
- 241001672694 Citrus reticulata Species 0.000 description 2
- 240000002319 Citrus sinensis Species 0.000 description 2
- 235000005976 Citrus sinensis Nutrition 0.000 description 2
- 244000166124 Eucalyptus globulus Species 0.000 description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
- 235000009122 Rubus idaeus Nutrition 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 235000020279 black tea Nutrition 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 235000013325 dietary fiber Nutrition 0.000 description 2
- 230000003292 diminished effect Effects 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 235000009569 green tea Nutrition 0.000 description 2
- 235000020333 oolong tea Nutrition 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000209507 Camellia Species 0.000 description 1
- 241000269817 Centrarchidae Species 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 241000468081 Citrus bergamia Species 0.000 description 1
- 241000054078 Citrus depressa Species 0.000 description 1
- 241000273649 Citrus hassaku Species 0.000 description 1
- 241001337999 Citrus iyo Species 0.000 description 1
- 241000679029 Citrus kinokuni Species 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000276331 Citrus maxima Species 0.000 description 1
- 235000001759 Citrus maxima Nutrition 0.000 description 1
- 235000001938 Citrus medica Nutrition 0.000 description 1
- 235000000228 Citrus myrtifolia Nutrition 0.000 description 1
- 241001561395 Citrus natsudaidai Species 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 241000158474 Citrus sphaerocarpa Species 0.000 description 1
- 240000008701 Citrus sudachi Species 0.000 description 1
- 235000017727 Citrus sudachi Nutrition 0.000 description 1
- 241000675136 Citrus sulcata Species 0.000 description 1
- 241001140724 Citrus tachibana Species 0.000 description 1
- 235000016646 Citrus taiwanica Nutrition 0.000 description 1
- 241000273652 Citrus tamurana Species 0.000 description 1
- 241000675108 Citrus tangerina Species 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 235000004692 Eucalyptus globulus Nutrition 0.000 description 1
- 235000017317 Fortunella Nutrition 0.000 description 1
- 235000017316 Fortunella japonica Nutrition 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241001528513 Malus tschonoskii Species 0.000 description 1
- 244000179970 Monarda didyma Species 0.000 description 1
- 235000010672 Monarda didyma Nutrition 0.000 description 1
- 241001092459 Rubus Species 0.000 description 1
- 235000011034 Rubus glaucus Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 235000010358 acesulfame potassium Nutrition 0.000 description 1
- 229960004998 acesulfame potassium Drugs 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 235000012501 ammonium carbonate Nutrition 0.000 description 1
- 235000021016 apples Nutrition 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
- 235000020688 green tea extract Nutrition 0.000 description 1
- 235000015092 herbal tea Nutrition 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 235000019462 natural additive Nutrition 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 229910000031 sodium sesquicarbonate Inorganic materials 0.000 description 1
- 235000018341 sodium sesquicarbonate Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
Abstract
Description
本発明は不溶性繊維成分と発泡成分を含有し、舌上で作用させることを特徴とする口腔洗浄用発泡性固形製剤に関し、特に不溶性繊維成分がミカン科植物及び／又はバラ科リンゴ属植物及び／又はツバキ科植物由来であり、発泡成分が炭酸塩である口腔洗浄用発泡性固形製剤に関する。 The present invention relates to a foamable solid preparation for oral cleaning, which contains an insoluble fiber component and a foaming component and acts on the tongue. In particular, the insoluble fiber component is a citrus plant and / or a rose family apple genus plant and / or Alternatively, the present invention relates to a foamable solid preparation for oral cleaning, which is derived from a camellia plant and the foaming component is carbonate.
近年口中ケア市場は年々伸長しており、舌苔の除去による口臭防止をうたった商品が増加している。なお、口臭は一般に生理的口臭、食事由来の口臭、疾病由来の口臭に分類される。このうち生理的口臭の主原因は舌苔であることが知られている。舌苔は口腔内の老廃物タンパクや菌などから構成されている。 In recent years, the oral cavity care market has been growing year by year, and products that prevent bad breath by removing tongue coating are increasing. In addition, halitosis is generally classified into physiological halitosis, meal-derived halitosis, and disease-derived halitosis. Of these, it is known that the main cause of physiological bad breath is tongue coating. Tongue moss is composed of waste protein and bacteria in the oral cavity.
食品でこれまで舌苔を除去する手段としては、酵素により分解する方法（特許文献１）が知られている。しかしながら、これは効果が得られるまで時間を要することが難点であった。また、物理的に舌苔を除去するものとして、不溶性植物繊維を固形基材に配合させることにより固形基材の溶解によってその表面に繊維の突起が形成されそれによって舌苔を除去する口腔用固形組成物が報告されている（特許文献２）。 As a means for removing tongue coating with food, a method of degrading with an enzyme (Patent Document 1) is known. However, it was difficult to take time until the effect was obtained. In addition, as a method for physically removing tongue coating, a solid composition for oral cavity in which insoluble plant fibers are blended into a solid base material, and fiber protrusions are formed on the surface by dissolution of the solid base material, thereby removing tongue coating. Has been reported (Patent Document 2).
一方、高濃度の発泡性成分と口臭防止成分として銅クロロフィリンナトリウム等を配合させて口臭効果を高めたことが報告されている（特許文献３）。しかしながら、これらの製剤は舌苔除去としては十分な効果が得られなかった。 On the other hand, it has been reported that copper chlorophyllin sodium or the like is added as a high-concentration foaming component and a bad breath prevention component to enhance the bad breath effect (Patent Document 3). However, these preparations were not effective enough for removing tongue coating.
また、ユズ繊維をざらつき素材として配合したキャンディの口臭抑制と舌苔除去効果についても報告されている（非特許文献１）。 Moreover, the bad breath suppression and tongue coating removal effect of the candy which mix | blended Yuzu fiber as a rough material are also reported (nonpatent literature 1).
本発明は生理的口臭の主原因である舌苔を効果的に除去し、且つ即効性のある口腔洗浄用発泡性固形製剤を提供することにある。 An object of the present invention is to provide an effervescent solid preparation for oral cleaning which can effectively remove tongue coating which is a main cause of physiological bad breath and has an immediate effect.
上記の課題を解決するために鋭意検討を重ねた結果、不溶性植物繊維と発泡成分を錠剤、トローチ剤、キャンディ、錠菓などの固形製剤に含有し、舌上で作用させることにより、製剤表面に形成される微細な突起によって生理的口臭の主原因である舌苔を物理的に舌から分離させ、さらに発泡成分の発泡効果によって分離した舌苔物を効果的に回収除去することにより、従来の舌苔除去剤等と比較し、著しく高い舌苔除去効果を有すると共に口臭除去効果が即効性を有し長時間にわたり持続的に発現することを確認し、本発明品を完成させた。 As a result of intensive studies to solve the above problems, insoluble plant fibers and foaming ingredients are contained in solid preparations such as tablets, lozenges, candy, and tablet confectionery, and are allowed to act on the tongue by applying them on the tongue. Tongue moss, which is the main cause of physiological bad breath, is physically separated from the tongue by the fine protrusions that are formed, and the tongue moss separated by the foaming effect of the foaming component is effectively recovered and removed, thereby removing the conventional tongue coating Compared with agents and the like, it was confirmed that it has a remarkably high tongue moss removal effect and a halitosis removal effect that is immediately effective and is sustained over a long period of time, thereby completing the product of the present invention.
すなわち本発明は、主に以下の構成を有する。
（１）不溶性植物繊維と発泡成分を含有する口腔洗浄用発泡性固形製剤。
（２）上記（１）に記載の不溶性植物繊維の含有量が０．１〜１０重量％であることを特徴とする口腔洗浄用発泡性固形製剤。
（３）上記（１）または（２）に記載の不溶性植物繊維がミカン科植物及び／又はバラ科リンゴ属植物及び／又はツバキ科植物由来である口腔洗浄用発泡性固形製剤。
（４）上記（１）に記載の発泡成分が１〜１５重量％である口腔洗浄用発泡性固形製剤。
（５）上記（１）または（４）に記載の発泡成分が炭酸塩である口腔洗浄用発泡性固形製剤。
（６）上記（１）ないし（５）のいずれかに記載の口腔洗浄用発泡性固形製剤は更に酵素を含有する口腔洗浄用発泡性固形製剤。
That is, the present invention mainly has the following configuration.
(1) A foamable solid preparation for oral cleaning containing an insoluble plant fiber and a foaming component.
(2) A foamable solid preparation for oral cleaning, wherein the content of the insoluble plant fiber according to (1) is 0.1 to 10% by weight.
(3) An effervescent solid preparation for mouth washing, wherein the insoluble plant fiber according to (1) or (2) is derived from a citrus plant and / or a rose family, and / or a camellia plant.
(4) A foamable solid preparation for oral cleaning, wherein the foaming component according to (1) is 1 to 15% by weight.
(5) A foamable solid preparation for oral cleaning wherein the foaming component according to (1) or (4) is a carbonate.
(6) The foamable solid preparation for oral cleaning according to any one of (1) to (5) above, further comprises an enzyme.
本発明により、従来になく飛躍的に即効性を有し、且つ効果的に舌苔が除去される口腔洗浄用発泡性固形製剤を提供することができる。 According to the present invention, it is possible to provide a foamable solid preparation for oral cleaning, which has an immediate effect and is effectively removed from the tongue coating.
特に、本発明の不溶性植物繊維と発泡成分を配合した口腔洗浄用固形組成物によると、固形製剤の表面に形成された不溶性天然繊維の微細な突起により物理的に舌苔が掻き出され、更に、発泡成分を併用することにより掻き出された舌苔が効率よく回収することができ舌表面及び口腔内を清潔に洗浄するよう物理的に作用し、口腔での応用直後からすぐに効果を発揮し、且つ長時間にわたり口臭除去効果を持続させることが可能である。また、本発明は不溶性植物繊維を使用することで、口腔内に好ましい感触を与え、発泡成分を使用することでより清涼感が増すため呈味性も良好である。また、本発明品の原料となる植物および発泡成分は、いずれも食品素材やハーブティ、天然添加物として古くより用いられているものであり、その安全性について全く問題はなく、呈味性に関しても好ましいものである。更に、追加的に酵素、好適には酸化酵素を配合させることにより、口臭除去効果をさらに高めることができた。 In particular, according to the solid composition for oral cleaning containing the insoluble plant fiber and foaming component of the present invention, the tongue coating is physically scraped by the fine protrusions of the insoluble natural fiber formed on the surface of the solid preparation, Tongue moss scraped by combining foaming components can be efficiently recovered, physically acting to clean the tongue surface and oral cavity, and immediately effective immediately after application in the oral cavity, Moreover, it is possible to maintain the bad breath removing effect for a long time. Moreover, since this invention gives a favorable touch in an oral cavity by using an insoluble plant fiber, and a refreshing feeling increases more by using a foaming component, taste property is also favorable. In addition, the plant and foaming ingredients that are the raw materials of the present invention are all used as food materials, herbal teas, and natural additives for a long time, and there is no problem with regard to their safety. It is preferable. Furthermore, the effect of removing bad breath could be further enhanced by adding an enzyme, preferably an oxidase.
従って、本発明品である口腔用固形組成物を使用することにより、口臭を手軽にかつ素早く効果的に除去することが可能である。また、キャンディ、錠剤、錠菓は携帯性に優れ、時間を気にせずにいつでも摂取し、効果をすぐに体感ができることから舌ブラシなどの方法よりも優れている。 Therefore, by using the oral composition which is the product of the present invention, it is possible to easily and quickly remove bad breath. In addition, candy, tablets, and tablet confections are superior to methods such as a tongue brush because they are excellent in portability and can be taken at any time without worrying about time, and the effects can be immediately experienced.
以下に、本発明について詳細に説明する。 The present invention is described in detail below.
本発明の口腔洗浄用発泡性固形製剤は、トローチなどの錠剤、キャンディ、飴などの口腔内で溶解させて服用する固形製剤であって、医薬品、医薬部外品又は食品に分類されるものである。このうち、トローチなどの錠剤の形態が特に好ましい。 The foamable solid preparation for oral cleaning of the present invention is a solid preparation taken by dissolving in the oral cavity, such as a tablet such as a troche, a candy, and a candy, and is classified as a pharmaceutical, a quasi-drug or a food. is there. Of these, a tablet form such as a troche is particularly preferred.
種々検討を行った結果、不溶性植物繊維と発泡成分を固形製剤に配合し、舌上で作用させることにより、基材表面に形成される微細な突起によって生理的口臭の主原因である舌苔を物理的に掻き取り、さらに掻き出された舌苔を、発泡成分によって更に効果的に物理的な回収を行うことで舌苔量を低減させ、従来の舌苔除去組成物と比較し、著しく高い舌苔除去効果が即効性を持って発現することを確認し、結果的に口臭除去効果を得ることができ本発明品を完成させた。更に、固形製剤に、酵素を配合させることにより、口臭除去効果を高めることができた。 As a result of various investigations, insoluble plant fibers and foaming ingredients were mixed into a solid preparation and allowed to act on the tongue. The amount of tongue coating is reduced by more effective physical recovery of the tongue coating that has been scraped and then scraped off more effectively with the foaming component, and has a significantly higher tongue coating removal effect compared to conventional tongue coating removal compositions. It was confirmed that it was expressed with immediate effect, and as a result, a bad breath removal effect could be obtained and the product of the present invention was completed. Furthermore, the bad breath removal effect was able to be improved by mix | blending an enzyme with a solid formulation.
ここで、不溶性植物繊維としては、種々検討を行った結果、果実等由来の天然植物繊維を用いることにより、舌苔除去効果、口臭除去効果、口腔内での感触等の面から適していることが見出された。この不溶性植物繊維は、植物の果皮、葉、果肉、果実、材、樹皮、根、好ましくは果実を乾燥し、ミルなどにより粉砕後篩分けして得られた天然の不溶性植物繊維であり、不溶性植物繊維の成分としては不溶性セルロース及び不溶性ペクチン等が挙げられる。なお「不溶性」とは、口腔内に含んだ場合、唾液に溶けないか或いは溶け難い性質を意味する。 Here, as an insoluble plant fiber, as a result of various studies, it is preferable to use natural plant fiber derived from fruits and the like in terms of tongue coating removal effect, bad breath removal effect, oral touch, etc. It was found. This insoluble plant fiber is a natural insoluble plant fiber obtained by drying a fruit peel, leaf, pulp, fruit, wood, bark, root, preferably fruit, pulverizing with a mill, etc., and sieving. Examples of plant fiber components include insoluble cellulose and insoluble pectin. The term “insoluble” means a property that, when contained in the oral cavity, does not dissolve in saliva or is difficult to dissolve.
本発明のミカン科植物果実としては、イヨカン（Citrus iyo）、ウチムラサキ（Citrus grandis）、ウンシュウミカン（Citrus unshu）、オオベニミカン（Citrus tangerina）、オレンジ（Citrus sinensis）、カボス（Citrus sphaerocarpa）、キシュウミカン（Citrus kinokuni）、グレープフルーツ（Citrus paradis）、サンボウカン（Citrus sulcata）、シーカーシャー（Citrus depressa）、シトロン（Citrus medica）、スダチ（Citrus sudachi）、タチバナ（Citrus tachibana）、ダイダイ（Citrus aurantium）、ナツミカン（Citrus natsudaidai）、ネーブル（Citrus sinensis）、ハッサク（Citrus hassaku）、ヒュウガナツ（Citrus tamurana）、ベルガモット（Citrus bergamia）、ポンカン（Citrus reticulata）、ユズ（Citrus junos）、ライム（Citrus aurantifolia）、レモン（Citrus limon）、キンカン（Fortunella japonica）などが挙げられ、バラ科リンゴ属植物としては、セイヨウリンゴ、オオウラジロノキ、エゾノコリンゴなどが挙げられ、ツバキ科植物としては、緑茶、烏龍茶及び紅茶（Camellia sinensis）などが挙げられ、特に好ましくは、ユズである。 Citrus fruits of the present invention include Citrus iyo, Citrus grandis, Citrus unshu, Citrus tangerina, Orange (Citrus sinensis), Cabos (Citrus sphaerocarpa), Citrus mandarin (Citrus kinokuni), grapefruit (Citrus paradis), sunfish (Citrus sulcata), seekershire (Citrus depressa), citron (Citrus medica), sudachi (Citrus sudachi), tachibana (Citrus tachibana), daidai (Citrus aurantium), natsu Citrus natsudaidai), Navel (Citrus sinensis), Hassaku (Citrus hassaku), Hyuganatsu (Citrus tamurana), Bergamot (Citrus bergamia), Ponkan (Citrus reticulata), Yuzu (Citrus junos), Lime (Citrus aurantiforus), Lemon (Citrus aurantiforus) ), Kumquat (Fortunella japonica), etc. The family apple plants of the genus, oilseed apples, Malus Tschonoskii, Ezonokoringo. Examples of the Theaceae plants, green tea, oolong tea and black tea (Camellia sinensis) and the like, particularly preferably citron.
不溶性植物繊維は果皮、葉、果肉、果実、材、樹皮、根、好ましくは果実を熱風送風乾燥法などにより乾燥処理を行なった後、粉砕し、篩分けを行うことで得られる。不溶性植物繊維の粒度が細かすぎる場合には食感は良いが抵抗感（舌苔除去能力）が小さく、粒度が粗すぎる場合には異物感が強く使用に適さない。したがって、好ましくは粒径が約１〜２００μｍの範囲が好ましい。 The insoluble plant fiber is obtained by subjecting the fruit skin, leaves, pulp, fruit, wood, bark, root, preferably fruit to a drying treatment by hot air blowing drying method, etc., and then pulverizing and sieving. If the particle size of the insoluble plant fiber is too fine, the texture is good, but the resistance (the ability to remove tongue coating) is small, and if the particle size is too coarse, the feeling of foreign matter is strong and unsuitable for use. Therefore, the particle size is preferably in the range of about 1 to 200 μm.
不溶性植物繊維の配合量は、固形製剤中に乾燥粉末を約０．１〜１０．０重量％含有するとよい。特に嗜好性の面を考慮すると約０．５〜２．０重量％が好適である。 The amount of insoluble plant fiber is preferably about 0.1 to 10.0% by weight of dry powder in the solid preparation. In consideration of palatability, about 0.5 to 2.0% by weight is preferable.
また、本発明に用いる発泡成分としては、炭酸塩を含有する炭酸ガス発生成分が好ましい。炭酸塩としては炭酸ナトリウム、炭酸水素ナトリウム、炭酸カリウム、炭酸水素カリウム、炭酸アンモニウム、セスキ炭酸ナトリウム等が挙げられるが、このうち炭酸水素ナトリウムが特に好ましい。 Moreover, as a foaming component used for this invention, the carbon dioxide generating component containing carbonate is preferable. Examples of the carbonate include sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate, ammonium carbonate, sodium sesquicarbonate, etc. Among them, sodium hydrogen carbonate is particularly preferable.
発泡性成分の配合量は、良好な発泡性により十分に舌苔を除去するためには製剤中約１〜１５重量％であるが、特に３．０〜１０．０重量％が好ましい。 The blending amount of the foaming component is about 1 to 15% by weight in the preparation in order to sufficiently remove tongue coating due to good foaming properties, but 3.0 to 10.0% by weight is particularly preferable.
また、本発明の口腔用洗浄固形製剤に、適宜酵素を配合することができる。酵素としては、酸化酵素が好適に使用できる。酸化酵素の例としては、ポリフェノール酸化酵素が挙げられる。配合量としては、好適には、製剤中約０．０１〜１．０重量％が好ましい。 Moreover, an enzyme can be suitably mix | blended with the solid preparation for oral cavity of this invention. As the enzyme, an oxidase can be preferably used. Examples of oxidase include polyphenol oxidase. The blending amount is preferably about 0.01 to 1.0% by weight in the preparation.
また、本発明の口腔洗浄固形製剤には、適宜一般的な消臭剤を追加的に使用することが可能であり、特に天然由来の消臭物を使用できる。天然消臭物としては、ツバキ科植物の緑茶、烏龍茶及び紅茶（Camellia sinensis）、バラ科キイチゴ属植物の甜茶（Rubus suavissimus）、ラズベリー（Rubus idaeus）、フトモモ科植物のユーカリ（Eucalyptus globulus）などが呈味性や効果の点で消臭成分原料として適当であるが特に規定はない。これらの植物の果皮、葉、果肉、果実、材、樹皮、根、好ましくはその葉を乾燥させたものを従来行われている抽出方法、抽出溶剤により調製して、製剤中に適宜配合することができ、例えば、約０．０１〜０．５重量％の範囲で配合することができる。 Moreover, a general deodorant can be additionally used as appropriate for the oral cleansing solid preparation of the present invention, and a naturally derived deodorant can be used. Natural deodorants include Camellia plant green tea, Oolong tea and black tea (Camellia sinensis), Rosaceae Raspberry genus tea (Rubus suavissimus), Raspberry (Rubus idaeus), Eucalyptus plant Eucalyptus (Eucalyptus globulus), etc. Although it is suitable as a raw material for deodorizing ingredients in terms of taste and effect, there is no particular rule. The peels, leaves, pulp, fruits, wood, bark, roots of these plants, preferably dried leaves thereof, are prepared using conventional extraction methods and extraction solvents, and appropriately mixed in the preparation. For example, it can mix | blend in the range of about 0.01 to 0.5 weight%.
上記成分以外には通常の製剤化に用いられる蔗糖、ぶどう糖、乳糖、澱粉、デキストリン類等の糖類、還元麦芽糖、ソルビトール、エリスリトール等の糖アルコール類、セルロース類、食物繊維、ビタミン類やカフェイン等の目的に即した成分、アスパルテーム、スクラロース、アセスルファムカリウム等の甘味料、および、クエン酸等の酸味料を適宜配合することができる。 In addition to the above components, sugars such as sucrose, glucose, lactose, starch, dextrin, etc., sugar alcohols such as reduced maltose, sorbitol, erythritol, celluloses, dietary fiber, vitamins, caffeine, etc. Ingredients suitable for the above purpose, sweeteners such as aspartame, sucralose, and acesulfame potassium, and acidulants such as citric acid can be appropriately blended.
本発明の口腔洗浄用固形製剤の形態としては錠剤が好ましく、常法に従って製造することができる。本発明の口腔洗浄用固形製剤は、口腔内で効果的に作用させるため、直接口に投入し、舌の上にて口中で溶解させながら舌苔を掻き出し、更に発泡させることが必要である。 As a form of the solid preparation for oral cleaning of the present invention, a tablet is preferable, and it can be produced according to a conventional method. The solid preparation for oral cleaning of the present invention needs to be directly put into the mouth, scraped out the tongue coating while being dissolved in the mouth on the tongue, and further foamed in order to act effectively in the oral cavity.
以下に実施例を挙げて、本発明を実施するための最良の形態について詳細に説明するが、本発明は以下の実施例に限定されるものではない。 Hereinafter, the best mode for carrying out the present invention will be described in detail with reference to examples, but the present invention is not limited to the following examples.
以下に、試験例を示して本発明の口腔洗浄用固形製剤について詳細に記載する。
［試験例１］
Below, a test example is shown and it describes in detail about the solid preparation for oral cavity washing | cleaning of this invention.
[Test Example 1]
この試験は、本発明の口腔洗浄用固形製剤の舌苔除去効果と強い口臭除去効果を調べるために行った。 This test was conducted in order to investigate the tongue coating removal effect and the strong bad breath removal effect of the solid preparation for oral cleaning of the present invention.
（１）試料の調製：この試験には次の試料を使用した。
１）試料１：ユズ完熟果の搾汁処理により得られるユズ果汁搾汁残渣５０ｇを温風の通風により乾燥させ乾燥物１０．４ｇを得た。本乾燥物をミルにより粉砕し粒径が約１〜２００μｍ（平均５０μｍ）の不溶性植物繊維を調製した。次に、甜茶乾燥葉粉末１０ｇに５０％エタノール１００ｍｌを加え、還流冷却器で１時間還流しながら抽出した。得られた抽出液を濾別し、溶媒を除去した後、凍結乾燥することにより抽出物として天然消臭物を２．３９ｇ得た。上記不溶性植物繊維を１．０重量％、発泡成分として炭酸水素ナトリウムを５．０重量％および酸化酵素を０．１重量％、天然消臭成分として甜茶抽出物を０．１重量％配合し、更に、以下の表４に記載の各成分を配合して錠剤(１．５ｇ、直径１９ｍｍ)を調製した。
２）試料２：試料１のうち不溶性植物繊維、発泡成分ともに配合しない錠剤を調製した。
３）試料３：試料１のうち、不溶性植物繊維を１．０重量％添加し、発泡成分を添加しない錠剤を調製した。
４）試料４：試料１のうち、不溶性植物繊維を１．０重量％添加し、発泡成分を３．０重量％添加した錠剤を調製した。
５）試料５：試料１のうち、不溶性植物繊維を１．０重量％添加し、発泡成分を１０．０重量％添加した錠剤を調製した。
６）試料６：試料１のうち、発泡成分を５．０重量％添加し、不溶性植物繊維を添加しない錠剤を調製した。
７）試料７：試料１のうち、不溶性植物繊維の配合量を０．５重量％に変更した錠剤を調製した。
８）試料８：試料１のうち、不溶性植物繊維の配合量を２．０重量％に変更した錠剤を調製した。
９）試料９：試料１のうち、天然消臭物を添加しない錠剤を調製した。
１０）試料１０：試料１のうち、酸化酵素を添加しない錠剤を調製した。
１１）試料１１：発泡成分の比較対照物として、試料１のうち、タンパク質分解酵素を３．０重量％配合し、不溶性植物繊維及び発泡成分を添加しない錠剤を調製した。
１２）試料１２：発泡成分の比較対照物として、試料１のうち、タンパク質分解酵素を３．０重量％添加し、発泡成分を添加しない錠剤を調製した。
１３）試料１３：不溶性植物繊維の比較対照物として、試料１のうち、口臭防止成分の銅クロロフィリンナトリウムを０．２重量％添加し、不溶性植物繊維及び発泡成分を添加しない錠剤を調製した。
１４）試料１４：不溶性植物繊維の比較対照物として、試料１のうち、口臭防止成分の銅クロロフィリンナトリウムを０．２重量％添加し、不溶性植物繊維を添加しない錠剤を調製した。
(1) Sample preparation: The following samples were used for this test.
1) Sample 1: 50 g of yuzu juice squeezed residue obtained by squeezing yuzu ripe fruit was dried with warm air to obtain 10.4 g of a dried product. The dried product was pulverized by a mill to prepare insoluble plant fibers having a particle size of about 1 to 200 μm (average 50 μm). Next, 100 ml of 50% ethanol was added to 10 g of dried tea leaf powder, and extraction was performed while refluxing for 1 hour with a reflux condenser. The obtained extract was filtered off, the solvent was removed, and freeze-dried to obtain 2.39 g of a natural deodorant as an extract. 1.0% by weight of the insoluble plant fiber, 5.0% by weight of sodium bicarbonate as a foaming component, 0.1% by weight of oxidase, 0.1% by weight of strawberry tea extract as a natural deodorant component, Furthermore, each component described in Table 4 below was blended to prepare a tablet (1.5 g, diameter 19 mm).
2) Sample 2: A tablet of Sample 1 containing no insoluble plant fiber or foaming component was prepared.
3) Sample 3: 1.0% by weight of insoluble plant fiber was added to Sample 1, and a tablet without the foaming component was prepared.
4) Sample 4: A tablet was prepared by adding 1.0% by weight of insoluble plant fiber and adding 3.0% by weight of the foaming component of Sample 1.
5) Sample 5: A tablet was prepared by adding 1.0% by weight of insoluble plant fiber and 10.0% by weight of the foaming component of Sample 1.
6) Sample 6: Among Sample 1, a tablet was prepared by adding 5.0% by weight of the foaming component and not adding insoluble plant fiber.
7) Sample 7: A tablet was prepared by changing the blending amount of the insoluble plant fiber to 0.5% by weight.
8) Sample 8: A tablet was prepared by changing the blending amount of insoluble plant fiber to 2.0% by weight.
9) Sample 9: Among samples 1, a tablet to which no natural deodorant was added was prepared.
10) Sample 10: Among samples 1, a tablet to which no oxidase was added was prepared.
11) Sample 11: As a comparative control of the foaming component, a tablet containing 3.0% by weight of proteolytic enzyme in Sample 1 and not containing insoluble plant fiber and foaming component was prepared.
12) Sample 12: As a comparative control of the foaming component, among the samples 1, 3.0% by weight of proteolytic enzyme was added, and a tablet without the foaming component was prepared.
13) Sample 13: As a control for comparison of insoluble plant fiber, 0.2% by weight of copper chlorophyllin sodium as a bad breath preventing component of Sample 1 was added, and a tablet to which insoluble plant fiber and foaming component were not added was prepared.
14) Sample 14: As a control for comparison of insoluble plant fiber, among samples 1, 0.2% by weight of copper chlorophyllin sodium as a bad breath prevention component was added, and a tablet without the addition of insoluble plant fiber was prepared.
（２）試験方法
パネラー１０名により、舌苔除去効果と強い口臭除去効果について次のとおり試験を行なった。試験当日、朝食及び歯磨きを行わない状態のパネラーの舌苔量及び口臭を測定し、続いて調製した錠剤１粒を舌上で適度に擦る様に作用させながら無くなるまで噛まずに摂取し、再び舌苔量及び口臭を測定した。舌苔量は、舌を写真撮影することで視覚により錠剤摂取前後の変化を観察し、表１の基準で分類した。評価データはパネラー１０名の平均で示した。口臭は、錠剤を舐める直前、舐めた直後、１時間後、２時間後に呼気を３Ｌ容量のにおい袋に採取し、官能パネラー５名が臭気を以下の表２に示したように判定し平均化した。錠剤摂取後の使用感は、摂取後に各パネラーが表３に示したように判定し平均化した。結果を表４に示す。
(2) Test method Ten panelists tested the tongue coating removal effect and the strong bad breath removal effect as follows. On the day of the test, we measured the amount of tongue coating and bad breath of the paneler without breakfast and toothpaste, then ingested one tablet without any chewing until it disappeared while acting appropriately rubbing on the tongue, and again tongue coating The amount and bad breath were measured. The amount of tongue coating was classified according to the criteria in Table 1 by visually observing changes before and after taking the tablet by taking a photograph of the tongue. The evaluation data is shown as an average of 10 panelists. The bad breath was immediately before licking the tablet, immediately after licking, and after 1 hour and 2 hours, exhaled breath was collected in a 3 L capacity odor bag, and five sensual panelists judged the odor as shown in Table 2 below and averaged it. . The usability after taking the tablets was determined and averaged by each paneler as shown in Table 3 after ingestion. The results are shown in Table 4.
（３）試験結果
表４の如く、不溶性植物繊維と発泡成分を配合した試料１は、不溶性植物繊維および発泡成分をいずれか、あるいは両方とも含まない試料２、３および６に比べ、顕著な舌苔除去効果を示した。また、試料１、４、５の結果から、発泡成分は３．０〜１０．０重量％が好ましい。また、試料１、７、８の結果から、不溶性植物繊維は約０．５〜２．０重量％が好適である。また、天然消臭成分を含まない試料９が同等の舌苔除去効果を示したことから、舌苔除去効果は不溶性植物繊維と発泡成分によると考えられる。また、試料１と１０の対比から、消臭効果は、酸化酵素を添加した方がより強かった。また、試料１２の結果から、タンパク質分解酵素にも同様の効果が見られたが、試料１と試料１２の対比から、タンパク質分解酵素よりも本発明の発泡成分の方が舌苔除去効果がより強かった。
(3) Test results As shown in Table 4, the sample 1 containing the insoluble plant fiber and the foaming component is more prominent than the samples 2, 3 and 6 that do not contain either or both of the insoluble plant fiber and the foaming component. The removal effect was shown. From the results of Samples 1, 4, and 5, the foaming component is preferably 3.0 to 10.0% by weight. In addition, from the results of Samples 1, 7, and 8, the insoluble plant fiber is preferably about 0.5 to 2.0% by weight. Moreover, since the sample 9 which does not contain a natural deodorant component showed the equivalent tongue coating removal effect, it is thought that the tongue coating removal effect is based on an insoluble plant fiber and a foaming component. Further, from the comparison of Samples 1 and 10, the deodorizing effect was stronger when oxidase was added. In addition, from the results of Sample 12, the same effect was observed for the proteolytic enzyme, but from the comparison of Sample 1 and Sample 12, the foam component of the present invention had a stronger effect of removing tongue coating than the proteolytic enzyme. It was.
また、試料１と試料１４との対比から、銅クロロフィリンナトリウムよりも本発明の不溶性植物繊維の方が、舌苔除去効果が強かった。 Moreover, from the comparison between Sample 1 and Sample 14, the insoluble plant fiber of the present invention was stronger in tongue coating removal effect than copper chlorophyllin sodium.
また、口臭については、試料９の結果から、天然消臭物を含まなくとも不溶性植物繊維と発泡成分を含むことにより口臭除去効果は発現した。試料１と１０との比較により、酸化酵素を添加した方がより口臭除去効果に即効性があった。同様に、試料３と試料１３との対比から、銅クロロフィリンナトリウムよりも本発明の不溶性植物繊維の方が、口臭除去効果において、摂取直後から効果が表れていた。更に、本発明の製剤の不溶性植物繊維および発泡成分の両者が適切に含まれる試料１は摂取直後において、顕著に口臭除去効果が高く、即効性に優れ、２時間後においても効果が維持されていた。また、試料６の結果から発泡成分のみでは、摂取直後は、口臭除去効果を示すが、１時間後では、効果は薄れ、２時間後では、顕著に薄れた。 Moreover, about the bad breath, from the result of the sample 9, even if it did not contain a natural deodorant, the bad breath removal effect was expressed by including an insoluble plant fiber and a foaming component. By comparing Samples 1 and 10, the effect of removing bad breath was more immediate when the oxidase was added. Similarly, from the comparison of Sample 3 and Sample 13, the insoluble plant fiber of the present invention was more effective in removing bad breath than the copper chlorophyllin sodium immediately after ingestion. Furthermore, Sample 1 containing both the insoluble plant fiber and the foaming component of the preparation of the present invention has an excellent effect of removing bad breath immediately after ingestion, is excellent in immediate effect, and the effect is maintained even after 2 hours. It was. In addition, from the results of Sample 6, the foaming component alone showed a bad breath removal effect immediately after ingestion, but the effect diminished after 1 hour, and was significantly diminished after 2 hours.
以上の試験結果から舌苔除去効果を有する不溶性植物繊維と発泡成分を含むことで口臭除去効果が認められ、さらに発泡成分を併用することで使用直後において顕著に優れた口臭除去効果及び持続効果を示すことが認められ、口腔内に与える感触が好ましいことが判明した。更には、酸化酵素を含むことにより、より優れた消臭効果が得られた。 From the above test results, the bad breath removal effect is recognized by including the insoluble plant fiber having a tongue coating removal effect and the foaming component, and further, the combined use of the foaming component shows a remarkably excellent bad breath removal effect and a sustained effect immediately after use. It was found that the feel given to the oral cavity was preferable. Furthermore, by including an oxidase, a more excellent deodorizing effect was obtained.
以上の試験結果から得られた本発明の口腔洗浄用発泡性固形製剤における実施例を記載して本発明を実施するための最良の形態について詳細に説明するが、本発明は以下の実施例に限定されるものではない。
［実施例１］
The best mode for carrying out the present invention will be described in detail by describing examples in the foamable solid preparation for oral cleaning of the present invention obtained from the above test results, but the present invention will be described in the following examples. It is not limited.
[Example 1]
ユズ完熟果の搾汁処理により得られるユズ果汁搾汁残渣５０ｇを温風の通風により乾燥させ乾燥物１０．４ｇを得た。本乾燥物をミルにより粉砕し粒径が約１〜２００μｍ（平均５０μｍ）の不溶性植物繊維を得た。次に、発泡成分の炭酸水素ナトリウムを添加した。次に、酸化酵素のポリフェノールオキシダーゼを添加した。次に、甜茶乾燥葉粉末１０ｇに５０％メタノール１００ｍｌを加え、還流冷却器で１時間還流しながら抽出した。得られた抽出液を濾別し、溶媒を除去した後、凍結乾燥することにより抽出物を２．３９ｇ得た。さらに以下に記載の各成分を配合して錠剤を調製した。 50 g of yuzu juice juice residue obtained by squeezing yuzu ripe fruit was dried by warm air to obtain 10.4 g of a dried product. The dried product was pulverized by a mill to obtain insoluble plant fibers having a particle size of about 1 to 200 μm (average 50 μm). Next, foaming component sodium bicarbonate was added. Next, the oxidase polyphenol oxidase was added. Next, 100 ml of 50% methanol was added to 10 g of dried tea leaf powder, and extraction was performed while refluxing for 1 hour with a reflux condenser. The obtained extract was separated by filtration, the solvent was removed, and lyophilized to obtain 2.39 g of the extract. Furthermore, each component described below was blended to prepare a tablet.
錠剤１ （重量％）
還元麦芽糖 ７０．７
食物繊維 １０．０
不溶性植物繊維（ユズ由来） １．０
炭酸水素ナトリウム ５．０
甜茶抽出物 ０．１
着色料 ０．５
乳化剤 １．５
酸味料 １０．０
甘味料 ０．１
酵素（ポリフェノールオキシダーゼ） ０．１
香料 １．０
Tablet 1 (wt%)
Reduced maltose 70.7
Dietary fiber 10.0
Insoluble plant fiber (derived from Yuzu) 1.0
Sodium bicarbonate 5.0
Green tea extract 0.1
Coloring agent 0.5
Emulsifier 1.5
Acidulant 10.0
Sweetener 0.1
Enzyme (polyphenol oxidase) 0.1
Fragrance 1.0
この錠剤は舌苔除去効果および口臭防止効果の即効性および持続性並びに呈味性のいずれにおいても優れていた。 This tablet was excellent in both the immediate effect and the sustainability and taste of the tongue coating removal effect and the bad breath prevention effect.
本発明の口腔洗浄用発泡性固形製剤は、前記のとおり、強い舌苔除去効果と即効性のある口臭除去効果並びに呈味性を有する携帯性に優れた口腔用固形組成物として利用可能である。 As described above, the foamable solid preparation for oral cleaning according to the present invention can be used as a solid composition for oral cavity having a strong tongue coating removing effect, an immediate effect of removing bad breath and a portability having taste.
Claims (6)
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| JP2008033773A JP5809775B2 (en) | 2008-02-14 | 2008-02-14 | Effervescent solid preparation for oral cleaning |
| PCT/JP2009/052419 WO2009102024A1 (en) | 2008-02-14 | 2009-02-13 | Foaming solid preparation for washing oral cavity |
| KR1020107010486A KR101590649B1 (en) | 2008-02-14 | 2009-02-13 | Foaming solid preparation for washing oral cavity |
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| CN105705128B (en) * | 2013-11-14 | 2019-06-28 | 荷兰联合利华有限公司 | Oral care composition |
| KR101591410B1 (en) | 2014-03-18 | 2016-02-03 | 김현수 | Effervescent Compositions Having Reinforced Stability and Preparing Methods thereof |
| CN107397805B (en) * | 2017-07-07 | 2018-06-08 | 山东统盛医药科技有限公司 | Improve oral hygiene, prevention and the composition and preparation method for the treatment of mouth disease |
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| KR100769573B1 (en) * | 2001-07-02 | 2007-10-23 | 주식회사 엘지생활건강 | Composition for tablet oral cavity washing agent containing enzymes |
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- 2008-02-14 JP JP2008033773A patent/JP5809775B2/en not_active Expired - Fee Related
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| KR20100124702A (en) | 2010-11-29 |
| WO2009102024A1 (en) | 2009-08-20 |
| KR101590649B1 (en) | 2016-02-01 |
| JP5809775B2 (en) | 2015-11-11 |
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