JP2009114176A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To solve the problem associated with conventional turmeric massage or cosmetics using dry powder of turmeric rhizomes dissolved in a carrier oil, which offer high beauty effect and are thus common in Asia, wherein yellow staining of the skin caused by curcumin, a fat-soluble component in turmeric, hinders their spread in Japan and beauty functions other than those imparted by turmeric are required. <P>SOLUTION: Fat-soluble components contained in turmeric rhizomes are extracted with an organic solvent, and the extract is subsequently treated with a bleaching agent to remove curcumin. Tetrahydrodemethoxydiferuloylmethanes, which are colorless endogenous metabolites of curcumin, are added to the extract from which curcumin has been removed. The obtained liquid is added to the carrier oil to produce a massage oil or added to an aqueous base comprising deep ocean water taken from a plurality of depths to produce a cosmetic. Fat-soluble components of shell ginger and Gotu Kola are also added to enhance cosmetic functions such as anti-inflammatory, antipruritic and anti-aging effects. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to cosmetics such as massage oil, facial cleanser, cosmetic liquid, lotion, gel, milky lotion, cream, soap, peeling, and pack that contain a turmeric component but do not dye the skin yellow, and a method for producing the same.

  Massage has been performed since ancient times for the purpose of enhancing the physiological and psychological functions of a living body by applying physical stimuli to the face, body, and feet, and its effect has been recognized by many people. Nowadays, as the means of alternative medicine, integrated medicine, and anti-aging medicine, its recognition is increasing and expectations are high. Recently, the massage industry, which is linked to tourism with the recognition of the global beauty salon and spa, has been remarkably developed.

Traditionally, massage oils are combined with various carrier oils (or base oils), and at the same time, various essential oils (aroma oils) are added to sedate, promote blood circulation, bactericidal, insecticidal, anti-inflammatory, and promote digestion. Functionality such as action, analgesic action, moisturizing action, anti-depressant action, emollient action is given. One method of massage is the famous turmeric massage in India and Asia. This is a massage method in which rhizome powder of autumn turmeric (curcuma longa) is dissolved in carrier oil and rubbed into the skin. It is a skin bactericidal, insecticidal, keratin softening (emollient), anti-light, anti-aging, The effect of beautifying skin is particularly remarkable, such as suppression of wrinkles, that is, collagen regeneration of skin. Turmeric massage is used in some parts of Japan because of its skin-beautifying effect, but curcumin, an active ingredient in turmeric, is a powerful dye that discolors its skin and is not popular.

Oils in which turmeric essential oil, curcumin is dissolved in cooking oil are provided as health foods. For example, it is described in Patent Documents 1 and 2.
Further, for example, Patent Document 3 discloses an external preparation for protecting against UV damage using tetrahydrocurcumin, which is a metabolic substance in the body produced by reduction of curcumin in the small intestine.
Curcumin is a powerful antioxidant, and anti-aging cosmetics that can prevent, prevent, and improve skin aging by preventing the degradation of the matrix components of skin cells by its antioxidant action are provided. For example, it is described in Patent Document 4.
Further, curcumin is provided as a skin external preparation for preventing aging and improving rough skin, formulated as a gelatinase activity inhibitor of skin cells. For example, it is described in Patent Document 5.
JP 2001-086931 A JP 2003-137799 A JP-A-6-128133 JP2001-139466 JP2002-80338

Traditionally, turmeric massage, which uses turmeric rhizome powder dissolved in carrier oil as a massage oil, has a strong skin effect, but curcumin (English name: curcumin) is a strong yellow dye, and the skin turns yellow by massage. However, there was a drawback that it was difficult to remove even with detergent.

The present invention removes curcumin from the fat-soluble component of turmeric and then adds a colorless tetrahydrodemethoxydiferuloylmethane mixture (tetrahydrocurcumin mixture) that is a metabolite of curcumin, which is equivalent to turmeric massage or The object is to provide a colorless massage oil that achieves a skin beautifying effect that is higher than that and that does not color the skin yellow.

First, turmeric is described. Turmeric is a plant belonging to the genus Turmeric, which is distributed and cultivated mainly in the tropical region from India to Indonesia, and in the subtropical regions such as Okinawa Prefecture and Amami Oshima, and about 50 species are known in Japan. (Scientific name: Curcuma Longa), Spring turmeric (Scientific name: Curcuma Aromatica), Gajutsu (purple turmeric) (Scientific name: Curcuma Zedoania Roscoe) are used as foods such as curry and health foods. Fat-soluble components contained in turmeric rhizomes include curcumin and essential oil, and the content of curcumin varies considerably depending on the species. Gadju (purple turmeric) is 0% (in dry matter) and spring turmeric is about 0.1 to 0. 5%, fall turmeric is about 1% to 5%. In addition, the essential oil component is contained in about 3% in the guts, 3-5% in the spring turmeric, and 2-5% in the autumn turmeric. In the present invention, the genus of turmeric such as autumn turmeric, spring turmeric, gadget, and other turmeric is generically referred to simply as turmeric.

Means for solving the above problems of the present invention will be described.
The first solution is to extract a fat-soluble component contained in the turmeric rhizome.
The second solution is to remove curcumin from the fat-soluble component extracted by the first solution.
A third solution is to add a mixture of tetrahydrodemethoxydiferroylmethanes instead of the removed curcumin.

The raw material turmeric is described. In order to obtain an extract containing only a fat-soluble component not containing curcumin from turmeric, a raw material with a small amount of curcumin is preferred, although it contains many essential oil components.
As described above, curcumin is not contained in gadget, so that an extract containing no curcumin can be directly obtained by using gadget powder as a raw material. However, gadgets have the disadvantage of having few essential oil components. Autumn turmeric has a high content of essential oils but a high content of curcumin, and the removal process is complicated and not economical. On the other hand, spring turmeric also contains a large amount of essential oil component, but curcumin content is a little less than that of autumn turmeric, the removal process is relatively easy, and it is most preferable as a raw material.

Next, a method for extracting the fat-soluble component contained in the turmeric rhizome, which is the first solution means, will be described. Spring turmeric rhizome powder is mixed with carrier oil and extracted by heating at 40 to 120 ° C. The essential oil can be easily extracted, but curcumin is preferably 60 to 70 ° C. as a temperature at which it is difficult to extract. The extraction time is from 30 minutes to several hours. Alternatively, there is a method of leaving at room temperature for several hours to several months. On the other hand, only the fat-soluble component excluding curcumin can be extracted by the supercritical carbon dioxide extraction method. Since curcumin cannot be extracted by supercritical carbon dioxide extraction, it is convenient to extract only fat-soluble components excluding curcumin. Since the resulting extract is 100% essential oil component, it is diluted with carrier oil before use. There is also a method in which powder extracted from methanol and ethanol and then free of methanol and ethanol is dissolved in carrier oil.

The carrier oil referred to here is apricot kernel oil, avocado oil, aloe oil, olive oil, grape seed oil, carophyllum inophilum oil, coconut oil, wheat germ oil, sweet almond oil, sesame oil, evening primrose Oil, peanut oil, sunflower oil, hazelnut oil, jojoba oil, polydi oil, macadamia nut oil, rosehip oil, calendula oil, carrot oil, squalane oil, diacylglycerol, castor oil, soybean oil, sesame oil, rapeseed oil, corn oil, peanut oil From vegetable oil such as germ oil, perilla oil, safflower oil, rice oil, cottonseed oil, or animal oil such as beef tallow, lard, fish oil, egg oil, rib chicken egg oil, snake oil, EPA, DHA, etc. Choice Those were.
In addition to the carrier oil, the organic solvent includes methanol, ethanol, 1,3BG and the like.

Next, a second solution means for removing curcumin from the fat-soluble component extracted by the first solution means will be described. In order to remove curcumin from an extract extracted from spring turmeric as a raw material with carrier oil, a dye adsorbent such as activated clay and activated carbon is effective. Other adsorbents may be used as long as they are effective for removing curcumin. On the other hand, as described above, according to the supercritical carbon dioxide extraction method, only the fat-soluble component excluding curcumin can be extracted.

Next, the third solution will describe the addition of a mixture of tetrahydrodemethoxydiferroylmethanes in place of the removed curcumin.
A mixture of tetrahydrodemethoxydiferroylmethanes is a mixture of the generic names tetrahydrocurcumins, and when curcumin is absorbed from epithelial cells of the small intestine when turmeric is ingested, It has a structure in which two double bonds in the chain part are opened and 4 hydrogen atoms are added, and it is a fat-soluble component like curcumin, dissolves well in carrier oil, and is colorless. The antioxidant effect is greater than that of curcumin, and the anti-aging effect is proportionally greater. Moreover, this component is a component of the component display name list of the Japan Cosmetic Industry Association. Therefore, after removing curcumin, a colorless oil having an effect equivalent to that of turmeric massage oil can be produced by adding a mixture of tetrahydrodemethoxydiferroylmethanes.
The tetrahydrodemethoxydiferuloylmethane mixture is a mixture of tetrahydrodemethoxydiferuloylmethane (scientific name: Tetrahydrodemethoxydiferuloylmethane), tetrahydrobisdemethoxydiferuloylmethane, and tetrahydrodiferuloylmethane. Naturally, there is a mixture of curcumins (also called curcuminoids), that is, a mixture of curcumin, demethoxycurcumin, bisdemethoxycurcumin, and tetrahydrodemethoxydiferuloyl by reducing the natural curcumin mixture. A methane mixture is produced.

Tetrahydrodemethoxydiferroylmethane mixtures can be produced by chemically reducing and using curcuminoids contained in large quantities in autumn turmeric as starting materials, and by reductive fermentation of microorganisms. Tetrahydrodemethoxydiferroylmethane mixtures are extremely safe because they are metabolites in the body. However, separating each component from the tetrahydrodemethoxydiferroylmethane mixture alone is complicated and not economical. Therefore, the present invention can be produced economically by using a mixture of tetrahydrodemethoxydiferroylmethanes. A highly concentrated extract produced using carrier oil as a solvent is referred to as an oil-based stock solution.

If a required amount of the oil-based stock solution thus produced is added to a favorite carrier oil, a massage oil that does not dye the skin yellow despite the inclusion of the turmeric component can be produced. So far, oil-based cosmetic massage oil has been described. The carrier oil used here is referred to as an oil-based substrate in the present invention.

On the other hand, cosmetics include oil-based massage oils and water-based cosmetics, that is, lotions, facial cleansers, cosmetic liquids, gels, milky lotions, creams, soaps, peelings, packs, and the like. In order to produce these water-based cosmetics, the fat-soluble component of turmeric, a mixture of tetrahydrodemethoxydiferroylmethanes, must be dissolved in water. Therefore, the above components can be dissolved in water by dissolving them in an aqueous organic solvent such as ethanol, methanol or 1,3BG instead of an oily carrier oil. Further, curcumin can be removed by using an activated clay or a decolorizing agent for activated carbon. The high-concentration extract produced by the above method is referred to as an aqueous stock solution.

Next, a method for producing a water-based cosmetic will be described.
1. In the case of lotion, the required amount of the obtained aqueous undiluted solution is added to raw water, that is, double-layer deep water, or distilled water, purified water, tap water, deep ocean water, spring water, well water, mountain water, etc. Can be obtained.
2. In the case of a cosmetic liquid, the obtained aqueous stock solution can be obtained by adding it to the raw material water at a high concentration.
3. In the case of gel, the obtained aqueous undiluted solution can be obtained by adding a required amount to the gel base material composed of the raw material water and xanthan gum, carbomer, aloe, mozuku, collagen and the like.
4). In the case of an emulsion, the obtained aqueous stock solution can be obtained by adding a required amount to an emulsion base material composed of the raw material water.
5). In the case of a cream, the obtained aqueous undiluted solution can be obtained by adding a required amount to the cream base material composed of the raw material water.
6). In the case of soap, it can be obtained by adding a required amount of the obtained extract to a soap base composed of the raw material water.
Similarly, other water-based cosmetics can be produced. In addition, lotion, beauty water, gel base material, emulsion base material, cream base material, soap base material, peeling base material, pack base material, etc. using the above raw water used here are collectively referred to as an aqueous base material. Called.

  Next, the two-layer deep water and the multi-layer deep water used in the water-based cosmetic of the present invention will be described. Usually, deep ocean water is obtained by taking seawater deeper than 200 m, and purified water obtained by a reverse osmosis membrane is used in cosmetics. However, there is research that deep ocean water is toxic to organisms at a certain depth, that is, water taken from only one layer is not preferable as cosmetic raw material water. On the other hand, if the deep sea water taken from two layers of 200m to 1000m and deeper than 1000m is mixed to the required ratio and diluted more than 100 times, preferably 1000 to 2000 times, the toxicity of deep sea water disappears and replaced. It has been found that there are favorable functionalities such as burn or tanning skin regeneration, improving atopy. In the present invention, deep water from 400 m to 800 m, preferably 600 m, and two kinds of deep water from 1,000 m to 2000 m, preferably 1400 m are mixed in a required ratio, and distilled water is mixed. Water that has been diluted 1000 times to 2000 times in purified water, spring water, well water, mountain water, etc. is used as raw material water for water-based cosmetics. In the present invention, raw water using two layers of deep water is referred to as two-layer deep water. Further, the depth of water intake is not limited to the above two layers, and deep water taken in a plurality of layers having different depths may be used. In the present invention, two or more layers (including two layers) of deep water are mixed, and raw water diluted 100 times or more in distilled water, purified water, spring water, well water, mountain water, etc. To tell. By the way, if you identify the intake point of deep ocean water, it is around 30km south of Itoman City, Okinawa Prefecture.

The method for producing cosmetics using turmeric as a raw material has been described above. In addition to turmeric, ingredients that provide a skin-beautifying effect and synergistic effects, such as anti-inflammatory action, anti-wrinkle action, atopy improving action, moisturizing action, anti-aging action, etc. will be described.
First, the fat-soluble component of moon peach is described. Moon peach is a perennial evergreen vegetation belonging to the genus Ganoderma of the same ginger family as turmeric, and is native to Okinawa and Taiwan. The moon peaches include the Okinawa Tsuki-Momo (which grows naturally in Okinawa) (scientific name: Alpinia Speciosa) and the Owaki Tsuki-peach (scientific name: Alpinia Uraiensis).
The fat-soluble component of moon peach is contained in all of the leaves, stems, and roots, although there are differences in content, and any part is used as a raw material, but the parts of leaves and stems are most preferable in terms of economy. As a raw material, a large harvest moon peach is preferable, but any kind of Okinawa moon peach may be used.
Tsuki-Momo is a highly volatile essential oil component that can be extracted by steam distillation, and contains dozens of ingredients such as β-pinene, cineol, methyl cinnamate, and isothymol. It is used as a peach extract in cosmetics, foods, bactericides, deodorants and the like.
On the other hand, heavy non-volatile components with a large molecular weight that cannot be extracted by steam distillation contain cavine (dihydro-5,6-dehydrocaine), which has an action of promoting the synthesis of collagen in the skin and an action of inhibiting the degradation of collagen. There are studies that are effective in maintaining elasticity and elasticity.

Next, a method for extracting the fat-soluble component of moon peach is described. Moon peach is extracted by supercritical carbon dioxide extraction method like turmeric, and after extracting fat-soluble components with organic solvents such as methanol, ethanol, propanol, 1,3 butylene glycol, propylene glycol and carrier oil, the extract is used as a carrier. Add to oil. Alternatively, there is a method of obtaining a fat-soluble component by separating water from an oil / water mixture squeezed by pressing extraction. By extracting moon peach with an organic solvent, it is possible to extract not only the components obtained by steam distillation but also the wine that cannot be obtained by steam distillation. Since the moon peach extract is colored in the same manner as the turmeric extract, a transparent moon peach component-containing oil can be obtained by decolorizing with a dye adsorbent such as activated clay or activated carbon.
In this case, the oil stock solution extracted with carrier oil can be used as massage oil, or methanol. The aqueous stock solution extracted with ethanol and 1,3BG can be used for aqueous cosmetics.

Next, we will describe the box. Clover (scientific name: Centella asiatica) (English name: Gotu Kola)
Originally an Indian herb, the most important rejuvenating herb in Ayurveda, it activates nerves and brain cells mainly by oral seizure. As a result of experiments, it was found that moisturizing and anti-aging effects (rejuvenation effects) are enhanced by ingesting or applying to skin. Ribbon is now used in places other than Ayurveda, and is regularly consumed as a drink in Thailand and as a vegetable in other Asian countries.
Active ingredients include alkaloids, glycosides (sancnicide asiatic acid, asiaticoside, etc.), sterols, tannins, amino acids, minerals, saponins, triterpenes, etc. The main ingredients are fat-soluble asiatico. The side is known. In order to extract an active ingredient from a camellia, it can be extracted with an organic solvent like the moon peach. The use area of the camellia is leaves, stems or whole plants.
In this case, the oil stock solution extracted with carrier oil can be used as massage oil, or methanol. The aqueous stock solution extracted with ethanol and 1,3BG can be used for aqueous cosmetics.

To extract fat-soluble ingredients from turmeric, moon peach, and camellia, soak and extract each herb dry powder in a solvent, then mix the required amount of each ingredient and all herbs together and extract Any of the methods may be used. Alternatively, each herb may be extracted with methanol or ethanol instead of the herb powder and then dried.

The above findings and the results of the present invention were confirmed by confirming the skin-beautifying effect by using examples of massage products and beauty salons on the spot, and the present invention is combined with the fat-soluble components of turmeric, moon peach, and camellia. Provided are cosmetics such as colorless massage oils and cosmetics that achieve a further skin beautifying effect due to the synergistic pharmacological effect of deep-layer water and the skin is not colored yellow.

Since the effects as shown in Table 1 described below have been confirmed, the present invention can be used not only as massage oil and cosmetics but also as a skin disease drug. The cosmetic of the present invention includes a skin disease drug.

As described above, the cosmetic of the present invention can be used with confidence that the skin is not colored yellow in spite of the use of the turmeric component, and can provide a skin-specific skin effect unique to turmeric.
Furthermore, cosmetics having an anti-inflammatory effect, an anti-wrinkle effect, a moisturizing effect, an anti-aging effect and the like could be obtained by adding the moon peach and the camellia component.

本発明は美肌効果のうち特に痒み、炎症、つるつる感、保湿に短時間で効果が確認できた。 Next, Table 1 shows the experimental results obtained by applying the massage oil of the present invention to the human body. The subjects were calculated as 13 healthy men and women except for the skin of teenagers to 70s, and 1 site. The application method was dripped 2 to several drops depending on the site. The application was performed once a day in the morning and evening, and the number of applications was from 1 day to 2 months depending on the site.

The effect of the present invention was confirmed in a short time especially for itching, inflammation, slipperiness and moisturizing among the skin beautifying effects.

Examples are as shown below.

Example 1 of the oil-based cosmetic of the present invention will be described below.
4 g of dried spring turmeric rhizome powder is mixed with 100 ml of grape seed oil and extracted by heating at 70-80 ° C. for 30 minutes. The obtained extract is subjected to solid-liquid separation. Add 2 to 3% of activated clay to the separated liquid and heat at 70 ° C. with stirring for 15 minutes. After confirming that curcumin has been removed, a transparent oil (1) is obtained by filtration.

Next, 1 g of a tetrahydrodemethoxydiferroylmethane mixture is mixed with 100 ml of grape seed oil and dissolved by heating at 70 to 80 ° C. for 30 minutes. Activated clay 2-3% is added to the obtained liquid, and it heats for 15 minutes, stirring at 70 degreeC. After confirming that it has been decolorized, it is filtered to obtain a transparent oil (2).

4 g of dry powder of moon peach leaves is mixed with 100 ml of grape seed oil and heated and extracted at 70-80 ° C. for 30 minutes. The obtained extract is subjected to solid-liquid separation. Add 2 to 3% of activated clay to the separated liquid and heat at 70 ° C. with stirring for 15 minutes. After confirming that it has been decolored, it is filtered to obtain a transparent oil (3).

4 g of dry powder of all cypress plants are mixed with 100 ml of grape seed oil and extracted by heating at 70-80 ° C. for 30 minutes. The obtained extract is subjected to solid-liquid separation. Add 2 to 3% of activated clay to the separated liquid and heat at 70 ° C. with stirring for 15 minutes. After confirming that it has been decolorized, it is filtered to obtain a transparent oil (4).

Add 2-3% of oil (1), oil (2), oil (3) and oil (4) to your favorite carrier oil such as grape seed oil, jojoba oil, squalane, etc. Manufactured. Add oil (1), oil (3), and oil (4) to increase the effect of turmeric, moon peach, and camellia. On the other hand, a large amount of oil (2) is added to enhance the antioxidant function.

Next, Example 2 about water-based cosmetics will be described.
4 g of dried spring turmeric rhizome powder is mixed with 100 ml of 1,3BG and extracted. The obtained extract is subjected to solid-liquid separation. Add 2-3% of activated carbon to the separated liquid and leave it for 30 minutes with stirring. After confirming that curcumin has been removed, a transparent liquid (5) is obtained by filtration.

Next, 1 g of a tetrahydrodemethoxydiferroylmethane mixture is dissolved in 100 ml of 1,3BG. To the obtained liquid, 2-3% of activated carbon is added and left for 30 with stirring. After confirming that the color has been removed, a transparent liquid (6) is obtained by filtration.

4 g of dry powder of moon peach leaves is mixed with 100 ml of 1,3BG and extracted. The obtained extract is subjected to solid-liquid separation. Add 2-3% of activated carbon to the separated liquid and leave it for 30 minutes with stirring. After confirming that the color has been removed, a transparent liquid (7) is obtained by filtration.

4 g of dry powder of camellia whole plant is mixed with 100 ml of 1,3BG and extracted. The obtained extract is subjected to solid-liquid separation. Add 2-3% of activated carbon to the separated liquid and leave it for 30 minutes with stirring. After confirming decolorization, the solution is filtered to obtain a transparent liquid (8).

Toner lotion was produced by adding 2-3% of each of the obtained liquid (5), liquid (6), liquid (7), and liquid (8) to double-layer deep water.

In Example 2, the method for producing the lotion was described, but in Example 3, another method for producing the water-based cosmetic is described.
1. In the case of a cosmetic liquid, 3 to 10% of each of liquid (5), liquid (6), liquid (7), and liquid (8) was added to double-layer deep water.
2. In the case of the gel, it was produced by adding 2-3% of each of the liquid (5), the liquid (6), the liquid (7), and the liquid (8) to the gel base material produced by the double layer deep water.
3. In the case of the emulsion, it was produced by adding 2-3% of each of the liquid (5), the liquid (6), the liquid (7), and the liquid (8) to the emulsion base material produced by the double layer deep water.
4). In the case of the cream, 2-3% of each of the liquid (5), the liquid (6), the liquid (7), and the liquid (8) was added to the cream base material that was manufactured with the double layer deep water.
5). In the case of soap, it was produced by adding 2-3% of each of the liquid (5), liquid (6), liquid (7), and liquid (8) to a soap base made of double-layer deep water.

As described above, the present invention can be used for dermatological drugs by utilizing functionality in addition to being used for massage oil and cosmetics.

Claims (5)

A cosmetic comprising a fat-soluble component obtained by removing curcumin from a fat-soluble component contained in a turmeric rhizome and a mixture of tetrahydrodemethoxydiferroylmethanes. The cosmetic according to claim 1, further comprising a fat-soluble component contained in the leaves and / or stems of moon peach and / or a fat-soluble component contained in the whole plant of camellia. The step of extracting fat-soluble components contained in the turmeric rhizome, the step of removing curcumin from the extracted solution, the step of adding a mixture of tetrahydrodemethoxydiferroylmethanes, and the resulting solution as an oil-based substrate or aqueous system The cosmetic according to claim 1 or 2, and a method for producing the same, wherein the cosmetic is added to a base material. 4. The cosmetic according to claim 3, further comprising a fat-soluble component contained in the leaves and stems of moon peach and / or a fat-soluble component contained in the whole plant of camellia. 5. The cosmetic according to claim 1, wherein the oil-based base material is a carrier oil, and the water-based base material is composed of multiple layers of deep water.