JP2009046412A - Oral administration adjuvant composition for pet - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an oral administration adjuvant composition for pets in order to easily orally administer a drug to the pets such as a dog or a cat without deteriorating the pharmacodynamic effects. <P>SOLUTION: The oral administration adjuvant composition for the pets comprises (a) a gelling agent, (b) a protein hydrolyzate and (c) water. The oral administration adjuvant composition may further comprise (d) a sugar or a sugar alcohol and may further comprise (e) a flavor. The protein hydrolyzate (b) is preferably a collagen peptide. The sugar alcohol (d) is preferably erythritol. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to an oral administration adjuvant composition for pets for facilitating oral administration of drugs.

Conventionally, it is known that patients who have difficulty in swallowing, children, elderly people and the like have difficulty in swallowing drugs even when using normal drinking water.
A drug containing water and glue for facilitating or facilitating swallowing of a drug without giving difficulty or a foreign body feeling to such patients, children, elderly people, etc. who have difficulty swallowing A swallowing assistance drink is known (for example, Patent Document 1).
JP-A-11-124342

Such conventional swallowing assistance drinks are used for people who have difficulty swallowing, for example, patients, children, and elderly people, and have been developed in consideration of human preferences. Therefore, it is not clear whether the above-mentioned swallowing assistance drink can be suitably used for pets such as dogs and cats other than humans.
Even if pets such as dogs and cats are mixed with food or the like, they may not eat the food itself or may only extract the drug.
Moreover, when the present inventors used the same swallowing assistance drink as a human for a pet in order to make a medicine easy to drink, since a pet's taste differs from a human's taste, a pet does not drink a swallowing assistance drink. It has been found that there are cases where drugs are expelled.

  The present invention has been made in view of such problems of the prior art, and its object is to easily orally administer drugs to pets such as dogs and cats without impairing their efficacy. An object of the present invention is to provide an oral dosage auxiliary composition for pets.

  As a result of intensive studies to achieve the above object, the present inventors have found that by using a protein hydrolyzate, it is possible to encapsulate a drug and easily orally administer the drug to a pet. It came to be completed.

  That is, the oral administration adjuvant composition for pets of the present invention comprises (a) a gelling agent, (b) a protein hydrolyzate, and (c) water.

  Moreover, the suitable form of the oral administration adjuvant composition for pets of this invention is characterized by further containing (d) sugar or sugar alcohol.

  Moreover, the suitable form of the oral administration adjuvant composition for pets of this invention is characterized by further containing (e) flavor.

Moreover, the suitable form of the oral administration adjuvant composition for pets of this invention is characterized by the said protein hydrolyzate (b) being a collagen peptide.

Moreover, the suitable form of the oral administration adjuvant composition for pets of this invention is characterized by containing an erythritol as said sugar alcohol (d).

  Moreover, the suitable form of the oral administration adjuvant composition for pets of this invention is characterized by the content rate of the said gelatinizer (a) being 0.5-12.0 mass%.

  Moreover, the suitable form of the oral administration adjuvant composition for pets of this invention is characterized by the content rate of the said protein hydrolyzate (b) being 1.0-40.0 mass%.

  Moreover, the suitable form of the oral administration adjuvant composition for pets of this invention is characterized by the content rate of the said sugar or sugar alcohol (d) being 1.0-10.0 mass%.

  ADVANTAGE OF THE INVENTION According to this invention, the oral administration adjuvant composition for pets for easily orally administering a chemical | medical agent with respect to pets, such as a dog and a cat, can be provided by using protein hydrolyzate.

Hereinafter, the molded article of the present invention will be described in detail. In the present specification, “%” means mass percentage unless otherwise specified.
As described above, the composition for oral administration adjuvant for pets of the present invention contains (a) a gelling agent, (b) a hydrolyzed protein, and (c) water.
Here, (c) water is sufficient as long as it is suitable for ordinary pet beverages. For example, tap water, various ion-exchanged water, purified water, and the like can be used.
The water content relative to the total amount of the pet oral administration adjuvant composition is not particularly limited, but is preferably 36.0 to 98.5%.

In addition, (a) as a gelling agent, it is sufficient if it is mixed almost uniformly with water to impart viscosity or promote gelation. Specifically, agar, carrageenan, gellan gum, fur celerane , Gelatin, pectin, curdlan, locust bean gum, tara gum, guar gum, xanthan gum, alginic acid, alginate, azotobacter vinegar gum, cassia gum, silium seed gum, tamarind gum, CMCNa (carboxymethylcellulose Na) or CMCCa, whey Mention may be made of proteins, starches, modified starches, and any mixtures thereof.
The content of the gelling agent (a) is preferably 0.5 to 12.0%, more preferably 0.5 to 10.0%, and particularly preferably 1.0 with respect to the total amount of the pet oral administration adjuvant composition. ~ 10.0%.
When the gelling agent content is 0.5 to 12.0%, the composition for oral administration adjuvant for pets regardless of the form of the drug such as liquid, powder, granule, tablet, etc. Can be wrapped in. Also, if the content of the gelling agent is within the above range, it is possible to suppress an increase in the calories of the oral dosage auxiliary composition for pets of the present invention, so that the pet's caloric intake is not excessive, The drug can be easily orally administered to pets.
In addition, when the content rate of a gelatinizer is less than 5.0%, it can use suitably also when administering a chemical | medical agent orally through a catheter, for example besides direct oral administration to the mouth of a pet.

Examples of (b) protein hydrolyzate include those obtained by hydrolyzing a protein with an enzyme or enzyme preparation such as peptidase or protease to reduce the average peptide chain length and molecular weight. Among these, it is preferable to use a collagen peptide.
Pets such as dogs and cats prefer protein-based tastes, but generally proteins tend to reduce the gelling ability of gelling agents.
Collagen peptides can provide a protein-based taste that pets prefer without reducing the gelling ability of the gelling agent.
In addition, collagen peptides have good solubility in water, and therefore can mask bitter components (for example, L-arginine and the like) of drugs that dissolve in water. In addition, when the composition for oral administration of pets of the present invention enters the body of a pet, the masking function and the wrapping function are lost due to body temperature, moisture, etc., thereby inhibiting the drug from disintegrating and dissolving in the body. It does not affect the efficacy.
In addition, since collagen peptides have little influence on food texture such as an increase in viscosity, by using the composition for oral administration adjuvant for pets of the present invention, it is possible to wrap the drug so that the throat is improved.
Furthermore, the collagen peptide itself has functions such as skin affinity and a moisturizing effect, and has advantages such as improving pet skin and hair.
The molecular weight of the collagen peptide is preferably 200-9900.

The protein raw material of the protein hydrolyzate is not particularly limited, and examples thereof include animals (for example, cows, pigs, birds, etc.) or seafood (for example, shark, ray, thailand, sardines, mackerel, flounder, flounder, skipjack, Tuna, scallops, clams, swordfish, shrimps, crabs, etc.) or plants (eg, soybeans, wheat, etc.) can be used.
Also, the method for producing protein hydrolyzate is not particularly limited, and for example, animals (including animal parts such as bones, skin, meat, tendons, etc.) or seafood (fish parts such as bones, Protein, collagen, or gelatin obtained by adding water to a skin, meat, scales, float, shell, etc.) or plant (including plant parts, eg, seeds), etc., and heating and / or pressure extraction It is possible to obtain a protein hydrolyzate by concentrating and purifying the low molecular weight product obtained by enzymatic treatment with a reverse osmosis membrane, if necessary, after reducing the molecular weight with an enzyme or enzyme preparation such as peptidase or prosthesis it can.

The content of (b) protein hydrolyzate with respect to the total amount of the composition for oral administration adjuvant for pets is preferably 1.0 to 40.0%, more preferably 1.0 to 35.0%, and particularly preferably 4.0. ~ 30.0%.
Pet's palatability will become favorable in the content rate of a protein hydrolyzate being 1.0-40.0%.
In addition, if the content of the protein hydrolyzate is within the above range, an increase in calories of the oral dosage auxiliary composition for pets of the present invention can be suppressed as much as possible. Without the need to easily orally administer the drug to the pet.

Moreover, the oral administration adjuvant composition for pets of this invention can contain (d) saccharide | sugar or saccharide alcohol further.
Examples of the saccharide include sucrose, oligosaccharide, glucose, fructose, maltose, and lactose. Examples of the sugar alcohol include sorbitol, erythritol, xylitol, D-mannitol, maltitol, lactitol, and reduced palatinose. One or two of these can be used. Of these, erythritol is preferably used. The sugar alcohol may be an extract from a natural product, a synthetic product, or a commercially available product.
The oral dosage adjuvant composition for pets of the present invention further comprises (d) a saccharide or a saccharide alcohol, so that the dispersibility of the gelling agent in water is improved and the dispersion time is shortened to improve the production efficiency. Can be made.
The content of (d) saccharide or saccharide alcohol with respect to the total amount of the composition for oral administration adjuvant for pet is preferably 1.0 to 10.0%, more preferably 1.0 to 7.0%, and particularly preferably 1. 0 to 5.0%.
When the content of the saccharide or saccharide alcohol is 1.0 to 10.0%, the dispersibility of the gelling agent in water is improved and the dispersion time is shortened without reducing the palatability of the pet. Can do. Moreover, the raise of a calorie can also be suppressed as this content rate exists in said range.

Moreover, the oral administration adjuvant composition for pets of the present invention may further contain (e) a flavor.
(E) Examples of the flavor include beef extract and Thai (salmon) extract. Not only these extracts and the like, but also those having other odor components preferred by pets, for example, seasonings derived from fish and meat may be used.
In addition, in this specification, a flavor means what contains an odor component, for example, a seasoning etc. are also used as a flavor.
Moreover, it is preferable to use a water-soluble flavor. Although the content rate of the flavor with respect to the oral administration adjuvant composition for pets whole quantity is not specifically limited, Preferably it is 0.01 to 2.0%.

  In addition, the oral administration adjuvant composition for pets of the present invention has (a) a gelling agent, and (a) a gelling agent, In addition to b) protein hydrolyzate, (c) water, (d) saccharides or saccharide alcohols, and (e) flavor, gelation accelerators and other additives may be added. Examples of the additive include gelling aids such as dextrin.

  The liquid property of the composition for oral administration of pets of the present invention is preferably pH 3-9, more preferably pH 4-8. When the liquid property of the oral administration adjuvant composition for pets is within the above range, it tends to be a gel having an appropriate viscosity, and the drug can be wrapped regardless of the form of the drug. Moreover, since a pet shows favorable palatability | liquidity, it is preferable that liquidity is in the said range.

Moreover, the property of the oral dosage auxiliary composition for pets of the present invention is a viscous liquid to a gel at normal temperature. Specifically, in the case of a viscous liquid, the viscosity at 20 ° C. is preferably 500 to 25000 cps, more preferably 1000 to 4000 cps. In the case of a gel, the jelly strength at 20 ° C. is preferably 10 to 100 g / cm ² . If the properties of the oral dosage adjuvant composition for pets are within the above range, the drug can be wrapped regardless of the form of liquid, powder, granules, pills, capsules, tablets, etc. Show a good taste.

Next, an example of a method for producing an oral dosage auxiliary composition for pets will be described with reference to the drawings. In addition, the manufacturing method of the oral administration adjuvant composition for pets is not limited to the method demonstrated below.
FIG. 1 is a flow chart showing an example of a production process of an oral dosage auxiliary composition for pets.
First, the step of preparing (a) a gelling agent, (b) a protein hydrolyzate and (c) water will be described.
As shown in FIG. 1, (a) gelling agent and (b) protein hydrolyzate are each separately mixed with (c) water, and then water and protein hydrolyzate mixture A and water and gelled. It is preferable to mix the mixture C of the agents.
Specifically, first, water and protein hydrolyzate are mixed in a mixing tank. The water to be mixed with the protein hydrolyzate is preferably slightly warm water of 40 ° C. or lower. Moreover, mixing of the water and protein hydrolyzate in a mixing tank mixes protein hydrolyzate in the ratio of 4.0-60.0 weight part preferably with respect to 100.0 weight part of water.
In addition, as a mixing method, it is preferable to add the protein hydrolyzate to the water in the mixing tank in a plurality of times and mix the protein hydrolyzate and water while stirring with stirring means such as a hand mixer.
The residence time of water and protein hydrolyzate in the mixing tank is preferably 0.5 to 15 minutes, and the stirring speed of the stirring means is preferably 50 to 3000 rpm.
And the mixture A which mixed water and protein hydrolyzate is thrown in in a preparation pot.

In the case where (d) saccharide or saccharide alcohol is added to an oral administration adjuvant composition for pets, first, (a) a gelling agent and (d) saccharide or saccharide alcohol are mixed with powder, It is preferable to mix the powder mixture B with water. The method of powder mixing the gelling agent and the saccharide or saccharide alcohol is not particularly limited. For example, a commonly used powder mixer such as a rocking mixer or a V-type mixer may be used. it can.
The powder mixing of the gelling agent and saccharide or saccharide alcohol is 1 to 10 times as much saccharide or saccharide alcohol as the gelling agent (gelling agent: saccharide or saccharide alcohol is 1: 1 to 10). It is preferable to mix at a ratio.

The gelling agent or powder mixture B is first mixed with water in a mixing tank. As the water to be mixed with the gelling agent or the powder mixture B, it is preferable to use slightly warm water of 40 ° C. or less. In mixing the water and the gelling agent, the gelling agent is preferably mixed at a ratio of 1.0 to 30.0 parts by weight with respect to 100.0 parts by weight of water.
Moreover, mixing of water and the powder mixture B mixes the said powder mixture with the ratio of 5.0-60.0 weight part preferably with respect to 100.0 weight part of water.
And the mixture C which mixed water and a gelling agent or water and a powder mixture (gelling agent and saccharide | sugar or saccharide alcohol) is thrown in in a preparation pot.

The mixture A and the mixture C thrown into the preparation kettle are stirred by stirring means such as a stirring blade.
When the composition for oral administration adjuvant for pets contains (e) flavor, add (e) flavor into the above-mentioned preparation kettle and add an appropriate amount of water to make the entire mixture an appropriate amount. Fill up and fill the service tank with these mixtures.
Prior to filling the mixture into the tank, the mixture may be passed through a strainer and homogenized so that the gelling agent and protein hydrolyzate are not clumped in the mixture.
In the step of preparing (a) gelling agent, (b) protein hydrolyzate and (c) water, gelation of the mixture in the preparation step is prevented, and the ease of filling and accuracy are maintained while maintaining fluidity. From the viewpoint of increasing the safety, it is preferable to carry out the preparation while maintaining the temperature of the mixture at 40 ° C. or lower.

Next, the desired mixture is filled into the desired container and heated for sterilization. By heating, the gelling agent dispersed in the mixture is dissolved, and an oral administration adjuvant composition containing (a) gelling agent, (b) protein hydrolyzate and (c) water is obtained. it can.
The sterilization is preferably performed by retort sterilization. In the case of retort sterilization, it is not necessary to add a preservative, so that it is possible to obtain an oral administration auxiliary composition for pets maintained in a pH 4-8 region preferred by pets such as dogs and cats.
Specifically, a retort pouch or the like is used as a packaging container, and the mixture is put into the retort pouch and sealed and packaged.
The packaged mixture is put into a pressure steam sterilizer (for example, an autoclave) and subjected to retort sterilization for a predetermined time while applying pressure. In order not to impair the pet's palatability with respect to the oral administration adjuvant composition for pets, the heating temperature is preferably 115 to 125 ° C., the heating time is 4 to 30 minutes, and retort sterilization is preferable.
By retort sterilization, the gelling agent dissolves, and a desirable viscous liquid to gel-like material is obtained.
In addition, the retort pouch used as a packaging container means the packaging container which consists of multilayer structures, such as a polypropylene layer, an aluminum layer, a polyethylene terephthalate layer, for example.

The oral administration adjuvant composition for pets of the present invention has a function that envelops a drug without affecting the medicinal effects of the pet, and therefore the oral administration when the pet is swallowed. It can be suitably used as an auxiliary agent.
Here, examples of the pet include dogs, cats, rabbits, guinea pigs, and ferrets. In addition, the oral administration adjuvant composition for pets of the present invention is not limited to pets that are small mammals as described above, and may be applied to pets such as birds and reptiles if pet preference is not affected. Good. In addition to pets bred for pets, if the pet's palatability is not affected, it applies to animals bred as domestic animals, animals bred for viewing at zoos, etc. be able to.

  EXAMPLES Hereinafter, although an Example and a comparative example demonstrate this invention further in detail, this invention is not limited to these Examples.

(Formulation of gelling agent)
As a gelling agent, a gelling agent obtained by powder-mixing the following polysaccharides at the following ratio was used. Note that the gelling agent used in the composition for oral administration of pets of the present invention is not limited to the gelling agent of this example, and contains sugars or sugar alcohols in addition to polysaccharides. May be. Examples of the sugar or sugar alcohol contained in the gelling agent include glucose, erythritol, mannitol and the like.
[Combination ratio of gelling agent]
Composition ratio (%)
Carrageenan 35.0
Locust bean gum 30.0
Xanthan gum 30.0
Guar gum 5.0
Total amount 100.0

(Viscosity and suction test)
First, the relationship between the content of the gelling agent in the composition, the viscosity, and the suction property of the catheter was tested.
After the above-mentioned gelling agent and sugar alcohol (erythritol) are mixed with powder, the powder mixture and water (tap water) are stirred and mixed with a hand mixer, and the mixture is put into a retort pouch and sealed. did. The mixture is put in a retort sterilizer together with the retort pouch, sterilized by retort at 121 ° C. for 10 minutes, and then cooled to 20 ° C. so that the gelling agent content is 0.01 to 10.0%. The thing (Comparative Examples 1-6) was obtained. In addition, the content rate of the sugar alcohol (erythritol) in each composition is 5.0%.
Next, the viscosity of each composition (Comparative Examples 1 to 6) was measured at 20 ° C. using a B-type rotational viscometer.
In addition, each composition was aspirated with a 50 mL catheter syringe to test the aspiration of the composition. In addition, when the composition can be sucked with the catheter syringe, the suction property is good (◯), when it can be sucked but hard, the suction property is poor (Δ), and when it cannot be sucked, there is no suction property (× ). The results are shown in Table 1.
As shown in Table 1, when the content of the composition exceeded 1.0% (Comparative Examples 5 and 6), it was difficult to measure the viscosity with a B-type rotational viscometer. Further, when the content of the gelling agent in the composition is 10.0% by weight or more, the composition cannot be sucked with the catheter syringe.
From this result, it was confirmed that it is preferable to use a composition having at least a gelling agent content of less than 5.0% by weight when orally administered using a catheter.

(Test of drug wrapping function)
Next, the relationship between the content of the gelling agent in the composition and the drug wrapping function of the composition was tested.
In the same manner as in the test method described above, compositions (Comparative Examples 1 and 3 to 7) having a gelling agent content of 0.01 to 15.0% were obtained. In addition, the content rate of the sugar alcohol (erythritol) of each composition is 5.0 weight%.
Using these compositions, the function of encapsulating various forms of tablets (soft capsule, capsule, round, rugby ball), powder (granular, powder), and liquid (viscous liquid) was tested.
Specifically, tablets, powders, and liquid drugs were wrapped with compositions that covered various drugs, and then placed on a flat plate to visually check the state of the composition and the drugs.
When the drug can be easily wrapped in the composition, the wrapping function is assumed to be good (○), and the drug is wrapped in the composition, but then the drug comes out of the composition or the composition is separated. If the composition is soft and the tester feels that the drug is difficult to wrap, the wrapping function is poor (△). If the composition cannot be wrapped or the drug dissolves, wrap it. No function (×). The results are shown in Table 2.
As shown in Table 2, when the content of the gelling agent in the composition is 1.0 to 10.0% (Comparative Examples 4 to 6), the liquid is encapsulated in the composition as well as the powder and various forms of tablets. It was confirmed that the function was good. On the other hand, if the content of the gelling agent in the composition is 0.01 to 0.5% (Comparative Examples 1 and 3) or 15.0% (Comparative Example 7), any form of the drug has a poor wrapping function. Or couldn't wrap up the drug.

(Test of sugar alcohol content and dispersibility of gelling agent)
The relationship between the sugar alcohol content and the dispersibility of the gelling agent mixed with the sugar alcohol in water was tested.
After the above-mentioned gelling agent and sugar alcohol (erythritol) are mixed with powder, this powder mixture is put into water (tap water) and stirred and mixed until the powder mixture is uniformly dispersed in water. Time was measured.
The powder mixture is prepared such that when the powder mixture is dispersed in water, the gelling agent content is 1.0% and the sugar alcohol (erythritol) content is 0.0-20.0%. What was done was used. The results are shown in Table 3.
As shown in Table 3, the powder mixture (Comparative Examples 10-14) in which the sugar alcohol and the gelling agent were mixed so that the content of the sugar alcohol in the composition was 1.0% or more was gelated. It was confirmed that the dispersion time of the agent was shortened to 6 minutes 30 seconds or less.
When the sugar alcohol content is 10.0% or more (Comparative Examples 13 and 14), there is no significant difference in the dispersion time of the gelling agent, so that the sugar alcohol improves the dispersibility of the gelling agent in water. It was confirmed that the effect to be sufficiently exerted when the sugar alcohol content is 1.0 to 10.0%.

(Relationship test between liquidity and palatability)
Next, the relationship between the liquidity of the composition and the pet's palatability was tested.
After the above-mentioned gelling agent and sugar alcohol (erythritol) are mixed with powder, this powder mixture and water (tap water) are mixed by stirring with a hand mixer, and then citric acid or disodium hydrogen phosphate is used. Then, liquidity (pH) was adjusted, and this mixture was put into a retort pouch and sealed.
The above mixture is put in a retort sterilizer together with the retort pouch, retort sterilized at 121 ° C. for 10 minutes, then cooled to 20 ° C., and the liquidity of the composition is pH 2.69 to 8.65 (Comparative Examples 16 to 21) were obtained.
The content of the gelling agent in each composition is 1.0%, and the content of sugar alcohol (erythritol) is 5.0%.
In addition, as Comparative Example 15, a composition having a pH of 3.52 (manufactured by Ryukakusan Co., Ltd., trade name: strawberry taste that can be drunk) was used as a human swallowing assistance beverage.
Test animals (dogs A to G) shown in Table 4 and test animals shown in Table 5 containing the composition (Comparative Example 15) which is a human swallowing assistance drink and the above-mentioned compositions (Comparative Examples 16 to 21) (Cats A to E) and the palatability of these test animals (dogs, cats) was tested.
When the test animal (dog, cat) ate the given composition, the palatability is good (○), and when the composition is licked, the palatability is poor (△) When there was no interest in the composition, it was determined that there was no preference (×). The results are shown in Table 6.

(Consideration of relationship test between liquidity and palatability)
As shown in Table 6, compositions having a liquidity of pH 3.0 to 9.0 (Comparative Examples 17 to 21) have a large number of test animals exhibiting good palatability, and particularly the liquidity is pH 5.0. In the composition of ~ 8.0 (Comparative Examples 18 to 20), all the test animals showed good palatability.
On the other hand, the composition (Comparative Example 16) having a liquid property of less than pH 3.0 increased the number of test animals exhibiting poor palatability. In particular, the composition (Comparative Example 15), which is a human swallowing assistance drink, has only one animal that showed good palatability among the 12 test animals. It was confirmed that the sex was different.

(Bitterness alleviation test)
Next, in consideration of the above-mentioned various test results, an oral administration adjuvant composition containing (a) a gelling agent, (b) a protein hydrolyzate, and (c) water is prepared. The content of protein hydrolyzate and the masking effect of bitter components were tested.

Example 1
According to the flow shown in FIG. 2, (c) water (100.0 kg) and (b) protein hydrolyzate (collagen peptide SCP-3100: 16.0 kg) are stirred and mixed in a mixing vessel, and mixture A is mixed. Got. This mixture A was put into the preparation kettle.
In addition, (b) protein hydrolyzate was thrown into water in multiple steps and mixed while stirring with a hand mixer.
Next, the above-mentioned (a) gelling agent (4.0 kg) and (d) sugar alcohol (erythritol Eridex16952: 20.0 kg) are powder-mixed with a V-type mixer to obtain a powder mixture B. It was.
Next, the powder mixture B and water (230.0 kg) were stirred and mixed in the mixing tank to obtain a mixture C. This mixture C was put into a preparation kettle.
In addition, the powder mixture B was divided into a plurality of times, poured into water, and mixed while stirring with a hand mixer.
Next, water (30.0 kg) was further added to the mixing kettle into which the mixture A and the mixture C were charged to prepare (fill up) so that the total amount was 400.0 kg.
The mixture was then stirred again and the mixture was charged to the service tank through a strainer (24 mesh pass).
Next, the mixture filled in the service tank was put into a retort pouch and sealed. The mixture is put together with the retort pouch in a retort sterilizer and sterilized by retort at 121 ° C. for 10 minutes, and then cooled to 20 ° C. to (a) a gelling agent, (b) a protein hydrolyzate (collagen peptide) and (C) A pet oral administration adjuvant composition (Example 1) containing water was obtained.
The oral administration adjuvant composition for pets (Example 1) has (a) a gelling agent content of 1.0%, (b) a protein hydrolyzate (collagen peptide) content of 4.0%, ( c) The content of water is 90.0%, and the content of (d) sugar alcohol (erythritol) is 5.0%.

(Comparative Examples 22, 24, 25, 26)
As Comparative Example 22, a composition was obtained in the same manner as in Example 1 except that (b) protein hydrolyzate (collagen peptide) was not contained. In addition, the composition of Comparative Example 22 has (a) a gelling agent content of 1.0% and (d) a sugar alcohol (erythritol) content of 5.0%.
As Comparative Example 24, a composition was obtained in the same manner as in Example 1 except that it did not contain (a) a gelling agent and (b) a protein hydrolyzate (collagen peptide). In addition, the composition of the comparative example 24 contains only (d) sugar alcohol (erythritol), and the content rate of sugar alcohol (erythritol) is 5.0%.
As Comparative Example 25, a composition was obtained in the same manner as in Example 1 except that (a) the gelling agent was not contained. In the composition of Comparative Example 25, (b) protein hydrolyzate (collagen peptide) is 4.0%, and (d) the sugar alcohol (erythritol) content is 5.0%.
In addition, as Comparative Example 26, a composition (manufactured by Ryukakusan Co., Ltd., trade name: Ichigo Ichigo Taste) was used as a human swallowing assistance beverage.

The above-mentioned composition for oral administration adjuvant for pets (Example 1) and (b) a composition not containing protein hydrolyzate (collagen peptide) (Comparative Example 22) show these compositions as they are in Table 5. Test animals (cats A to E) were given. Table 5 shows the composition for oral administration adjuvant for pets of Example 1 and the composition of Comparative Example 22 with 1 g of L-arginine as a bitter component (Example 2, Comparative Example 23). The test animals shown (cats A to E) were given.
Moreover, what added 1g of L-arginine to the composition of the above-mentioned Comparative Examples 24-26 was given to the test animal (cat A-E) shown in Table 5.
When the test animal (cats A to E) ate the given composition, the palatability is good (◯), and when the composition is licked, the palatability is poor (Δ If there was no interest in the composition, it was determined that there was no preference (x). The results are shown in Table 7.

(Consideration of bitterness alleviation test)
As shown in Table 7, all the test animals showed good palatability in the pet oral administration adjuvant composition (Example 1). Furthermore, even when the oral administration adjuvant composition for pets contains a bitter component (Example 2), all the test animals show good palatability and the bitter component is masked. It could be confirmed.
On the other hand, the composition containing (a) a gelling agent and (b) no protein hydrolyzate (collagen peptide) (Comparative Examples 22 and 23) has a small number of test animals showing good palatability, It was confirmed that the masking effect of the bitter component was low.
Moreover, the composition (Comparative Examples 24 and 25) which does not contain a gelling agent showed poor palatability for all test animals regardless of the presence or absence of (b) protein hydrolyzate (collagen peptide).
Moreover, the composition marketed as a human swallowing assistance drink (Comparative Example 26) does not show the palatability of the test animal, and the masking effect of the bitter component is not exerted on the test animal. I was able to confirm.

(Relationship between protein hydrolyzate content and palatability)
(Examples 3 to 11)
According to the flow chart shown in FIG. 1, the same procedure as in Example 1 was conducted except that the content of (b) protein hydrolyzate (collagen peptide SCP-3100) was adjusted to 0.01 to 40.0%. Thus, an oral administration adjuvant composition for pets (Examples 3 to 11) was obtained.
The oral administration adjuvant composition for pets (Examples 3 to 11) has (a) a gelling agent content of 1.0% and (d) a sugar alcohol (erythritol) content of 5.0%. .

(Comparative Examples 27 and 28)
As Comparative Example 27, a composition was obtained in the same manner as in Example 1 except that (b) protein hydrolyzate (collagen peptide SCP-3100) was not contained. In the composition of Comparative Example 27, (a) the content of the gelling agent is 1.0%, and (d) the content of the sugar alcohol (erythritol) is 5.0%.
In addition, as Comparative Example 28, a composition (manufactured by Ryukakusan Co., Ltd., trade name: Ichigo Ichigo Taste) was used as a human swallowing assistance beverage.

The above-mentioned Examples 3 to 11 and Comparative Examples 27 and 28 were given to the test animals (cats A to E) shown in Table 5 and the test animals (dogs A to G) shown in Table 4, and these samples were given. The palatability of the test animals was confirmed.
When the composition to which the test animals (dogs A to G and cats A to E) are given is eaten, the palatability is good (○), and when the composition is licked, the palatability Was not good (Δ), and when there was no interest in the composition, it was determined that there was no preference (×). The results are shown in Table 8.

(Consideration of relationship test between protein hydrolyzate content and palatability)
As shown in Table 8, the oral administration adjuvant composition for pets (Examples 3 to 11) includes (b) a composition not containing protein hydrolyzate (Comparative Example 27) and a commercially available composition (Comparative Example 28). ), The number of test animals showing good palatability was larger.
In particular, when the content of the (b) protein hydrolyzate is 1.0 to 40.0%, the test animal shows good palatability, and (b) the content of the protein hydrolyzate is 4 0.0 to 30.0% of the oral administration adjuvant composition for pets (Examples 7 to 10) showed good palatability in all the test animals.
On the other hand, (b) the composition containing no protein hydrolyzate (Comparative Example 27) was about 2 out of 12 tested animals, and about 2 were licked. The nature is low. Moreover, the composition marketed as a human swallowing assistance drink (Comparative Example 28) eats only 1 out of 12 test animals, and also licks one, and has a palatability. Low.

(Flavor preference test)
Next, it tested about the palatability of the oral administration adjuvant composition for pets containing a flavor.

(Examples 12 to 19)
According to the flow chart shown in FIG. 1, the same as in Example 1 except that (e) flavor (beef extract or tie (kaki) extract: 4.0 kg) is added before the total amount is prepared (fill-up). Thus, an oral administration adjuvant composition for pets was obtained.
This pet oral administration adjuvant composition was directly applied to the test animals shown in Tables 4 and 5. In addition, each form of drug (hard capsule, granule, tablet, liquid) was mixed into the above-mentioned pet oral administration adjuvant composition and given to the test animals shown in Tables 4 and 5.
When all the compositions given by the test animals (dogs A to G and cats A to E) are eaten, the palatability is very good (◎), and the composition is licked When the preference was slightly good (◯) and the composition was eaten or licked, but the drug was left, the preference was poor (Δ). Moreover, when there was no interest in a composition, it was set as non-preference (x). The results are shown in Table 9.

(Consideration of results of flavor preference test)
As shown in Table 9, there were many test animals that showed very good palatability when the oral dosage adjuvant composition for pets contained flavor.
In particular, in the case where the test animal is a dog, if the pet oral administration adjuvant composition contains a flavor, it exhibits very good palatability. Even so, there were many test animals that showed very good palatability.
On the other hand, when the test animal is a cat, if the composition for oral administration supplement for pets contains a flavor, a large number of test animals that show very good palatability, In the oral administration adjuvant composition for use, the number of test animals showing poor palatability increased. In particular, the number of test animals showing poor palatability increased when the drug form was liquid. From this result, even if it was the same oral administration adjuvant composition for pets, it has confirmed that palatability was influenced by the form of the medicine to wrap, and the pet (animal) used as object.

It is a flowchart which shows an example of the manufacturing process of the oral administration adjuvant composition for pets of this invention. It is a flowchart which shows an example of the manufacturing process of the oral administration adjuvant composition for pets of this invention.

Claims (8)

  An oral administration adjuvant composition for pets, comprising (a) a gelling agent, (b) a protein hydrolyzate, and (c) water.   (D) Sugar or sugar alcohol is contained further, The oral dosage auxiliary composition for pets of Claim 1 characterized by the above-mentioned.   (E) The composition for oral administration adjuvant for pets according to claim 1 or 2, further comprising a flavor.   The oral protein supplement composition for pets according to any one of claims 1 to 3, wherein the protein hydrolyzate (b) is a collagen peptide.   The composition for oral administration adjuvant for pets according to any one of claims 2 to 4, comprising the sugar alcohol (d), wherein the sugar alcohol (d) is erythritol.   The composition for oral administration of pets according to any one of claims 1 to 5, wherein the content of the gelling agent (a) is 0.5 to 12.0 mass%.   The content of the protein hydrolyzate (b) is 1.0 to 40.0 mass%, and the oral administration adjuvant composition for pets according to any one of claims 1 to 6,   The composition for oral administration adjuvant for pets according to any one of claims 2 to 7, wherein the content of the sugar or sugar alcohol (d) is 1.0 to 10.0% by mass. .

Images