JP2009040759A - Skin-protecting composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin-protecting composition for improving skin roughness, enhanced in humidity-retaining and skin protecting effects by improving feelings in use such as sticky and slimy feeling. <P>SOLUTION: The skin-protecting composition contains a fluorine-based polymer and a polyhydric alcohol. The fluorine-based polymer is selected from a group having a perfluoropolyether group or a perfluoropolyether group having a modified terminal group. Particularly, a perfluoropolyether group having a phosphate group-modified terminal group is preferable. The polyhydric alcohol is not limited as far as it is used as a conventional pharmaceutical, a quasi drug and a cosmetic, but one selected from the group consisting of 1,3-butylene glycol, diglycerol, glycerol, dipropylene glycol, propylene glycol, polyethylene glycol, diglycerol trehalos, sorbitol and maltitol is preferable. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention provides a skin protection composition for rough skin, which has a high moisturizing effect and a skin protecting effect containing a fluoropolymer and a polyhydric alcohol, and also improves the feeling of use such as stickiness and sliminess.

  People who frequently perform hand-washing and disinfection, such as barbers, cooks, medical workers, and housewives at home, often suffer from rough hands. Hands and fingers receive mechanical friction and are degreased with water, surfactants, alcohol, and the like. As a result, it is said that the barrier function of the skin of hands and fingers is lowered, the surface is dried and cracks are generated. For this reason, various compositions for preventing rough hands have been put into practical use for the purpose of preventing the occurrence of rough hands by forming a protective film on the skin before carrying out work to protect the skin from water and surfactants.

  However, the conventional anti-roughing composition is prepared using silicone, wax, and cationic water-soluble resin (Patent Documents 1 and 2), while most of the work performed using water is washed. In many cases, a detergent is used at the same time, and the conventional anti-roughing composition will immediately wash off the protective film once formed on the skin, thus completely preventing roughing. There was a problem that could not. In addition, barbers, cooks, healthcare workers, homewives, etc. have a sense of incongruity that it is difficult to slip and grasp things even though there are many tasks to grab things or cherish the sense of fingers. There were also problems such as obstructing the sense of fingers.

  On the other hand, the skin is roughly divided into three layers, the epidermis, dermis, and subcutaneous tissue, from the outside, and protects internal organs from changes in temperature and humidity, ultraviolet rays, and other physical or chemical external environmental stimuli. It has a function. In particular, the epidermis plays an important role in preventing moisture evaporation inside the human body. The epidermis is divided into the stratum corneum, granule layer, spiny layer, and basal layer in order from the outside, and a high concentration of natural moisturizing factor (NMF) is present in the horny layer of a healthy person, which is the moisture of the skin. It plays a role in helping to maintain and preventing skin dryness (Non-Patent Document 1).

  Conventionally, attempts have been made to increase the amount of water retained in the stratum corneum by using a moisturizing agent that absorbs moisture or a coated moisturizing agent that prevents moisture evaporation as a moisturizing agent. Examples of the wetting agent include glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, sodium 2-pyrrolidone-5-carboxylate, and the like, which is sticky when applied to the skin. There is a disadvantage that the feeling is intense or sticky. In addition, lipid components such as ceramide and essential fatty acids and lipid complexes have been used as coating moisturizers (Non-patent Document 2), but it is difficult to maintain the stability of the emulsifier type, and it is a transparent gel There is a disadvantage that it is not suitable for manufacturing the products.

  The present invention solves the conventional problems as described above, and provides a skin protection composition that has a high moisturizing effect and a skin protecting effect, and can exhibit an excellent feeling of use without a sense of incongruity in use. It was completed for the purpose of doing.

  That is, the present invention relates to a skin protecting composition for rough skin, which has a high moisturizing effect and skin protecting effect containing a fluoropolymer and a polyhydric alcohol, and also improves the feeling of use such as stickiness and sliminess.

  The present invention has a characteristic configuration in that a fluorine-based polymer is contained as a skin protecting component and a polyhydric alcohol is contained as a moisturizing component. Focusing on the point that the fluoropolymer film is strong and safe, the skin is protected and there is no sense of incongruity with high safety, and a moisturizing component such as polyhydric alcohol is encapsulated on the skin surface. A higher moisturizing effect can be expected. Moreover, the film | membrane characteristic of a fluorine-type polymer is improved by use of a polyhydric alcohol, the skin protection composition was discovered, and this invention is completed.

  Examples of the fluorine-based polymer include those having a perfluoropolyether group. The perfluoropolyether group is a perfluoropolyether itself, or the end of the perfluoropolyether group is a carboxyl group, a hydroxyl group, a phosphate group, a silane group, an isocyanate group, a hydroxymethyl group, a polyoxyethylene phosphate group, etc. Examples thereof include modified compounds.

  Although it will not restrict | limit especially if a polyhydric alcohol is normally used in a pharmaceutical, a quasi-drug, and cosmetics, Specifically, 1, 3- butylene glycol, diglycerin, glycerin, dipropylene glycol, propylene glycol, It consists of polyethylene glycol, diglycerin trehalose, sorbitol, and maltitol.

Tabachnick J, J. et al. Invest. Dermatol, 54, 24-31 (1970) Rawlings AV, J.A. Invest. Dermatol 5, 731-740 (1994) JP-A-6-234625 JP-A-2005-97224

  In the present invention, the dosage forms include, for example, lotions, emulsions, creams, packs, gels, etc., and can be used as a skin external preparation. In the preparation of the present invention, a preservative, a thickener, an oil agent, a solvent, a fragrance, a pH adjuster, and the like in addition to the fluoropolymer and the polyhydric alcohol are appropriately blended within the scope of achieving the object of the present invention. Can do.

  The blending amount of the polyhydric alcohol is 0.1% to 20.0% by weight, more preferably 1 to 10% by weight in the total component composition. If it is this range, a moisturizing effect can be anticipated, the rough skin improvement effect can be strengthened, and the usability | use_condition of a fluorine-type polymer can be improved. On the other hand, the blending amount of the fluorine-based polymer is 0.1 to 10% by weight, more preferably 1 to 5% by weight, in the total composition of cosmetics and skin external preparations. If it is this range, the moisturizing effect of a polyhydric alcohol can be remarkably improved and it can utilize as a skin protection composition with a favorable usability | use_condition.

  The blend ratio of the fluoropolymer and polyhydric alcohol used in the present invention is 15: 1 to 1:15 by weight. When the blending ratio is less than 15: 1, the moisturizing effect of the polyhydric alcohol is difficult to be exhibited, and it is not preferable because improvement in the feeling of use can not be expected, and when the blending ratio is greater than 1:15, the stickiness of the polyhydric alcohol is increased. Absent. More preferably, it is 1: 1 to 1: 6.

  EXAMPLES Hereinafter, although this invention is explained in full detail based on an Example, this invention is not specifically limited by these. The test method used is shown below.

Comparative examples and examples in Table 1 and Table 2 were prepared and performance evaluation was performed.

<Measurement of friction coefficient>
40 cm ² (4 cm wide × 10 cm long) of a bio skin plate (Buelux) was used as a test site, and 0.1 g of a sample was uniformly applied thereto. The friction characteristic of the test part immediately after application was measured using a friction tester KES-SE (manufactured by Kato Tech Co., Ltd.).

  The properties of the formed film were evaluated by measuring the friction. Even if polyperfluoroethoxymethoxydifluoroethyl PEG, which is a fluorinated polymer, is increased to 5.0% with glycerin, which is a polyhydric alcohol, being constant as in Examples 3 to 5, polyperfluoroethoxymethoxydifluoroethyl PEG It was found that the friction was lower than that of Comparative Example 3 using phosphoric acid alone (FIG. 1), and the friction was improved. On the other hand, even if polyperfluoroethoxymethoxydifluoroethyl PEG phosphate was made constant as in Examples 8 to 10 and glycerin was increased, it was lower than Comparative Example 3. Therefore, it can be seen that 1 to 5% of polyperfluoroethoxymethoxydifluoroethyl PEG phosphate and 1 to 10% of glycerin are optimal. The combination of a fluoropolymer and a polyhydric alcohol reduces the friction and causes stickiness, etc. It is expected that the feeling of use will be improved.

  Moreover, since it was most effective in Examples 3-5 and Examples 8-10, it turned out that it is 1: 1-1: 6 as a more preferable mixture ratio of a fluorine-type polymer and a polyhydric alcohol.

<Evaluation of use>
Eight subjects gave Example 9, Comparative Examples 2, 3, and 4 to use them for 2 weeks, and the usability was evaluated for the items in Table 2.

  It was found that Example 9 in which glycerin and polyperfluoroethoxymethoxydifluoroethyl PEG phosphate were blended with both of Comparative Examples 2 and 3 was easier to stretch and had less stickiness and sliminess (FIG. 2). . Therefore, it has been found that the feeling of use can be improved by combining the fluoropolymer and the polyhydric alcohol. In addition, Example 9 was easier to extend than Comparative Example 4, was less sticky and slimy, and was found to have a better feeling than silicone.

<Corn layer moisture retention ability>
Distilled water was dropped onto a test site of 1 × 2 cm set on the forearm flexion side inside the left and right forearms of the subject and left for 30 seconds. The water was completely wiped off, and immediately after and after 30 seconds, 60 seconds, 90 seconds and 120 seconds, the conductance was measured with a cornometer CM825 (Courage + Khazaka). 0.02 g of each sample was applied to the test site. After 4 hours, water was loaded again, and conductance was measured for each test site.
The change in the stratum corneum moisture retention capacity was determined by the following equation.
Stratum corneum moisture retention capacity (%) = A / B × 100
A: Average conductance after 30, 60, 90 and 120 seconds from water load
B: Conductance immediately after water load (after 0 seconds) Rate of change in water retention capacity (%) = C / D × 100
C: Retention capacity of stratum corneum before sample processing
D: Ability to retain stratum corneum after 4 hours of treatment

  Example 9 in which both polyperfluoroethoxymethoxydifluoroethyl PEG phosphate and glycerin were blended showed a high change in water retention capacity (FIG. 3). Therefore, it was found that the moisturizing ability is remarkably increased by combining the fluoropolymer and the polyhydric alcohol.

<Inhibition of stratum corneum cell detachment>
As a test sample processing hand, 0.25 g of the test sample was applied to one of the left and right hands, and the other uncoated hand was used as an untreated hand. The test sample was dried for 5 minutes after application. Hand washing was repeated 8 times with 15% soap solution. Thereafter, the same test sample was applied again to the same hand, and the same hand washing operation was repeated 8 times. The amount of stratum corneum detachment before hand washing and after a total of 16 hand washings was measured with an image analyzer, and the change in the amount of stratum corneum detachment due to hand washing was evaluated.

  Example 9 in which both polyperfluoroethoxymethoxydifluoroethyl PEG phosphate and glycerin are blended in both the back of the hand and the finger is found to suppress the detachment of the stratum corneum cells by soap hand washing. The suppression effect was higher than that of Comparative Example 4 (FIGS. 4 and 5). Thus, the effect which remarkably raises the rough skin prevention effect was recognized by applying Example 9 by which both a fluorine-type polymer and a polyhydric alcohol are mix | blended.

<Continuation of protective effect>
0.3 g of each composition was taken and applied to the glass surface. After air-drying for 3 minutes, it was immersed in tap water, 0.05% soap solution and ethanol. The items in Table 3 were evaluated and scored.

  The results of evaluating the duration of the protective effect are shown in Tables 4-6.

  In Example 9, in which both polyperfluoroethoxymethoxydifluoroethyl PEG phosphate and glycerin were blended, a high protective effect was observed, which was higher than Comparative Example 4 blended with silicone. Therefore, the combination of the fluoropolymer and the polyhydric alcohol has the highest protective effect.

  From the above, it has been clarified that the inclusion of the fluorine-based polymer and the polyhydric alcohol has a high moisturizing effect, has a better feeling of use than the silicone-based, and exhibits a skin protecting effect remarkably.

  If the polyhydric alcohol content is 0.1 or less, the moisturizing effect cannot be expected, and if it is 20% or more, the feeling of stickiness becomes considerably strong. On the other hand, if the fluorine-based polymer is 0.1% or less, the skin protecting effect cannot be expected, and if it is 10% or more, the cost is high and the stability after the formulation is poor. Therefore, the blending composition is expected to be 0.1 to 10% for the fluorine-based polymer and 0.1 to 20% for the polyhydric alcohol. From the above results, the optimum blending composition is 1 to 5% for the fluorine-based polymer and many The monohydric alcohol was found to be 1-10%.

  Further, the blending ratio of the fluoropolymer and the polyhydric alcohol is 15: 1 to 1:15 by weight. If the blending ratio is less than 15: 1, the moisturizing effect of the polyhydric alcohol is difficult to be exhibited, and it is not preferable because improvement in the feeling of use cannot be expected. If the blending ratio is more than 1:15, the skin protecting effect of the fluoropolymer can be expected. This is not preferable because the stickiness of the polyhydric alcohol is increased. More preferably, it is 1: 1 to 1: 6.

It is the figure which measured the friction coefficient.

It is the figure which evaluated the usability | use_condition.

It is the figure which measured the stratum corneum moisture retention ability.

It is a figure (back of hand) of stratum corneum cell peeling suppression.

It is a figure (finger) of stratum corneum cell peeling suppression.

Claims (7)

A skin protective composition containing a fluorine-based polymer and a polyhydric alcohol. The skin protective composition according to claim 1, wherein the fluoropolymer of claim 1 is one or more selected from the group having a perfluoropolyether group. The perfluoropolyether group is a perfluoropolyether itself, or the end of the perfluoropolyether group is a carboxyl group, a hydroxyl group, a phosphate group, a silane group, an isocyanate group, a hydroxymethyl group, a polyoxyethylene phosphate group, etc. Examples thereof include modified compounds. Although it will not restrict | limit especially if the polyhydric alcohol of Claim 1 is normally used in a pharmaceutical, a quasi-drug, and cosmetics, Specifically, 1, 3- butylene glycol, diglycerin, glycerin, dipropylene glycol The skin protective composition according to claim 1, wherein the composition is one or more selected from the group consisting of propylene glycol, polyethylene glycol, diglycerin trehalose, sorbitol, and maltitol. The skin protective composition according to claim 1, which provides a skin protective effect for treating / preventing dry skin and / or rough skin. The skin protective composition according to claim 1, wherein the blending amount of the fluorine-based polymer is 0.1 wt% to 10 wt%, more preferably 1 to 5 wt%, based on the total composition. The skin protection composition according to claim 1, wherein the blending amount of the polyhydric alcohol is 0.1% to 20% by weight, more preferably 1 to 10% by weight, based on the total composition. The skin protective composition according to claim 1, wherein the blending ratio of the fluoropolymer and the polyhydric alcohol is 15: 1 to 1:15, more preferably 1: 1 to 1: 6.

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