JP2009035545A5 - - Google Patents
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- Publication number
- JP2009035545A5 JP2009035545A5 JP2008178569A JP2008178569A JP2009035545A5 JP 2009035545 A5 JP2009035545 A5 JP 2009035545A5 JP 2008178569 A JP2008178569 A JP 2008178569A JP 2008178569 A JP2008178569 A JP 2008178569A JP 2009035545 A5 JP2009035545 A5 JP 2009035545A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- amlodipine
- stable
- jelly
- solution according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 claims 19
- 229960000528 amlodipine Drugs 0.000 claims 19
- 235000015110 jellies Nutrition 0.000 claims 11
- 239000008274 jelly Substances 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 10
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical group [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 6
- 239000003945 anionic surfactant Substances 0.000 claims 4
- 239000003349 gelling agent Substances 0.000 claims 4
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 3
- 239000000679 carrageenan Substances 0.000 claims 3
- 235000010418 carrageenan Nutrition 0.000 claims 3
- 229920001525 carrageenan Polymers 0.000 claims 3
- 229940113118 carrageenan Drugs 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 235000003599 food sweetener Nutrition 0.000 claims 3
- 238000001879 gelation Methods 0.000 claims 3
- 239000001103 potassium chloride Substances 0.000 claims 3
- 235000011164 potassium chloride Nutrition 0.000 claims 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 3
- 239000003765 sweetening agent Substances 0.000 claims 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical group [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 239000003607 modifier Substances 0.000 claims 2
- 239000002736 nonionic surfactant Substances 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 2
- 235000012239 silicon dioxide Nutrition 0.000 claims 2
- 239000000600 sorbitol Substances 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- -1 sucrose fatty acid ester Chemical class 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008178569A JP5072748B2 (ja) | 2007-07-10 | 2008-07-09 | アムロジピンの安定な液剤とゼリー剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007180579 | 2007-07-10 | ||
| JP2007180579 | 2007-07-10 | ||
| JP2008178569A JP5072748B2 (ja) | 2007-07-10 | 2008-07-09 | アムロジピンの安定な液剤とゼリー剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009035545A JP2009035545A (ja) | 2009-02-19 |
| JP2009035545A5 true JP2009035545A5 (enrdf_load_stackoverflow) | 2010-05-20 |
| JP5072748B2 JP5072748B2 (ja) | 2012-11-14 |
Family
ID=40437775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008178569A Expired - Fee Related JP5072748B2 (ja) | 2007-07-10 | 2008-07-09 | アムロジピンの安定な液剤とゼリー剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5072748B2 (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1813274B1 (en) * | 2004-10-06 | 2009-12-16 | Eisai R&D Management Co., Ltd. | Medicinal composition, process for producing the same, and method of stabilizing dihydropyridine compound in medicinal composition |
| JP6023164B2 (ja) * | 2012-02-14 | 2016-11-09 | 救急薬品工業株式会社 | 口腔内溶解型フィルム製剤 |
| EP3801460B1 (en) * | 2018-06-01 | 2025-03-12 | Tavanta Therapeutics Hungary Incorporated | Topical amlodipine salts for the treatment of anorectal diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3424553A1 (de) * | 1984-07-04 | 1986-01-09 | Bayer Ag, 5090 Leverkusen | Feste arzneizubereitungen mit dihydropyridinen und verfahren zu ihrer herstellung |
| JP4439499B2 (ja) * | 2005-08-01 | 2010-03-24 | 大日本住友製薬株式会社 | アムロジピン含有粒子およびそれからなる口腔内崩壊錠 |
| JP2009256216A (ja) * | 2008-04-14 | 2009-11-05 | Towa Yakuhin Kk | 溶液状態で安定なアムロジピンベシル酸塩内服用液剤 |
-
2008
- 2008-07-09 JP JP2008178569A patent/JP5072748B2/ja not_active Expired - Fee Related
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