JP2008542414A5 - - Google Patents
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- Publication number
- JP2008542414A5 JP2008542414A5 JP2008515121A JP2008515121A JP2008542414A5 JP 2008542414 A5 JP2008542414 A5 JP 2008542414A5 JP 2008515121 A JP2008515121 A JP 2008515121A JP 2008515121 A JP2008515121 A JP 2008515121A JP 2008542414 A5 JP2008542414 A5 JP 2008542414A5
- Authority
- JP
- Japan
- Prior art keywords
- drug
- drugs
- disease
- cocaine
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000003814 drug Substances 0.000 claims description 44
- 229940079593 drug Drugs 0.000 claims description 32
- 230000002265 prevention Effects 0.000 claims description 18
- 208000011117 substance-related disease Diseases 0.000 claims description 18
- 208000019695 Migraine disease Diseases 0.000 claims description 16
- 206010027599 migraine Diseases 0.000 claims description 16
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 16
- 208000011580 syndromic disease Diseases 0.000 claims description 16
- 230000004770 neurodegeneration Effects 0.000 claims description 14
- 208000024827 Alzheimer disease Diseases 0.000 claims description 12
- 206010013663 drug dependence Diseases 0.000 claims description 11
- 230000001684 chronic effect Effects 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 206010013654 Drug abuse Diseases 0.000 claims description 9
- 208000003251 Pruritus Diseases 0.000 claims description 9
- 208000019901 Anxiety disease Diseases 0.000 claims description 8
- 201000006474 Brain Ischemia Diseases 0.000 claims description 8
- 208000032841 Bulimia Diseases 0.000 claims description 8
- 206010006550 Bulimia nervosa Diseases 0.000 claims description 8
- 206010006895 Cachexia Diseases 0.000 claims description 8
- 206010008120 Cerebral ischaemia Diseases 0.000 claims description 8
- 206010011224 Cough Diseases 0.000 claims description 8
- 206010012735 Diarrhoea Diseases 0.000 claims description 8
- 208000007882 Gastritis Diseases 0.000 claims description 8
- 208000010412 Glaucoma Diseases 0.000 claims description 8
- 208000023105 Huntington disease Diseases 0.000 claims description 8
- 206010061218 Inflammation Diseases 0.000 claims description 8
- 208000007101 Muscle Cramp Diseases 0.000 claims description 8
- 208000008589 Obesity Diseases 0.000 claims description 8
- 206010033664 Panic attack Diseases 0.000 claims description 8
- 208000004880 Polyuria Diseases 0.000 claims description 8
- 208000007107 Stomach Ulcer Diseases 0.000 claims description 8
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 8
- 208000009205 Tinnitus Diseases 0.000 claims description 8
- 206010046543 Urinary incontinence Diseases 0.000 claims description 8
- 208000022531 anorexia Diseases 0.000 claims description 8
- 230000001598 anti-natriuretic effect Effects 0.000 claims description 8
- 208000006673 asthma Diseases 0.000 claims description 8
- 210000000748 cardiovascular system Anatomy 0.000 claims description 8
- 206010008118 cerebral infarction Diseases 0.000 claims description 8
- 230000007278 cognition impairment Effects 0.000 claims description 8
- 208000010877 cognitive disease Diseases 0.000 claims description 8
- 206010061428 decreased appetite Diseases 0.000 claims description 8
- 230000006735 deficit Effects 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 8
- 230000035619 diuresis Effects 0.000 claims description 8
- 206010015037 epilepsy Diseases 0.000 claims description 8
- 230000037406 food intake Effects 0.000 claims description 8
- 235000012631 food intake Nutrition 0.000 claims description 8
- 201000005917 gastric ulcer Diseases 0.000 claims description 8
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims description 8
- 230000004054 inflammatory process Effects 0.000 claims description 8
- 238000002690 local anesthesia Methods 0.000 claims description 8
- 206010027175 memory impairment Diseases 0.000 claims description 8
- 230000008450 motivation Effects 0.000 claims description 8
- 201000006417 multiple sclerosis Diseases 0.000 claims description 8
- 201000003631 narcolepsy Diseases 0.000 claims description 8
- 235000020824 obesity Nutrition 0.000 claims description 8
- 229940005483 opioid analgesics Drugs 0.000 claims description 8
- 208000019906 panic disease Diseases 0.000 claims description 8
- 230000001314 paroxysmal effect Effects 0.000 claims description 8
- 201000000980 schizophrenia Diseases 0.000 claims description 8
- 231100000886 tinnitus Toxicity 0.000 claims description 8
- 208000028698 Cognitive impairment Diseases 0.000 claims description 7
- 206010010904 Convulsion Diseases 0.000 claims description 7
- 230000036461 convulsion Effects 0.000 claims description 7
- 230000035807 sensation Effects 0.000 claims description 7
- 208000030814 Eating disease Diseases 0.000 claims description 6
- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 6
- 235000014632 disordered eating Nutrition 0.000 claims description 6
- 230000001419 dependent effect Effects 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 208000022497 Cocaine-Related disease Diseases 0.000 claims 2
- 201000001272 cocaine abuse Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000011282 treatment Methods 0.000 description 8
- 239000000203 mixture Substances 0.000 description 6
- 208000002193 Pain Diseases 0.000 description 3
- 208000018737 Parkinson disease Diseases 0.000 description 3
- 230000036407 pain Effects 0.000 description 3
- NLMVYUBGWZWUGB-UHFFFAOYSA-N 1,2-benzoxazol-3-amine Chemical class C1=CC=C2C(N)=NOC2=C1 NLMVYUBGWZWUGB-UHFFFAOYSA-N 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 230000036506 anxiety Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000012453 solvate Substances 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 208000021722 neuropathic pain Diseases 0.000 description 1
- 230000020341 sensory perception of pain Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005026194A DE102005026194A1 (de) | 2005-06-06 | 2005-06-06 | Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
| PCT/EP2006/005356 WO2006131296A1 (de) | 2005-06-06 | 2006-06-06 | Substituierte n-benzo [d] isoxazol-3-yl-amin-derivative als inhibitoren von mglur5, serotonin- (5-ht) und noradrenalin rezeptoren und deren verwendung zur herstellung von arzneimitteln |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008542414A JP2008542414A (ja) | 2008-11-27 |
| JP2008542414A5 true JP2008542414A5 (https=) | 2012-11-22 |
Family
ID=36792815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008515121A Ceased JP2008542414A (ja) | 2005-06-06 | 2006-06-06 | ＭＧｌＵＲ５、セロトニン（５−ＨＴ）及びノルアドレナリン受容体の阻害剤としての置換されたＮ−ベンゾ［Ｄ］イソオキサゾール−３−イル−アミン誘導体及び医薬の製造へのその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080312301A1 (https=) |
| EP (1) | EP1893589B1 (https=) |
| JP (1) | JP2008542414A (https=) |
| AT (1) | ATE524451T1 (https=) |
| CA (1) | CA2610373A1 (https=) |
| CY (1) | CY1112449T1 (https=) |
| DE (1) | DE102005026194A1 (https=) |
| DK (1) | DK1893589T3 (https=) |
| ES (1) | ES2373684T3 (https=) |
| PL (1) | PL1893589T3 (https=) |
| PT (1) | PT1893589E (https=) |
| SI (1) | SI1893589T1 (https=) |
| WO (1) | WO2006131296A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005038947A1 (de) * | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| EP2170834B1 (en) * | 2007-07-16 | 2014-01-08 | AbbVie Inc. | Indazoles, benzisoxazoles and benzisothiazoles as inhibitors of protein kinases |
| AU2015302908B2 (en) | 2014-08-13 | 2020-02-13 | Auckland Uniservices Limited | Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy |
| CA2996681C (en) * | 2015-08-27 | 2024-04-09 | Auckland Uniservices Limited | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy |
| US20190099404A1 (en) * | 2016-03-16 | 2019-04-04 | Zeno Royalties & Milestones, LLC | Analgesic compounds |
| CN110117278B (zh) * | 2018-02-07 | 2022-07-19 | 石家庄以岭药业股份有限公司 | 烷氧基苯并五元(六元)杂环胺类化合物及其药物用途 |
| WO2022015938A1 (en) * | 2020-07-15 | 2022-01-20 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| WO2022025636A1 (ko) * | 2020-07-29 | 2022-02-03 | 주식회사 비보존 | Mglur5 및 5-ht2a 수용체의 이중 조절제 및 이의 용도 |
| UY39892A (es) | 2021-08-10 | 2023-03-31 | Novartis Pharma Ag | Compuestos y composiciones para tratar afecciones asociadas con la actividad de STING |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5721377A (en) * | 1980-07-11 | 1982-02-04 | Shionogi & Co Ltd | 3-substituted-1,2-benzisoxazole derivative |
| US4322429A (en) * | 1980-09-16 | 1982-03-30 | Eli Lilly And Company | Isoxazolylbenzamides as insecticides |
| FR2654104B1 (fr) * | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2701026B1 (fr) * | 1993-02-02 | 1995-03-31 | Adir | Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| UA62015C2 (en) * | 1998-12-28 | 2003-12-15 | Pfizer Prod Inc | Benzoizoxazol derivatives, a pharmaceutical composition (variants) based thereon (variants) and a method for treatment (variants) |
| US6593349B2 (en) * | 2001-03-19 | 2003-07-15 | Icagen, Inc. | Bisarylamines as potassium channel openers |
| AU2002323474B2 (en) * | 2001-09-13 | 2006-10-05 | Synta Pharmaceuticals Corp | 3-glyoxlylamideindoles for treating cancer |
| KR100789567B1 (ko) * | 2001-11-06 | 2007-12-28 | 동화약품공업주식회사 | 3-아미도-1,2-벤조이소옥사졸 유도체, 그 염, 제조방법 및 용도 |
| GB0319150D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
| JP4932495B2 (ja) * | 2004-01-23 | 2012-05-16 | アムゲン インコーポレイテッド | 化合物及び使用方法 |
| US20070197610A1 (en) * | 2004-03-16 | 2007-08-23 | Janssen Pharmaceutica N.V. | Benzisoxazoles |
| US7759337B2 (en) * | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
-
2005
- 2005-06-06 DE DE102005026194A patent/DE102005026194A1/de not_active Withdrawn
-
2006
- 2006-06-06 EP EP06761974A patent/EP1893589B1/de not_active Not-in-force
- 2006-06-06 US US11/916,613 patent/US20080312301A1/en not_active Abandoned
- 2006-06-06 DK DK06761974.2T patent/DK1893589T3/da active
- 2006-06-06 WO PCT/EP2006/005356 patent/WO2006131296A1/de not_active Ceased
- 2006-06-06 CA CA002610373A patent/CA2610373A1/en not_active Abandoned
- 2006-06-06 AT AT06761974T patent/ATE524451T1/de active
- 2006-06-06 JP JP2008515121A patent/JP2008542414A/ja not_active Ceased
- 2006-06-06 PT PT06761974T patent/PT1893589E/pt unknown
- 2006-06-06 SI SI200631193T patent/SI1893589T1/sl unknown
- 2006-06-06 ES ES06761974T patent/ES2373684T3/es active Active
- 2006-06-06 PL PL06761974T patent/PL1893589T3/pl unknown
-
2011
- 2011-12-13 CY CY20111101238T patent/CY1112449T1/el unknown
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