JP2008542270A

JP2008542270A - インターフェロンを哺乳動物に送達するための脂質構築物

インターフェロンを哺乳動物に送達するための脂質構築物 Download PDF

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Publication number: JP2008542270A
Authority: JP; Japan
Prior art keywords: interferon; lipid; construct; alpha; biotin
Prior art date: 2005-05-23
Legal status : Withdrawn

Application number

JP2008513540A

Other languages

English (en)

Japanese (ja)

Other versions

JP2008542270A5 (https=

Inventor

ラウ，ジヨン・アール

ジエホ，ダブリユー・ブレア

Original Assignee

エスデイージー・インコーポレーテツド

Priority date

2005-05-23

Filing date

2006-05-16

Publication date

2008-11-27

2006-03-20 Priority claimed from US11/384,575 external-priority patent/US20070218117A1/en

2006-05-16 Application filed by エスデイージー・インコーポレーテツド filed Critical エスデイージー・インコーポレーテツド

2008-11-27 Publication of JP2008542270A publication Critical patent/JP2008542270A/ja

2009-07-02 Publication of JP2008542270A5 publication Critical patent/JP2008542270A5/ja

Status Withdrawn legal-status Critical Current

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150000002632 lipids Chemical class 0.000 title claims abstract description 428
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108010050904 Interferons Proteins 0.000 title claims abstract description 230
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241000124008 Mammalia Species 0.000 title claims description 8
239000000203 mixture Substances 0.000 claims abstract description 157
238000000034 method Methods 0.000 claims abstract description 109
210000003494 hepatocyte Anatomy 0.000 claims abstract description 70
230000027455 binding Effects 0.000 claims abstract description 53
238000004519 manufacturing process Methods 0.000 claims abstract description 23
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238000011049 filling Methods 0.000 claims abstract description 14
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230000008685 targeting Effects 0.000 claims abstract description 8
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238000006731 degradation reaction Methods 0.000 claims abstract description 4
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HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 26
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