JP2008540683A5 - - Google Patents
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- Publication number
- JP2008540683A5 JP2008540683A5 JP2008512566A JP2008512566A JP2008540683A5 JP 2008540683 A5 JP2008540683 A5 JP 2008540683A5 JP 2008512566 A JP2008512566 A JP 2008512566A JP 2008512566 A JP2008512566 A JP 2008512566A JP 2008540683 A5 JP2008540683 A5 JP 2008540683A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound
- hydroxymethyl
- oxolan
- purin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 22
- 239000001257 hydrogen Substances 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- -1 6-[((3R) oxolan-3-yl) amino] -2- {4- [4- (trifluoromethyl) phenyl] (1,2,3-triazolyl)} purin-9-yl Chemical group 0.000 claims 6
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 5
- 125000003107 substituted aryl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000000547 substituted alkyl group Chemical group 0.000 claims 4
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000004258 purin-2-yl group Chemical group [H]N1C2=NC(*)=NC([H])=C2N([H])C1([H])[H] 0.000 claims 2
- JWFPXVFJPXMSJB-ZOICRDBHSA-N (3r,4s,5r)-2-[2-(5-benzyl-2h-triazol-4-yl)-6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)OC1N1C2=NC(C=3C(=NNN=3)CC=3C=CC=CC=3)=NC(NC3CCCC3)=C2N=C1 JWFPXVFJPXMSJB-ZOICRDBHSA-N 0.000 claims 1
- OEBYTPORZBFSSD-ITAOHXQZSA-N (3r,4s,5r)-2-[6-(cyclopentylamino)-2-(2h-tetrazol-5-yl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)OC1N1C2=NC(C=3NN=NN=3)=NC(NC3CCCC3)=C2N=C1 OEBYTPORZBFSSD-ITAOHXQZSA-N 0.000 claims 1
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims 1
- JPDMSXOVYWRIBS-IKYDMHQPSA-N 1-[6-(cyclohexylamino)-9-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]triazole-4-carboxylic acid Chemical compound C1CCC(CC1)NC2=C3C(=NC(=N2)N4C=C(N=N4)C(=O)O)N(C=N3)C5[C@@H]([C@@H]([C@H](O5)CO)O)O JPDMSXOVYWRIBS-IKYDMHQPSA-N 0.000 claims 1
- NTJFCRDCFITCLR-XWHOZGLOSA-N 1-[6-(cyclopentylamino)-9-[(3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]-n-methyltriazole-4-carboxamide Chemical compound N1=NC(C(=O)NC)=CN1C1=NC(NC2CCCC2)=C(N=CN2C3[C@@H]([C@H](O)[C@@H](CO)O3)O)C2=N1 NTJFCRDCFITCLR-XWHOZGLOSA-N 0.000 claims 1
- AMZRGLCQCSEUIU-VGWNDNRCSA-N 1-[6-(cyclopentylamino)-9-[(3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]triazole-4-carboxamide Chemical compound N1=NC(C(=O)N)=CN1C1=NC(NC2CCCC2)=C(N=CN2C3[C@@H]([C@H](O)[C@@H](CO)O3)O)C2=N1 AMZRGLCQCSEUIU-VGWNDNRCSA-N 0.000 claims 1
- DFMYMVNQKRLFPQ-AARXTDBFSA-N 1-[6-(cyclopentylamino)-9-[(3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]triazole-4-carboxylic acid Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)OC1N1C2=NC(N3N=NC(=C3)C(O)=O)=NC(NC3CCCC3)=C2N=C1 DFMYMVNQKRLFPQ-AARXTDBFSA-N 0.000 claims 1
- 102000009346 Adenosine receptors Human genes 0.000 claims 1
- 108050000203 Adenosine receptors Proteins 0.000 claims 1
- 206010002388 Angina unstable Diseases 0.000 claims 1
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 1
- 206010003662 Atrial flutter Diseases 0.000 claims 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000007718 Stable Angina Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000006312 cyclopentyl amino group Chemical group [H]N(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- SSYDTHANSGMJTP-UHFFFAOYSA-N oxolane-3,4-diol Chemical compound OC1COCC1O SSYDTHANSGMJTP-UHFFFAOYSA-N 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000004031 partial agonist Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004545 purin-9-yl group Chemical group N1=CN=C2N(C=NC2=C1)* 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68326305P | 2005-05-19 | 2005-05-19 | |
| US60/683,263 | 2005-05-19 | ||
| PCT/US2006/019599 WO2006125190A1 (en) | 2005-05-19 | 2006-05-19 | A1 adenosine receptor agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008540683A JP2008540683A (ja) | 2008-11-20 |
| JP2008540683A5 true JP2008540683A5 (enExample) | 2009-06-25 |
| JP5042996B2 JP5042996B2 (ja) | 2012-10-03 |
Family
ID=37022210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512566A Expired - Fee Related JP5042996B2 (ja) | 2005-05-19 | 2006-05-19 | Ａ１アデノシンレセプターアゴニスト |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7381714B2 (enExample) |
| EP (1) | EP1883646A1 (enExample) |
| JP (1) | JP5042996B2 (enExample) |
| CA (1) | CA2609051A1 (enExample) |
| WO (1) | WO2006125190A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5349461B2 (ja) * | 2007-05-17 | 2013-11-20 | ギリアード・パロ・アルト・インコーポレイテッド | Ａ２ａ−アデノシン受容体アゴニストおよびその多形体を調製するための方法 |
| US8916570B2 (en) | 2008-03-31 | 2014-12-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A3 adenosine receptor agonists and antagonists |
| CA2720037C (en) | 2008-03-31 | 2016-08-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Purine derivatives as a3 adenosine receptor-selective agonists |
| US9181253B2 (en) | 2008-08-01 | 2015-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adenosine receptor agonists, partial agonists, and antagonists |
| AU2009276411B2 (en) | 2008-08-01 | 2014-08-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A3 adenosine receptor antagonists and partial agonists |
| CN101712709A (zh) | 2008-10-06 | 2010-05-26 | 中国医学科学院药物研究所 | 三乙酰基-3-羟基苯基腺苷及其调血脂的用途 |
| CZ2009298A3 (cs) * | 2009-05-14 | 2010-11-24 | Univerzita Palackého v Olomouci | Substituované 6-benzylaminopurin ribosidy, jejich použití a farmaceutický prípravek tyto slouceniny obsahující |
| US8414852B1 (en) * | 2011-11-21 | 2013-04-09 | Fluor Technologies Corporation | Prevention of nitro-amine formation in carbon dioxide absorption processes |
| US9040498B2 (en) | 2012-07-06 | 2015-05-26 | Research Foundation Of The City University Of New York | 1,2,3-Triazolyl purine derivatives |
| ES2707323T3 (es) | 2012-12-07 | 2019-04-03 | Chemocentryx Inc | Diazol lactamas |
| ES2648994T3 (es) | 2012-12-21 | 2018-01-09 | Chemocentryx, Inc. | Diazolamidas como antagonistas del receptor CCR1 |
| US9422267B2 (en) | 2012-12-26 | 2016-08-23 | Medivation Technologies, Inc. | Fused pyrimidine compounds and use thereof |
| WO2014138485A1 (en) * | 2013-03-08 | 2014-09-12 | Irm Llc | Ex vivo production of platelets from hematopoietic stem cells and the product thereof |
| WO2017176965A1 (en) | 2016-04-07 | 2017-10-12 | Chemocentryx, Inc. | Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors |
| WO2019232554A2 (en) * | 2018-05-26 | 2019-12-05 | Primetime Life Sciences, Llc | Compounds and methods for modulation of g-protein-coupled receptors |
| KR20250025414A (ko) * | 2022-06-17 | 2025-02-21 | 상하이 센후이 메디슨 컴퍼니 리미티드 | 시클로펜틸아데노신 유도체 및 이의 약학적 용도 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514949B1 (en) * | 1994-07-11 | 2003-02-04 | University Of Virginia Patent Foundation | Method compositions for treating the inflammatory response |
| US5789416B1 (en) * | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
| JP3517127B2 (ja) * | 1998-10-19 | 2004-04-05 | 矢崎総業株式会社 | 自動切断圧着装置 |
| US6403567B1 (en) * | 1999-06-22 | 2002-06-11 | Cv Therapeutics, Inc. | N-pyrazole A2A adenosine receptor agonists |
| AU782715B2 (en) | 1999-11-23 | 2005-08-25 | Aderis Pharmaceuticals, Inc. | Treatment of heart rhythm disturbances with N6-substituted-5'-(N-substituted) carboxamidoadenosines |
| US7262176B2 (en) * | 2001-08-08 | 2007-08-28 | Cv Therapeutics, Inc. | Adenosine A3 receptor agonists |
| US20030078232A1 (en) * | 2001-08-08 | 2003-04-24 | Elfatih Elzein | Adenosine receptor A3 agonists |
| AU2003259264A1 (en) * | 2002-07-29 | 2004-02-16 | Cv Therapeutics, Inc. | Myocardial perfusion imaging using a2a receptor agonists |
-
2006
- 2006-05-19 US US11/437,774 patent/US7381714B2/en active Active
- 2006-05-19 EP EP06770753A patent/EP1883646A1/en not_active Withdrawn
- 2006-05-19 JP JP2008512566A patent/JP5042996B2/ja not_active Expired - Fee Related
- 2006-05-19 WO PCT/US2006/019599 patent/WO2006125190A1/en not_active Ceased
- 2006-05-19 CA CA002609051A patent/CA2609051A1/en not_active Abandoned
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