JP2008540594A5 - - Google Patents

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Publication number
JP2008540594A5
JP2008540594A5 JP2008511621A JP2008511621A JP2008540594A5 JP 2008540594 A5 JP2008540594 A5 JP 2008540594A5 JP 2008511621 A JP2008511621 A JP 2008511621A JP 2008511621 A JP2008511621 A JP 2008511621A JP 2008540594 A5 JP2008540594 A5 JP 2008540594A5
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JP
Japan
Prior art keywords
pain
treatment
research
effective
field
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Application number
JP2008511621A
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English (en)
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JP5376942B2 (ja
JP2008540594A (ja
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Priority claimed from DE102005044814A external-priority patent/DE102005044814A1/de
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Publication of JP2008540594A publication Critical patent/JP2008540594A/ja
Publication of JP2008540594A5 publication Critical patent/JP2008540594A5/ja
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Publication of JP5376942B2 publication Critical patent/JP5376942B2/ja
Expired - Fee Related legal-status Critical Current
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Description

痛み、特に神経障害性痛の治療は、医療において重要な意味を有する。有効な痛みの治療が世界的に要求されている。慢性及び非慢性痛状態の患者に合い、かつ目的にかなった治療への研究（但しこの場合これは患者に対して効果があり、そして満足のいく痛みの治療を意味する）が強く要求されており、この研究は適用される鎮痛剤の分野で又は侵害受容に関する基礎研究の分野で最近発行されている多数の科学文献中に提示されている。
JP2008511621A 2005-05-19 2006-05-17 置換されたスピロ化合物及び医薬の製造へのその使用 Expired - Fee Related JP5376942B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE102005023779 2005-05-19
DE102005023779.7 2005-05-19
DE102005044814.3 2005-09-20
DE102005044814A DE102005044814A1 (de) 2005-05-19 2005-09-20 Substituierte Sprio-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
PCT/EP2006/004653 WO2006136245A1 (de) 2005-05-19 2006-05-17 Substituierte spiro-verbindungen und deren verwendung zur herstellung von arzneimitteln

Publications (3)

Publication Number Publication Date
JP2008540594A JP2008540594A (ja) 2008-11-20
JP2008540594A5 true JP2008540594A5 (ja) 2012-06-14
JP5376942B2 JP5376942B2 (ja) 2013-12-25

Family

ID=36917274

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008511621A Expired - Fee Related JP5376942B2 (ja) 2005-05-19 2006-05-17 置換されたスピロ化合物及び医薬の製造へのその使用

Country Status (6)

Country Link
US (1) US7981883B2 (ja)
EP (1) EP1888542A1 (ja)
JP (1) JP5376942B2 (ja)
CA (1) CA2608319C (ja)
DE (1) DE102005044814A1 (ja)
WO (1) WO2006136245A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110166124A1 (en) * 2008-07-23 2011-07-07 Mccormick Kevin D Tricyclic spirocycle derivatives and methods of use
US8232409B2 (en) 2008-10-15 2012-07-31 Janssen Pharmaceutica N.V. Heterocyclic benzimidazoles as TRPM8 modulators
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
AU2010210776A1 (en) * 2009-02-04 2011-08-11 Msd Oss B.V. Isoxazole-3-carboxamide derivatives
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
AR080055A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de los receptores de crf -1
EP2531490B1 (en) 2010-02-02 2014-10-15 Novartis AG Cyclohexyl amide derivatives as crf receptor antagonists
HRP20230502T1 (hr) * 2017-10-27 2023-09-15 Boehringer Ingelheim International Gmbh Inhibitori trpc6

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997033887A1 (en) * 1996-03-15 1997-09-18 Du Pont Pharmaceuticals Company Spirocycle integrin inhibitors
WO1998043962A1 (en) * 1997-03-28 1998-10-08 Du Pont Pharmaceuticals Company Heterocyclic integrin inhibitor prodrugs
NZ516452A (en) * 1999-07-21 2004-06-25 Astrazeneca Ab Spirooxindole Derivatives
DE10130020A1 (de) * 2001-06-25 2003-12-04 Gruenenthal Gmbh Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
EP1506166B1 (en) * 2002-05-17 2011-11-16 Janssen Pharmaceutica NV Aminotetralin-derived urea modulators of vanilloid vr1 receptor
DE60335635D1 (de) * 2002-05-22 2011-02-17 Amgen Inc Aminopyrimidin-derivate zur verwendung als vanilloid-rezeptor-liganden zur behandlung von schmerzen
AU2003301903A1 (en) * 2002-11-06 2004-06-03 Bristol-Myers Squibb Company Isoxazoline derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme
NZ545748A (en) * 2003-08-29 2010-03-26 Ranbaxy Lab Ltd Isoxazoline derivatives as inhibitors of phosphodiesterase type-IV
US7786141B2 (en) * 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
US20070208001A1 (en) * 2006-03-03 2007-09-06 Jincong Zhuo Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same

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