JP2008540513A5 - - Google Patents
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- Publication number
- JP2008540513A5 JP2008540513A5 JP2008510723A JP2008510723A JP2008540513A5 JP 2008540513 A5 JP2008540513 A5 JP 2008540513A5 JP 2008510723 A JP2008510723 A JP 2008510723A JP 2008510723 A JP2008510723 A JP 2008510723A JP 2008540513 A5 JP2008540513 A5 JP 2008540513A5
- Authority
- JP
- Japan
- Prior art keywords
- nicotinamide
- vitamin
- aging
- cadpr
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 22
- BQOHYSXSASDCEA-KEOHHSTQSA-N Cyclic ADP-Ribose Chemical compound C([C@@H]1[C@H]([C@H]([C@@H](O1)N1C=2N=CN3C(C=2N=C1)=N)O)O)OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H]3O1 BQOHYSXSASDCEA-KEOHHSTQSA-N 0.000 claims 20
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 18
- 230000032683 aging Effects 0.000 claims 17
- 239000013543 active substance Substances 0.000 claims 14
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 11
- 150000005480 nicotinamides Chemical class 0.000 claims 10
- 239000000556 agonist Substances 0.000 claims 9
- 210000003491 skin Anatomy 0.000 claims 8
- 229960002882 calcipotriol Drugs 0.000 claims 7
- LWQQLNNNIPYSNX-UROSTWAQSA-N calcipotriol Chemical compound C1([C@H](O)/C=C/[C@@H](C)[C@@H]2[C@]3(CCCC(/[C@@H]3CC2)=C\C=C\2C([C@@H](O)C[C@H](O)C/2)=C)C)CC1 LWQQLNNNIPYSNX-UROSTWAQSA-N 0.000 claims 7
- 229940002612 prodrug Drugs 0.000 claims 7
- 239000000651 prodrug Substances 0.000 claims 7
- 206010051246 Photodermatosis Diseases 0.000 claims 6
- 210000002615 epidermis Anatomy 0.000 claims 6
- 230000008845 photoaging Effects 0.000 claims 6
- 229960003966 nicotinamide Drugs 0.000 claims 5
- 235000005152 nicotinamide Nutrition 0.000 claims 5
- 239000011570 nicotinamide Substances 0.000 claims 5
- 206010040799 Skin atrophy Diseases 0.000 claims 4
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims 4
- 229960005084 calcitriol Drugs 0.000 claims 4
- 235000020964 calcitriol Nutrition 0.000 claims 4
- 239000011612 calcitriol Substances 0.000 claims 4
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 4
- 206010003694 Atrophy Diseases 0.000 claims 3
- 230000037444 atrophy Effects 0.000 claims 3
- DIFSFFZHWQSHBX-CLECVEASSA-N (1ar,3s,4as,7s,8as)-3-[(1s,2r,3r)-3-[(2r,5s)-5,6-dimethylheptan-2-yl]-2-(2-hydroxyethyl)-2-methylcyclopentyl]-7-hydroxy-4a-methyl-2,3,5,6,7,8-hexahydro-1ah-naphtho[4,4a-b]oxiren-4-one Chemical compound OCC[C@]1(C)[C@@H]([C@H](C)CC[C@H](C)C(C)C)CC[C@H]1[C@H]1C(=O)[C@@]2(C)CC[C@H](O)C[C@@]32O[C@@H]3C1 DIFSFFZHWQSHBX-CLECVEASSA-N 0.000 claims 2
- 239000002537 cosmetic Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 2
- 230000037303 wrinkles Effects 0.000 claims 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 206010013786 Dry skin Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002845 discoloration Methods 0.000 claims 1
- 230000037336 dry skin Effects 0.000 claims 1
- 208000024963 hair loss Diseases 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 230000009245 menopause Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 238000007665 sagging Methods 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67932905P | 2005-05-10 | 2005-05-10 | |
| PCT/IL2006/000552 WO2006120681A2 (en) | 2005-05-10 | 2006-05-10 | Compositions and methods for skin care |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008540513A JP2008540513A (ja) | 2008-11-20 |
| JP2008540513A5 true JP2008540513A5 (cg-RX-API-DMAC10.html) | 2009-06-18 |
Family
ID=37396969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008510723A Pending JP2008540513A (ja) | 2005-05-10 | 2006-05-10 | スキンケアのための組成物及び方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8034788B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1879449A4 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2008540513A (cg-RX-API-DMAC10.html) |
| CN (1) | CN101217868A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2006245282A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2608021A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2006120681A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090098065A1 (en) * | 2000-01-11 | 2009-04-16 | Avikam Harel | Composition and methods for the treatment of skin disorders |
| JP2008540514A (ja) * | 2005-05-10 | 2008-11-20 | ダーミプソル リミテッド | 過剰増殖表皮疾患の治療用組成物及び方法 |
| WO2008131256A1 (en) * | 2007-04-19 | 2008-10-30 | Trinity Laboratories Inc. | Improved treatments for premature ejaculation in humans |
| US20110123481A1 (en) * | 2007-08-16 | 2011-05-26 | Remedor Biomed Ltd. | Erythropoietin and fibronectin compositions for therapeutic and cosmetic applications |
| FR2925314B1 (fr) * | 2007-12-19 | 2012-11-23 | Oreal | Utilisation cosmetique de proteines de type transglutaminase 3 |
| FR2925313A1 (fr) * | 2007-12-19 | 2009-06-26 | Oreal | Utilisation cosmetique de proteines de type plakoglobine |
| FR2936421B1 (fr) * | 2008-09-29 | 2011-02-11 | Bouill Mariya Le | Produit de beaute et de soin pour faire disparaitre les rides du visage, empecher leur apparition et maintenir la tonicite de la peau |
| RU2397770C1 (ru) * | 2008-12-30 | 2010-08-27 | Закрытое акционерное общество Фармацевтическое научно-производственное предприятие "Ретиноиды" | Поливитаминная мазь для смягчения, питания и заживления кожи и способ ее получения |
| MX366076B (es) * | 2009-08-14 | 2019-06-27 | Berg Llc | Vitamina d3 y analogos de la misma para tratar alopecia. |
| RU2560677C2 (ru) * | 2009-12-22 | 2015-08-20 | Лео Фарма А/С | Кожная композиция, включающая аналог витамина d и смесь растворителя и поверхностно-активных веществ |
| WO2011087525A1 (en) * | 2010-01-17 | 2011-07-21 | The Procter & Gamble Company | Biomarker-based methods for formulating compositions that improve skin quality and reduce the visible signs of aging in skin for individuals in a selected population |
| KR102114892B1 (ko) * | 2016-01-11 | 2020-05-26 | 더 프록터 앤드 갬블 캄파니 | 피부 상태의 치료 방법 및 그를 위한 조성물 |
| ES2859777T3 (es) * | 2017-02-06 | 2021-10-04 | 3Skin As | Composición de filtro solar |
| KR102069088B1 (ko) * | 2018-04-02 | 2020-01-22 | 양미경 | 탈모의 예방 또는 치료용, 또는 발모 또는 육모 촉진용 약학 또는 화장료 조성물 |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
| CN114126623A (zh) * | 2019-05-17 | 2022-03-01 | 宾夕法尼亚大学董事会 | 治疗肥胖和/或皮肤紊乱的方法和组合物 |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| CN115843238B (zh) | 2020-06-01 | 2025-06-10 | 宝洁公司 | 改善维生素b3化合物渗透到皮肤中的方法 |
| CN118384058A (zh) * | 2024-04-08 | 2024-07-26 | 云南贝泰妮生物科技集团股份有限公司 | 烟酰胺在制备预防和/或治疗皮肤光老化护肤品和药物中的应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5120722A (en) | 1984-02-08 | 1992-06-09 | Hoffmann-La Roche Inc. | Trihydroxy-cholecacliferol and trihydroxy-ergocalciferol for treating leukemia |
| WO1987000834A1 (en) | 1985-08-02 | 1987-02-12 | Leo Pharmaceutical Products Ltd. A/S | Novel vitamin d analogues |
| US4804502A (en) | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
| US5145846A (en) | 1988-01-20 | 1992-09-08 | Hoffmann-La Roche Inc. | Vitamin D3 analogs |
| US4851401A (en) | 1988-07-14 | 1989-07-25 | Wisconsin Alumni Research Foundation | Novel cyclopentano-vitamin D analogs |
| CA1333616C (en) | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| GB9007236D0 (en) | 1990-03-30 | 1990-05-30 | Leo Pharm Prod Ltd | Chemical compounds |
| GB9017890D0 (en) | 1990-08-15 | 1990-09-26 | Leo Pharm Prod Ltd | Chemical compounds i |
| DE69213844T2 (de) | 1991-07-05 | 1997-04-10 | Duphar Int Res | Vitamin-D Derivat, Verfahren zu dessen Herstellung sowie Zwischenprodukte dafür |
| DE4141746A1 (de) | 1991-12-13 | 1993-06-17 | Schering Ag | 20-methyl-substituierte vitamin d-derivate |
| US5237629A (en) * | 1992-03-19 | 1993-08-17 | The United States Of America As Represented By The United States Department Of Energy | Digitally controlled distributed phase shifter |
| GB9206648D0 (en) | 1992-03-26 | 1992-05-06 | Leo Pharm Prod Ltd | Chemical compounds |
| US5747479A (en) | 1996-01-03 | 1998-05-05 | Hoffmann-La Roche Inc. | Vitamin D3 analogs useful for reversing the photodamage in sun-exposed skin |
| EP0900185B1 (en) | 1996-05-02 | 2001-03-14 | Duphar International Research B.V | Vitamin d analogs and methods of preparing these compounds |
| US5811414A (en) | 1997-05-16 | 1998-09-22 | Hoffmann-La Roche Inc. | Vitamin D3 analogs useful for reversing the photodamage in sun-exposed skin |
| US6262041B1 (en) | 1998-04-06 | 2001-07-17 | Bertek Pharmaceuticals, Inc. | Use of vitamin D analogs to treat conditions related to increased oxidative stress |
| US6552009B2 (en) | 1998-07-16 | 2003-04-22 | Gentrix Llc | Compositions and methods of treating abnormal cell proliferation |
| US20010002396A1 (en) * | 1998-07-16 | 2001-05-31 | Charles Achkar | Compositions and methods of treating skin conditions |
| US6284234B1 (en) | 1998-08-04 | 2001-09-04 | Johnson & Johnson Consumer Companies, Inc. | Topical delivery systems for active agents |
| CN1173703C (zh) | 1999-04-23 | 2004-11-03 | 里奥药物制品有限公司 | 药物组合物 |
| FR2801305B1 (fr) | 1999-11-24 | 2002-12-06 | Galderma Res & Dev | Analogues de la vitamine d |
| IL133976A (en) | 2000-01-11 | 2006-09-05 | Dermipsor Ltd | Agents for the treatment of skin disorders |
| CA2492248A1 (en) * | 2002-07-11 | 2004-01-22 | Avikam Harel | Composition and methods for the treatment of skin disorders |
-
2006
- 2006-05-10 WO PCT/IL2006/000552 patent/WO2006120681A2/en not_active Ceased
- 2006-05-10 CA CA002608021A patent/CA2608021A1/en not_active Abandoned
- 2006-05-10 EP EP06728341A patent/EP1879449A4/en not_active Ceased
- 2006-05-10 JP JP2008510723A patent/JP2008540513A/ja active Pending
- 2006-05-10 CN CNA2006800220611A patent/CN101217868A/zh active Pending
- 2006-05-10 AU AU2006245282A patent/AU2006245282A1/en not_active Abandoned
- 2006-05-10 US US11/914,093 patent/US8034788B2/en not_active Expired - Fee Related
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