JP2008539258A5 - - Google Patents
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- Publication number
- JP2008539258A5 JP2008539258A5 JP2008509091A JP2008509091A JP2008539258A5 JP 2008539258 A5 JP2008539258 A5 JP 2008539258A5 JP 2008509091 A JP2008509091 A JP 2008509091A JP 2008509091 A JP2008509091 A JP 2008509091A JP 2008539258 A5 JP2008539258 A5 JP 2008539258A5
- Authority
- JP
- Japan
- Prior art keywords
- tanaproget
- polymorph
- solution
- water
- concentrated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- PYVFWTPEBMRKSR-UHFFFAOYSA-N tanaproget Chemical compound CN1C(C#N)=CC=C1C1=CC=C(NC(=S)OC2(C)C)C2=C1 PYVFWTPEBMRKSR-UHFFFAOYSA-N 0.000 claims 32
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 24
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 24
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 24
- 238000000034 method Methods 0.000 claims 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 12
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims 10
- 229950001471 tanaproget Drugs 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 4
- 238000010438 heat treatment Methods 0.000 claims 4
- 238000002441 X-ray diffraction Methods 0.000 claims 3
- 238000000113 differential scanning calorimetry Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000001757 thermogravimetry curve Methods 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 2
- BQMPGKPTOHKYHS-UHFFFAOYSA-N 1h-pyrrole-2-carbonitrile Chemical group N#CC1=CC=CN1 BQMPGKPTOHKYHS-UHFFFAOYSA-N 0.000 claims 1
- -1 4,4-dimethyl-2-thioxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl Chemical group 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 206010046798 Uterine leiomyoma Diseases 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 230000037406 food intake Effects 0.000 claims 1
- 235000012631 food intake Nutrition 0.000 claims 1
- 238000002657 hormone replacement therapy Methods 0.000 claims 1
- 201000010260 leiomyoma Diseases 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 230000002632 myometrial effect Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67573705P | 2005-04-28 | 2005-04-28 | |
| PCT/US2006/015852 WO2006116526A2 (en) | 2005-04-28 | 2006-04-26 | Polymorph form ii of tanaproget |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013242731A Division JP2014088385A (ja) | 2005-04-28 | 2013-11-25 | タナプロゲットの精製形態ｉｉ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008539258A JP2008539258A (ja) | 2008-11-13 |
| JP2008539258A5 true JP2008539258A5 (enExample) | 2009-06-04 |
Family
ID=36954854
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008509091A Pending JP2008539258A (ja) | 2005-04-28 | 2006-04-26 | タナプロゲットの精製形態ｉｉ |
| JP2013242731A Pending JP2014088385A (ja) | 2005-04-28 | 2013-11-25 | タナプロゲットの精製形態ｉｉ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013242731A Pending JP2014088385A (ja) | 2005-04-28 | 2013-11-25 | タナプロゲットの精製形態ｉｉ |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US7759341B2 (enExample) |
| EP (1) | EP1874763A2 (enExample) |
| JP (2) | JP2008539258A (enExample) |
| CN (1) | CN101166736B (enExample) |
| AR (1) | AR053596A1 (enExample) |
| AU (1) | AU2006241125B2 (enExample) |
| BR (1) | BRPI0610433A2 (enExample) |
| CA (1) | CA2603807A1 (enExample) |
| MX (1) | MX2007013469A (enExample) |
| TW (1) | TW200716621A (enExample) |
| WO (1) | WO2006116526A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2544678C (en) | 2003-11-05 | 2013-12-31 | Sunesis Pharmaceuticals, Inc. | Modulators of cellular adhesion |
| SI1896034T1 (sl) | 2005-04-28 | 2010-07-30 | Wyeth Llc | Mikronizirani sestavki tanaprogeta in postopki priprave le-tega |
| EP1877059B8 (en) * | 2005-04-28 | 2010-05-19 | Wyeth a Corporation of the State of Delaware | Micronized tanaproget and compostions containing same |
| BRPI0610433A2 (pt) * | 2005-04-28 | 2010-11-23 | Wyeth Corp | forma polimórfica ii de tanaproget, processos para preparar a mesma, e para preparar forma micronizada de um composto, composição farmacêutica, método de preparação de uma composição farmacêutica, e, uso da forma polimórfica ii de tanaproget ou da forma micronizada |
| WO2007030153A2 (en) * | 2005-04-28 | 2007-03-15 | Wyeth | Compositions containing micronized tanaproget |
| CN103989687A (zh) | 2005-06-09 | 2014-08-20 | 惠氏公司 | 含有炔雌醇的tanaproget组合物 |
| BRPI0819571A2 (pt) | 2007-12-20 | 2019-09-24 | Teva Womenss Health Inc | "método para contracepção de emergência, pacote farmacêutico para contracepção de emergência e composição farmacêutica" |
| US20110237605A1 (en) * | 2010-03-26 | 2011-09-29 | Eric Phillips | Molecular Crystal of (4-(1,8-Naphthyridin-2-YL)Piperidin-1-YL)Pyrimidine Derivative |
| CN104364239B (zh) | 2012-06-13 | 2017-08-25 | 霍夫曼-拉罗奇有限公司 | 二氮杂螺环烷烃和氮杂螺环烷烃 |
| KR20200108932A (ko) * | 2012-07-25 | 2020-09-21 | 에스에이알코드 바이오사이언스 인코포레이티드 | Lfa-1 저해제 및 그의 다형체 |
| MX368615B (es) | 2012-09-25 | 2019-10-09 | Hoffmann La Roche | Derivados bicíclicos como inhibidores de la autotaxina (atx) que son inhibidores de la producción de ácido lisofosfatídico (lpa) y el uso de los mismos. |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| DK3074400T3 (en) | 2013-11-26 | 2018-01-15 | Hoffmann La Roche | Octahydro-cyclobuta [1,2-c; 3,4-c '] dipyrrole derivatives as autotaxin inhibitors |
| CA2937616A1 (en) | 2014-03-26 | 2015-10-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| EA032357B1 (ru) | 2014-03-26 | 2019-05-31 | Ф. Хоффманн-Ля Рош Аг | Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| CA2992889A1 (en) | 2015-09-04 | 2017-03-09 | F. Hoffmann-La Roche Ag | Phenoxymethyl derivatives |
| JP6876685B2 (ja) | 2015-09-24 | 2021-05-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ａｔｘ阻害剤としての二環式化合物 |
| WO2017050732A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| BR112017026682A2 (pt) | 2015-09-24 | 2018-08-14 | Hoffmann La Roche | novos compostos bicíclicos como inibidores de dupla ação de atx/ca |
| AU2016328436B2 (en) | 2015-09-24 | 2020-05-14 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual ATX/CA inhibitors |
| RU2019132254A (ru) | 2017-03-16 | 2021-04-16 | Ф. Хоффманн-Ля Рош Аг | Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca |
| JP7090099B2 (ja) | 2017-03-16 | 2022-06-23 | エフ．ホフマン－ラ ロシュ アーゲー | Ａｔｘインヒビターとしての新規二環式化合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE386729T1 (de) * | 1999-05-04 | 2008-03-15 | Wyeth Corp | Cyclothiocarbamatderivate als progesteron- rezeptormodulatoren |
| UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| RU2005101638A (ru) * | 2002-06-25 | 2006-01-20 | Уайт (Us) | Использование циклокарбаматных производных для лечения гормонзависимых состояний |
| US7268149B2 (en) * | 2002-06-25 | 2007-09-11 | Wyeth | Cyclothiocarbamate derivatives as progesterone receptor modulators and methods of treating skin disorders |
| US8399013B2 (en) * | 2003-06-26 | 2013-03-19 | Poly-Med, Inc. | Partially absorbable fiber-reinforced composites for controlled drug delivery |
| TW200604137A (en) | 2004-04-27 | 2006-02-01 | Wyeth Corp | Coupling process for generating reactive boron-containing derivatives of n-substituted pyrrole-2-carbonitriles to produce biaryls |
| EP1756072A2 (en) * | 2004-04-27 | 2007-02-28 | Wyeth | Purification of progesterone receptor modulators |
| SI1778710T1 (sl) * | 2004-08-13 | 2012-05-31 | Wyeth Llc | Derivati tanaprogeta metaboliti in njihove uporabe |
| SI1896034T1 (sl) * | 2005-04-28 | 2010-07-30 | Wyeth Llc | Mikronizirani sestavki tanaprogeta in postopki priprave le-tega |
| JP2008539254A (ja) * | 2005-04-28 | 2008-11-13 | ワイス | タナプロゲットの精製形態 |
| EP1877059B8 (en) | 2005-04-28 | 2010-05-19 | Wyeth a Corporation of the State of Delaware | Micronized tanaproget and compostions containing same |
| WO2007030153A2 (en) * | 2005-04-28 | 2007-03-15 | Wyeth | Compositions containing micronized tanaproget |
| BRPI0610433A2 (pt) | 2005-04-28 | 2010-11-23 | Wyeth Corp | forma polimórfica ii de tanaproget, processos para preparar a mesma, e para preparar forma micronizada de um composto, composição farmacêutica, método de preparação de uma composição farmacêutica, e, uso da forma polimórfica ii de tanaproget ou da forma micronizada |
| CN103989687A (zh) * | 2005-06-09 | 2014-08-20 | 惠氏公司 | 含有炔雌醇的tanaproget组合物 |
-
2006
- 2006-04-25 BR BRPI0610433-9A patent/BRPI0610433A2/pt not_active IP Right Cessation
- 2006-04-25 MX MX2007013469A patent/MX2007013469A/es active IP Right Grant
- 2006-04-25 CN CN2006800142218A patent/CN101166736B/zh not_active Expired - Fee Related
- 2006-04-26 TW TW095114816A patent/TW200716621A/zh unknown
- 2006-04-26 US US11/412,015 patent/US7759341B2/en not_active Expired - Fee Related
- 2006-04-26 CA CA002603807A patent/CA2603807A1/en not_active Abandoned
- 2006-04-26 AR ARP060101668A patent/AR053596A1/es not_active Application Discontinuation
- 2006-04-26 AU AU2006241125A patent/AU2006241125B2/en not_active Ceased
- 2006-04-26 EP EP06751521A patent/EP1874763A2/en not_active Withdrawn
- 2006-04-26 JP JP2008509091A patent/JP2008539258A/ja active Pending
- 2006-04-26 WO PCT/US2006/015852 patent/WO2006116526A2/en not_active Ceased
-
2010
- 2010-06-03 US US12/792,978 patent/US7968709B2/en not_active Expired - Fee Related
-
2011
- 2011-05-12 US US13/106,494 patent/US8114869B2/en not_active Expired - Fee Related
-
2012
- 2012-01-10 US US13/347,080 patent/US20120115858A1/en not_active Abandoned
-
2013
- 2013-11-25 JP JP2013242731A patent/JP2014088385A/ja active Pending
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