JP2008538280A5 - - Google Patents
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- Publication number
- JP2008538280A5 JP2008538280A5 JP2008504448A JP2008504448A JP2008538280A5 JP 2008538280 A5 JP2008538280 A5 JP 2008538280A5 JP 2008504448 A JP2008504448 A JP 2008504448A JP 2008504448 A JP2008504448 A JP 2008504448A JP 2008538280 A5 JP2008538280 A5 JP 2008538280A5
- Authority
- JP
- Japan
- Prior art keywords
- lipid
- planar
- polypeptide
- lipid bilayer
- solid support
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000002632 lipids Chemical class 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 239000000232 Lipid Bilayer Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000007787 solid Substances 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 101800002011 Amphipathic peptide Proteins 0.000 claims 3
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- ZGSPNIOCEDOHGS-UHFFFAOYSA-L disodium [3-[2,3-di(octadeca-9,12-dienoyloxy)propoxy-oxidophosphoryl]oxy-2-hydroxypropyl] 2,3-di(octadeca-9,12-dienoyloxy)propyl phosphate Chemical compound [Na+].[Na+].CCCCCC=CCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COP([O-])(=O)OCC(O)COP([O-])(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COC(=O)CCCCCCCC=CCC=CCCCCC ZGSPNIOCEDOHGS-UHFFFAOYSA-L 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 2
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims 2
- 101800001014 Non-structural protein 5A Proteins 0.000 claims 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 1
- 239000003012 bilayer membrane Substances 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 230000001687 destabilization Effects 0.000 claims 1
- 230000000368 destabilizing effect Effects 0.000 claims 1
- 150000002343 gold Chemical class 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 229910001922 gold oxide Inorganic materials 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229910003446 platinum oxide Inorganic materials 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- 239000010703 silicon Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66664705P | 2005-03-29 | 2005-03-29 | |
| PCT/US2006/012085 WO2006110350A2 (en) | 2005-03-29 | 2006-03-29 | Method of fabricating lipid bilayer membranes on solid supports |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008538280A JP2008538280A (ja) | 2008-10-23 |
| JP2008538280A5 true JP2008538280A5 (enExample) | 2009-04-23 |
Family
ID=37087499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008504448A Pending JP2008538280A (ja) | 2005-03-29 | 2006-03-29 | 脂質二分子膜の製造方法 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US8211712B2 (enExample) |
| JP (1) | JP2008538280A (enExample) |
| WO (1) | WO2006110350A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8728793B2 (en) | 2007-07-19 | 2014-05-20 | The Board Of Trustees Of The Leland Stanford Junior University | Amphipathic alpha-helical peptide compositions as antiviral agents |
| GB0716264D0 (en) | 2007-08-21 | 2007-09-26 | Isis Innovation | Bilayers |
| MX2010011680A (es) * | 2008-04-25 | 2011-05-03 | Univ Northwestern | Nanoestructuras adecuadas para secuestrar colesterol y otras moleculas. |
| US20130034599A1 (en) | 2010-01-19 | 2013-02-07 | Northwestern University | Synthetic nanostructures including nucleic acids and/or other entities |
| EP2444808A1 (en) | 2010-10-21 | 2012-04-25 | Fredrik Höök | Method for fusion of lipid bilayers |
| WO2015013673A1 (en) | 2013-07-25 | 2015-01-29 | Aurasense Therapeutics, Llc | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| US10568898B2 (en) | 2013-08-13 | 2020-02-25 | Northwestern University | Lipophilic nanoparticles for drug delivery |
| US10427124B2 (en) * | 2013-09-19 | 2019-10-01 | Nanyang Technological University | Methods for controlling assembly of lipids on a solid support |
| EP2886663A1 (en) | 2013-12-19 | 2015-06-24 | Centre National de la Recherche Scientifique (CNRS) | Nanopore sequencing using replicative polymerases and helicases |
| US10434064B2 (en) | 2014-06-04 | 2019-10-08 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| JP6741673B2 (ja) | 2014-10-06 | 2020-08-19 | イグジキュア, インコーポレーテッドExicure, Inc. | 抗ｔｎｆ化合物 |
| FR3027679B1 (fr) | 2014-10-28 | 2016-12-09 | Univ Claude Bernard Lyon | Ensemble support / peptide / bicouche lipidique, procedes de preparation et procedes de detection associes |
| US10078092B2 (en) | 2015-03-18 | 2018-09-18 | Northwestern University | Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules |
| KR102617833B1 (ko) | 2016-05-06 | 2023-12-27 | 엑시큐어 오퍼레이팅 컴퍼니 | 인터류킨 17 수용체 mRNA의 특이적 녹다운을 위한 안티센스 올리고뉴클레오티드 (ASO)를 제시하는 리포좀성 구형 핵산 (SNA) 구축물 |
| KR102477244B1 (ko) * | 2017-02-15 | 2022-12-15 | 난양 테크놀러지컬 유니버시티 | 고체-지지된 인지질 이중층의 제조방법 |
| US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| WO2020041480A1 (en) | 2018-08-21 | 2020-02-27 | The Regents Of The University Of California | High-throughput system and method for the temporary permeabilization of cells using lipid bilayers |
| CN113599861B (zh) * | 2021-08-13 | 2023-06-27 | 广东石油化工学院 | 一种利用修饰基底分离磷脂膜中胆固醇的方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5364851A (en) * | 1991-06-14 | 1994-11-15 | International Synthecon, Llc | Conformationally restricted biologically active peptides, methods for their production and uses thereof |
| US6306598B1 (en) * | 1992-11-13 | 2001-10-23 | Regents Of The University Of California | Nucleic acid-coupled colorimetric analyte detectors |
| US5502022A (en) * | 1994-05-16 | 1996-03-26 | Biosepra, Inc. | Chromatography adsorbents utilizing mercapto heterocyclic ligands |
| US5521702A (en) * | 1994-06-14 | 1996-05-28 | Salamon; Zdzislaw | Reusable biocompatible interface for immobilization of materials on a solid support |
| US5997861A (en) * | 1994-10-31 | 1999-12-07 | Burstein Laboratories, Inc. | Antiviral supramolecules containing target-binding molecules and therapeutic molecules bound to spectrin |
| US6344436B1 (en) * | 1996-01-08 | 2002-02-05 | Baylor College Of Medicine | Lipophilic peptides for macromolecule delivery |
| DE19607279A1 (de) * | 1996-02-27 | 1997-08-28 | Bayer Ag | Durch Festkörper unterstützte Membran-Biosensoren |
| US5864814A (en) * | 1996-12-04 | 1999-01-26 | Justsystem Corp. | Voice-generating method and apparatus using discrete voice data for velocity and/or pitch |
| ATE293135T1 (de) * | 1998-12-22 | 2005-04-15 | Ciba Sc Pfersee Gmbh | Wässrige dispersionen für die textilveredlung |
| US6541071B1 (en) * | 2000-03-23 | 2003-04-01 | Corning Incorporated | Method for fabricating supported bilayer-lipid membranes |
| US7326536B2 (en) * | 2001-05-03 | 2008-02-05 | Eli Lilly And Company | Agents for treatment of HCV and methods of use |
| WO2005084369A2 (en) * | 2004-03-03 | 2005-09-15 | The Regents Of The University Of California | Arrays of colloidal crystals |
| US20060068503A1 (en) * | 2004-09-10 | 2006-03-30 | John Cuppoletti | Solid support membranes for ion channel arrays and sensors: application ro rapid screening of pharmacological compounds |
| JP4263154B2 (ja) * | 2004-09-30 | 2009-05-13 | 日立ソフトウエアエンジニアリング株式会社 | 機能性微粒子アレイ及びその使用方法 |
| SE0403139D0 (sv) * | 2004-12-23 | 2004-12-23 | Nanoxis Ab | Device and use thereof |
| JP2007040974A (ja) * | 2005-06-30 | 2007-02-15 | Omron Corp | 生体分子固定化基板、バイオチップ及びバイオセンサ |
| US20070224637A1 (en) * | 2006-03-24 | 2007-09-27 | Mcauliffe Joseph C | Oxidative protection of lipid layer biosensors |
| KR20080012605A (ko) * | 2006-08-04 | 2008-02-12 | 삼성에스디아이 주식회사 | 탄성 에너지 장벽을 이용한 생체막 소자 |
-
2006
- 2006-03-29 WO PCT/US2006/012085 patent/WO2006110350A2/en not_active Ceased
- 2006-03-29 JP JP2008504448A patent/JP2008538280A/ja active Pending
- 2006-03-29 US US11/887,669 patent/US8211712B2/en not_active Expired - Fee Related
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