JP2008538114A5 - - Google Patents
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- Publication number
- JP2008538114A5 JP2008538114A5 JP2008503267A JP2008503267A JP2008538114A5 JP 2008538114 A5 JP2008538114 A5 JP 2008538114A5 JP 2008503267 A JP2008503267 A JP 2008503267A JP 2008503267 A JP2008503267 A JP 2008503267A JP 2008538114 A5 JP2008538114 A5 JP 2008538114A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- following formula
- pharmaceutical composition
- disease
- cholecalciferol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 43
- 150000001875 compounds Chemical class 0.000 claims 38
- 239000011647 vitamin D3 Substances 0.000 claims 36
- 229940021056 vitamin d3 Drugs 0.000 claims 36
- 201000010099 disease Diseases 0.000 claims 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 23
- -1 4-hydroxy-4-methyl-pentyl Chemical group 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 125000001188 haloalkyl group Chemical group 0.000 claims 9
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 7
- 230000002159 abnormal effect Effects 0.000 claims 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 6
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims 6
- 125000001153 fluoro group Chemical group F* 0.000 claims 5
- 101000984186 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 4 Proteins 0.000 claims 4
- 102100025578 Leukocyte immunoglobulin-like receptor subfamily B member 4 Human genes 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 229960002061 ergocalciferol Drugs 0.000 claims 3
- 208000026278 immune system disease Diseases 0.000 claims 3
- 235000001892 vitamin D2 Nutrition 0.000 claims 3
- 239000011653 vitamin D2 Substances 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 2
- 206010069632 Bladder dysfunction Diseases 0.000 claims 2
- 208000013558 Developmental Bone disease Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 2
- 206010072610 Skeletal dysplasia Diseases 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 2
- 210000003890 endocrine cell Anatomy 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 230000003463 hyperproliferative effect Effects 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 208000019553 vascular disease Diseases 0.000 claims 2
- 235000005282 vitamin D3 Nutrition 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000021959 Abnormal metabolism Diseases 0.000 claims 1
- 206010000234 Abortion spontaneous Diseases 0.000 claims 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 208000026872 Addison Disease Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000004300 Atrophic Gastritis Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 206010008909 Chronic Hepatitis Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 201000003066 Diffuse Scleroderma Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
- 208000036495 Gastritis atrophic Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000001204 Hashimoto Disease Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 1
- 206010019755 Hepatitis chronic active Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020649 Hyperkeratosis Diseases 0.000 claims 1
- 206010020853 Hypertonic bladder Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000001126 Keratosis Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 102000003982 Parathyroid hormone Human genes 0.000 claims 1
- 108090000445 Parathyroid hormone Proteins 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010034277 Pemphigoid Diseases 0.000 claims 1
- 241000721454 Pemphigus Species 0.000 claims 1
- 208000031845 Pernicious anaemia Diseases 0.000 claims 1
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000003782 Raynaud disease Diseases 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 208000033464 Reiter syndrome Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 206010038910 Retinitis Diseases 0.000 claims 1
- 208000005770 Secondary Hyperparathyroidism Diseases 0.000 claims 1
- 206010039984 Senile osteoporosis Diseases 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 201000007023 Thrombotic Thrombocytopenic Purpura Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000025609 Urogenital disease Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 208000032594 Vascular Remodeling Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 206010047124 Vasculitis necrotising Diseases 0.000 claims 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 1
- 208000037849 arterial hypertension Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims 1
- 210000002449 bone cell Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 208000016644 chronic atrophic gastritis Diseases 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000003831 deregulation Effects 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 230000001079 digestive effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 206010014599 encephalitis Diseases 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 claims 1
- 230000006058 immune tolerance Effects 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 230000023404 leukocyte cell-cell adhesion Effects 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 230000006371 metabolic abnormality Effects 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 208000005368 osteomalacia Diseases 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 208000020629 overactive bladder Diseases 0.000 claims 1
- 230000000849 parathyroid Effects 0.000 claims 1
- 239000000199 parathyroid hormone Substances 0.000 claims 1
- 229960001319 parathyroid hormone Drugs 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- 208000002574 reactive arthritis Diseases 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 201000003068 rheumatic fever Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000007442 rickets Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 210000004927 skin cell Anatomy 0.000 claims 1
- 208000000995 spontaneous abortion Diseases 0.000 claims 1
- 230000002269 spontaneous effect Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 210000001745 uvea Anatomy 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 0 CC(C)(CCCC(C)(CCCC(C)(C)O)[C@@](CC1)[C@@](C)(CCC2)C1C2=CC=C(C[C@@](C[C@@]1*)O)C1=*C)O Chemical compound CC(C)(CCCC(C)(CCCC(C)(C)O)[C@@](CC1)[C@@](C)(CCC2)C1C2=CC=C(C[C@@](C[C@@]1*)O)C1=*C)O 0.000 description 6
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66436705P | 2005-03-23 | 2005-03-23 | |
| US66439705P | 2005-03-23 | 2005-03-23 | |
| PCT/US2006/011000 WO2006102647A1 (en) | 2005-03-23 | 2006-03-23 | 20-alkyl, gemini vitamin d3 compounds and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008538114A JP2008538114A (ja) | 2008-10-09 |
| JP2008538114A5 true JP2008538114A5 (https=) | 2009-05-07 |
Family
ID=37024174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503267A Pending JP2008538114A (ja) | 2005-03-23 | 2006-03-23 | ２０−アルキル、ジェミニビタミンｄ３化合物及びその使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090099140A1 (https=) |
| EP (1) | EP1879596A4 (https=) |
| JP (1) | JP2008538114A (https=) |
| CA (1) | CA2601914A1 (https=) |
| TW (1) | TW200738244A (https=) |
| WO (1) | WO2006102647A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009115398A1 (en) * | 2008-03-18 | 2009-09-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Vitamin d compounds for the treatment of biliary diseases |
| CN102628872A (zh) * | 2012-03-31 | 2012-08-08 | 广州菲康生物技术有限公司 | 25羟基维生素d检测试剂盒及其制备方法 |
| US20130295083A1 (en) * | 2012-05-02 | 2013-11-07 | Wisconsin Alumni Research Foundation | 2a-Methyl-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2AMD) or 2 methylene-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2MD) Support Survival and Function of Transplanted Islet Cells In Type 1 Diabetes |
| CN102692514A (zh) * | 2012-06-21 | 2012-09-26 | 厦门大学 | 血液25-羟基维生素d3腺癌检测试剂盒及其制备方法 |
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| EP4593867A2 (en) | 2022-09-30 | 2025-08-06 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG70010A1 (en) * | 1996-05-23 | 2000-01-25 | Hoffmann La Roche | Fluorinated vitamin d3 analogs |
| BR9809313B1 (pt) * | 1997-04-28 | 2010-11-16 | compostos análogos de vitamina d3, processo para a sua preparação e utilização dos mesmos para a preparação de medicamentos para o tratamento de hiperparatiroidismo primário e secundário, osteodistrofia renal, doenças de auto imunização, esclerose múltipla ou lúpus, e doenças neoplásticas. | |
| US6030962A (en) * | 1997-04-28 | 2000-02-29 | Synttex (U.S.A.) Inc. | Vitamin D3 analogs with bis C-20 side chains |
| WO1999049870A1 (en) * | 1998-03-27 | 1999-10-07 | Oregon Health Sciences University | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
| US6516294B1 (en) * | 1999-07-01 | 2003-02-04 | The Regents Of The University Of California | Nuclear receptor for 1α,25-dihydroxyvitamin D3 useful for selection of vitamin D3 ligands and a method therefor |
| US20030095937A1 (en) * | 2001-10-02 | 2003-05-22 | Koeffler H. Philip | Method for stimulating hair growth by administering vitamin D analogs |
| EP1622455A4 (en) * | 2003-04-30 | 2009-12-16 | Bioxell Spa | GEMINI VITAMIN D3 COMPOUNDS AND METHOD FOR THEIR USE |
| CN101198336A (zh) * | 2005-03-23 | 2008-06-11 | 拜奥艾克塞尔股份公司 | 20－烷基双生维生素d3化合物及其使用方法 |
-
2006
- 2006-03-23 WO PCT/US2006/011000 patent/WO2006102647A1/en not_active Ceased
- 2006-03-23 EP EP06748707A patent/EP1879596A4/en not_active Withdrawn
- 2006-03-23 JP JP2008503267A patent/JP2008538114A/ja active Pending
- 2006-03-23 CA CA002601914A patent/CA2601914A1/en not_active Abandoned
- 2006-03-23 US US11/886,826 patent/US20090099140A1/en not_active Abandoned
- 2006-03-28 TW TW095110652A patent/TW200738244A/zh unknown
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