JP2008535803A - 有糸分裂キネシン阻害剤 - Google Patents
有糸分裂キネシン阻害剤 Download PDFInfo
- Publication number
- JP2008535803A JP2008535803A JP2008501920A JP2008501920A JP2008535803A JP 2008535803 A JP2008535803 A JP 2008535803A JP 2008501920 A JP2008501920 A JP 2008501920A JP 2008501920 A JP2008501920 A JP 2008501920A JP 2008535803 A JP2008535803 A JP 2008535803A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- heterocyclyl
- cycloalkyl
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 *C(*(C(C1)c2ccccc2)*=C1c1ccccc1)=O Chemical compound *C(*(C(C1)c2ccccc2)*=C1c1ccccc1)=O 0.000 description 4
- YNWBHWFATMKRLN-UHFFFAOYSA-N CC(N(C(CC=C)(C1)c2ccccc2)N=C1c1cc(F)ccc1F)=O Chemical compound CC(N(C(CC=C)(C1)c2ccccc2)N=C1c1cc(F)ccc1F)=O YNWBHWFATMKRLN-UHFFFAOYSA-N 0.000 description 1
- LJURJBPDJQEPFS-UHFFFAOYSA-N CC(N(C(CCC[Si+](C)(C)O)(C1)c2ccccc2)N=C1c1cc(F)ccc1F)=O Chemical compound CC(N(C(CCC[Si+](C)(C)O)(C1)c2ccccc2)N=C1c1cc(F)ccc1F)=O LJURJBPDJQEPFS-UHFFFAOYSA-N 0.000 description 1
- VONUFUUABKXHAY-UHFFFAOYSA-N C[IH][IH]NC(c1ccccc1)=O Chemical compound C[IH][IH]NC(c1ccccc1)=O VONUFUUABKXHAY-UHFFFAOYSA-N 0.000 description 1
- WPCXDBCEDWUSOU-UHFFFAOYSA-N O=C(c1ccccc1)I Chemical compound O=C(c1ccccc1)I WPCXDBCEDWUSOU-UHFFFAOYSA-N 0.000 description 1
- ZTCFOSQTSRNLHW-UHFFFAOYSA-N OC(CC(c1ccccc1)=O)c1ccccc1 Chemical compound OC(CC(c1ccccc1)=O)c1ccccc1 ZTCFOSQTSRNLHW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66222605P | 2005-03-16 | 2005-03-16 | |
| PCT/US2006/008482 WO2006101761A2 (en) | 2005-03-16 | 2006-03-10 | Mitotic kinesin inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008535803A true JP2008535803A (ja) | 2008-09-04 |
| JP2008535803A5 JP2008535803A5 (enExample) | 2009-04-16 |
Family
ID=37024314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008501920A Withdrawn JP2008535803A (ja) | 2005-03-16 | 2006-03-10 | 有糸分裂キネシン阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7625936B2 (enExample) |
| EP (1) | EP1861366A2 (enExample) |
| JP (1) | JP2008535803A (enExample) |
| CN (1) | CN101142183A (enExample) |
| AU (1) | AU2006227854A1 (enExample) |
| CA (1) | CA2599436A1 (enExample) |
| WO (1) | WO2006101761A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7629373B2 (en) | 2005-04-07 | 2009-12-08 | Merck & Co. Inc. | Mitotic kinesin inhibitors |
| PE20091349A1 (es) | 2007-10-19 | 2009-09-07 | Schering Corp | Compuestos derivados de espiro 1,3,4-tiadiazol como inhibidores de la actividad quinesina ksp |
| PL214017B1 (pl) * | 2009-09-11 | 2013-06-28 | Univ Adama Mickiewicza | Nowe (E)-styrylo-alkinylopodstawione zwiazki krzemu oraz sposób otrzymywania (E)-styrylo-alkinylopodstawionych zwiazków krzemu |
| CN111116419B (zh) * | 2014-03-04 | 2022-03-29 | 江苏豪森药业集团有限公司 | 曲前列尼尔中间体及其制备工艺 |
| CN111138338A (zh) * | 2020-01-20 | 2020-05-12 | 中国人民解放军61699部队 | 一种光催化氟烷基吲哚啉的合成方法 |
| WO2024229406A1 (en) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
| TW202530228A (zh) | 2023-10-12 | 2025-08-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
-
2006
- 2006-03-10 EP EP06737641A patent/EP1861366A2/en not_active Withdrawn
- 2006-03-10 CA CA002599436A patent/CA2599436A1/en not_active Abandoned
- 2006-03-10 WO PCT/US2006/008482 patent/WO2006101761A2/en not_active Ceased
- 2006-03-10 US US11/886,274 patent/US7625936B2/en not_active Expired - Fee Related
- 2006-03-10 JP JP2008501920A patent/JP2008535803A/ja not_active Withdrawn
- 2006-03-10 CN CNA2006800081430A patent/CN101142183A/zh active Pending
- 2006-03-10 AU AU2006227854A patent/AU2006227854A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1861366A2 (en) | 2007-12-05 |
| AU2006227854A1 (en) | 2006-09-28 |
| CA2599436A1 (en) | 2006-09-28 |
| CN101142183A (zh) | 2008-03-12 |
| US7625936B2 (en) | 2009-12-01 |
| WO2006101761A3 (en) | 2007-03-08 |
| WO2006101761A2 (en) | 2006-09-28 |
| US20080194582A1 (en) | 2008-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090227 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20090227 |
|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20090828 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20090828 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20101027 |