JP2008533986A5 - - Google Patents
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- Publication number
- JP2008533986A5 JP2008533986A5 JP2008502560A JP2008502560A JP2008533986A5 JP 2008533986 A5 JP2008533986 A5 JP 2008533986A5 JP 2008502560 A JP2008502560 A JP 2008502560A JP 2008502560 A JP2008502560 A JP 2008502560A JP 2008533986 A5 JP2008533986 A5 JP 2008533986A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- isolated
- isolated polypeptide
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims 27
- 108091033319 polynucleotide Proteins 0.000 claims 11
- 102000040430 polynucleotide Human genes 0.000 claims 11
- 239000002157 polynucleotide Substances 0.000 claims 11
- 150000007523 nucleic acids Chemical group 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 102000008300 Mutant Proteins Human genes 0.000 claims 4
- 108010021466 Mutant Proteins Proteins 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 239000003981 vehicle Substances 0.000 claims 4
- 108010077850 Nuclear Localization Signals Proteins 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000027455 binding Effects 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000009870 specific binding Effects 0.000 claims 2
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 claims 1
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66496705P | 2005-03-25 | 2005-03-25 | |
| US69891905P | 2005-07-14 | 2005-07-14 | |
| PCT/IL2006/000372 WO2006100681A2 (en) | 2005-03-25 | 2006-03-23 | Human synthetic single-chain antibodies directed against the common epitope of mutant p53 and their uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008533986A JP2008533986A (ja) | 2008-08-28 |
| JP2008533986A5 true JP2008533986A5 (cg-RX-API-DMAC7.html) | 2009-03-12 |
Family
ID=36617330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008502560A Pending JP2008533986A (ja) | 2005-03-25 | 2006-03-23 | 変異型ｐ５３の共通エピトープに対するヒト合成単鎖抗体およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8039594B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1863846B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2008533986A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE437185T1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE602006007967D1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006100681A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE437185T1 (de) | 2005-03-25 | 2009-08-15 | Univ Ramot | Gegen das gemeinsame epitop von mutierten p53 gerichtete humane synthetische einzelkettenantikörper und anwendungen davon |
| US20090324554A1 (en) * | 2006-07-21 | 2009-12-31 | Ramot At Tel Aviv University Ltd. | Method for inhibiting or treating a disease associated with intracellular formation of protein fibrillar or aggregates |
| US20100196403A1 (en) * | 2007-01-29 | 2010-08-05 | Jacob Hochman | Antibody conjugates for circumventing multi-drug resistance |
| CA2705353C (en) * | 2007-11-14 | 2017-07-25 | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | Methods of treating cancer using anti cd24 antibodies |
| IL208820A0 (en) * | 2010-10-19 | 2011-01-31 | Rachel Teitelbaum | Biologic female contraceptives |
| EP2573565A1 (en) | 2011-09-23 | 2013-03-27 | Gerhard Matthias Kresbach | Immune detection method for common epitopes of two or more analytes in samples of complex compositions, device, and kit for enabling said immune detection method |
| EP3286222A4 (en) * | 2015-03-23 | 2018-08-08 | The Johns Hopkins University | Hla-restricted epitopes encoded by somatically mutated genes |
| CN107922927A (zh) | 2015-06-19 | 2018-04-17 | 学校法人东京理科大学 | 蛋白质分解诱导标签及其用途 |
| GB201617564D0 (en) * | 2016-10-17 | 2016-11-30 | Agency For Science Technology And Research And National University Of Singapore And Singapore Health | Anti-p53 antibodies |
| CA3043805A1 (en) | 2016-11-15 | 2018-05-24 | Tokyo University Of Science Foundation | Ras protein degradation inducing molecule and pharmaceutical composition |
| US11007269B2 (en) | 2016-11-15 | 2021-05-18 | Tokyo University Of Science Foundation | P53 degradation inducing molecule and pharmaceutical composition |
| US11807662B2 (en) | 2017-05-16 | 2023-11-07 | The Johns Hopkins University | MANAbodies and methods of using |
| EP4412650A1 (en) * | 2021-10-05 | 2024-08-14 | The Penn State Research Foundation | Methods for treating cancers with mutated p53 |
| KR20250035548A (ko) * | 2022-07-10 | 2025-03-12 | 엠브레이스 테라퓨틱스, 인크. | 재조합 항체 생산의 무세포 방법 |
| CN115876993B (zh) * | 2022-11-17 | 2024-10-15 | 沈阳农业大学 | 基于生物膜干涉技术检测病原生物凝集素与唾液酸乳糖亲和力方法的建立 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2755144B1 (fr) * | 1996-10-29 | 1998-11-27 | Rhone Poulenc Rorer Sa | Fragments d'anticorps a chaine unique anti-p53 et utilisation |
| US6630584B1 (en) * | 2000-03-16 | 2003-10-07 | Ramot At Tel-Aviv University Ltd. | Single chain antibody against mutant p53 |
| ATE437185T1 (de) | 2005-03-25 | 2009-08-15 | Univ Ramot | Gegen das gemeinsame epitop von mutierten p53 gerichtete humane synthetische einzelkettenantikörper und anwendungen davon |
-
2006
- 2006-03-23 AT AT06711342T patent/ATE437185T1/de not_active IP Right Cessation
- 2006-03-23 US US11/887,123 patent/US8039594B2/en not_active Expired - Fee Related
- 2006-03-23 EP EP06711342A patent/EP1863846B1/en not_active Not-in-force
- 2006-03-23 JP JP2008502560A patent/JP2008533986A/ja active Pending
- 2006-03-23 WO PCT/IL2006/000372 patent/WO2006100681A2/en not_active Ceased
- 2006-03-23 DE DE602006007967T patent/DE602006007967D1/de active Active
-
2011
- 2011-07-12 US US13/180,581 patent/US8207309B2/en not_active Expired - Fee Related
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