JP2008533161A - PPAR−γアンタゴニストを使用するがんの治療方法 - Google Patents

PPAR−γアンタゴニストを使用するがんの治療方法 Download PDF

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Publication number
JP2008533161A
JP2008533161A JP2008501998A JP2008501998A JP2008533161A JP 2008533161 A JP2008533161 A JP 2008533161A JP 2008501998 A JP2008501998 A JP 2008501998A JP 2008501998 A JP2008501998 A JP 2008501998A JP 2008533161 A JP2008533161 A JP 2008533161A
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JP
Japan
Prior art keywords
cancer
pparγ
antagonist
subject
anticancer agent
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Pending
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JP2008501998A
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English (en)
Japanese (ja)
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JP2008533161A5 (https=
Inventor
バートン,ジャック
ブルメンタール,ロザリン
Original Assignee
イムノメディクス, インコーポレイテッド
センター・フォー・モレキュラー・メディシン・アンド・イムノロジー
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Publication of JP2008533161A publication Critical patent/JP2008533161A/ja
Publication of JP2008533161A5 publication Critical patent/JP2008533161A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2008501998A 2005-03-14 2006-03-14 PPAR−γアンタゴニストを使用するがんの治療方法 Pending JP2008533161A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66102405P 2005-03-14 2005-03-14
PCT/US2006/009309 WO2006099479A2 (en) 2005-03-14 2006-03-14 Methods of treating cancer using ppar-gamma antagonists

Publications (2)

Publication Number Publication Date
JP2008533161A true JP2008533161A (ja) 2008-08-21
JP2008533161A5 JP2008533161A5 (https=) 2009-05-07

Family

ID=36992402

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008501998A Pending JP2008533161A (ja) 2005-03-14 2006-03-14 PPAR−γアンタゴニストを使用するがんの治療方法

Country Status (6)

Country Link
US (1) US20060217425A1 (https=)
EP (1) EP1858512A4 (https=)
JP (1) JP2008533161A (https=)
AU (1) AU2006223000B2 (https=)
CA (1) CA2600712A1 (https=)
WO (1) WO2006099479A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012526079A (ja) * 2009-05-06 2012-10-25 バイオテスト・アクチエンゲゼルシヤフト Cd138を標的とする免疫複合体の使用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008094860A2 (en) 2007-01-30 2008-08-07 Allergan, Inc. Treating ocular diseases using peroxisome proliferator-activated receptor delta antagonists
US20080206194A1 (en) * 2007-02-16 2008-08-28 Glazer Robert I Method for the treatment of breast cancer
EP4490147A1 (en) * 2022-03-08 2025-01-15 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof
CA3254026A1 (en) * 2022-03-08 2023-09-14 Flare Therapeutics Inc. Inverse PPARG agonists and their uses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001510462A (ja) * 1996-12-11 2001-07-31 ダナ・フアーバー・キヤンサー・インスチチユート 腫瘍細胞の成長を阻害するための方法および製薬学的組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7585512B1 (en) * 1990-05-08 2009-09-08 Thomas Jefferson University Composition and method of using tumor cells
WO2001083427A1 (en) * 2000-04-28 2001-11-08 Sankyo Company, Limited PPARη MODULATORS
WO2002076177A2 (en) * 2001-03-23 2002-10-03 Bethesda Pharmaceuticals, Inc. Design and synthesis of optimized ligands for ppar
US6972175B2 (en) * 2002-11-27 2005-12-06 David Pinsky Inhibition of Egr-1 expression by ppar-gamma agonists and related compositions and methods
KR100576575B1 (ko) * 2003-09-16 2006-05-04 한국생명공학연구원 피피에이알감마에 대한 단일클론 항체, 특이 항체분비 융합세포주 및 항체를 이용한 염증, 암, 대사성 질환과 같은 질병 관련 조절인자를 검색하는 방법
WO2005077126A2 (en) * 2004-02-10 2005-08-25 Boston Medical Center Corporation Use of ppargamma specific inhibitors as anti-cancer therapeutics

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001510462A (ja) * 1996-12-11 2001-07-31 ダナ・フアーバー・キヤンサー・インスチチユート 腫瘍細胞の成長を阻害するための方法および製薬学的組成物

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012526079A (ja) * 2009-05-06 2012-10-25 バイオテスト・アクチエンゲゼルシヤフト Cd138を標的とする免疫複合体の使用
US9289509B2 (en) 2009-05-06 2016-03-22 Biotest Ag Uses of immunoconjugates targeting CD138
JP2016053053A (ja) * 2009-05-06 2016-04-14 バイオテスト・アクチエンゲゼルシヤフト Cd138を標的とする免疫複合体の使用

Also Published As

Publication number Publication date
AU2006223000B2 (en) 2011-06-30
AU2006223000A1 (en) 2006-09-21
EP1858512A2 (en) 2007-11-28
EP1858512A4 (en) 2009-08-05
WO2006099479A2 (en) 2006-09-21
US20060217425A1 (en) 2006-09-28
CA2600712A1 (en) 2006-09-21
WO2006099479A3 (en) 2006-11-16

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