JP2008533050A5 - - Google Patents

Download PDF

Info

Publication number
JP2008533050A5
JP2008533050A5 JP2008501049A JP2008501049A JP2008533050A5 JP 2008533050 A5 JP2008533050 A5 JP 2008533050A5 JP 2008501049 A JP2008501049 A JP 2008501049A JP 2008501049 A JP2008501049 A JP 2008501049A JP 2008533050 A5 JP2008533050 A5 JP 2008533050A5
Authority
JP
Japan
Prior art keywords
seq
interfering rna
nucleotides
composition
nucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2008501049A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008533050A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/009000 external-priority patent/WO2006099353A1/en
Publication of JP2008533050A publication Critical patent/JP2008533050A/ja
Publication of JP2008533050A5 publication Critical patent/JP2008533050A5/ja
Withdrawn legal-status Critical Current

Links

JP2008501049A 2005-03-11 2006-03-10 緑内障を処置するためのフリッツルド関連蛋白質―1のrnai媒介性阻害 Withdrawn JP2008533050A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66055605P 2005-03-11 2005-03-11
US68863305P 2005-06-08 2005-06-08
PCT/US2006/009000 WO2006099353A1 (en) 2005-03-11 2006-03-10 Rnai-mediated inhibition of frizzled related protein-1 for treatment of glaucoma

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012154550A Division JP2012193197A (ja) 2005-03-11 2012-07-10 緑内障を処置するためのフリッツルド関連蛋白質―1のrnai媒介性阻害

Publications (2)

Publication Number Publication Date
JP2008533050A JP2008533050A (ja) 2008-08-21
JP2008533050A5 true JP2008533050A5 (https=) 2012-03-08

Family

ID=36649793

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008501049A Withdrawn JP2008533050A (ja) 2005-03-11 2006-03-10 緑内障を処置するためのフリッツルド関連蛋白質―1のrnai媒介性阻害
JP2012154550A Pending JP2012193197A (ja) 2005-03-11 2012-07-10 緑内障を処置するためのフリッツルド関連蛋白質―1のrnai媒介性阻害

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012154550A Pending JP2012193197A (ja) 2005-03-11 2012-07-10 緑内障を処置するためのフリッツルド関連蛋白質―1のrnai媒介性阻害

Country Status (9)

Country Link
US (5) US7947660B2 (https=)
EP (1) EP1856259A1 (https=)
JP (2) JP2008533050A (https=)
KR (1) KR20080018858A (https=)
AU (1) AU2006223131A1 (https=)
BR (1) BRPI0609206A2 (https=)
CA (1) CA2598234A1 (https=)
MX (1) MX2007010608A (https=)
WO (1) WO2006099353A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20171010T8 (hr) 2004-08-23 2017-11-03 Sylentis S.A.U. Liječenje poremećaja očiju koji su karakterizirani povišenim intraokularnim pritiskom pomoću sirnk
KR20080018858A (ko) * 2005-03-11 2008-02-28 알콘, 인코퍼레이티드 녹내장 치료용 플리즐 관련 단백질―1의 RNAⅰ-중재저해
GB0521351D0 (en) 2005-10-20 2005-11-30 Genomica Sau Modulation of TRPV expression levels
GB0521716D0 (en) 2005-10-25 2005-11-30 Genomica Sau Modulation of 11beta-hydroxysteriod dehydrogenase 1 expression for the treatment of ocular diseases
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
RU2010117178A (ru) * 2007-10-01 2011-11-10 Алькон Рисерч, Лтд. (Us) Опосредованная самокомплементарными aav доставка молекул, интерферирующих рнк для лечения или профилактики глазных заболеваний
US7973019B1 (en) 2007-10-03 2011-07-05 Alcon Research, Ltd. Transferrin/transferrin receptor-mediated siRNA delivery
AR069328A1 (es) 2007-11-15 2010-01-13 Alcon Mfg Ltd Liberacion de rna interferente corto o sirna, intermediada por receptor de lipoproteina de baja densidad
TW200932274A (en) 2007-12-18 2009-08-01 Alcon Res Ltd Interfering RNA delivery system and uses thereof
US20120271272A1 (en) 2010-10-15 2012-10-25 Iscience Interventional Corporation Device for ocular access
WO2012161677A1 (en) 2011-05-20 2012-11-29 Alcon Research, Ltd. TRANSFERRIN/TRANSFERRIN RECEPTOR-MEDIATED siRNA DELIVERY
US20130178421A1 (en) 2012-01-06 2013-07-11 Alcon Research, Ltd. Interfering rna delivery system and uses thereof
GB201215857D0 (en) 2012-09-05 2012-10-24 Sylentis Sau siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
SG11201501385UA (en) 2012-09-05 2015-03-30 Sylentis Sau Sirna and their use in methods and compositions for the treatment and/or prevention of eye conditions
EP2916827B1 (en) 2012-11-08 2020-06-10 Clearside Biomedical Inc. Methods for the treatment of ocular disease in human subjects
SG10201702674PA (en) 2013-05-03 2017-06-29 Clearside Biomedical Inc Apparatus and methods for ocular injection
EP3003454B1 (en) 2013-06-03 2020-01-08 Clearside Biomedical, Inc. Apparatus for drug delivery using multiple reservoirs
US10011837B2 (en) 2014-03-04 2018-07-03 Sylentis Sau SiRNAs and their use in methods and compositions for the treatment and/or prevention of eye conditions
RU2710491C2 (ru) 2014-06-20 2019-12-26 Клиасайд Байомедикал, Инк. Устройство для инъекции лекарственного средства в глазную ткань и способ инъекции лекарственного средства в глазную ткань
USD750223S1 (en) 2014-10-14 2016-02-23 Clearside Biomedical, Inc. Medical injector for ocular injection
WO2017139375A1 (en) 2016-02-10 2017-08-17 Clearside Biomedical, Inc. Ocular injection kit, packaging, and methods of use
CA3062845A1 (en) 2016-05-02 2017-11-09 Clearside Biomedical, Inc. Systems and methods for ocular drug delivery
EP3496680B1 (en) 2016-08-12 2024-10-02 Clearside Biomedical, Inc. Device for adjusting the insertion depth of a needle for medicament delivery
WO2018204515A1 (en) 2017-05-02 2018-11-08 Georgia Tech Research Corporation Targeted drug delivery methods using a microneedle
JP7641902B2 (ja) * 2019-01-29 2025-03-07 ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア 緑内障の新規治療法
US20230201371A1 (en) * 2020-03-19 2023-06-29 Clearside Biomedical, Inc. Compositions and methods for treating ocular disorders
EP4536197A1 (en) 2022-06-07 2025-04-16 Generation Bio Co. Lipid nanoparticle compositions and uses thereof

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506569B1 (en) * 1997-05-30 2003-01-14 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor TR10
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
EP2314700A1 (en) * 1999-01-28 2011-04-27 Medical College of Georgia Research Institute, Inc Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
US20080166356A9 (en) * 1999-09-13 2008-07-10 Peter Bodine Pharmaceutical compositions and methods of using secreted frizzled related protein
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
GB9927444D0 (en) * 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
WO2002081628A2 (en) * 2001-04-05 2002-10-17 Ribozyme Pharmaceuticals, Incorporated Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies
WO2005019453A2 (en) * 2001-05-18 2005-03-03 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)
EP1974738A3 (en) * 2000-02-29 2008-12-17 Alcon, Inc. Diagnostics and therapeutics for glaucoma
DE10012340A1 (de) 2000-03-14 2001-09-20 Merck Patent Gmbh Verfahren zur Baeyer-Villiger-Oxidation organischer Carbonylverbindungen
EP1272630A2 (en) * 2000-03-16 2003-01-08 Genetica, Inc. Methods and compositions for rna interference
PT1309726E (pt) * 2000-03-30 2010-03-08 Whitehead Biomedical Inst Mediadores de interferência por rna específicos de sequência de rna
US20040259247A1 (en) * 2000-12-01 2004-12-23 Thomas Tuschl Rna interference mediating small rna molecules
US20050148530A1 (en) * 2002-02-20 2005-07-07 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
TW201041580A (en) * 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
DE10230997A1 (de) 2001-10-26 2003-07-17 Ribopharma Ag Medikament zur Erhöhung der Wirksamkeit eines Rezeptor-vermittelt Apoptose in Tumorzellen auslösenden Arzneimittels
WO2003049773A1 (en) * 2001-12-11 2003-06-19 Fibrogen, Inc. Methods for inhibiting ocular processes
AU2003237143A1 (en) 2002-05-03 2003-11-17 Alcon, Inc. Diagnosis and treatment of glaucoma
AU2003225233A1 (en) * 2002-05-03 2003-11-17 Alcon, Inc. Diagnosis and treatment of glaucoma and methods for discovering new glaucoma therapeutic agents based on the wnt/ca2+ signaling pathway
WO2003093441A2 (en) * 2002-05-03 2003-11-13 Duke University A method of regulating gene expression
WO2004014933A1 (en) * 2002-08-07 2004-02-19 University Of Massachusetts Compositions for rna interference and methods of use thereof
US20040029275A1 (en) 2002-08-10 2004-02-12 David Brown Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
US20040198967A1 (en) 2002-09-04 2004-10-07 Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Compositions and methods for tissue specific or inducible inhibition of gene expression
US20040072769A1 (en) * 2002-09-16 2004-04-15 Yin James Qinwei Methods for design and selection of short double-stranded oligonucleotides, and compounds of gene drugs
EP2305812A3 (en) * 2002-11-14 2012-06-06 Dharmacon, Inc. Fuctional and hyperfunctional sirna
US20040175732A1 (en) * 2002-11-15 2004-09-09 Rana Tariq M. Identification of micrornas and their targets
US20040191818A1 (en) * 2003-02-26 2004-09-30 O'toole Margot Mary Compositions and methods for diagnosing and treating autoimmune diseases
WO2005090606A2 (en) * 2004-01-23 2005-09-29 Dharmacon, Inc. Identification of toxic nucleotide sequences
GB0403600D0 (en) 2004-02-18 2004-03-24 Trinity College Dublin Methods and reagents for treating disease
KR101147147B1 (ko) * 2004-04-01 2012-05-25 머크 샤프 앤드 돔 코포레이션 Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
TWI401316B (zh) 2004-12-23 2013-07-11 Alcon Inc 用於治療青光眼之血清澱粉樣蛋白A的RNAi抑制作用
TWI386225B (zh) 2004-12-23 2013-02-21 Alcon Inc 用於治療眼睛病症的結締組織生長因子(CTGF)RNA干擾(RNAi)抑制技術
TW200639252A (en) 2005-02-01 2006-11-16 Alcon Inc RNAi-mediated inhibition of ocular hypertension targets
KR20080018858A (ko) * 2005-03-11 2008-02-28 알콘, 인코퍼레이티드 녹내장 치료용 플리즐 관련 단백질―1의 RNAⅰ-중재저해

Similar Documents

Publication Publication Date Title
US20220364097A1 (en) RNAi-MEDIATED INHIBITION OF HIF1A FOR TREATMENT OF OCULAR ANGIOGENESIS
US9550994B2 (en) RNAI-mediated inhibition of frizzled related protein-1 for treatment of glaucoma
JP2008533050A5 (https=)
US20080051361A1 (en) Rnai-mediated inhibition of gremlin for treatment of iop-related conditions
JP2012193210A (ja) 眼の障害の治療のためのRhoキナーゼのRNAi媒介抑制
JP2008528632A (ja) 眼標的のRNAi媒介型阻害
US20170009235A1 (en) RNAi-MEDIATED INHIBITION OF CONNEXIN 43 FOR TREATMENT OF IOP-RELATED CONDITIONS
WO2009020894A2 (en) RNAι-RELATED INHIBITION OF TNFα SIGNALING PATHWAY FOR TREATMENT OF MACULAR EDEMA
WO2009020848A2 (en) RNAI-RELATED INHIBITION OF TNFα SIGNALING PATHWAY FOR TREATMENT OF GLAUCOMA
AU2012200976A1 (en) RNAI-Mediated inhibition of frizzled related protein-1 for treatment of gluacoma