JP2008531613A - Ｃｐｔを阻害するアミノブタン酸誘導体 - Google Patents

Ｃｐｔを阻害するアミノブタン酸誘導体 Download PDF

Info

Publication number
JP2008531613A
JP2008531613A JP2007557357A JP2007557357A JP2008531613A JP 2008531613 A JP2008531613 A JP 2008531613A JP 2007557357 A JP2007557357 A JP 2007557357A JP 2007557357 A JP2007557357 A JP 2007557357A JP 2008531613 A JP2008531613 A JP 2008531613A
Authority
JP
Japan
Prior art keywords
compound
tetradecylcarbamoyl
compounds
amino
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2007557357A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008531613A5 (US07981874-20110719-C00313.png
Inventor
ファビオ・ジャンネッシ
エマヌエラ・タッソーニ
マリア・オルネッラ・ティンティ
ロベルト・コンティ
ナタリーナ・デルオモ
ティツィアナ・ブルネッティ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of JP2008531613A publication Critical patent/JP2008531613A/ja
Publication of JP2008531613A5 publication Critical patent/JP2008531613A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
JP2007557357A 2005-03-02 2006-02-13 Ｃｐｔを阻害するアミノブタン酸誘導体 Withdrawn JP2008531613A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000090A ITRM20050090A1 (it) 2005-03-02 2005-03-02 Derivati dell'acido ammino-butanoico inibitore della cpt.
PCT/EP2006/001290 WO2006092204A1 (en) 2005-03-02 2006-02-13 Derivatives of aminobutanoic acid inhibiting cpt

Publications (2)

Publication Number Publication Date
JP2008531613A true JP2008531613A (ja) 2008-08-14
JP2008531613A5 JP2008531613A5 (US07981874-20110719-C00313.png) 2009-04-02

Family

ID=36090946

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007557357A Withdrawn JP2008531613A (ja) 2005-03-02 2006-02-13 Ｃｐｔを阻害するアミノブタン酸誘導体

Country Status (15)

Country Link
US (1) US20080161395A1 (US07981874-20110719-C00313.png)
EP (1) EP1853556A1 (US07981874-20110719-C00313.png)
JP (1) JP2008531613A (US07981874-20110719-C00313.png)
KR (1) KR20070114197A (US07981874-20110719-C00313.png)
CN (1) CN101133019A (US07981874-20110719-C00313.png)
AR (1) AR052677A1 (US07981874-20110719-C00313.png)
AU (1) AU2006220097B2 (US07981874-20110719-C00313.png)
BR (1) BRPI0607558A2 (US07981874-20110719-C00313.png)
CA (1) CA2599165A1 (US07981874-20110719-C00313.png)
EA (1) EA200701868A1 (US07981874-20110719-C00313.png)
IT (1) ITRM20050090A1 (US07981874-20110719-C00313.png)
MX (1) MX2007009007A (US07981874-20110719-C00313.png)
SG (1) SG159569A1 (US07981874-20110719-C00313.png)
TW (1) TW200640842A (US07981874-20110719-C00313.png)
WO (1) WO2006092204A1 (US07981874-20110719-C00313.png)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011518853A (ja) * 2008-04-29 2011-06-30 エフ．ホフマン−ラ ロシュ アーゲー Ｃｐｔ２インヒビターとしての４−トリメチルアンモニオ−ブチラート類

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2927045A1 (en) * 2006-10-03 2008-04-10 Muthiah Manoharan Lipid containing formulations
US8410150B2 (en) 2007-03-09 2013-04-02 University Health Network Inhibitors of carnitine palmitoyltransferase and treating cancer
CA2694724C (en) 2007-08-01 2017-09-12 University Health Network Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer
ES2507089T3 (es) 2008-04-29 2014-10-14 F. Hoffmann-La Roche Ag Derivados del ácido 4-dimetilaminobutírico

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1299266B1 (it) * 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
US6822115B2 (en) * 1999-06-30 2004-11-23 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
US8410150B2 (en) 2007-03-09 2013-04-02 University Health Network Inhibitors of carnitine palmitoyltransferase and treating cancer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011518853A (ja) * 2008-04-29 2011-06-30 エフ．ホフマン−ラ ロシュ アーゲー Ｃｐｔ２インヒビターとしての４−トリメチルアンモニオ−ブチラート類

Also Published As

Publication number Publication date
MX2007009007A (es) 2007-09-14
CN101133019A (zh) 2008-02-27
ITRM20050090A1 (it) 2006-09-03
US20080161395A1 (en) 2008-07-03
SG159569A1 (en) 2010-03-30
KR20070114197A (ko) 2007-11-29
BRPI0607558A2 (pt) 2009-09-15
WO2006092204A1 (en) 2006-09-08
TW200640842A (en) 2006-12-01
AU2006220097B2 (en) 2011-07-07
AU2006220097A1 (en) 2006-09-08
AR052677A1 (es) 2007-03-28
EA200701868A1 (ru) 2008-02-28
EP1853556A1 (en) 2007-11-14
CA2599165A1 (en) 2006-09-08

Similar Documents

Publication Publication Date Title
JP5127093B2 (ja) カルニチンパルミトイル−トランスフェラーゼの可逆的阻害活性を有する化合物
WO2007096251A1 (en) Inhibitors of cpt in the central nervous system as antidiabetic and/or anti-obesity drugs
US20140018436A1 (en) Deuterium-enriched bupropion
EP2914580B1 (en) Thioaryl derivatives as gpr120 agonists
NZ564130A (en) N-propargyl-1-aminoindan compounds useful for treating obesity
JP2008531613A (ja) Ｃｐｔを阻害するアミノブタン酸誘導体
US11365209B2 (en) Crystalline forms
BR112015001207B1 (pt) Derivados de carbamato/ureia, seus usos, combinação e composição farmacêutica
JP2009545549A (ja) Ｃｐｔ阻害剤としての４−トリメチルアンモニウム−３−アミノブチレートおよび４−トリメチルフォスフォニウム−３−アミノブチレート誘導体
CN113149902B (zh) 苯甲酰胺类衍生物
JP3231775B2 (ja) 心循環器系に作用する２−アミノ−１，２，３，４−テトラヒドロナフタレン誘導体、それらを製造する方法、及びそれらを含む医薬組成物
CN108794517A (zh) 一种精氨酸酶抑制剂及其制备方法与用途
JP2931986B2 (ja) アラルキルアミン誘導体
JP2008500985A (ja) ブチリルコリンエステラーゼ選択的阻害剤
CA2832693C (en) Use of 3-carboxy-n-ethyl-n,n-dimethylpropan-1-aminium salts in the treatment of cardiovascular disease
US6232348B1 (en) Hydroxymethyl derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene as cardiovascular agent
JP2009519300A (ja) カルシウムチャネルブロッカーとしてのジベンゼン誘導体
EP1798220A1 (en) Dibenzene derivatives as calcium channel blockers
JP2005519951A (ja) β３アドレナリン性受容体作動薬としてのアミノアルコール誘導体
NZ616467B2 (en) Use of 3-carboxy-n-ethyl-n,n-dimethylpropan-1-aminium salts in the treatment of cardiovascular disease

Legal Events

Date Code Title Description
A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090212

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090212

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20111125