JP2008528503A - 不斉水素化によるキラルなベータアミノ酸誘導体への方法 - Google Patents

不斉水素化によるキラルなベータアミノ酸誘導体への方法 Download PDF

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Publication number
JP2008528503A
JP2008528503A JP2007552303A JP2007552303A JP2008528503A JP 2008528503 A JP2008528503 A JP 2008528503A JP 2007552303 A JP2007552303 A JP 2007552303A JP 2007552303 A JP2007552303 A JP 2007552303A JP 2008528503 A JP2008528503 A JP 2008528503A
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JP
Japan
Prior art keywords
alkyl
unsubstituted
ammonium
structural formula
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2007552303A
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English (en)
Japanese (ja)
Inventor
シヤオ，イー
アームストロング，ジヨウジフ・デイー，ザ・サード
クルスカ，シエーン・ダブリユ
ニヨリート，ユージーニア
リベラ，ネロ・アール
スン，ヨンクイ
ロスナー，トールステン
クラウゼン，アンドリユー・エム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
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Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JP2008528503A publication Critical patent/JP2008528503A/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2007552303A 2005-01-24 2006-01-20 不斉水素化によるキラルなベータアミノ酸誘導体への方法 Withdrawn JP2008528503A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64669705P 2005-01-24 2005-01-24
PCT/US2006/002147 WO2006081151A1 (en) 2005-01-24 2006-01-20 Process to chiral beta amino acid derivatives by asymmetric hydrogenation

Publications (1)

Publication Number Publication Date
JP2008528503A true JP2008528503A (ja) 2008-07-31

Family

ID=36587261

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007552303A Withdrawn JP2008528503A (ja) 2005-01-24 2006-01-20 不斉水素化によるキラルなベータアミノ酸誘導体への方法

Country Status (8)

Country Link
EP (1) EP1856028A1 (de)
JP (1) JP2008528503A (de)
CN (1) CN101175714A (de)
AR (1) AR052879A1 (de)
AU (1) AU2006208297A1 (de)
CA (1) CA2594494A1 (de)
TW (1) TW200637805A (de)
WO (1) WO2006081151A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8334385B2 (en) 2007-11-02 2012-12-18 Glenmark Generics Limited Process for the preparation of R-sitagliptin and its pharmaceutically acceptable salts thereof
US8278486B2 (en) 2008-12-31 2012-10-02 Chiral Quest, Inc. Process and intermediates for the preparation of N-acylated-4-aryl beta-amino acid derivatives
EP2223923A1 (de) 2009-02-25 2010-09-01 Esteve Química, S.A. Verfahren zur Herstellung eines chiralen Beta-Aminosäurederivats und Zwischenprodukte davon
IT1395596B1 (it) 2009-06-30 2012-10-16 Dipharma Francis Srl Procedimento per la preparazione di sitagliptin
CZ303113B6 (cs) 2010-03-16 2012-04-11 Zentiva, K.S. Zpusob prípravy sitagliptinu
KR20120139764A (ko) 2010-03-31 2012-12-27 테바 파마슈티컬 인더스트리즈 리미티드 시타글립틴염의 고체 형태
US8765668B2 (en) 2010-06-04 2014-07-01 Lek Pharmaceuticals D.D. Methods of synthesis of β-aminobutyryl substituted compounds
EP2392575A1 (de) 2010-06-04 2011-12-07 LEK Pharmaceuticals d.d. Neuartiger synthetischer Ansatz für ß-Aminobutyryl-substituierte Verbindungen
EP2397141A1 (de) 2010-06-16 2011-12-21 LEK Pharmaceuticals d.d. Verfahren zur Synthese von Beta-Aminosäuren und Derivaten daraus
EP2609099A2 (de) 2010-08-27 2013-07-03 USV Limited Sitagliptin, salze und polymorphe davon
WO2012035549A2 (en) 2010-09-13 2012-03-22 Panacea Biotec Ltd An improved process for the synthesis of beta amino acid derivatives
EP2508506A1 (de) 2011-04-08 2012-10-10 LEK Pharmaceuticals d.d. Herstellung von Sitagliptin-Zwischenprodukten
EP2527320A1 (de) 2011-05-27 2012-11-28 LEK Pharmaceuticals d.d. Herstellung von Sitagliptin-Zwischenprodukten
EP2736909B1 (de) 2011-07-27 2017-03-29 Farma GRS, d.o.o. Verfahren zur herstellung von sitagliptin und dessen pharmazeutisch verträglichen salzen
WO2013065066A1 (en) 2011-11-02 2013-05-10 Cadila Healthcare Limited Processes for preparing 4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro [l,2,41-triazolo[43-a]pyrazin-7(8h)-yl]-l-(2,4,5- trifluorophenyl)butan-2-amine
EP2615080A1 (de) 2012-01-12 2013-07-17 LEK Pharmaceuticals d.d. Herstellung von optisch reinen aktiven pharmazeutischen Bestandteilen des ß-Aminosäuretyps und Zwischenverbindungen davon
EP2674432A1 (de) 2012-06-14 2013-12-18 LEK Pharmaceuticals d.d. Neuer synthetischer Weg zur Herstellung von ß-Aminobutyryl-substituierten 5,6,7,8-Tetrahydro[1,4]diazolo[4,3-alpha]pyrazin-7-YL-Verbindungen
US9227901B2 (en) * 2012-07-05 2016-01-05 Abbvie Inc. Process for preparing bicyclic amine derivatives
CN102898387B (zh) * 2012-09-26 2015-01-07 浙江工业大学 管道化连续生产n-[(2z)-哌嗪-2-亚基]-2,2,2-三氟乙酰肼的方法
CN105315286B (zh) * 2014-07-30 2018-08-17 连云港润众制药有限公司 西格列汀的制备
KR102359436B1 (ko) * 2015-06-05 2022-02-09 (주)아모레퍼시픽 메틸 2-프로필-6-(트리플루오로메틸) 니코티네이트의 제조방법
CN105254519B (zh) * 2015-11-25 2017-05-17 常州吉恩药业有限公司 一种西他列汀关键中间体的合成方法
EP3424927B1 (de) 2017-07-04 2019-04-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Effizientes verfahren zur herstellung von sitagliptin durch sehr effektive herstellung des zwischenprodukts 2,4,5-trifluorophenylessigsäure
CN107325025B (zh) * 2017-07-17 2019-04-09 中国科学院化学研究所 一种手性α-氨基酸衍生物及其制备方法
CN113636950B (zh) * 2020-05-11 2023-01-17 浙江医药股份有限公司新昌制药厂 一种手性4-芳基-β-氨基酸衍生物的制备方法
WO2024121301A1 (en) 2022-12-09 2024-06-13 Krka, D.D., Novo Mesto Process for the preparation of sitagliptin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0646590B1 (de) * 1993-10-01 1999-08-25 Novartis AG Mit Fluoralkyl substituierte Ferrocenyldiphosphine als Liganden für homogene Katalysatoren
AR043515A1 (es) * 2003-03-19 2005-08-03 Merck & Co Inc Procedimiento para preparar derivados quirales beta aminoacidos mediante hidrogenacion asimetrica
TW200602293A (en) * 2004-04-05 2006-01-16 Merck & Co Inc Process for the preparation of enantiomerically enriched beta amino acid derivatives

Also Published As

Publication number Publication date
AU2006208297A1 (en) 2006-08-03
AR052879A1 (es) 2007-04-11
CA2594494A1 (en) 2006-08-03
CN101175714A (zh) 2008-05-07
WO2006081151A1 (en) 2006-08-03
TW200637805A (en) 2006-11-01
EP1856028A1 (de) 2007-11-21

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