JP2008525398A5 - - Google Patents
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- Publication number
- JP2008525398A5 JP2008525398A5 JP2007547625A JP2007547625A JP2008525398A5 JP 2008525398 A5 JP2008525398 A5 JP 2008525398A5 JP 2007547625 A JP2007547625 A JP 2007547625A JP 2007547625 A JP2007547625 A JP 2007547625A JP 2008525398 A5 JP2008525398 A5 JP 2008525398A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- halo
- group
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 71
- 125000003545 alkoxy group Chemical group 0.000 claims 61
- 125000005843 halogen group Chemical group 0.000 claims 48
- 229910052736 halogen Inorganic materials 0.000 claims 24
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 239000001257 hydrogen Substances 0.000 claims 23
- 150000002367 halogens Chemical class 0.000 claims 22
- 125000004414 alkyl thio group Chemical group 0.000 claims 19
- 150000002431 hydrogen Chemical class 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 13
- 229910052757 nitrogen Inorganic materials 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 10
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 10
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 10
- 229920006395 saturated elastomer Polymers 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000005059 halophenyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 5
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 4
- 125000005332 alkyl sulfoxy group Chemical group 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims 3
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 3
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 3
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 3
- 206010012289 Dementia Diseases 0.000 claims 3
- 208000028017 Psychotic disease Diseases 0.000 claims 3
- 102100023145 Sodium- and chloride-dependent glycine transporter 1 Human genes 0.000 claims 3
- 101710083171 Sodium- and chloride-dependent glycine transporter 1 Proteins 0.000 claims 3
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 125000001246 bromo group Chemical group Br* 0.000 claims 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 201000000980 schizophrenia Diseases 0.000 claims 3
- 229930192474 thiophene Natural products 0.000 claims 3
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical group C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 230000001430 anti-depressive effect Effects 0.000 claims 2
- 239000000935 antidepressant agent Substances 0.000 claims 2
- 229940005513 antidepressants Drugs 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- -1 chloro, bromo, iodo, hydroxy Chemical group 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims 2
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 101000783611 Takifugu rubripes 5-hydroxytryptamine receptor 1D Proteins 0.000 claims 1
- 229940123445 Tricyclic antidepressant Drugs 0.000 claims 1
- 229940125681 anticonvulsant agent Drugs 0.000 claims 1
- 239000001961 anticonvulsive agent Substances 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000003693 atypical antipsychotic agent Substances 0.000 claims 1
- 229940127236 atypical antipsychotics Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000003291 dopaminomimetic effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003395 histamine H3 receptor antagonist Substances 0.000 claims 1
- 239000002742 neurokinin 1 receptor antagonist Substances 0.000 claims 1
- 239000002664 nootropic agent Substances 0.000 claims 1
- 230000001777 nootropic effect Effects 0.000 claims 1
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 claims 1
- 229940126569 noradrenaline reuptake inhibitor Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 239000003727 serotonin 1A antagonist Substances 0.000 claims 1
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 claims 1
- 239000003775 serotonin noradrenalin reuptake inhibitor Substances 0.000 claims 1
- 239000000952 serotonin receptor agonist Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 150000003577 thiophenes Chemical class 0.000 claims 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0428231A GB0428231D0 (en) | 2004-12-23 | 2004-12-23 | Compounds |
| GB0509204A GB0509204D0 (en) | 2005-05-05 | 2005-05-05 | Compounds |
| PCT/GB2005/004937 WO2006067414A2 (en) | 2004-12-23 | 2005-12-21 | Glycine transport inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008525398A JP2008525398A (ja) | 2008-07-17 |
| JP2008525398A5 true JP2008525398A5 (enExample) | 2009-02-26 |
Family
ID=36013388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007547625A Pending JP2008525398A (ja) | 2004-12-23 | 2005-12-21 | グリシン輸送阻害剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20100216837A1 (enExample) |
| EP (1) | EP1874721A2 (enExample) |
| JP (1) | JP2008525398A (enExample) |
| WO (1) | WO2006067414A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20061330A1 (es) * | 2004-12-23 | 2006-12-27 | Glaxo Group Ltd | Compuestos derivados de benzamida como inhibidores del transportador de glicina |
| GB0428233D0 (en) * | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Compounds |
| PE20061156A1 (es) | 2004-12-23 | 2006-12-16 | Glaxo Group Ltd | Derivados de benzamida como agentes inhibidores del transportador de glicina |
| GB0600427D0 (en) | 2006-01-10 | 2006-02-15 | Glaxo Group Ltd | Compounds |
| GB0612425D0 (en) * | 2006-06-22 | 2006-08-02 | Glaxo Group Ltd | Compounds |
| WO2010020548A1 (en) | 2008-08-20 | 2010-02-25 | F. Hoffmann-La Roche Ag | Glyt1 receptor antagonists |
| AR075182A1 (es) * | 2009-01-28 | 2011-03-16 | Astrazeneca Ab | Compuestos 2-aza-biciclo (2.2.2) octano y sus usos |
| WO2010087762A1 (en) * | 2009-01-28 | 2010-08-05 | Astrazeneca Ab | 2-aza-bicyclo[2.2.1]heptane compounds and uses thereof |
| CA2801074A1 (en) | 2010-06-04 | 2011-12-08 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3145209A (en) * | 1961-07-31 | 1964-08-18 | Olin Mathieson | Substituted aminophenyl-ethylamine derivatives |
| BE789025A (fr) * | 1971-09-23 | 1973-03-20 | Allen & Hanburys Ltd | Nouvelles ethylene diamines substituees |
| JPS57193594A (en) * | 1981-05-22 | 1982-11-27 | Kindai Kagaku Kogyo Kk | Paper sizing method |
| NZ237443A (en) * | 1990-04-10 | 1993-11-25 | Asta Medica Ag | Phenalkylethylenediamine and aminomethyltetra hydroisoquinoline derivatives, platinum (ii) and (iv) complexes, methods of preparation and pharmaceutical compositions |
| US6092832A (en) * | 1998-03-04 | 2000-07-25 | General Motors Corporation | Air bag module mounting mechanism and method of making |
| CA2406652A1 (en) * | 2000-04-20 | 2001-11-01 | Nps Allelix Corp. | Aminopiperidines for use as glyt-1 inhibitors |
| WO2003010132A1 (en) * | 2001-07-17 | 2003-02-06 | Akzo Nobel N.V. | N-[(1-dimethylaminocycloalkyl)methyl]benzamide derivatives |
| GB0130696D0 (en) * | 2001-12-21 | 2002-02-06 | Smithkline Beecham Plc | Chemical Compounds |
| WO2004072034A1 (en) * | 2003-02-17 | 2004-08-26 | F. Hoffmann-La Roche Ag | Piperidine-benzenesulfonamide derivatives |
| JP4563386B2 (ja) * | 2003-09-09 | 2010-10-13 | エフ．ホフマン−ラ ロシュ アーゲー | 精神病の処置のためのグリシン取り込み阻害剤としての１−（２−アミノ−ベンゾール）−ピペラジン誘導体 |
| FR2861073B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| GB0408777D0 (en) * | 2004-04-20 | 2004-05-26 | Glaxo Group Ltd | Compounds |
| AU2005243192A1 (en) * | 2004-04-29 | 2005-11-24 | Merck & Co., Inc. | Azetidine glycine transporter inhibitors |
| PE20061156A1 (es) * | 2004-12-23 | 2006-12-16 | Glaxo Group Ltd | Derivados de benzamida como agentes inhibidores del transportador de glicina |
| GB0428232D0 (en) * | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Compounds |
| PE20061330A1 (es) * | 2004-12-23 | 2006-12-27 | Glaxo Group Ltd | Compuestos derivados de benzamida como inhibidores del transportador de glicina |
-
2005
- 2005-12-21 WO PCT/GB2005/004937 patent/WO2006067414A2/en not_active Ceased
- 2005-12-21 JP JP2007547625A patent/JP2008525398A/ja active Pending
- 2005-12-21 US US11/722,210 patent/US20100216837A1/en not_active Abandoned
- 2005-12-21 EP EP05821167A patent/EP1874721A2/en not_active Withdrawn
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