JP2008522970A - 脂質療法用のオメガ−3脂肪酸類及び異常脂質血症薬剤 - Google Patents
脂質療法用のオメガ−3脂肪酸類及び異常脂質血症薬剤 Download PDFInfo
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US69986605P | 2005-07-18 | 2005-07-18 | |
| PCT/US2005/042648 WO2006062748A2 (en) | 2004-12-06 | 2005-11-22 | Omega-3 fatty acids and dyslipidemic agent for lipid therapy |
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| JP2012136691A Division JP2012176987A (ja) | 2004-12-06 | 2012-06-18 | 脂質療法用のオメガ−3脂肪酸類及び異常脂質血症薬剤 |
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| JP2012136691A Pending JP2012176987A (ja) | 2004-12-06 | 2012-06-18 | 脂質療法用のオメガ−3脂肪酸類及び異常脂質血症薬剤 |
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| JP2012136691A Pending JP2012176987A (ja) | 2004-12-06 | 2012-06-18 | 脂質療法用のオメガ−3脂肪酸類及び異常脂質血症薬剤 |
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| EP (1) | EP1830830A4 (enExample) |
| JP (2) | JP2008522970A (enExample) |
| KR (1) | KR101356335B1 (enExample) |
| AU (1) | AU2005314361B2 (enExample) |
| BR (1) | BRPI0518398A2 (enExample) |
| CA (1) | CA2589654C (enExample) |
| EA (1) | EA014420B1 (enExample) |
| MX (1) | MX2007006707A (enExample) |
| NO (1) | NO20073456L (enExample) |
| WO (1) | WO2006062748A2 (enExample) |
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| JP2008524120A (ja) * | 2004-12-06 | 2008-07-10 | レリアント ファーマスーティカルズ インコーポレイテッド | オメガ−3脂肪酸類及びpparアゴニスト及び/又はアンタゴニスト並びにその併用製品を用いた治療 |
| JP2014505732A (ja) * | 2011-02-16 | 2014-03-06 | ピヴォタル セラピューティクス インコーポレイテッド | 心血管疾患において用いるための、スタチンおよびω3脂肪酸(EPA、DHAおよびDPA) |
| JP2014505731A (ja) * | 2011-02-16 | 2014-03-06 | ピヴォタル セラピューティクス インコーポレイテッド | 心血管疾患のリスク因子を治療するための、EPA、DHAおよびDPAを含むω3製剤 |
| JP2014506891A (ja) * | 2011-02-16 | 2014-03-20 | ピヴォタル セラピューティクス インコーポレイテッド | 心血管疾患(CVD)患者の食事管理のためのω3脂肪酸診断アッセイ |
| JP2014508802A (ja) * | 2011-03-23 | 2014-04-10 | ハンミ ファーム. シーオー., エルティーディー. | オメガ3脂肪酸エステル及びhmg−coa還元酵素阻害剤を含む経口複合組成物 |
| JP2014533685A (ja) * | 2011-11-17 | 2014-12-15 | ハンミ ファーム. シーオー., エルティーディー. | 安定性が向上したω−3脂肪酸およびHMG−COA還元酵素阻害剤を含む経口複合製剤 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004058281A1 (de) * | 2002-12-24 | 2004-07-15 | Nutrinova Nutrition Specialties & Food Ingedients Gmbh | Cholesterinsenkendes mittel, enthaltend eine n-3-fettsäure |
| WO2006017692A2 (en) * | 2004-08-06 | 2006-02-16 | Transform Pharmaceuticals, Inc. | Novel fenofibrate formulations and related methods of treatment |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2627696B1 (fr) * | 1988-02-26 | 1991-09-13 | Fournier Innovation Synergie | Nouvelle forme galenique du fenofibrate |
| GB8819110D0 (en) * | 1988-08-11 | 1988-09-14 | Norsk Hydro As | Antihypertensive drug & method for production |
| GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| US5545628A (en) * | 1995-01-10 | 1996-08-13 | Galephar P.R. Inc. | Pharmaceutical composition containing fenofibrate |
| MY118354A (en) * | 1995-05-01 | 2004-10-30 | Scarista Ltd | 1,3-propane diol derivatives as bioactive compounds |
| FR2737121B1 (fr) * | 1995-07-27 | 1997-10-03 | Cl Pharma | Nouvelles formulations galeniques du fenofibrate et leurs applications |
| FR2758459B1 (fr) * | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
| AU6959898A (en) * | 1997-04-11 | 1998-11-11 | David J. Grainger | Compounds and therapies for the prevention of vascular and non-vascular pathol ogies |
| US6344482B1 (en) * | 1997-04-23 | 2002-02-05 | Andrew L. Stoll | Omega-3 fatty acids in the treatment of bipolar disorder |
| US6281920B1 (en) * | 1997-07-03 | 2001-08-28 | Fuji Photo Film Co., Ltd. | Image recording apparatus |
| IE970731A1 (en) * | 1997-10-07 | 2000-10-04 | Fuisz Internat Ltd | Product and method for the treatment of hyperlipidemia |
| ATE497384T1 (de) * | 1997-12-10 | 2011-02-15 | Cyclosporine Therapeutics Ltd | Omega-3 fettsäure enthaltende pharmazeutische zusammensetzungen |
| US6814977B1 (en) * | 1998-12-18 | 2004-11-09 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
| US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
| US6372251B2 (en) * | 1999-06-11 | 2002-04-16 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
| US6982281B1 (en) * | 2000-11-17 | 2006-01-03 | Lipocine Inc | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
| US6720001B2 (en) * | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| US20030170643A1 (en) * | 1999-10-26 | 2003-09-11 | Edward Fisher | Regulation of apoB treatment and drug screening for cardiovascular and metabolic disorders or syndromes |
| FR2803203B1 (fr) * | 1999-12-31 | 2002-05-10 | Fournier Ind & Sante | Nouvelles formulations galeniques du fenofibrate |
| US6667064B2 (en) * | 2000-08-30 | 2003-12-23 | Pilot Therapeutics, Inc. | Composition and method for treatment of hypertriglyceridemia |
| EP1339429A4 (en) * | 2000-11-29 | 2007-03-14 | Smithkline Beecham Corp | COMPOSITION CONTAINING STATINS AND CALCIUM FOR IMPROVING CARDIOVASCULAR HEALTH |
| US20020077317A1 (en) * | 2000-12-15 | 2002-06-20 | Das Undurti Narasimha | Method of potentating the action of 2-methoxyoestradiol, statins and C-peptide of proinsulin |
| FR2818905A1 (fr) * | 2000-12-28 | 2002-07-05 | Cll Pharma | Compositions pharmaceutiques colloidales micellaires renfermant un principe actif lipophile |
| WO2002095402A2 (en) * | 2001-04-18 | 2002-11-28 | Mcgill University | Individualization of therapy with hyperlipidemia agents |
| FR2841138B1 (fr) * | 2002-06-25 | 2005-02-25 | Cll Pharma | Composition pharmaceutique solide contenant un principe actif lipophile, son procede de preparation |
| AU2005271413A1 (en) * | 2004-08-06 | 2006-02-16 | Transform Pharmaceuticals, Inc. | Novel statin pharmaceutical compositions and related methods of treatment |
| CN101098690A (zh) * | 2004-12-06 | 2008-01-02 | 瑞莱恩特医药品有限公司 | 用于血脂治疗的ω-3脂肪酸和脂血异常剂 |
| US20060211763A1 (en) * | 2005-03-08 | 2006-09-21 | Abdel Fawzy | Treatment with Statin and Omega-3 Fatty Acids and a Combination Product Thereof |
-
2005
- 2005-11-22 KR KR1020077015515A patent/KR101356335B1/ko not_active Expired - Fee Related
- 2005-11-22 CA CA2589654A patent/CA2589654C/en not_active Expired - Fee Related
- 2005-11-22 US US11/284,095 patent/US20060211762A1/en not_active Abandoned
- 2005-11-22 MX MX2007006707A patent/MX2007006707A/es not_active Application Discontinuation
- 2005-11-22 AU AU2005314361A patent/AU2005314361B2/en not_active Ceased
- 2005-11-22 BR BRPI0518398-7A patent/BRPI0518398A2/pt active Search and Examination
- 2005-11-22 WO PCT/US2005/042648 patent/WO2006062748A2/en not_active Ceased
- 2005-11-22 EA EA200701229A patent/EA014420B1/ru not_active IP Right Cessation
- 2005-11-22 EP EP05825478A patent/EP1830830A4/en not_active Withdrawn
- 2005-11-22 JP JP2007544405A patent/JP2008522970A/ja active Pending
-
2007
- 2007-07-04 NO NO20073456A patent/NO20073456L/no not_active Application Discontinuation
-
2008
- 2008-09-15 US US12/210,872 patent/US20090012167A1/en not_active Abandoned
-
2012
- 2012-06-18 JP JP2012136691A patent/JP2012176987A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004058281A1 (de) * | 2002-12-24 | 2004-07-15 | Nutrinova Nutrition Specialties & Food Ingedients Gmbh | Cholesterinsenkendes mittel, enthaltend eine n-3-fettsäure |
| WO2006017692A2 (en) * | 2004-08-06 | 2006-02-16 | Transform Pharmaceuticals, Inc. | Novel fenofibrate formulations and related methods of treatment |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008524120A (ja) * | 2004-12-06 | 2008-07-10 | レリアント ファーマスーティカルズ インコーポレイテッド | オメガ−3脂肪酸類及びpparアゴニスト及び/又はアンタゴニスト並びにその併用製品を用いた治療 |
| JP2014505732A (ja) * | 2011-02-16 | 2014-03-06 | ピヴォタル セラピューティクス インコーポレイテッド | 心血管疾患において用いるための、スタチンおよびω3脂肪酸(EPA、DHAおよびDPA) |
| JP2014505731A (ja) * | 2011-02-16 | 2014-03-06 | ピヴォタル セラピューティクス インコーポレイテッド | 心血管疾患のリスク因子を治療するための、EPA、DHAおよびDPAを含むω3製剤 |
| JP2014506891A (ja) * | 2011-02-16 | 2014-03-20 | ピヴォタル セラピューティクス インコーポレイテッド | 心血管疾患(CVD)患者の食事管理のためのω3脂肪酸診断アッセイ |
| JP2014508802A (ja) * | 2011-03-23 | 2014-04-10 | ハンミ ファーム. シーオー., エルティーディー. | オメガ3脂肪酸エステル及びhmg−coa還元酵素阻害剤を含む経口複合組成物 |
| JP2014533685A (ja) * | 2011-11-17 | 2014-12-15 | ハンミ ファーム. シーオー., エルティーディー. | 安定性が向上したω−3脂肪酸およびHMG−COA還元酵素阻害剤を含む経口複合製剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012176987A (ja) | 2012-09-13 |
| KR20070098849A (ko) | 2007-10-05 |
| WO2006062748A2 (en) | 2006-06-15 |
| EP1830830A2 (en) | 2007-09-12 |
| KR101356335B1 (ko) | 2014-02-06 |
| MX2007006707A (es) | 2008-01-16 |
| NO20073456L (no) | 2007-09-05 |
| AU2005314361A1 (en) | 2006-06-15 |
| EP1830830A4 (en) | 2010-02-10 |
| CA2589654A1 (en) | 2006-06-15 |
| AU2005314361B2 (en) | 2012-04-12 |
| EA200701229A1 (ru) | 2007-12-28 |
| EA014420B1 (ru) | 2010-12-30 |
| US20090012167A1 (en) | 2009-01-08 |
| CA2589654C (en) | 2016-02-16 |
| US20060211762A1 (en) | 2006-09-21 |
| BRPI0518398A2 (pt) | 2008-11-18 |
| WO2006062748A3 (en) | 2007-05-18 |
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