JP2008520594A - カルボキサミドおよびその使用 - Google Patents
カルボキサミドおよびその使用 Download PDFInfo
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- JP2008520594A JP2008520594A JP2007541629A JP2007541629A JP2008520594A JP 2008520594 A JP2008520594 A JP 2008520594A JP 2007541629 A JP2007541629 A JP 2007541629A JP 2007541629 A JP2007541629 A JP 2007541629A JP 2008520594 A JP2008520594 A JP 2008520594A
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- isopropyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/44—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms at least one of the singly-bound nitrogen atoms being acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Confectionery (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Description
英国特許GB 1,421,744は、生理的冷却効果を有する、単純なN−置換アミドの発見を報告している。これらの化学品は、完全に合成的に製造できるため、用途が広い。その出発材料は、米国特許US 4,150,052に記載のN−置換p−メンタンカルボキサミドとは対照的に、天然の給源に依存しない。
YおよびZは、独立して、H、OH、C1〜C4アルキル、C1〜C4アルコキシから選択されるか、または、Zは、H、OH、C1〜C4アルキルまたはC1〜C4アルコキシであり、
XおよびYは、一緒に、−O−CH2−O−、−N=CH−O−、−N=CH−NH−、および−N=CH−S−からなる群から選択される二価の基を形成し、これが、これらが結合している炭素原子と一緒に5員環、すなわち、1,3−ジオキサラン環、1,3−オキサゾール環、1,3−ジアゾール環または1,3−チアゾール環をそれぞれ形成し、
mは、0または1であり、
R1は、H、C1〜C4アルキル、好ましくはHまたはメチルであり、
R2およびR3は、独立して、C1〜C4アルキル、好ましくは分枝C3またはC4アルキルを表し、
炭素原子の合計R1+R2+R3が少なくとも6である。
R1が水素であり、R2およびR3がイソプロピルである式Iの化合物、またはR1がメチルであり、R2およびR3がイソプロピルである化合物が特に好ましい。
式Iの好ましい化合物はまた、Xが2、4または6位にある、すなわちオルトまたはパラにある化合物である。最も好ましい化合物は、Xが2、4または6位にあり、YおよびZが、独立して、水素、ヒドロキシ、メトキシまたはメチルを表すものである。
で表される化合物に関する。
本発明の範囲に含まれる他の化合物の例は、N−バニリル2−イソプロピル−イソバレルアミドおよびN−ベンゾ[1,3]ジオキソール−5−イル2−イソプロピルイソバレルアミドである。
本発明の化合物は、単独で、または、当該技術分野で知られている他の冷却化合物、例えばメントール、メントン、イソプレゴール、N−エチルp−メンタンカルボキサミド(WS-3)、N,2,3−トリメチル−2−イソプロピルブタンアミド(WS-23)、乳酸メンチル、コハク酸モノメンチル(Physcool(商標))、グルタル酸モノメンチル、O−メンチルグリセリン(CoolAct(商標)10)および2−sec−ブチルシクロヘキサノン(Freskomenthe(商標))と組み合わせて用いることができる。
で表されるアミンと、当該技術分野でよく知られた処理条件下で反応させることにより製造することができる。式R1R2R3C−COOHの酸の一部は市販されている。一般に、これらは例えば、Tetrahedron, 1980, 36(6), 775-7またはJournal of Chemical Research, 1978, 2, 46に記載の方法により製造することができる。
これから本発明を、以下の非限定例によってさらに説明する。
フラスコに、5.9g(50mmol)の4−アミノベンゾニトリル、4mlのピリジンおよび100mlのMtBEを加えた。この混合物に、8gの2−イソプロピルイソバレリルクロリドを、5分間にわたって摘加した。反応混合物を24時間攪拌した。反応混合物に、50mlの水を加えた。混合物を分離した。有機層を、50mlの水および50mlの塩水で洗浄した。有機層を、MgSO4で乾燥した。溶媒を真空下で蒸発させて粗生成物を得、これをヘキサンから再結晶化して10gの所望の産物を得た。
例1と同様の手順に従い、表1に列記した化合物を合成した。
化合物の冷却強度は、4〜8人の訓練されたパネルにより、以下に記載する等強度法に従って決定した。
種々の濃度の化学物質の水溶液を用意し、試験を行った。各溶液の冷却強度は、2ppmの参照化合物、すなわち、N,2,3−トリメチル−2−イソプロピルブタンアミド(WS23)の水溶液の冷却強度と比較した。結果を下記リストに示す。
全ての成分を混合した。得られた溶液の30mlを口に入れ、口内を往復させ、うがいをして吐き出した。口および唇の各所で、強い冷感が感じられた。
Claims (9)
- 式中、Xは(CH2)n−Rであり、式中、Rは少なくとも1つの自由電子対を含む基であり、nは、0または1であり、
YおよびZは、独立して、H、OH、C1〜C4アルキル、C1〜C4アルコキシから選択されるか、または、Zは、H、OH、C1〜C4アルキルまたはC1〜C4アルコキシであり、
XおよびYは、一緒に、−O−CH2−O−、−N=CH−O−、−N=CH−NH−、および−N=CH−S−からなる群から選択される二価の基を形成し、これが、これらが結合している炭素原子と一緒に5員環を形成し、
mは、0または1であり、
R1は、H、C1〜C4アルキルであり、
R2およびR3は、独立して、C1〜C4アルキルを表し、
炭素原子の合計R1+R2+R3が少なくとも6である
で表される化合物。 - R2およびR3が、独立して、分枝C3またはC4アルキルを表す、請求項1に記載の化合物。
- R1がHまたはメチルであり、R2がイソプロピルであり、R3がイソプロピルである、請求項1に記載の化合物。
- Rが、Cl、F、Br、シアノ、ヒドロキシル、メトキシ、NO2、アセチル、SO2NH2、CHO、COOH、C1〜C4アルキルカルボン酸塩、C1〜C4アルキルカルボキサミド、および、N、SおよびOからなる群から選択される2個または3個以上のヘテロ原子を含む5員複素環からなる群から選択される、請求項1〜3のいずれかに記載の化合物。
- N−(4−シアノフェニル)2−イソプロピルイソバレルアミド、N−(4−シアノフェニル)2−メチル−2−イソプロピルイソバレルアミド、N−(4−メトキシフェニル)2−メチル−2−イソプロピルイソバレルアミド、N−(4−シアノメチル−フェニル)−2−メチル−2−イソプロピル−イソバレルアミド、4−(2−イソプロピル−2,3−ジメチル−ブチリルアミノ)−安息香酸イソプロピルエステル、N−(4−メトキシフェニル)2−イソプロピル−イソバレルアミド、N−(2−シアノフェニル)2−イソプロピルイソバレルアミド、N−バニリル2−メチル−2−イソプロピルイソバレルアミド、N−バニリル2−イソプロピル−イソバレルアミド、N−ベンゾ[1,3]ジオキソール−5−イル2−メチル−2−イソプロピルイソバレルアミド、およびN−ベンゾ[1,3]ジオキソール−5−イル2−イソプロピルイソバレルアミドからなる群から選択される、請求項1に記載の化合物。
- 請求項1〜5のいずれかに記載の式Iの化合物の、冷却剤としての使用。
- 請求項1〜5のいずれかに記載の式Iの化合物を含む製品を口または皮膚に適用することによる、口または皮膚に冷却効果をもたらす方法。
- 請求項1〜5のいずれかに記載の式Iの化合物の群から選択される少なくとも1種の化合物を含む、口または皮膚に冷却効果をもたらす製品。
- 製品基剤と、請求項1〜5のいずれかに記載の式Iの冷却化合物またはその混合物の有効量とを含む、局所用製品、オーラルケア製品、ノーズケア製品、化粧品、摂取可能な製品およびチューインガムからなる群から選択される製品。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0425661.6A GB0425661D0 (en) | 2004-11-23 | 2004-11-23 | Organic compounds |
PCT/CH2005/000687 WO2006056087A1 (en) | 2004-11-23 | 2005-11-21 | Carboxamides and their use |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008520594A true JP2008520594A (ja) | 2008-06-19 |
JP2008520594A5 JP2008520594A5 (ja) | 2008-12-25 |
Family
ID=33548661
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007541629A Pending JP2008520594A (ja) | 2004-11-23 | 2005-11-21 | カルボキサミドおよびその使用 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20080112899A1 (ja) |
EP (1) | EP1814845A1 (ja) |
JP (1) | JP2008520594A (ja) |
CN (1) | CN101065351A (ja) |
BR (1) | BRPI0518487A2 (ja) |
GB (1) | GB0425661D0 (ja) |
MX (1) | MX2007005406A (ja) |
WO (1) | WO2006056087A1 (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4786544B2 (ja) | 2003-11-21 | 2011-10-05 | ジボダン エス エー | N置換p−メンタンカルボキサミド類 |
EP1853565B1 (en) | 2005-03-01 | 2010-09-22 | Givaudan SA | Menthane carboxamide derivatives having cooling properties |
GB0504194D0 (en) | 2005-03-02 | 2005-04-06 | Givaudan Sa | Organic compounds |
ES2668361T3 (es) | 2005-08-15 | 2018-05-17 | Givaudan Sa | Compuestos refrigerantes |
BRPI0721140A2 (pt) * | 2006-12-20 | 2014-04-01 | Givaudan Nederland Services Bv | P-mentano-3-carboxamida n-substituída e usos da mesma. |
US8377422B2 (en) * | 2007-12-07 | 2013-02-19 | Givaudan S.A. | Carboxamide derivatives having cooling properties |
WO2010014872A1 (en) * | 2008-08-01 | 2010-02-04 | Nivis, Llc | Systems and methods for determining link quality |
US8664261B2 (en) | 2009-05-05 | 2014-03-04 | Givaudan S.A. | Organic compounds having cooling properties |
US20120196018A1 (en) | 2009-07-29 | 2012-08-02 | Francisco Valentino Villagran | Organic Compounds |
GB201103103D0 (en) | 2011-02-23 | 2011-04-06 | Givaudan Sa | Organic compounds |
MX2016013618A (es) | 2014-04-23 | 2017-02-28 | Procter & Gamble | Ciclohexanocarboxamida con propiedades de enfriamiento. |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR8121M (ja) * | 1968-12-27 | 1970-08-03 | ||
JPS50111264A (ja) * | 1974-01-31 | 1975-09-01 | ||
US4136163A (en) * | 1971-02-04 | 1979-01-23 | Wilkinson Sword Limited | P-menthane carboxamides having a physiological cooling effect |
US4230688A (en) * | 1972-04-18 | 1980-10-28 | Wilkinson Sword Limited | Acyclic carboxamides having a physiological cooling effect |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1507886A (fr) * | 1967-01-13 | 1967-12-29 | J Berthier Sa Lab | Nouveaux dérivés du dipropylacétylanilide |
CH493198A (de) * | 1968-05-06 | 1970-07-15 | Ciba Geigy | Schädlingsbekämpfungsmittel |
US3941581A (en) * | 1970-03-16 | 1976-03-02 | Stauffer Chemical Company | Meta-bis anilide derivatives and their utility as herbicides |
US4028093A (en) * | 1971-09-09 | 1977-06-07 | Stauffer Chemical Company | Meta-bis anilide derivatives and their utility as herbicides |
US3885947A (en) * | 1973-04-09 | 1975-05-27 | Stauffer Chemical Co | Meta-anilide ureas as algicidal agents |
JPS5714748A (en) * | 1980-07-01 | 1982-01-26 | Dainippon Pharmaceut Co Ltd | Kit for quantitative determination of valproic acid and its method for quantitative determination |
DE3373810D1 (de) * | 1982-07-27 | 1987-10-29 | Sumitomo Chemical Co | Fungicidal anilides |
JP2894445B2 (ja) * | 1997-02-12 | 1999-05-24 | 日本たばこ産業株式会社 | Cetp活性阻害剤として有効な化合物 |
DE19706237A1 (de) * | 1997-02-18 | 1998-08-20 | Agfa Gevaert Ag | Farbfotografisches Aufzeichnungsmaterial |
CN1311773A (zh) * | 1998-06-08 | 2001-09-05 | 先灵公司 | 神经肽y5受体拮抗剂 |
FR2826365B1 (fr) * | 2001-06-20 | 2003-09-26 | Oreal | Compositions cosmetiques photoprotectrices contenant des derives amides, sulfonamides ou carbamates aromatiques d'acrylonitrile et nouveaux derives amides, sulfonamides ou carbamates d'acrylonitrile |
NZ597500A (en) * | 2003-08-06 | 2014-08-29 | Senomyx Inc | Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof |
-
2004
- 2004-11-23 GB GBGB0425661.6A patent/GB0425661D0/en not_active Ceased
-
2005
- 2005-11-21 MX MX2007005406A patent/MX2007005406A/es not_active Application Discontinuation
- 2005-11-21 CN CNA2005800401839A patent/CN101065351A/zh active Pending
- 2005-11-21 JP JP2007541629A patent/JP2008520594A/ja active Pending
- 2005-11-21 WO PCT/CH2005/000687 patent/WO2006056087A1/en active Application Filing
- 2005-11-21 BR BRPI0518487-8A patent/BRPI0518487A2/pt not_active IP Right Cessation
- 2005-11-21 EP EP05803136A patent/EP1814845A1/en not_active Withdrawn
- 2005-11-21 US US11/666,625 patent/US20080112899A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR8121M (ja) * | 1968-12-27 | 1970-08-03 | ||
US4136163A (en) * | 1971-02-04 | 1979-01-23 | Wilkinson Sword Limited | P-menthane carboxamides having a physiological cooling effect |
US4230688A (en) * | 1972-04-18 | 1980-10-28 | Wilkinson Sword Limited | Acyclic carboxamides having a physiological cooling effect |
JPS50111264A (ja) * | 1974-01-31 | 1975-09-01 |
Also Published As
Publication number | Publication date |
---|---|
WO2006056087A1 (en) | 2006-06-01 |
BRPI0518487A2 (pt) | 2008-11-18 |
US20080112899A1 (en) | 2008-05-15 |
CN101065351A (zh) | 2007-10-31 |
MX2007005406A (es) | 2007-05-16 |
GB0425661D0 (en) | 2004-12-22 |
EP1814845A1 (en) | 2007-08-08 |
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