JP2008519845A5 - - Google Patents
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- Publication number
- JP2008519845A5 JP2008519845A5 JP2007541328A JP2007541328A JP2008519845A5 JP 2008519845 A5 JP2008519845 A5 JP 2008519845A5 JP 2007541328 A JP2007541328 A JP 2007541328A JP 2007541328 A JP2007541328 A JP 2007541328A JP 2008519845 A5 JP2008519845 A5 JP 2008519845A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic composition
- mixture
- cancer
- ptpase inhibitor
- pentavalent antimony
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 23
- 230000001225 therapeutic effect Effects 0.000 claims 17
- 102000002727 Protein Tyrosine Phosphatase Human genes 0.000 claims 8
- 239000003112 inhibitor Substances 0.000 claims 8
- 108020000494 protein-tyrosine phosphatase Proteins 0.000 claims 8
- ZDINGUUTWDGGFF-UHFFFAOYSA-N antimony(5+) Chemical group [Sb+5] ZDINGUUTWDGGFF-UHFFFAOYSA-N 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 229940126530 T cell activator Drugs 0.000 claims 4
- YQDGWZZYGYKDLR-UZVLBLASSA-K sodium stibogluconate Chemical compound O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].O1[C@H]([C@H](O)CO)[C@H](O2)[C@H](C([O-])=O)O[Sb]21([O-])O[Sb]1(O)(O[C@H]2C([O-])=O)O[C@H]([C@H](O)CO)[C@@H]2O1 YQDGWZZYGYKDLR-UZVLBLASSA-K 0.000 claims 4
- 229960001567 sodium stibogluconate Drugs 0.000 claims 4
- 108010002350 Interleukin-2 Proteins 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000004128 high performance liquid chromatography Methods 0.000 claims 2
- 150000002460 imidazoles Chemical class 0.000 claims 2
- YBVNFKZSMZGRAD-UHFFFAOYSA-N pentamidine isethionate Chemical class OCCS(O)(=O)=O.OCCS(O)(=O)=O.C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 YBVNFKZSMZGRAD-UHFFFAOYSA-N 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/987,217 US20050215629A1 (en) | 2001-09-07 | 2004-11-11 | PTPase inhibitors and methods of using the same |
| PCT/US2005/040825 WO2006053162A1 (en) | 2004-11-11 | 2005-11-10 | Ptpase inhibitors and t-cell activators for treating cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008519845A JP2008519845A (ja) | 2008-06-12 |
| JP2008519845A5 true JP2008519845A5 (enExample) | 2008-12-25 |
Family
ID=35945240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007541328A Pending JP2008519845A (ja) | 2004-11-11 | 2005-11-10 | 癌を治療するためのｐｔｐアーゼ阻害剤およびｔ細胞活性化剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050215629A1 (enExample) |
| EP (1) | EP1817057B1 (enExample) |
| JP (1) | JP2008519845A (enExample) |
| AT (1) | ATE469659T1 (enExample) |
| AU (1) | AU2005304422A1 (enExample) |
| CA (1) | CA2587336A1 (enExample) |
| DE (1) | DE602005021681D1 (enExample) |
| WO (1) | WO2006053162A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050215629A1 (en) * | 2001-09-07 | 2005-09-29 | Taolin Yi | PTPase inhibitors and methods of using the same |
| US20070202079A1 (en) * | 2006-01-11 | 2007-08-30 | Taolin Yi | Therapeutic compositions and methods useful in modulating protein tyrosine phosphatases |
| US20080226596A1 (en) * | 2006-06-19 | 2008-09-18 | Taolin Yi | Therapeutic compositions and methods useful in treating hepatitis |
| WO2007149381A2 (en) * | 2006-06-19 | 2007-12-27 | The Cleveland Clinic Foundation | Compositions comprising a ptp-ase inhibitor and use thereof in treating cancer |
| WO2007149382A2 (en) * | 2006-06-19 | 2007-12-27 | The Cleveland Clinic Foundation | Therapeutic compositions and methods useful in treating hepatitis |
| GB0916124D0 (en) | 2009-09-15 | 2009-10-28 | Univ Cardiff | Method and kit for the classification and prognosis of wounds |
| GB201021182D0 (en) | 2010-12-14 | 2011-01-26 | Univ Cardiff | Methdo and kit for the classification and prognosis of chronic wounds |
| GB201103898D0 (en) | 2011-03-08 | 2011-04-20 | Univ Cardiff | Molecular targets for healing or treating wounds |
| CN111803475B (zh) * | 2019-04-10 | 2023-06-23 | 中美（河南）荷美尔肿瘤研究院 | 喷他脒在制备抑制pd1和pd-l1蛋白之间相互作用药物中的应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63139134A (ja) * | 1986-12-02 | 1988-06-10 | Kyowa Hakko Kogyo Co Ltd | Ｔ細胞活性化剤 |
| EP0309519B1 (en) * | 1987-04-09 | 1992-07-08 | FISONS plc | Pharmaceutical compositions containing pentamidine |
| US5759837A (en) * | 1989-01-17 | 1998-06-02 | John Hopkins University | Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway |
| US5798339A (en) * | 1990-12-17 | 1998-08-25 | University Of Manitoba | Treatment method for cancer |
| US6177460B1 (en) * | 1995-04-12 | 2001-01-23 | The Procter & Gamble Company | Method of treatment for cancer or viral infections |
| US5798374A (en) * | 1995-06-07 | 1998-08-25 | Sugen Inc. | Methods of inhibiting phosphatase activity and treatment of disorders associated therewith |
| US6388076B1 (en) * | 1995-06-19 | 2002-05-14 | Ontogen Corporation | Protein tyrosine phosphatase-inhibiting compounds |
| US6207145B1 (en) * | 1997-05-09 | 2001-03-27 | Pharma Pacific Pty Ltd. | Therapeutic applications of high dose interferon |
| US6020179A (en) * | 1996-10-03 | 2000-02-01 | Incyte Pharmaceuticals, Inc. | Nucleic acids encoding human tyrosine phosphatases |
| US6262044B1 (en) * | 1998-03-12 | 2001-07-17 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (PTPASES) |
| IN183330B (enExample) * | 1998-03-23 | 1999-11-20 | Dalmia Ct For Biotechnology | |
| US6258582B1 (en) * | 1998-09-30 | 2001-07-10 | Millennium Pharmaceuticals, Inc. | CSAPTP nucleic acid molecules and uses therefor |
| US6569853B1 (en) * | 2000-11-06 | 2003-05-27 | Combinatorx, Incorporated | Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders |
| US6693125B2 (en) * | 2001-01-24 | 2004-02-17 | Combinatorx Incorporated | Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders |
| ATE401880T1 (de) * | 2001-05-31 | 2008-08-15 | Cleveland Clinic Foundation | Ptpase-inhibitoren und verfahren zu ihrer verwendung |
| US20030161893A1 (en) * | 2001-09-07 | 2003-08-28 | Taolin Yi | PTPase inhibitors and methods of using the same |
| US20050215629A1 (en) * | 2001-09-07 | 2005-09-29 | Taolin Yi | PTPase inhibitors and methods of using the same |
| CA2459793A1 (en) * | 2001-09-07 | 2003-08-28 | The Cleveland Clinic Foundation | Therapeutic compositions and methods useful in modulating protein tyrosine phosphatases |
| AU2003210741A1 (en) * | 2002-01-30 | 2003-09-02 | The Cleveland Clinic Foundation | Ptpase inhibitors and methods of using the same |
-
2004
- 2004-11-11 US US10/987,217 patent/US20050215629A1/en not_active Abandoned
-
2005
- 2005-11-10 AU AU2005304422A patent/AU2005304422A1/en not_active Abandoned
- 2005-11-10 DE DE602005021681T patent/DE602005021681D1/de not_active Expired - Lifetime
- 2005-11-10 AT AT05851520T patent/ATE469659T1/de not_active IP Right Cessation
- 2005-11-10 WO PCT/US2005/040825 patent/WO2006053162A1/en not_active Ceased
- 2005-11-10 JP JP2007541328A patent/JP2008519845A/ja active Pending
- 2005-11-10 EP EP05851520A patent/EP1817057B1/en not_active Expired - Lifetime
- 2005-11-10 CA CA002587336A patent/CA2587336A1/en not_active Abandoned
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