JP2008518949A - リン酸塩結合剤のための１日１回製剤 - Google Patents
リン酸塩結合剤のための１日１回製剤 Download PDFInfo
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- JP2008518949A JP2008518949A JP2007539272A JP2007539272A JP2008518949A JP 2008518949 A JP2008518949 A JP 2008518949A JP 2007539272 A JP2007539272 A JP 2007539272A JP 2007539272 A JP2007539272 A JP 2007539272A JP 2008518949 A JP2008518949 A JP 2008518949A
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- dosage unit
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- oral dosage
- phosphate
- aliphatic amine
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- 229910019142 PO4 Inorganic materials 0.000 title claims abstract description 43
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title claims abstract description 43
- 239000010452 phosphate Substances 0.000 title claims abstract description 43
- 239000011230 binding agent Substances 0.000 title description 15
- 239000012735 once-a-day formulation Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 58
- 239000002694 phosphate binding agent Substances 0.000 claims abstract description 26
- 210000002966 serum Anatomy 0.000 claims abstract description 24
- 102000006335 Phosphate-Binding Proteins Human genes 0.000 claims abstract description 12
- 108010058514 Phosphate-Binding Proteins Proteins 0.000 claims abstract description 12
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- 239000000203 mixture Substances 0.000 claims description 34
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- 229960003693 sevelamer Drugs 0.000 claims description 27
- 238000009472 formulation Methods 0.000 claims description 26
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- 150000002603 lanthanum Chemical class 0.000 claims description 17
- 239000000725 suspension Substances 0.000 claims description 17
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- NZPIUJUFIFZSPW-UHFFFAOYSA-H lanthanum carbonate Chemical group [La+3].[La+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O NZPIUJUFIFZSPW-UHFFFAOYSA-H 0.000 claims description 5
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- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 4
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- 201000005991 hyperphosphatemia Diseases 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 229910052698 phosphorus Inorganic materials 0.000 description 4
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- 125000001424 substituent group Chemical group 0.000 description 4
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- 125000001931 aliphatic group Chemical group 0.000 description 3
- IRXBNHGNHKNOJI-UHFFFAOYSA-N butanedioyl dichloride Chemical compound ClC(=O)CCC(Cl)=O IRXBNHGNHKNOJI-UHFFFAOYSA-N 0.000 description 3
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 159000000014 iron salts Chemical class 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 3
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- 239000008194 pharmaceutical composition Substances 0.000 description 3
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- 239000008117 stearic acid Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
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- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 description 2
- KUDUQBURMYMBIJ-UHFFFAOYSA-N 2-prop-2-enoyloxyethyl prop-2-enoate Chemical compound C=CC(=O)OCCOC(=O)C=C KUDUQBURMYMBIJ-UHFFFAOYSA-N 0.000 description 2
- HVBSAKJJOYLTQU-UHFFFAOYSA-N 4-aminobenzenesulfonic acid Chemical compound NC1=CC=C(S(O)(=O)=O)C=C1 HVBSAKJJOYLTQU-UHFFFAOYSA-N 0.000 description 2
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- A61K33/24—Heavy metals; Compounds thereof
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Obesity (AREA)
- Endocrinology (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62398504P | 2004-11-01 | 2004-11-01 | |
| PCT/US2005/039365 WO2006050314A2 (en) | 2004-11-01 | 2005-11-01 | Once a day formulation for phosphate binders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008518949A true JP2008518949A (ja) | 2008-06-05 |
| JP2008518949A5 JP2008518949A5 (enExample) | 2008-12-25 |
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| JP2007539272A Withdrawn JP2008518949A (ja) | 2004-11-01 | 2005-11-01 | リン酸塩結合剤のための１日１回製剤 |
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| Country | Link |
|---|---|
| US (2) | US20060177415A1 (enExample) |
| EP (1) | EP1812021A2 (enExample) |
| JP (1) | JP2008518949A (enExample) |
| CN (1) | CN101043895A (enExample) |
| AU (1) | AU2005302242A1 (enExample) |
| BR (1) | BRPI0517948A (enExample) |
| CA (1) | CA2586021A1 (enExample) |
| MX (1) | MX2007004940A (enExample) |
| WO (1) | WO2006050314A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016065029A (ja) * | 2014-09-15 | 2016-04-28 | 富田製薬株式会社 | ランタン低吸収型経口リン吸着剤 |
| JP2016069365A (ja) * | 2014-09-30 | 2016-05-09 | 富田製薬株式会社 | ランタン低吸収型経口リン吸着剤 |
| JP2018030873A (ja) * | 2010-12-01 | 2018-03-01 | シャイア エルエルシー | ランタン化合物を含むカプセル製剤及び粉末製剤 |
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| US20060083791A1 (en) | 2002-05-24 | 2006-04-20 | Moerck Rudi E | Rare earth metal compounds methods of making, and methods of using the same |
| JP2008516971A (ja) * | 2004-10-15 | 2008-05-22 | アルテアーナノ，インコーポレーテッド | 錠剤による負荷が軽減されるリン酸塩結合剤 |
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| WO2006072054A1 (en) * | 2004-12-30 | 2006-07-06 | Genzyme Corporation | Zinc-containing treatments for hyperphosphatemia |
| JP2009507019A (ja) | 2005-09-02 | 2009-02-19 | ジェンザイム・コーポレーション | リン酸塩を除去する方法およびそれに使用される重合体 |
| KR101547925B1 (ko) * | 2005-09-15 | 2015-08-27 | 젠자임 코포레이션 | 아민 중합체에 대한 샤셋 제형 |
| WO2007056405A2 (en) * | 2005-11-08 | 2007-05-18 | Genzyme Corporation | Magnesium-containing polymers for the treatment of hyperphosphatemia |
| US20070104799A1 (en) * | 2005-11-09 | 2007-05-10 | Shire International Licensing B.V. | Treatment of chronic kidney disease (CKD) subjects using lanthanum compounds |
| MY157620A (en) * | 2006-01-31 | 2016-06-30 | Cytochroma Dev Inc | A granular material of a solid water-soluble mixed metal compound capable of binding phosphate |
| JP2009536246A (ja) * | 2006-05-05 | 2009-10-08 | ゲンズイメ コーポレーション | ホスフェート捕捉剤としてのアミン縮合重合体 |
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| WO2008076242A1 (en) * | 2006-12-14 | 2008-06-26 | Genzyme Corporation | Amido-amine polymer compositions |
| EP2114376A1 (en) * | 2007-02-23 | 2009-11-11 | Genzyme Corporation | Amine polymer compositions |
| WO2008109095A1 (en) * | 2007-03-08 | 2008-09-12 | Genzyme Corporation | Sulfone polymer compositions |
| US20100166696A1 (en) * | 2007-04-27 | 2010-07-01 | Dhal Pradeep K | Amido-amine dendrimer compositions |
| GB0714670D0 (en) * | 2007-07-27 | 2007-09-05 | Ineos Healthcare Ltd | Use |
| GB0720220D0 (en) * | 2007-10-16 | 2007-11-28 | Ineos Healthcare Ltd | Compound |
| JP2011506449A (ja) * | 2007-12-14 | 2011-03-03 | ジェンザイム コーポレーション | コーティング医薬組成物 |
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| GB201001779D0 (en) | 2010-02-04 | 2010-03-24 | Ineos Healthcare Ltd | Composition |
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-
2005
- 2005-10-27 US US11/262,502 patent/US20060177415A1/en not_active Abandoned
- 2005-11-01 WO PCT/US2005/039365 patent/WO2006050314A2/en not_active Ceased
- 2005-11-01 MX MX2007004940A patent/MX2007004940A/es not_active Application Discontinuation
- 2005-11-01 BR BRPI0517948-3A patent/BRPI0517948A/pt not_active IP Right Cessation
- 2005-11-01 EP EP05815376A patent/EP1812021A2/en not_active Withdrawn
- 2005-11-01 CN CNA2005800361687A patent/CN101043895A/zh active Pending
- 2005-11-01 CA CA002586021A patent/CA2586021A1/en not_active Abandoned
- 2005-11-01 JP JP2007539272A patent/JP2008518949A/ja not_active Withdrawn
- 2005-11-01 AU AU2005302242A patent/AU2005302242A1/en not_active Abandoned
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2009
- 2009-05-14 US US12/466,004 patent/US20090304623A1/en not_active Abandoned
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018030873A (ja) * | 2010-12-01 | 2018-03-01 | シャイア エルエルシー | ランタン化合物を含むカプセル製剤及び粉末製剤 |
| JP2016065029A (ja) * | 2014-09-15 | 2016-04-28 | 富田製薬株式会社 | ランタン低吸収型経口リン吸着剤 |
| JP2016069365A (ja) * | 2014-09-30 | 2016-05-09 | 富田製薬株式会社 | ランタン低吸収型経口リン吸着剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0517948A (pt) | 2008-10-21 |
| AU2005302242A1 (en) | 2006-05-11 |
| WO2006050314A3 (en) | 2006-07-06 |
| MX2007004940A (es) | 2007-06-12 |
| CN101043895A (zh) | 2007-09-26 |
| US20090304623A1 (en) | 2009-12-10 |
| EP1812021A2 (en) | 2007-08-01 |
| US20060177415A1 (en) | 2006-08-10 |
| CA2586021A1 (en) | 2006-05-11 |
| WO2006050314A2 (en) | 2006-05-11 |
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