JP2008518671A5 - - Google Patents
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- Publication number
- JP2008518671A5 JP2008518671A5 JP2007539203A JP2007539203A JP2008518671A5 JP 2008518671 A5 JP2008518671 A5 JP 2008518671A5 JP 2007539203 A JP2007539203 A JP 2007539203A JP 2007539203 A JP2007539203 A JP 2007539203A JP 2008518671 A5 JP2008518671 A5 JP 2008518671A5
- Authority
- JP
- Japan
- Prior art keywords
- agent
- medical device
- therapeutic substance
- pharmaceutically acceptable
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003795 chemical substances by application Substances 0.000 claims 11
- 239000000126 substance Substances 0.000 claims 11
- 230000001225 therapeutic effect Effects 0.000 claims 11
- 229940002612 prodrug Drugs 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000002260 anti-inflammatory agent Substances 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 4
- 238000000576 coating method Methods 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 206010030113 Oedema Diseases 0.000 claims 3
- 230000001028 anti-proliverative effect Effects 0.000 claims 3
- 229940127218 antiplatelet drug Drugs 0.000 claims 3
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 claims 3
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 claims 3
- 102000019034 Chemokines Human genes 0.000 claims 2
- 108010012236 Chemokines Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 2
- 230000002927 anti-mitotic effect Effects 0.000 claims 2
- 239000003146 anticoagulant agent Substances 0.000 claims 2
- 239000003080 antimitotic agent Substances 0.000 claims 2
- 229960004676 antithrombotic agent Drugs 0.000 claims 2
- 230000007348 cell dedifferentiation Effects 0.000 claims 2
- 239000000824 cytostatic agent Substances 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000003527 fibrinolytic agent Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229960000103 thrombolytic agent Drugs 0.000 claims 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
- 229940122803 Vinca alkaloid Drugs 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 claims 1
- 229960005309 estradiol Drugs 0.000 claims 1
- 229930182833 estradiol Natural products 0.000 claims 1
- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 claims 1
- 229960002297 fenofibrate Drugs 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 230000010118 platelet activation Effects 0.000 claims 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 1
- 210000005166 vasculature Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/977,288 US7399480B2 (en) | 1997-09-26 | 2004-10-29 | Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices |
| PCT/US2005/039097 WO2006050170A2 (en) | 2004-10-29 | 2005-10-28 | Medical devices containing rapamycin analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008518671A JP2008518671A (ja) | 2008-06-05 |
| JP2008518671A5 true JP2008518671A5 (enExample) | 2009-04-16 |
Family
ID=36128340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007539203A Pending JP2008518671A (ja) | 2004-10-29 | 2005-10-28 | ラパマイシンアナログを含む医療用具 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US7399480B2 (enExample) |
| EP (8) | EP2277569A3 (enExample) |
| JP (1) | JP2008518671A (enExample) |
| WO (1) | WO2006050170A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8257726B2 (en) | 1997-09-26 | 2012-09-04 | Abbott Laboratories | Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices |
| US7357942B2 (en) * | 1997-09-26 | 2008-04-15 | Abbott Laboratories | Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens |
| US7378105B2 (en) | 1997-09-26 | 2008-05-27 | Abbott Laboratories | Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens |
| US20090093875A1 (en) * | 2007-05-01 | 2009-04-09 | Abbott Laboratories | Drug eluting stents with prolonged local elution profiles with high local concentrations and low systemic concentrations |
| US8431145B2 (en) | 2004-03-19 | 2013-04-30 | Abbott Laboratories | Multiple drug delivery from a balloon and a prosthesis |
| US20100030183A1 (en) * | 2004-03-19 | 2010-02-04 | Toner John L | Method of treating vascular disease at a bifurcated vessel using a coated balloon |
| US8709469B2 (en) * | 2004-06-30 | 2014-04-29 | Abbott Cardiovascular Systems Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
| US8236338B2 (en) | 2004-07-13 | 2012-08-07 | The University Of Tennessee Research Foundation | Adhesive composition for carrying therapeutic agents as delivery vehicle on coatings applied to vascular grafts |
| WO2007033375A2 (en) * | 2005-09-14 | 2007-03-22 | Robert Rosen | Methods and devices for drug eluding embolization |
| US7700614B2 (en) * | 2005-12-14 | 2010-04-20 | Abbott Laboratories | One pot synthesis of tetrazole derivatives of rapamycin |
| EP2068932B1 (en) * | 2006-08-15 | 2013-11-06 | Abbott Laboratories | Compositions and drug-delivery systems comprising rapamycin analogs and paclitaxel |
| US8088789B2 (en) * | 2006-09-13 | 2012-01-03 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| US10695327B2 (en) | 2006-09-13 | 2020-06-30 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| CN101557814B (zh) * | 2006-09-13 | 2015-05-20 | 万能医药公司 | 大环内酯化合物及它们的使用方法 |
| US9205080B2 (en) | 2006-11-16 | 2015-12-08 | Transderm, Inc. | Methods of treating keratin hyperproliferation disorders using mTOR inhibitors |
| US10265407B2 (en) | 2007-02-15 | 2019-04-23 | Yale University | Modular nanodevices for smart adaptable vaccines |
| WO2008109347A2 (en) * | 2007-03-02 | 2008-09-12 | Yale University | Methods for ex vivo administration of drugs to grafts using polymeric nanoparticles |
| US9205449B1 (en) * | 2008-09-19 | 2015-12-08 | Terumo Kabushiki Kaisha | Heating method and heating apparatus |
| US8092822B2 (en) * | 2008-09-29 | 2012-01-10 | Abbott Cardiovascular Systems Inc. | Coatings including dexamethasone derivatives and analogs and olimus drugs |
| US8480620B2 (en) | 2009-12-11 | 2013-07-09 | Abbott Cardiovascular Systems Inc. | Coatings with tunable solubility profile for drug-coated balloon |
| US8951595B2 (en) * | 2009-12-11 | 2015-02-10 | Abbott Cardiovascular Systems Inc. | Coatings with tunable molecular architecture for drug-coated balloon |
| US20110144577A1 (en) * | 2009-12-11 | 2011-06-16 | John Stankus | Hydrophilic coatings with tunable composition for drug coated balloon |
| US9220759B2 (en) | 2012-02-23 | 2015-12-29 | Abbott Cardiovascular Systems Inc. | Treatment of diabetic patients with a drug eluting stent and adjunctive therapy |
| US9220584B2 (en) | 2012-03-30 | 2015-12-29 | Abbott Cardiovascular Systems Inc. | Treatment of diabetic patients with a stent and locally administered adjunctive therapy |
| US9597385B2 (en) | 2012-04-23 | 2017-03-21 | Allertein Therapeutics, Llc | Nanoparticles for treatment of allergy |
| AU2013338051C1 (en) | 2012-10-29 | 2017-08-10 | Ariste Medical, Llc. | Polymer coating compositions and coated products |
| AU2014209141B2 (en) | 2013-01-24 | 2018-05-10 | Palvella Therapeutics, Inc. | Compositions for transdermal delivery of mTOR inhibitors |
| US9545301B2 (en) | 2013-03-15 | 2017-01-17 | Covidien Lp | Coated medical devices and methods of making and using same |
| US9320592B2 (en) * | 2013-03-15 | 2016-04-26 | Covidien Lp | Coated medical devices and methods of making and using same |
| EP3760223A1 (en) | 2013-04-03 | 2021-01-06 | N-Fold Llc | Nanoparticle composition for desensitizing a subject to peanut allergens |
| US9668890B2 (en) | 2013-11-22 | 2017-06-06 | Covidien Lp | Anti-thrombogenic medical devices and methods |
| AU2015249769A1 (en) | 2014-04-22 | 2016-11-10 | Ariste Medical, Llc. | Methods and processes for application of drug delivery polymeric coatings |
| WO2016094732A1 (en) * | 2014-12-10 | 2016-06-16 | Transderm, Inc. | METHODS OF TREATING PAIN AND/OR ITCH WITH SMALL MOLECULE INHIBITORS TARGETING AN mTOR PATHWAY |
| JP7108631B2 (ja) | 2017-01-06 | 2022-07-28 | パルヴェラ セラピューティクス、インク． | ｍＴＯＲ阻害剤の無水組成物およびその使用方法 |
| JP2021530463A (ja) | 2018-07-02 | 2021-11-11 | パルヴェラ セラピューティクス、インク． | ｍＴＯＲ阻害剤の無水組成物および使用方法 |
| CN111638483B (zh) * | 2020-06-05 | 2022-07-19 | 国网山东省电力公司营销服务中心(计量中心) | 高压电压互感器计量性能检测的方法及系统 |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR900523A (fr) | 1942-11-11 | 1945-07-02 | Procédé de préparation d'extraits de protéines d'origine animale | |
| FR900520A (fr) | 1943-12-13 | 1945-07-02 | Nouveau système de trusquin | |
| FR900525A (fr) | 1943-12-13 | 1945-07-02 | Réchaud, notamment pour le plein air | |
| ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| US3993749A (en) * | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
| US4885171A (en) * | 1978-11-03 | 1989-12-05 | American Home Products Corporation | Use of rapamycin in treatment of certain tumors |
| US4316885A (en) * | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
| US4401653A (en) * | 1981-03-09 | 1983-08-30 | Ayerst, Mckenna & Harrison Inc. | Combination of rapamycin and picibanil for the treatment of tumors |
| US4894366A (en) | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| US4650803A (en) * | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
| US5527337A (en) * | 1987-06-25 | 1996-06-18 | Duke University | Bioabsorbable stent and method of making the same |
| US4916193A (en) * | 1987-12-17 | 1990-04-10 | Allied-Signal Inc. | Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides |
| US5092877A (en) * | 1988-09-01 | 1992-03-03 | Corvita Corporation | Radially expandable endoprosthesis |
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| US5304121A (en) * | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
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| JPH04230389A (ja) | 1990-07-16 | 1992-08-19 | American Home Prod Corp | ラパマイシン誘導体 |
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| US5163952A (en) * | 1990-09-14 | 1992-11-17 | Michael Froix | Expandable polymeric stent with memory and delivery apparatus and method |
| PT98990A (pt) | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
| US5120842A (en) * | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
| US5120727A (en) * | 1991-05-29 | 1992-06-09 | American Home Products Corporation | Rapamycin dimers |
| US5120725A (en) * | 1991-05-29 | 1992-06-09 | American Home Products Corporation | Bicyclic rapamycins |
| US5705583A (en) * | 1991-07-05 | 1998-01-06 | Biocompatibles Limited | Polymeric surface coatings |
| US6090901A (en) * | 1991-07-05 | 2000-07-18 | Biocompatibles Limited | Polymeric surface coatings |
| US5457111A (en) * | 1991-09-05 | 1995-10-10 | Abbott Laboratories | Macrocyclic immunomodulators |
| US5516781A (en) * | 1992-01-09 | 1996-05-14 | American Home Products Corporation | Method of treating restenosis with rapamycin |
| US5177203A (en) * | 1992-03-05 | 1993-01-05 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents |
| US5288711A (en) | 1992-04-28 | 1994-02-22 | American Home Products Corporation | Method of treating hyperproliferative vascular disease |
| KR100284210B1 (ko) | 1992-04-28 | 2001-03-02 | 이건 이. 버그 | 과증식성 혈관 질환 치료용 배합 제제 |
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| JP4105761B2 (ja) * | 1993-11-19 | 2008-06-25 | アボット・ラボラトリーズ | ラパミシン（マクロライド）の半合成類似体免疫調節剤 |
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| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US5609629A (en) | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
| WO1998036784A1 (en) | 1997-02-20 | 1998-08-27 | Cook Incorporated | Coated implantable medical device |
| CA2256323C (en) * | 1997-03-31 | 2007-05-22 | Kabushikikaisha Igaki Iryo Sekkei | Stent for vessel |
| US6273913B1 (en) * | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
| US6306166B1 (en) | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
| US20030129215A1 (en) * | 1998-09-24 | 2003-07-10 | T-Ram, Inc. | Medical devices containing rapamycin analogs |
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| TW557297B (en) | 1997-09-26 | 2003-10-11 | Abbott Lab | Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same |
| AU749623B2 (en) | 1998-03-26 | 2002-06-27 | Astellas Pharma Inc. | Sustained release preparations |
| US8029561B1 (en) | 2000-05-12 | 2011-10-04 | Cordis Corporation | Drug combination useful for prevention of restenosis |
| ATE466603T1 (de) | 1998-04-27 | 2010-05-15 | Surmodics Inc | Bioaktive wirkstoffe freisetzende beschichtungen |
| CA2340652C (en) * | 1998-08-20 | 2013-09-24 | Cook Incorporated | Coated implantable medical device comprising paclitaxel |
| US6033562A (en) | 1998-08-28 | 2000-03-07 | Budeit; Donald A | Apparatus for aerating wastewater from pressurized or gravity flow sources |
| US6665728B1 (en) * | 1998-12-30 | 2003-12-16 | Intel Corporation | Establishing optimal latency in streaming data applications that use data packets |
| US6419692B1 (en) * | 1999-02-03 | 2002-07-16 | Scimed Life Systems, Inc. | Surface protection method for stents and balloon catheters for drug delivery |
| ATE307625T1 (de) | 2000-05-12 | 2005-11-15 | Cordis Corp | Wirkstoffabgabesysteme zur behandlung von gefässerkrankungen |
| US20040018228A1 (en) * | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
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| EP2314293B1 (en) | 2001-01-16 | 2017-01-04 | Vascular Therapies, LLC | Implantable device containing resorbable matrix material and rapamycin for preventing or treating vasuloproliferative diseases |
| US7651695B2 (en) | 2001-05-18 | 2010-01-26 | Advanced Cardiovascular Systems, Inc. | Medicated stents for the treatment of vascular disease |
| US6641611B2 (en) | 2001-11-26 | 2003-11-04 | Swaminathan Jayaraman | Therapeutic coating for an intravascular implant |
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| US7364586B2 (en) * | 2001-12-21 | 2008-04-29 | The Trustees Of Columbia University In The City Of New York | C3 exoenzyme-coated stents and uses thereof for treating and preventing restenosis |
| BR0306858A (pt) | 2002-01-10 | 2004-11-03 | Novartis Ag | Sistemas de liberação de drogas para a prevenção e tratamento de doenças vasculares compreendendo rapamicina e derivados da mesma |
| EP1480688A1 (en) * | 2002-02-28 | 2004-12-01 | Novartis AG | N-(5- 4-(4-methyl-piperazino-methyl)-benzoylamido)-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine coated stents |
| JP2005528956A (ja) * | 2002-06-10 | 2005-09-29 | レオ ルービン， | 薬剤の管腔内送達のための医療用デバイス |
| DE10237571A1 (de) * | 2002-08-13 | 2004-02-26 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Endovaskuläres Implantat mit aktiver Beschichtung |
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| US20040213826A1 (en) | 2003-04-28 | 2004-10-28 | Marx Steven O. | Medical devices and methods for inhibiting proliferation of smooth muscle cells |
| MXPA06003163A (es) | 2003-09-23 | 2006-06-05 | Novartis Ag | Combinacion de un inhibidor de receptor de vegf con un agente quimioterapeutico. |
| BRPI0414604A (pt) | 2003-09-23 | 2006-11-07 | Novartis Ag | combinações de um inibiddor do receptor de vegf com outros agentes terapêuticos |
| WO2005049021A1 (en) * | 2003-11-03 | 2005-06-02 | Oy Helsinki Transplantation R & D Ltd | Materials and methods for inhibiting neointimal hyperplasia |
| US8652502B2 (en) | 2003-12-19 | 2014-02-18 | Cordis Corporation | Local vascular delivery of trichostatin A alone or in combination with sirolimus to prevent restenosis following vascular injury |
| US7550443B2 (en) * | 2004-03-26 | 2009-06-23 | Surmodics, Inc. | Process and systems for biocompatible surfaces |
| US9561309B2 (en) * | 2004-05-27 | 2017-02-07 | Advanced Cardiovascular Systems, Inc. | Antifouling heparin coatings |
-
2004
- 2004-10-29 US US10/977,288 patent/US7399480B2/en not_active Expired - Fee Related
-
2005
- 2005-10-28 EP EP10012122A patent/EP2277569A3/en not_active Withdrawn
- 2005-10-28 WO PCT/US2005/039097 patent/WO2006050170A2/en not_active Ceased
- 2005-10-28 EP EP10012121A patent/EP2277568A3/en not_active Ceased
- 2005-10-28 EP EP10012124A patent/EP2292280A1/en not_active Withdrawn
- 2005-10-28 EP EP10012119A patent/EP2277566A3/en not_active Ceased
- 2005-10-28 EP EP10012118A patent/EP2277565A3/en not_active Withdrawn
- 2005-10-28 EP EP10012123A patent/EP2277570A3/en not_active Withdrawn
- 2005-10-28 JP JP2007539203A patent/JP2008518671A/ja active Pending
- 2005-10-28 EP EP10012120A patent/EP2277567A1/en not_active Ceased
- 2005-10-28 EP EP05820209A patent/EP1814608A2/en not_active Ceased
-
2008
- 2008-06-20 US US12/143,689 patent/US8153150B2/en not_active Expired - Lifetime
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