TW200730171A - Compositions and methods of administering rapamycin analogs with paclitaxel using medical devices - Google Patents

Compositions and methods of administering rapamycin analogs with paclitaxel using medical devices

Info

Publication number
TW200730171A
TW200730171A TW095137943A TW95137943A TW200730171A TW 200730171 A TW200730171 A TW 200730171A TW 095137943 A TW095137943 A TW 095137943A TW 95137943 A TW95137943 A TW 95137943A TW 200730171 A TW200730171 A TW 200730171A
Authority
TW
Taiwan
Prior art keywords
agents
drugs
compositions
medical devices
paclitaxel
Prior art date
Application number
TW095137943A
Other languages
Chinese (zh)
Other versions
TWI484952B (en
Inventor
John L Toner
Sandra E Burke
Keith R Cromack
Matthew Mack
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/548,974 external-priority patent/US8057816B2/en
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of TW200730171A publication Critical patent/TW200730171A/en
Application granted granted Critical
Publication of TWI484952B publication Critical patent/TWI484952B/en

Links

Abstract

Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceurically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
TW095137943A 2005-10-14 2006-10-14 Compositions and methods of administering rapamycin analogs with paclitaxel using medical devices TWI484952B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72708005P 2005-10-14 2005-10-14
US72719605P 2005-10-14 2005-10-14
US72687805P 2005-10-14 2005-10-14
US73257705P 2005-10-17 2005-10-17
US11/548,974 US8057816B2 (en) 1997-09-26 2006-10-12 Compositions and methods of administering paclitaxel with other drugs using medical devices

Publications (2)

Publication Number Publication Date
TW200730171A true TW200730171A (en) 2007-08-16
TWI484952B TWI484952B (en) 2015-05-21

Family

ID=53723493

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095137943A TWI484952B (en) 2005-10-14 2006-10-14 Compositions and methods of administering rapamycin analogs with paclitaxel using medical devices

Country Status (1)

Country Link
TW (1) TWI484952B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005537854A (en) * 2002-09-06 2005-12-15 アボット・ラボラトリーズ Medical device comprising a hydration inhibitor
ITTO20040056A1 (en) * 2004-02-05 2004-05-05 Sorin Biomedica Cardio Spa STENT FOR THE ENDOLIMINAL DELIVERY OF PRINCIPLES OR ACTIVE AGENTS

Also Published As

Publication number Publication date
TWI484952B (en) 2015-05-21

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