JP2008517278A - ｐ２７のユビキチン化アッセイ及びその使用方法 - Google Patents

ｐ２７のユビキチン化アッセイ及びその使用方法 Download PDF

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Publication number
JP2008517278A
JP2008517278A JP2007536976A JP2007536976A JP2008517278A JP 2008517278 A JP2008517278 A JP 2008517278A JP 2007536976 A JP2007536976 A JP 2007536976A JP 2007536976 A JP2007536976 A JP 2007536976A JP 2008517278 A JP2008517278 A JP 2008517278A
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ubiquitin
label
compound
ubiquitination
ubiquitinated
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Japanese (ja)
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JP2008517278A5 (enExample
Inventor
シュウ，シェイチャン
コックス，サラ
シェ，ウェイリン
マーキュリオ，フランク，エム．
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シグナル ファーマシューティカルズ，エルエルシー
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Publication of JP2008517278A publication Critical patent/JP2008517278A/ja
Publication of JP2008517278A5 publication Critical patent/JP2008517278A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2007536976A 2004-10-15 2005-10-17 ｐ２７のユビキチン化アッセイ及びその使用方法 Pending JP2008517278A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61909204P 2004-10-15 2004-10-15
PCT/US2005/037171 WO2006044747A2 (en) 2004-10-15 2005-10-17 P27 ubiquitination assay and methods of use

Publications (2)

Publication Number Publication Date
JP2008517278A true JP2008517278A (ja) 2008-05-22
JP2008517278A5 JP2008517278A5 (enExample) 2008-12-04

Family

ID=36203595

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007536976A Pending JP2008517278A (ja) 2004-10-15 2005-10-17 ｐ２７のユビキチン化アッセイ及びその使用方法

Country Status (6)

Country Link
US (1) US20060194262A1 (enExample)
EP (1) EP1810008A4 (enExample)
JP (1) JP2008517278A (enExample)
AU (1) AU2005295517A1 (enExample)
CA (1) CA2584131A1 (enExample)
WO (1) WO2006044747A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014510926A (ja) * 2011-04-07 2014-05-01 ザ スクリップス リサーチ インスティテュート 細胞巨大分子の発現を調節する化合物のハイスループットスクリーニング

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010510771A (ja) * 2006-11-27 2010-04-08 シ ビオ アンテルナショナル 翻訳後修飾の検出のための方法
MX344557B (es) * 2007-05-08 2016-12-20 Hunter Douglas Ind Switzerland Sistema de color multivariado con aplicacion de textura.
JP2011528908A (ja) * 2008-07-25 2011-12-01 プロジェンラ インク． ユビキチンリガーゼのモジュレーターの特定法
GB201007185D0 (en) * 2010-04-29 2010-06-09 Iti Scotland Ltd Ubiquitination assay
CN103196877B (zh) * 2013-03-08 2015-06-03 刘小龙 基于均相时间分辨荧光的检测重金属含量的方法
CN104155452A (zh) * 2013-05-15 2014-11-19 复旦大学 一种检测细胞内蛋白质降解的方法
GB201415688D0 (en) * 2014-09-04 2014-10-22 Univ Edinburgh Method and Systems
WO2018029682A1 (en) * 2016-08-08 2018-02-15 Ramot At Tel-Aviv University Ltd. Bacterial systems for analyzing ubiquitylated polypeptides
EP3665283A4 (en) 2017-08-08 2021-04-21 Technology Innovation Momentum Fund (Israel) Limited Partnership CHLORAMPHENICOL RESISTANT TRUNCATED PROTEIN AND ITS USES

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003512008A (ja) * 1998-08-28 2003-04-02 ニューヨーク・ユニバーシティ 治療ターゲットとしての新規ユビキチンリガーゼ
WO2003095971A2 (en) * 2001-11-09 2003-11-20 Proteologics, Inc. Posh nucleic acids, polypeptides and related methods
WO2003100064A1 (en) * 2002-05-29 2003-12-04 Kyowa Hakko Kogyo Co., Ltd. Novel ubiquitin ligase
JP2004531218A (ja) * 2001-01-05 2004-10-14 ニューヨーク・ユニバーシティ 増殖性および分化性疾患の治療に有用な化合物の同定方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2174140C (en) * 1993-10-28 2004-04-06 Kenneth L. Beattie Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
US5463564A (en) * 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
US6747128B2 (en) * 1997-08-20 2004-06-08 Gpc Biotech, Inc. Components of ubiquitin ligase complexes, and uses related thereto
US6413725B1 (en) * 1998-08-07 2002-07-02 California Institute Of Technology Biochemical assay to monitor the ubiquitin ligase activities of cullins
US6740495B1 (en) * 2000-04-03 2004-05-25 Rigel Pharmaceuticals, Inc. Ubiquitin ligase assay

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003512008A (ja) * 1998-08-28 2003-04-02 ニューヨーク・ユニバーシティ 治療ターゲットとしての新規ユビキチンリガーゼ
JP2004531218A (ja) * 2001-01-05 2004-10-14 ニューヨーク・ユニバーシティ 増殖性および分化性疾患の治療に有用な化合物の同定方法
WO2003095971A2 (en) * 2001-11-09 2003-11-20 Proteologics, Inc. Posh nucleic acids, polypeptides and related methods
WO2003100064A1 (en) * 2002-05-29 2003-12-04 Kyowa Hakko Kogyo Co., Ltd. Novel ubiquitin ligase

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014510926A (ja) * 2011-04-07 2014-05-01 ザ スクリップス リサーチ インスティテュート 細胞巨大分子の発現を調節する化合物のハイスループットスクリーニング

Also Published As

Publication number Publication date
AU2005295517A1 (en) 2006-04-27
WO2006044747A3 (en) 2006-10-12
WO2006044747A2 (en) 2006-04-27
US20060194262A1 (en) 2006-08-31
CA2584131A1 (en) 2006-04-27
EP1810008A4 (en) 2008-09-10
EP1810008A2 (en) 2007-07-25

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