JP2008515903A - 拡張機能障害または拡張期心不全の予防または処置のためのレニン阻害剤の使用 - Google Patents

拡張機能障害または拡張期心不全の予防または処置のためのレニン阻害剤の使用 Download PDF

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JP2008515903A
JP2008515903A JP2007535795A JP2007535795A JP2008515903A JP 2008515903 A JP2008515903 A JP 2008515903A JP 2007535795 A JP2007535795 A JP 2007535795A JP 2007535795 A JP2007535795 A JP 2007535795A JP 2008515903 A JP2008515903 A JP 2008515903A
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alkyl
pharmaceutically acceptable
formula
acceptable salt
alkoxy
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JP2008515903A5 (enExample
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デイビッド・ルイス・フェルドマン
フリードリック・キャメロン・ラフト
ドミニク・ニコラス・ミューラー
ランディ・リー・ウェブ
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ノバルティス アクチエンゲゼルシャフト
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
JP2007535795A 2004-10-08 2005-10-06 拡張機能障害または拡張期心不全の予防または処置のためのレニン阻害剤の使用 Ceased JP2008515903A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61720204P 2004-10-08 2004-10-08
US66789905P 2005-04-01 2005-04-01
PCT/US2005/035914 WO2006041974A1 (en) 2004-10-08 2005-10-06 Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure

Publications (2)

Publication Number Publication Date
JP2008515903A true JP2008515903A (ja) 2008-05-15
JP2008515903A5 JP2008515903A5 (enExample) 2012-03-08

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ID=35789048

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JP2007535795A Ceased JP2008515903A (ja) 2004-10-08 2005-10-06 拡張機能障害または拡張期心不全の予防または処置のためのレニン阻害剤の使用

Country Status (15)

Country Link
US (2) US20080085914A1 (enExample)
EP (2) EP2248520A3 (enExample)
JP (1) JP2008515903A (enExample)
KR (2) KR20070101843A (enExample)
CN (1) CN101102755B (enExample)
AT (1) ATE551052T1 (enExample)
AU (2) AU2005294318A1 (enExample)
BR (1) BRPI0516128A (enExample)
CA (1) CA2580862A1 (enExample)
ES (1) ES2384637T3 (enExample)
MX (1) MX2007004020A (enExample)
PL (1) PL1799199T3 (enExample)
PT (1) PT1799199E (enExample)
RU (1) RU2407523C2 (enExample)
WO (1) WO2006041974A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012001545A (ja) * 2010-06-15 2012-01-05 Lab Servier 心不全の処置における洞房結節Ｉｆ電流阻害剤およびアンギオテンシン変換酵素阻害剤の組み合わせの使用
JP2012516299A (ja) * 2009-01-28 2012-07-19 ノバルティス アーゲー 有機化合物のガレヌス製剤

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1972335A1 (en) * 2007-03-23 2008-09-24 Krka Solid dosage forms comprising aliskiren and pharmaceutically acceptable salts thereof
KR20090127174A (ko) 2007-03-27 2009-12-09 칼피스가부시키가이샤 심부전 예방제
AR066168A1 (es) * 2007-09-28 2009-07-29 Novartis Ag Formulaciones galenicas de compuestos organicos
JP2010540548A (ja) * 2007-09-28 2010-12-24 ノバルティス アーゲー アリスキレンとバルサルタンの医薬組み合わせ剤
EP2340820A1 (en) * 2009-12-16 2011-07-06 KRKA, tovarna zdravil, d.d., Novo mesto Moisture-activated granulation process
EP2216020A1 (en) * 2009-02-05 2010-08-11 KRKA, tovarna zdravil, d.d., Novo mesto Moisture-activated granulation process
WO2010089105A2 (en) * 2009-02-05 2010-08-12 Krka, Tovarna Zdravil, D.D., Novo Mesto Moisture-activated granulation process
US20120107397A1 (en) * 2009-07-03 2012-05-03 Hetero Research Foundation Pharmaceutical compositions of valsartan
US20110268797A1 (en) * 2010-04-30 2011-11-03 Sanovel IIac Sanayi Ve Ticaret Anonim Sirketi Multicoated aliskiren formulations

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0748280A (ja) * 1990-05-11 1995-02-21 Pfizer Inc 相乗的治療用組成物
WO2003099279A1 (en) * 2002-05-29 2003-12-04 Novartis Ag Combination of a dpp iv inhibitor and a cardiovascular compound
WO2004002549A1 (en) * 2002-06-28 2004-01-08 Novartis Ag Use of organic compounds
JP2004513920A (ja) * 2000-11-17 2004-05-13 ノバルティス　アクチエンゲゼルシャフト 循環器系疾患のためのレニン阻害剤を含む相乗的組合せ剤

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ES2142789T3 (es) 1989-06-14 2000-05-01 Smithkline Beecham Corp Acidos imidazolil-alquenoicos.
IL97219A (en) 1990-02-19 1995-12-08 Ciba Geigy Ag Biphenyl substituted aliphatic amino compounds process for their preparation and pharmaceutical compositions containing them
PT97078B (pt) 1990-03-20 1997-07-31 Sanofi Sa Processo para a preparacao de derivados heterociclicos n-substituidos e de composicoes farmaceuticas que os contem
US5196444A (en) 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
CA2229000C (en) 1991-02-21 2002-04-09 Sankyo Company, Limited 1-biphenylimidazole derivatives, their preparation and their therapeutic use
DE4121975A1 (de) 1991-07-03 1993-01-07 Basf Ag Thermoplastische formmassen auf der basis von polycarbonaten, styrol/acrylnitril-polymerisaten und polyolefinen
TW226375B (enExample) 1991-10-24 1994-07-11 American Home Prod
MY119161A (en) 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
US6376672B1 (en) 1999-04-27 2002-04-23 Hoffmann-La Roche Inc. Naphthalenylmethoxypiperidines as renin inhibitors
US6197959B1 (en) 1999-04-27 2001-03-06 Hoffmann-La Roche Inc. Piperidine derivatives
AU2002226365A1 (en) * 2000-12-01 2002-06-11 Novartis Ag Combinations of an angiotensin receptor antagonist and an anti-hypertensive drug or a statin, for the treatment of sexual dysfunction
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DE602004022704D1 (de) * 2003-11-26 2009-10-01 Novartis Ag 4-phenylpiperidinderivate als renininhibitoren
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Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
JPH0748280A (ja) * 1990-05-11 1995-02-21 Pfizer Inc 相乗的治療用組成物
JP2004513920A (ja) * 2000-11-17 2004-05-13 ノバルティス　アクチエンゲゼルシャフト 循環器系疾患のためのレニン阻害剤を含む相乗的組合せ剤
WO2003099279A1 (en) * 2002-05-29 2003-12-04 Novartis Ag Combination of a dpp iv inhibitor and a cardiovascular compound
WO2004002549A1 (en) * 2002-06-28 2004-01-08 Novartis Ag Use of organic compounds

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JPN5007017873; ＭＡＩＢＡＵＭ　Ｊ: ＥＸＰＥＲＴ　ＯＰＩＮＩＯＮ　ＯＮ　ＴＨＥＲＡＰＥＵＴＩＣ　ＰＡＴＥＮＴＳ Ｖ１３　Ｎ５, 20030501, Ｐ５８９-６０３, ＡＳＨＬＥＹ　ＰＵＢＬＩＣＡＴＩＯＮＳ *
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JPN6011037104; Ａｍ．　Ｈｅａｒｔ　Ｊ．，　１９９５，　Ｖｏｌ．１３０，　Ｎｏ．１，　ｐｐ．１５３-１６６ *
JPN6012035847; 埼玉医科大学雑誌，　２００３，　Ｖｏｌ．３０，　Ｎｏ．１，　ｐｐ．１９-２８ *
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012516299A (ja) * 2009-01-28 2012-07-19 ノバルティス アーゲー 有機化合物のガレヌス製剤
JP2012001545A (ja) * 2010-06-15 2012-01-05 Lab Servier 心不全の処置における洞房結節Ｉｆ電流阻害剤およびアンギオテンシン変換酵素阻害剤の組み合わせの使用

Also Published As

Publication number Publication date
KR20070101843A (ko) 2007-10-17
EP1799199B1 (en) 2012-03-28
CN101102755A (zh) 2008-01-09
US20080085914A1 (en) 2008-04-10
BRPI0516128A (pt) 2008-08-26
MX2007004020A (es) 2007-05-24
AU2010200833A1 (en) 2010-04-01
PL1799199T3 (pl) 2012-09-28
RU2007116863A (ru) 2008-11-20
CN101102755B (zh) 2013-01-02
EP1799199A1 (en) 2007-06-27
US20130196977A1 (en) 2013-08-01
EP2248520A3 (en) 2010-11-17
EP2248520A2 (en) 2010-11-10
KR20130048281A (ko) 2013-05-09
RU2407523C2 (ru) 2010-12-27
AU2005294318A1 (en) 2006-04-20
CA2580862A1 (en) 2006-04-20
AU2010200833B2 (en) 2011-07-14
ES2384637T3 (es) 2012-07-10
WO2006041974A1 (en) 2006-04-20
PT1799199E (pt) 2012-07-03
ATE551052T1 (de) 2012-04-15

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