JP2008515859A5 - - Google Patents
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- Publication number
- JP2008515859A5 JP2008515859A5 JP2007535189A JP2007535189A JP2008515859A5 JP 2008515859 A5 JP2008515859 A5 JP 2008515859A5 JP 2007535189 A JP2007535189 A JP 2007535189A JP 2007535189 A JP2007535189 A JP 2007535189A JP 2008515859 A5 JP2008515859 A5 JP 2008515859A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- tobacco product
- holder
- aldehyde
- filter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 71
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims description 29
- 239000000126 substance Substances 0.000 claims description 25
- 230000000391 smoking Effects 0.000 claims description 22
- 238000009472 formulation Methods 0.000 claims description 18
- 235000019504 cigarettes Nutrition 0.000 claims description 17
- IKHGUXGNUITLKF-UHFFFAOYSA-N acetaldehyde Chemical group CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims description 16
- XUJNEKJLAYXESH-REOHCLBHSA-N L-cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 15
- 210000000214 Mouth Anatomy 0.000 claims description 11
- 229960002433 Cysteine Drugs 0.000 claims description 10
- 239000000969 carrier Substances 0.000 claims description 7
- 235000019506 cigar Nutrition 0.000 claims description 7
- 235000018417 cysteine Nutrition 0.000 claims description 7
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000004201 L-cysteine Substances 0.000 claims description 3
- 235000013878 L-cysteine Nutrition 0.000 claims description 3
- 229960004452 Methionine Drugs 0.000 claims description 2
- 235000019505 tobacco product Nutrition 0.000 claims 35
- 210000003296 Saliva Anatomy 0.000 claims 12
- 239000006189 buccal tablet Substances 0.000 claims 4
- 239000007910 chewable tablet Substances 0.000 claims 4
- 235000015218 chewing gum Nutrition 0.000 claims 4
- 235000009508 confectionery Nutrition 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 4
- 239000000796 flavoring agent Substances 0.000 claims 4
- 235000013355 food flavoring agent Nutrition 0.000 claims 4
- 235000003599 food sweetener Nutrition 0.000 claims 4
- 239000000499 gel Substances 0.000 claims 4
- 239000007937 lozenge Substances 0.000 claims 4
- 239000000314 lubricant Substances 0.000 claims 4
- 235000010603 pastilles Nutrition 0.000 claims 4
- 239000006190 sub-lingual tablet Substances 0.000 claims 4
- 239000003765 sweetening agent Substances 0.000 claims 4
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 3
- XUJNEKJLAYXESH-UWTATZPHSA-N D-cysteine Chemical compound SC[C@@H](N)C(O)=O XUJNEKJLAYXESH-UWTATZPHSA-N 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- OELDIVRKHTYFNG-WDSKDSINSA-N (2S)-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CS OELDIVRKHTYFNG-WDSKDSINSA-N 0.000 claims 1
- IAICFWDJMWEXAO-UHFFFAOYSA-N 2-(2-sulfanylethylamino)acetic acid Chemical compound OC(=O)CNCCS IAICFWDJMWEXAO-UHFFFAOYSA-N 0.000 claims 1
- 229960004308 ACETYLCYSTEINE Drugs 0.000 claims 1
- UFULAYFCSOUIOV-UHFFFAOYSA-N Cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 claims 1
- XVOYSCVBGLVSOL-UHFFFAOYSA-N Cysteic acid Chemical compound OC(=O)C(N)CS(O)(=O)=O XVOYSCVBGLVSOL-UHFFFAOYSA-N 0.000 claims 1
- 229960003067 Cystine Drugs 0.000 claims 1
- FFFHZYDWPBMWHY-UHFFFAOYSA-N DL-homocysteine Chemical compound OC(=O)C(N)CCS FFFHZYDWPBMWHY-UHFFFAOYSA-N 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- 210000003238 Esophagus Anatomy 0.000 claims 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N Glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 1
- 229960003180 Glutathione Drugs 0.000 claims 1
- 108010024636 Glutathione Proteins 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 1
- ZUKPVRWZDMRIEO-VKHMYHEASA-N L-cysteinylglycine zwitterion Chemical compound SC[C@H]([NH3+])C(=O)NCC([O-])=O ZUKPVRWZDMRIEO-VKHMYHEASA-N 0.000 claims 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine zwitterion Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 claims 1
- 210000000867 Larynx Anatomy 0.000 claims 1
- VVNCNSJFMMFHPL-VKHMYHEASA-N Penicillamine Chemical compound CC(C)(S)[C@@H](N)C(O)=O VVNCNSJFMMFHPL-VKHMYHEASA-N 0.000 claims 1
- 210000003800 Pharynx Anatomy 0.000 claims 1
- DUIOPKIIICUYRZ-UHFFFAOYSA-N Semicarbazide Chemical compound NNC(N)=O DUIOPKIIICUYRZ-UHFFFAOYSA-N 0.000 claims 1
- 210000002784 Stomach Anatomy 0.000 claims 1
- 229960000344 Thiamine hydrochloride Drugs 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 239000011797 cavity material Substances 0.000 claims 1
- 150000001944 cysteine derivatives Chemical class 0.000 claims 1
- 108010016616 cysteinylglycine Proteins 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 238000005470 impregnation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000003000 nontoxic Effects 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 229960001639 penicillamine Drugs 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N sulfonic acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims 1
- 235000019190 thiamine hydrochloride Nutrition 0.000 claims 1
- 239000011747 thiamine hydrochloride Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 210000000941 Bile Anatomy 0.000 description 1
- 230000035639 Blood Levels Effects 0.000 description 1
- 206010019133 Hangover Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K Potassium citrate Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 229940011671 Vitamin B6 Drugs 0.000 description 1
- 229930003629 Vitamin B6 Natural products 0.000 description 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Vitamin C Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 235000006109 methionine Nutrition 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 150000003544 thiamines Chemical class 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 239000011791 tripotassium citrate Substances 0.000 description 1
- 235000015870 tripotassium citrate Nutrition 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 150000003697 vitamin B6 derivatives Chemical class 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61729904P | 2004-10-08 | 2004-10-08 | |
| US60/617,299 | 2004-10-08 | ||
| US66072305P | 2005-03-11 | 2005-03-11 | |
| US60/660,723 | 2005-03-11 | ||
| PCT/FI2005/000429 WO2006037848A1 (en) | 2004-10-08 | 2005-10-10 | Method and preparation for binding aldehydes in saliva |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008515859A JP2008515859A (ja) | 2008-05-15 |
| JP2008515859A5 true JP2008515859A5 (fi) | 2008-11-27 |
| JP5654726B2 JP5654726B2 (ja) | 2015-01-14 |
Family
ID=36142320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007535189A Active JP5654726B2 (ja) | 2004-10-08 | 2005-10-10 | 唾液中のアルデヒド類を結合するための方法および製剤 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP5654726B2 (fi) |
| WO (1) | WO2006037848A1 (fi) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI20060501L (fi) * | 2006-05-22 | 2007-11-23 | Biohit Oyj | Koostumus ja menetelmä asetaldehydin sitomiseksi vatsassa |
| US20100166833A1 (en) * | 2007-05-07 | 2010-07-01 | Technion Research & Development Foundation Ltd. | Compositions, articles and methods for preventing or reducing tobacco-associated damage |
| EP2152102A2 (en) * | 2007-05-07 | 2010-02-17 | Technion Research & Development Foundation Ltd. | Compositions, articles and methods for preventing or reducing tobacco-associated damage |
| FI120526B (fi) * | 2007-05-16 | 2009-11-30 | Biohit Oyj | Filtteri tupakkatuotteeseen |
| FI20070705L (fi) | 2007-09-14 | 2009-06-02 | Biohit Oyj | Asetaldehydin sitominen suussa ja mahalaukussa |
| US20130089535A1 (en) * | 2010-06-19 | 2013-04-11 | Amano Enzyme Inc. | Agent for reducing acetaldehyde in oral cavity |
| FI129157B (fi) * | 2012-05-28 | 2021-08-13 | Biohit Oyj | Koostumus käytettäväksi vakavien päänsärkyjen esiintymistiheyden pienentämiseksi tai niiden vähentämiseksi |
| FI20135097L (fi) * | 2013-02-01 | 2014-08-02 | Biohit Oyj | Koostumus aldehydien sitomiseen suussa |
| JP5882535B2 (ja) * | 2013-03-08 | 2016-03-09 | 日本たばこ産業株式会社 | 非燃焼型香味吸引器 |
| JP2016514120A (ja) | 2013-03-12 | 2016-05-19 | ビオヒット・ユルキネン・オサケユキテュアＢｉｏｈｉｔ Ｏｙｊ | 胃腸管においてアルデヒドを結合するための経口投与用組成物 |
| KR20150126382A (ko) | 2013-03-12 | 2015-11-11 | 바이오히트 오와이제이 | 위 내의 알데하이드에 결합하는 캡슐화된 조성물 |
| FI20145217A (fi) | 2014-03-06 | 2015-09-07 | Biohit Oyj | Koostumus aldehydien ja vapaiden radikaalien sitomiseksi ruoansulatuskanavassa |
| KR102290512B1 (ko) | 2019-05-09 | 2021-08-18 | (주)엠지 | 흡연으로 인한 발암물질을 저감시킬 수 있는 캔디 조성물 및 그 제조방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8313044D0 (en) * | 1983-05-12 | 1983-06-15 | Caseley J R | Reducing toxic effects of tobacco |
| HU201865B (en) * | 1989-04-28 | 1991-01-28 | Pecsi Dohanygyar | Tobacco-smoke filter of high efficiency |
| US5829449A (en) * | 1997-09-19 | 1998-11-03 | Thione International, Inc. | Smoking products containing antioxidants |
| FI121528B (fi) * | 2000-10-30 | 2010-12-31 | Biohit Oyj | Farmaseuttinen koostumus syöpään sairastumisen riskin vähentämiseen paikallisesti sitomalla asetaldehydi syljessä, mahalaukussa tai paksusuolessa |
| ITPI20010014A1 (it) * | 2001-03-05 | 2002-09-05 | Ivo Pera | Composto per filtri per sigarette,o altri articoli da fumo,a base di sostanze antiossidanti ed il filtro cosi'ottenuto |
-
2005
- 2005-10-10 JP JP2007535189A patent/JP5654726B2/ja active Active
- 2005-10-10 WO PCT/FI2005/000429 patent/WO2006037848A1/en active Application Filing
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