WO2001072138A1 - Chewing gum containing sulfurated amino acid compounds - Google Patents
Chewing gum containing sulfurated amino acid compounds Download PDFInfo
- Publication number
- WO2001072138A1 WO2001072138A1 PCT/EP2001/003460 EP0103460W WO0172138A1 WO 2001072138 A1 WO2001072138 A1 WO 2001072138A1 EP 0103460 W EP0103460 W EP 0103460W WO 0172138 A1 WO0172138 A1 WO 0172138A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chewing gum
- gum according
- agent
- chosen
- group
- Prior art date
Links
- 235000015218 chewing gum Nutrition 0.000 title claims abstract description 43
- 229940112822 chewing gum Drugs 0.000 title claims abstract description 41
- -1 amino acid compounds Chemical class 0.000 title description 3
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims abstract description 32
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 28
- 108010024636 Glutathione Proteins 0.000 claims abstract description 15
- 229960003180 glutathione Drugs 0.000 claims abstract description 15
- 229960003080 taurine Drugs 0.000 claims abstract description 14
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims abstract description 13
- 229930182817 methionine Natural products 0.000 claims abstract description 13
- 239000013543 active substance Substances 0.000 claims abstract description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 16
- 239000000796 flavoring agent Substances 0.000 claims description 15
- 239000003963 antioxidant agent Substances 0.000 claims description 11
- 235000006708 antioxidants Nutrition 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 230000003078 antioxidant effect Effects 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 239000000080 wetting agent Substances 0.000 claims description 9
- 235000010323 ascorbic acid Nutrition 0.000 claims description 8
- 239000011668 ascorbic acid Substances 0.000 claims description 8
- 229960005070 ascorbic acid Drugs 0.000 claims description 8
- 235000019634 flavors Nutrition 0.000 claims description 8
- 235000013355 food flavoring agent Nutrition 0.000 claims description 7
- 241000207199 Citrus Species 0.000 claims description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 235000003599 food sweetener Nutrition 0.000 claims description 6
- 239000003765 sweetening agent Substances 0.000 claims description 6
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 6
- 235000020971 citrus fruits Nutrition 0.000 claims description 5
- 230000003472 neutralizing effect Effects 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 4
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 4
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 4
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000008139 complexing agent Substances 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 3
- 108010011485 Aspartame Proteins 0.000 claims description 3
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims description 3
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- 229940087168 alpha tocopherol Drugs 0.000 claims description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 3
- 239000000605 aspartame Substances 0.000 claims description 3
- 235000010357 aspartame Nutrition 0.000 claims description 3
- 229960003438 aspartame Drugs 0.000 claims description 3
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 3
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims description 3
- 235000015165 citric acid Nutrition 0.000 claims description 3
- 239000001630 malic acid Substances 0.000 claims description 3
- 235000011090 malic acid Nutrition 0.000 claims description 3
- 239000000845 maltitol Substances 0.000 claims description 3
- 235000010449 maltitol Nutrition 0.000 claims description 3
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 3
- 229940035436 maltitol Drugs 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 235000010356 sorbitol Nutrition 0.000 claims description 3
- 229960000984 tocofersolan Drugs 0.000 claims description 3
- 239000000811 xylitol Substances 0.000 claims description 3
- 235000010447 xylitol Nutrition 0.000 claims description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- 235000004835 α-tocopherol Nutrition 0.000 claims description 3
- 239000002076 α-tocopherol Substances 0.000 claims description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 229930091371 Fructose Natural products 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 239000005913 Maltodextrin Substances 0.000 claims description 2
- 229920002774 Maltodextrin Polymers 0.000 claims description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 2
- YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical compound CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 claims description 2
- 229960005164 acesulfame Drugs 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 235000021028 berry Nutrition 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 2
- 235000019219 chocolate Nutrition 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims description 2
- 239000008298 dragée Substances 0.000 claims description 2
- 125000004494 ethyl ester group Chemical group 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 235000001727 glucose Nutrition 0.000 claims description 2
- 229940035034 maltodextrin Drugs 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 2
- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims description 2
- 229940001584 sodium metabisulfite Drugs 0.000 claims description 2
- 235000010262 sodium metabisulphite Nutrition 0.000 claims description 2
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 claims description 2
- 229940001474 sodium thiosulfate Drugs 0.000 claims description 2
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- 239000005720 sucrose Substances 0.000 claims description 2
- 239000001069 triethyl citrate Substances 0.000 claims description 2
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 2
- 235000013769 triethyl citrate Nutrition 0.000 claims description 2
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical group COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 7
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- 239000000306 component Substances 0.000 description 7
- 210000000214 mouth Anatomy 0.000 description 5
- 235000001014 amino acid Nutrition 0.000 description 4
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 3
- 230000001055 chewing effect Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
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- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- FDKWRPBBCBCIGA-REOHCLBHSA-N (2r)-2-azaniumyl-3-$l^{1}-selanylpropanoate Chemical compound [Se]C[C@H](N)C(O)=O FDKWRPBBCBCIGA-REOHCLBHSA-N 0.000 description 1
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
- RJFAYQIBOAGBLC-UHFFFAOYSA-N 2-amino-4-methylselanyl-butanoic acid Chemical compound C[Se]CCC(N)C(O)=O RJFAYQIBOAGBLC-UHFFFAOYSA-N 0.000 description 1
- MRBKEAMVRSLQPH-UHFFFAOYSA-N 3-tert-butyl-4-hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1 MRBKEAMVRSLQPH-UHFFFAOYSA-N 0.000 description 1
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- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
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- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/14—Chewing gum characterised by the composition containing organic or inorganic compounds containing peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- a chewing gum containing glutathione with methionine and/or taurine, or methionine and/or taurine, enables transmucosal absorption of said active agents pre- venting their degradation in the stomach.
- Glutathione ( ⁇ -L-glutamyl-L-cysteinylglycin), methionine (2-amino-4- methylthiobutanoic acid) and taurine (2-aminoethansolfonic acid) are sulfurated amino acid compounds with a high pharmacological relevance.
- Glutathione is an antioxidant and is useful as such for all those situations in which there is an increase of free radicals, highly reactive molecules which can damage the organism. The increase of free radicals can occur in pathologic situations such as HIV infections, hepatic cirrhosis, or in more common conditions such as the abuse of spirits, fasting or physical weariness.
- Taurine is an antioxidant too, and it also favors the absorption and elimination of fats and can act as neurotransmitter in some brain areas and in the retina.
- Methionine is a cystine and creatine precursor, both cystine and creatine being antioxidant amino acids, it favors the reduction of cholesterol levels in blood, the elimination of toxic substances from the liver and the regeneration of hepatic and kidney tissue.
- glutathione As far as glutathione is concerned, despite its above-mentioned importance, it is commercially available in oral form only as a component of integrating food. As far as drugs containing it are concerned, these are present on the market in an extremely limited number and only as injectable substances, because said molecule is mostly de-activated by peptidase acting in the stomach.
- EP 0 339 508 describes a tablet to dissolve in the mouth, containing acetyl- cysteine mixed with sodium or potassium bicarbonate, a sweetener and a flavoring agent.
- acetyl- cysteine mixed with sodium or potassium bicarbonate, a sweetener and a flavoring agent.
- bicarbonate salts consists in neutralizing the pH of N-acetyl-cysteine, which is quite acid and can therefore cause irritation in the oral cavity.
- EP 0 349 797 describes among other things a chewing gum containing N-acetyl- cysteine stabilized by adding ascorbic acid or one of its salts.
- This patent is criticized in the following patent application WO 98/47534, since the use of ascorbic acid alone makes pH more acid, which increases the oxidative phenomenon of the active agent and makes its quite unpleasant taste even more disagreeable.
- This patent application describes among other things chewing gums containing cysteine or dicysteine compounds, in particular N-acetyl-cysteine, and/or glutathione in combination with a non steroidal anti-inflammatory, characterized by a mixture of stabilizers consisting of at least three components such as ascorbic acid, a salt or an ester thereof, one or more tocopherols, one or more carotenoids, one or more flavonoids or derivatives thereof.
- the amount of ascorbic acid in this mixture is quite lower than formulations of the state of the art.
- IT-1248998 discloses a chewing gum containing N-acetyl-cysteine which can be used in the prevention and treatment of dental plaque. To this purpose it is pointed out that the higher is the amount of gum, the slower is the release of the active agent.
- WO 91/15204 discloses among other things chewing gums containing active agents which can lower plasma levels of lipoprotein (a), such as for instance N- acetyl-cysteine, glutathione and other sulfurated compounds. No indication is provided concerning the excipients of the formulation.
- WO 99/00106 claims oral compositions to reduce damages caused by free radicals originated from smoking habits and environmental pollution, comprising a combination of reduced glutathione, a selenium source chosen among selenium methionine and selenium cysteine, ascorbic acid, ⁇ -tocopherol and an amino acid containing sulfur, in order to reduce said damage in the oral cavity, in the pharynx and in the first respiratory tract.
- EP-A- 0 890 538 describes chewing tablets containing an antiemetic or therapeutic active agent for the oral cavity and the throat.
- an antiemetic or therapeutic active agent for the oral cavity and the throat.
- one of the examples of this application deals with a tablet based on chewing soluble gum containing N-acetyl-cysteine.
- These tablets contain chewing components such as natural gums and dry syrups, syrup components, fat compo- nents such as esters of glycerol with long-chain acids, wax components such as bee wax, paraffin and ozokerite.
- the present invention therefore, relates to a chewing gum containing glutathione with methionine and/or taurine, or methionine and/or taurine, and as excipients gums, antioxidants, wetting agents, flavoring agents and sweetening agents. DESCRIPTION OF THE INVENTION
- the present invention therefore, relates to a chewing gum containing glutathione in association with methionine and/or taurine, or methionine and/or taurine, and as excipients at least one gum, at least one antioxidant, at least one wetting agent, flavoring and sweetening agents.
- the chewing gum according to the present invention can optionally contain at least one complexing agent, at least one neutralizing agent and/or at least one preserving agent.
- glutathione means both the reduced form (GSH) and the reduced form of ethyl ester.
- the chewing gum according to the present invention contains 1 to 300 mg, preferably 48 mg of single active principle per product unit.
- Gums which can be used in the present invention are all those which are commonly used to this purpose in the pharmaceutical field and in food industries.
- Examples of gums which can be used in the present invention are those which are marketed with the trademarks H Maryl T ® (Gum Base Co.) and Balear-T ® (Cafosa Gum SA).
- Antioxidants contained in the chewing gum according to the invention are chosen from the group consisting of ascorbic acid salts and esters thereof, butylated hy- droxyanisol (BHA), butylated hydroxytoluene (BHT), monothioglycerol, sodium metabisulfite, sodium thiosulfate, ⁇ -tocopherol. They are used in percentages of 0.001 to 0.1% with respect to the base gum, preferably 0.01%. Butylated hy- droxyanisol is preferably used.
- Complexing agents which can be used in the present invention are those which are commonly used in the pharmaceutical field and/or in food industries, such as for instance ethylenediaminotetraacetic acid (EDTA) and pharmaceutically acceptable salts thereof.
- Neutralizing agents which can be used in the present invention are sodium or potassium hydroxide in aqueous solution in such a concentration to be able to bring pH to physiologic values.
- Preservatives which can be used in the present invention can be chosen from the group consisting of methyl-p-hydroxybenzoate, propyl-p-hydroxybenzoate, ascor- bic acid, potassium sorbate and mixtures thereof.
- Flavors which can be used in the present invention are all those which are commonly used in the pharmaceutical field to improve/mask the unpleasant taste of sulfurated compounds. These are for instance citrus flavors, mint, chocolate, berries, which can be used both singularly and in suitable combinations. Flavors which are preferably used are citrus flavors or mint, still more preferably the chewing gum contains citric acid, malic acid, and citrus flavor.
- the chewing gum according to the present invention also contains sweetening agents, such as for instance acesulfame, aspartame, sucrose, fructose, maltose, glucose, mannitol, sorbitol, xylitol, maltitol, saccharine, maltodextrin.
- wetting agents which can be used in the present invention are one or more among those which are commonly used in the pharmaceutical field or in food industries, such as for instance glycerol, Twin, Span, PEG, triethyl citrate, tributyl citrate and mixtures thereof.
- the preferred wetting agent in the present invention is glycerol. These agents are present in amounts of 10 to 40 mg, preferably 27 mg per prod- uct unit.
- the units of chewing gum can optionally be prepared in the form of dragees with substances and methods commonly used in the pharmaceutical field. They can also contain suitable coloring agents.
- the chewing gum according to the present invention is prepared with methods known in the field.
- a chewing gum according to the invention is prepared, containing the following components whose amount is defined as g/100 g of final product: Reduced glutathione 2.5 g
- Flavoring agents 3.8 g
- the chewing gum according to the present invention has a pleasant taste and its use causes no irritation in the mucosa of the oral cavity. It releases the active agent/s which is/are absorbed by the mucosa, thus resulting in a significant hematic increase of said agent s.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
- Public Health (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU62137/01A AU6213701A (en) | 2000-03-27 | 2001-03-27 | Chewing gum containing sulfurated amino acid compounds |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2000MI000639A IT1318427B1 (en) | 2000-03-27 | 2000-03-27 | CHEWING RUBBER CONTAINING SULFURATED AMINO ACIDS COMPOUNDS. |
ITMI2000A000639 | 2000-03-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001072138A1 true WO2001072138A1 (en) | 2001-10-04 |
Family
ID=11444644
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/003460 WO2001072138A1 (en) | 2000-03-27 | 2001-03-27 | Chewing gum containing sulfurated amino acid compounds |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU6213701A (en) |
IT (1) | IT1318427B1 (en) |
WO (1) | WO2001072138A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017004396A1 (en) * | 2015-06-30 | 2017-01-05 | Nucorplabs, Inc. | Chewable composition to deliver gsh |
US10787476B2 (en) | 2013-09-24 | 2020-09-29 | Ajinomoto Co., Inc. | Glycoamino acid and use thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5272166A (en) * | 1990-04-09 | 1993-12-21 | The Rockefeller University | Method for selective reduction of Lp(a) |
WO1996005803A1 (en) * | 1994-08-22 | 1996-02-29 | Quest International B.V. | Breath malodour reduction |
WO1998047534A1 (en) * | 1997-04-18 | 1998-10-29 | Klinge Pharma Gmbh | Stabilized medicaments containing cysteinyl derivatives |
WO1999000106A1 (en) * | 1997-06-27 | 1999-01-07 | Thione International, Inc. | Intra-oral antioxidant preparations |
US5922346A (en) * | 1997-12-01 | 1999-07-13 | Thione International, Inc. | Antioxidant preparation |
CN1272324A (en) * | 1999-04-29 | 2000-11-08 | 长春市芦荟应用研究所 | Aloe chewing sweets |
WO2000069470A2 (en) * | 1999-05-17 | 2000-11-23 | Aesgen, Inc. | Improved cellular uptake of bioactive agents |
-
2000
- 2000-03-27 IT IT2000MI000639A patent/IT1318427B1/en active
-
2001
- 2001-03-27 WO PCT/EP2001/003460 patent/WO2001072138A1/en active Application Filing
- 2001-03-27 AU AU62137/01A patent/AU6213701A/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5272166A (en) * | 1990-04-09 | 1993-12-21 | The Rockefeller University | Method for selective reduction of Lp(a) |
WO1996005803A1 (en) * | 1994-08-22 | 1996-02-29 | Quest International B.V. | Breath malodour reduction |
WO1998047534A1 (en) * | 1997-04-18 | 1998-10-29 | Klinge Pharma Gmbh | Stabilized medicaments containing cysteinyl derivatives |
WO1999000106A1 (en) * | 1997-06-27 | 1999-01-07 | Thione International, Inc. | Intra-oral antioxidant preparations |
US5922346A (en) * | 1997-12-01 | 1999-07-13 | Thione International, Inc. | Antioxidant preparation |
CN1272324A (en) * | 1999-04-29 | 2000-11-08 | 长春市芦荟应用研究所 | Aloe chewing sweets |
WO2000069470A2 (en) * | 1999-05-17 | 2000-11-23 | Aesgen, Inc. | Improved cellular uptake of bioactive agents |
Non-Patent Citations (1)
Title |
---|
DATABASE WPI Section Ch Week 200121, Derwent World Patents Index; Class A96, AN 2001-203307, XP002173701 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10787476B2 (en) | 2013-09-24 | 2020-09-29 | Ajinomoto Co., Inc. | Glycoamino acid and use thereof |
WO2017004396A1 (en) * | 2015-06-30 | 2017-01-05 | Nucorplabs, Inc. | Chewable composition to deliver gsh |
Also Published As
Publication number | Publication date |
---|---|
IT1318427B1 (en) | 2003-08-25 |
AU6213701A (en) | 2001-10-08 |
ITMI20000639A1 (en) | 2001-09-27 |
ITMI20000639A0 (en) | 2000-03-27 |
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