JP2008513354A5 - - Google Patents
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- JP2008513354A5 JP2008513354A5 JP2007522632A JP2007522632A JP2008513354A5 JP 2008513354 A5 JP2008513354 A5 JP 2008513354A5 JP 2007522632 A JP2007522632 A JP 2007522632A JP 2007522632 A JP2007522632 A JP 2007522632A JP 2008513354 A5 JP2008513354 A5 JP 2008513354A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antibody
- cancer cells
- administered
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/894,672 US9249229B2 (en) | 2000-12-08 | 2004-07-20 | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| US10/996,316 US7408041B2 (en) | 2000-12-08 | 2004-11-23 | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| US11/171,567 US20060057651A1 (en) | 2000-12-08 | 2005-06-30 | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| PCT/US2005/025488 WO2006020266A2 (en) | 2004-07-20 | 2005-07-19 | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012053212A Division JP5727406B2 (ja) | 2004-07-20 | 2012-03-09 | 慢性リンパ性白血病細胞に由来するポリペプチドおよび抗体、ならびにそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008513354A JP2008513354A (ja) | 2008-05-01 |
| JP2008513354A5 true JP2008513354A5 (https=) | 2008-08-14 |
Family
ID=35907987
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007522632A Withdrawn JP2008513354A (ja) | 2004-07-20 | 2005-07-19 | 慢性リンパ性白血病細胞に由来するポリペプチドおよび抗体、ならびにそれらの使用 |
| JP2012053212A Expired - Fee Related JP5727406B2 (ja) | 2004-07-20 | 2012-03-09 | 慢性リンパ性白血病細胞に由来するポリペプチドおよび抗体、ならびにそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012053212A Expired - Fee Related JP5727406B2 (ja) | 2004-07-20 | 2012-03-09 | 慢性リンパ性白血病細胞に由来するポリペプチドおよび抗体、ならびにそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20060057651A1 (https=) |
| EP (2) | EP2441777B1 (https=) |
| JP (2) | JP2008513354A (https=) |
| AU (1) | AU2005274785B2 (https=) |
| CA (1) | CA2574488C (https=) |
| DK (1) | DK2441777T3 (https=) |
| ES (1) | ES2569240T3 (https=) |
| WO (1) | WO2006020266A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7408041B2 (en) * | 2000-12-08 | 2008-08-05 | Alexion Pharmaceuticals, Inc. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| AU2008206502A1 (en) * | 2007-01-11 | 2008-07-24 | Boehringer Ingelheim International Gmbh | CD200 and its receptor, CD200R, modulate bone mass via the differentiation of osteoclasts |
| HUE032563T2 (en) * | 2007-05-21 | 2017-09-28 | Alderbio Holdings Llc | Antibodies to IL-6 and their use |
| US20110014117A1 (en) * | 2007-06-28 | 2011-01-20 | Schering Corporation | Anti-igf1r |
| AU2016228280B2 (en) * | 2007-07-12 | 2019-02-21 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
| EP2014681A1 (en) * | 2007-07-12 | 2009-01-14 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
| US8252285B2 (en) * | 2007-07-25 | 2012-08-28 | Alexion Pharmaceuticals, Inc. | Antibodies to OX-2/CD200 and uses thereof in inhibiting immune responses |
| JP2011516840A (ja) * | 2008-04-04 | 2011-05-26 | トリリウム セラピューティクス インコーポレーティッド | 可溶性cd200に関するアッセイ法 |
| DE102008023820A1 (de) * | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
| WO2010067308A2 (en) | 2008-12-08 | 2010-06-17 | Compugen Ltd. | Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics |
| AU2009333580B2 (en) | 2008-12-09 | 2016-07-07 | Genentech, Inc. | Anti-PD-L1 antibodies and their use to enhance T-cell function |
| CA2786692A1 (en) * | 2010-01-11 | 2011-07-14 | Alexion Pharmaceuticals, Inc. | Biomarkers of immunomodulatory effects in humans treated with anti-cd200 antibodies |
| WO2011100538A1 (en) | 2010-02-11 | 2011-08-18 | Alexion Pharmaceuticals, Inc. | Therapeutic methods using an ti-cd200 antibodies |
| EP2616100B1 (en) | 2010-09-17 | 2016-08-31 | Compugen Ltd. | Compositions and methods for treatment of drug resistant multiple myeloma |
| AU2012212066A1 (en) | 2011-02-03 | 2013-08-15 | Alexion Pharmaceuticals, Inc. | Use of an anti-CD200 antibody for prolonging the survival of allografts |
| KR20120093002A (ko) * | 2011-02-14 | 2012-08-22 | (주)에이티젠 | Nk 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트 |
| US9309305B2 (en) | 2011-06-10 | 2016-04-12 | National Research Council Of Canada | Anti-ricin antibodies and uses thereof |
| EP2723380B1 (en) | 2011-06-24 | 2019-08-21 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
| US9382534B2 (en) | 2011-10-05 | 2016-07-05 | Ge Healthcare Dharmacon, Inc. | Optimization of vectors for effective delivery and expression of genetic content |
| CN112587671A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| CN105899539B (zh) | 2014-01-10 | 2021-11-09 | 博笛生物科技有限公司 | 用于免疫疗法的化合物和组合物 |
| EP3166976B2 (en) | 2014-07-09 | 2026-04-08 | Birdie Biopharmaceuticals Inc. | Anti-pd-l1 combinations for treating tumors |
| CN112587672A (zh) | 2014-09-01 | 2021-04-02 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
| ES2952064T3 (es) * | 2015-12-16 | 2023-10-26 | Walter & Eliza Hall Inst Medical Res | Inhibición de la proteína SH2 inducida por citocinas en células NK |
| CN115350279A (zh) | 2016-01-07 | 2022-11-18 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-her2组合 |
| CN115252792A (zh) | 2016-01-07 | 2022-11-01 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-egfr组合 |
| CN106943596A (zh) | 2016-01-07 | 2017-07-14 | 博笛生物科技(北京)有限公司 | 用于治疗肿瘤的抗-cd20组合 |
| KR102379464B1 (ko) | 2016-06-20 | 2022-03-29 | 키맵 리미티드 | 항-pd-l1 항체 |
| US20190048055A1 (en) * | 2017-03-31 | 2019-02-14 | Altor Bioscience Corporation | Alt-803 in combination with anti-cd38 antibody for cancer therapies |
| CN118515666A (zh) | 2017-04-27 | 2024-08-20 | 博笛生物科技有限公司 | 2-氨基-喹啉衍生物 |
| IL312120B2 (en) | 2017-06-23 | 2025-06-01 | Birdie Biopharmaceuticals Inc | Pharmaceutical compositions |
| US11761963B2 (en) | 2017-09-27 | 2023-09-19 | Alexion Pharmaceuticals, Inc. | Biomarker signature for predicting tumor response to anti-CD200 therapy |
| WO2019126133A1 (en) | 2017-12-20 | 2019-06-27 | Alexion Pharmaceuticals, Inc. | Liquid formulations of anti-cd200 antibodies |
| US11802154B2 (en) | 2017-12-20 | 2023-10-31 | Alexion Pharmaceuticals, Inc. | Humanized anti-CD200 antibodies and uses thereof |
| CN109239334A (zh) * | 2018-09-10 | 2019-01-18 | 吉林大学 | 建立时间分辨荧光免疫层析法检测MxA试剂盒 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN109633142B (zh) * | 2018-12-22 | 2021-08-27 | 中国人民解放军第四军医大学 | 一种急性髓细胞性白血病诊断模型的建立方法及其应用 |
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| US4289747A (en) | 1978-12-26 | 1981-09-15 | E-Y Laboratories, Inc. | Immunological determination using lectin |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| DE3307869A1 (de) | 1983-03-05 | 1984-09-06 | Dragoco Gerberding & Co Gmbh, 3450 Holzminden | Methylsubstituierte 1-((3-methylthio)-1-oxo-butyl)-cyclohex-2-ene, verfahren zu deren herstellung und deren verwendung als riech- und aromastoffe |
| ATE68703T1 (de) | 1984-02-08 | 1991-11-15 | Cetus Corp | Toxinkonjugate. |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| DE3852304T3 (de) | 1987-03-02 | 1999-07-01 | Enzon Labs Inc., Piscataway, N.J. | Organismus als Träger für "Single Chain Antibody Domain (SCAD)". |
| JPH0246297A (ja) * | 1988-08-08 | 1990-02-15 | Takeda Chem Ind Ltd | モノクローナル抗体、抗体産生ハイブリドーマおよび抗体の製造法 |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5780279A (en) | 1990-12-03 | 1998-07-14 | Genentech, Inc. | Method of selection of proteolytic cleavage sites by directed evolution and phagemid display |
| CA2405246A1 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
| EP0575485A1 (en) | 1991-03-01 | 1993-12-29 | Dyax Corp. | Process for the development of binding mini-proteins |
| DE69226871T3 (de) * | 1991-06-27 | 2009-09-24 | Bristol-Myers Squibb Co. | CTL4A-Rezeptor, ihn enthaltenden Fusionsproteine und deren Verwendung |
| US5728815A (en) | 1992-03-30 | 1998-03-17 | Board Of Regents, The University Of Texas System | Bone and prostate-derived protein factors affecting prostate cancer growth, differentiation, and metastasis |
| US5508717A (en) | 1992-07-28 | 1996-04-16 | Sony Corporation | Computer pointing device with dynamic sensitivity |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5686292A (en) | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
| AU725609C (en) | 1995-08-18 | 2002-01-03 | Morphosys Ag | Protein/(poly)peptide libraries |
| EP0858506A4 (en) * | 1995-10-31 | 2004-12-08 | Uab Research Foundation | GENETIC INDUCTION OF RECEPTORS TO TARGETED RADIOTHERAPY |
| AU1144097A (en) | 1995-12-08 | 1997-07-03 | Brigham And Women's Hospital | Ox-2 costimulatory molecule |
| IL125928A (en) * | 1996-03-20 | 2002-11-10 | Bristol Myers Squibb Co | The use of soluble ligands that react with CTLA4, B7, CD40, gp39 and / or CD28 for the preparation of pharmaceutical preparations |
| US6011138A (en) * | 1997-02-20 | 2000-01-04 | Idec Pharmaceuticals Corporation | Gamma-1 anti-human CD23 monoclonal antibodies |
| US6955811B2 (en) * | 1997-11-07 | 2005-10-18 | Trillium Therapeutics Inc. | Methods of inhibiting immune response suppression by administering antibodies to OX-2 |
| US7223729B2 (en) * | 1997-11-07 | 2007-05-29 | Trillium Therapeutics Inc. | Methods of treating allergy by administering a CD200 protein |
| EP1032662B1 (en) * | 1997-11-07 | 2006-03-08 | Trillium Therapeutics Inc. | Methods and compositions for immunomodulation |
| DE19829473C2 (de) * | 1998-07-01 | 2000-08-10 | Magnus Von Knebel Doeberitz Ch | Verfahren zur frühen Diagnose von Carcinomen |
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| US20020192215A1 (en) * | 1999-04-13 | 2002-12-19 | Schering Corporation, A New Jersey Corporation | Novel uses of mammalian OX2 protein and related reagents |
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| US7306801B2 (en) * | 2000-05-15 | 2007-12-11 | Health Research, Inc. | Methods of therapy for cancers characterized by overexpression of the HER2 receptor protein |
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| US7408041B2 (en) * | 2000-12-08 | 2008-08-05 | Alexion Pharmaceuticals, Inc. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| US7427665B2 (en) * | 2000-12-08 | 2008-09-23 | Alexion Pharmaceuticals, Inc. | Chronic lymphocytic leukemia cell line |
| AU2004217434B2 (en) * | 2000-12-08 | 2010-08-26 | Alexion Pharmaceuticals, Inc. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| US20040198661A1 (en) * | 2000-12-08 | 2004-10-07 | Bowdish Katherine S. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| US7368535B2 (en) | 2001-05-24 | 2008-05-06 | Trillium Therapeutics Inc. | CD200 receptors |
| US7306906B2 (en) | 2001-09-19 | 2007-12-11 | Alexion Pharmaceuticals, Inc. | Engineered templates and their use in single primer amplification |
| AU2003217912A1 (en) | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| MXPA05006978A (es) | 2002-12-27 | 2005-08-16 | Schering Corp | Metodos para inducir y mantener la tolerancia inmune. |
| EP1606387A4 (en) | 2003-03-04 | 2008-04-23 | Alexion Pharma Inc | VECTORS USED TO PRODUCE CONSTANT HYBRID AREAS |
| JP2007501021A (ja) | 2003-05-30 | 2007-01-25 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 遺伝子操作された定常領域を含む、抗体および融合タンパク質 |
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| US8815235B2 (en) * | 2004-06-02 | 2014-08-26 | Jan E. Schnitzer | Tissue-specific imaging and therapeutic agents targeting proteins expressed on lung endothelial cell surface |
| DK1817340T3 (da) | 2004-11-12 | 2012-08-13 | Xencor Inc | Fc-varianter med ændret binding til fcrn |
| US20070036786A1 (en) * | 2005-07-11 | 2007-02-15 | Nadine Tuaillon | Method of treating autoimmune disease using humanized anti-CD16A antibodies |
| WO2007041635A2 (en) * | 2005-10-03 | 2007-04-12 | Xencor, Inc. | Fc variants with optimized fc receptor binding properties |
| HUE028179T2 (en) | 2006-01-12 | 2016-12-28 | Alexion Pharma Inc | Antibodies to OX-2 / CD200 and their use |
| US20080131428A1 (en) * | 2006-02-24 | 2008-06-05 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
-
2005
- 2005-06-30 US US11/171,567 patent/US20060057651A1/en not_active Abandoned
- 2005-07-19 DK DK11009020.6T patent/DK2441777T3/en active
- 2005-07-19 CA CA2574488A patent/CA2574488C/en not_active Expired - Fee Related
- 2005-07-19 ES ES11009020.6T patent/ES2569240T3/es not_active Expired - Lifetime
- 2005-07-19 JP JP2007522632A patent/JP2008513354A/ja not_active Withdrawn
- 2005-07-19 AU AU2005274785A patent/AU2005274785B2/en not_active Ceased
- 2005-07-19 EP EP11009020.6A patent/EP2441777B1/en not_active Expired - Lifetime
- 2005-07-19 WO PCT/US2005/025488 patent/WO2006020266A2/en not_active Ceased
- 2005-07-19 EP EP05774630A patent/EP1786464A4/en not_active Withdrawn
-
2007
- 2007-11-13 US US11/985,322 patent/US7915000B2/en not_active Expired - Fee Related
-
2011
- 2011-03-25 US US13/072,470 patent/US8999328B2/en not_active Expired - Fee Related
-
2012
- 2012-03-09 JP JP2012053212A patent/JP5727406B2/ja not_active Expired - Fee Related
-
2015
- 2015-02-24 US US14/630,262 patent/US20150368341A1/en not_active Abandoned
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