JP2008511628A5 - - Google Patents
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- Publication number
- JP2008511628A5 JP2008511628A5 JP2007530000A JP2007530000A JP2008511628A5 JP 2008511628 A5 JP2008511628 A5 JP 2008511628A5 JP 2007530000 A JP2007530000 A JP 2007530000A JP 2007530000 A JP2007530000 A JP 2007530000A JP 2008511628 A5 JP2008511628 A5 JP 2008511628A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- preservative
- sec
- group
- bromo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003755 preservative agent Substances 0.000 claims 21
- 230000002335 preservative effect Effects 0.000 claims 17
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims 4
- 229940123208 Biguanide Drugs 0.000 claims 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 4
- 229940069328 povidone Drugs 0.000 claims 4
- IWEGDQUCWQFKHS-UHFFFAOYSA-N 1-(1,3-dioxolan-2-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole Chemical compound O1C(C)(C)C(C)(C)OB1C1=CN(CC2OCCO2)N=C1 IWEGDQUCWQFKHS-UHFFFAOYSA-N 0.000 claims 3
- 229960001724 brimonidine tartrate Drugs 0.000 claims 3
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 3
- QZHBYNSSDLTCRG-UHFFFAOYSA-N 5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)quinoxalin-6-amine;2,3-dihydroxybutanedioate;hydron Chemical compound OC(=O)C(O)C(O)C(O)=O.C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 QZHBYNSSDLTCRG-UHFFFAOYSA-N 0.000 claims 2
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 2
- 230000001590 oxidative effect Effects 0.000 claims 2
- 125000005430 oxychloro group Chemical group 0.000 claims 2
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 claims 2
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical group [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims 1
- 229920002413 Polyhexanide Polymers 0.000 claims 1
- 239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 claims 1
- 229960000686 benzalkonium chloride Drugs 0.000 claims 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical group [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
- 229960002798 cetrimide Drugs 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/928,906 US20050026924A1 (en) | 2000-07-14 | 2004-08-27 | Compositions containing alpha-2-adrenergic agonist components |
| PCT/US2005/029707 WO2006026215A1 (en) | 2004-08-27 | 2005-08-17 | Compositions containing alpha-2-adrenergic agonist components |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012180411A Division JP2012246304A (ja) | 2004-08-27 | 2012-08-16 | α−2−アドレナリンアゴニスト成分を含有する組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008511628A JP2008511628A (ja) | 2008-04-17 |
| JP2008511628A5 true JP2008511628A5 (enExample) | 2008-10-02 |
Family
ID=35589384
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530000A Pending JP2008511628A (ja) | 2004-08-27 | 2005-08-19 | α−2−アドレナリンアゴニスト成分を含有する組成物 |
| JP2012180411A Pending JP2012246304A (ja) | 2004-08-27 | 2012-08-16 | α−2−アドレナリンアゴニスト成分を含有する組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012180411A Pending JP2012246304A (ja) | 2004-08-27 | 2012-08-16 | α−2−アドレナリンアゴニスト成分を含有する組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050026924A1 (enExample) |
| JP (2) | JP2008511628A (enExample) |
| AU (1) | AU2005280259A1 (enExample) |
| BR (1) | BRPI0514723B8 (enExample) |
| CA (1) | CA2578784C (enExample) |
| MX (1) | MX2007002383A (enExample) |
| NZ (1) | NZ599669A (enExample) |
| WO (1) | WO2006026215A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2320911B1 (en) | 2008-08-01 | 2014-10-08 | Eye Therapies LLC | Vasoconstriction compositions and methods of use |
| US20100203165A1 (en) * | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of disorders or conditions of the eye |
| US12246013B2 (en) | 2008-08-01 | 2025-03-11 | Eye Therapies Llc | Vasoconstriction compositions and methods of use |
| US8987270B2 (en) | 2009-07-27 | 2015-03-24 | Eye Therapies Llc | Formulations of selective alpha-2 agonists and methods of use thereof |
| US20110251285A1 (en) * | 2010-04-07 | 2011-10-13 | Allergan, Inc. | Combinations of preservatives for ophthalmic compositions |
| CN110662543A (zh) * | 2017-03-23 | 2020-01-07 | 灰色视觉公司 | 用于治疗眼部疾病的药物和组合物 |
| JP7170436B2 (ja) * | 2017-06-28 | 2022-11-14 | 千寿製薬株式会社 | 水溶性高分子を含む点眼剤 |
| JP6603785B2 (ja) * | 2017-12-08 | 2019-11-06 | 千寿製薬株式会社 | 水溶性高分子を含む水性液剤 |
| JP6730500B2 (ja) * | 2018-10-01 | 2020-07-29 | 千寿製薬株式会社 | 水性液剤 |
| JP6797992B1 (ja) * | 2019-09-30 | 2020-12-09 | 千寿製薬株式会社 | 水性液剤 |
| JP6901619B2 (ja) * | 2019-09-30 | 2021-07-14 | 千寿製薬株式会社 | 水性液剤 |
| GR1010024B (el) | 2020-05-06 | 2021-06-01 | Φαρματεν Α.Β.Ε.Ε. | Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χορηγηση που περιλαμβανει βριμονιδινη |
| JP7002692B2 (ja) * | 2020-11-18 | 2022-02-04 | 千寿製薬株式会社 | 水性液剤 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1154119B (de) * | 1961-11-30 | 1963-09-12 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von 2-(2', 4', 6'-Trimethylbenzyl)-1, 3-diazacyclopenten-(2) und seinen Salzen |
| US3278447A (en) * | 1963-12-02 | 1966-10-11 | Cloro Bac Products Inc | Process for stabilizing chlorine dioxide solution |
| BE795970A (fr) * | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
| US3994828A (en) * | 1973-06-07 | 1976-11-30 | Dynapol Corporation | Nonabsorbable antioxidant |
| US4499077A (en) * | 1981-02-03 | 1985-02-12 | Stockel Richard F | Anti-microbial compositions and associated methods for preparing the same and for the disinfecting of various objects |
| US4407791A (en) * | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| US4530920A (en) * | 1983-11-07 | 1985-07-23 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist |
| US4806556A (en) * | 1985-12-12 | 1989-02-21 | Regents Of The University Of Minnesota | Gut-selective opiates |
| US5719197A (en) * | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5607698A (en) * | 1988-08-04 | 1997-03-04 | Ciba-Geigy Corporation | Method of preserving ophthalmic solution and compositions therefor |
| IL92351A (en) * | 1988-11-29 | 1994-02-27 | Allergan Inc Irvine | Aqueous opthalmic solutions containing stabilized chlorine dioxide and an inorganic salt |
| US5202128A (en) * | 1989-01-06 | 1993-04-13 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
| US5352796A (en) * | 1989-10-30 | 1994-10-04 | The Salk Institute For Biological Studies | Amino acids useful in making GnRH analogs |
| US5021416A (en) * | 1989-10-31 | 1991-06-04 | Allergan, Inc. | Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure |
| US5215991A (en) * | 1990-01-26 | 1993-06-01 | Allergan, Inc. | Combination of selective alpha-adrenergic agonists and Na+ /H+ ex |
| US5091528A (en) * | 1990-09-12 | 1992-02-25 | Allergan, Inc. | 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents |
| US5459133A (en) * | 1992-06-05 | 1995-10-17 | Telor Ophthalmic Pharmaceuticals, Inc. | Methods and products for treating presbyopia |
| JP3527256B2 (ja) * | 1992-12-09 | 2004-05-17 | ロート製薬株式会社 | 抗アレルギー点眼剤 |
| DE69431880T2 (de) * | 1993-10-13 | 2003-09-18 | Allergan, Inc. | Verwendung von (2-imidazolin-2-yl-amino) quinoxalinderivaten |
| SG44628A1 (en) * | 1993-12-17 | 1997-12-19 | Procter & Gamble | 6-(2-imidazolinylamino) Quinoxaline compounds useful as alpha-2 adrenoceptor agonists |
| US5994110A (en) * | 1995-02-10 | 1999-11-30 | Mosbach; Klaus | Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof |
| IL114193A (en) * | 1994-06-20 | 2000-02-29 | Teva Pharma | Ophthalmic pharmaceutical compositions based on sodium alginate |
| ZA965837B (en) * | 1995-07-11 | 1997-01-31 | Merck & Co Inc | A triazolylmethyl-indole ethylamine bisulfate salt |
| WO1998010758A1 (en) * | 1996-09-13 | 1998-03-19 | The Regents Of The University Of California | Methods for treatment of retinal diseases |
| EP0834308A1 (en) * | 1996-09-30 | 1998-04-08 | LG Chemical Limited | Ophthalmic formulation for treating myopia comprising dopamine agonist and cyclodextrin |
| EP1109581A1 (en) * | 1998-09-02 | 2001-06-27 | Allergan Sales, Inc. | Preserved cyclodextrin-containing compositions |
| US6242442B1 (en) * | 1998-12-17 | 2001-06-05 | Alcon Laboratories, Inc. | Brinzolamide and brimonidine for treating ocular conditions |
| US6166012A (en) * | 1999-07-30 | 2000-12-26 | Allergan Sales, Inc. | Antibiotic compositions and method for using same |
| CN101897704B (zh) * | 2000-07-14 | 2014-10-29 | 阿勒根公司 | 含有α-2肾上腺素能激动剂的组合物 |
| JP2004503593A (ja) * | 2000-07-14 | 2004-02-05 | アラーガン、インコーポレイテッド | 増大した溶解度を持つ治療活性成分を含む組成物 |
| US20020198210A1 (en) * | 2001-05-03 | 2002-12-26 | Allergan Sales Inc. | Alpha-2-adrenergic agonist/fatty acid compositions |
| US20030165545A1 (en) * | 2002-01-30 | 2003-09-04 | Allergan, Inc. | Ophthalmic compositions including oil-in-water emulsions, and methods for making and using same |
| US7030149B2 (en) * | 2002-04-19 | 2006-04-18 | Allergan, Inc. | Combination of brimonidine timolol for topical ophthalmic use |
| US20040185068A1 (en) * | 2003-03-18 | 2004-09-23 | Zhi-Jian Yu | Self-emulsifying compositions, methods of use and preparation |
| US20040191332A1 (en) * | 2003-03-27 | 2004-09-30 | Allergan, Inc. | Preserved ophthalmic compositions |
-
2004
- 2004-08-27 US US10/928,906 patent/US20050026924A1/en not_active Abandoned
-
2005
- 2005-08-17 MX MX2007002383A patent/MX2007002383A/es not_active Application Discontinuation
- 2005-08-17 AU AU2005280259A patent/AU2005280259A1/en not_active Abandoned
- 2005-08-17 BR BRPI0514723A patent/BRPI0514723B8/pt active IP Right Grant
- 2005-08-17 WO PCT/US2005/029707 patent/WO2006026215A1/en not_active Ceased
- 2005-08-17 CA CA2578784A patent/CA2578784C/en not_active Expired - Lifetime
- 2005-08-17 NZ NZ599669A patent/NZ599669A/xx not_active IP Right Cessation
- 2005-08-19 JP JP2007530000A patent/JP2008511628A/ja active Pending
-
2012
- 2012-08-16 JP JP2012180411A patent/JP2012246304A/ja active Pending
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