JP2008510493A - 腫瘍細胞の形質導入強化のための線維改変アデノウイルスベクター - Google Patents
腫瘍細胞の形質導入強化のための線維改変アデノウイルスベクター Download PDFInfo
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2013027427A1 (ja) * | 2011-08-23 | 2015-03-05 | 独立行政法人医薬基盤研究所 | 制限増殖型アデノウイルス |
| JP2015523412A (ja) * | 2012-07-30 | 2015-08-13 | ワウ ヒン イェウング,アレックス | 腫瘍細胞、GM‐CSFのトランスジェニック発現を伴う腫瘍溶解性ウイルスベクター、および免疫チェックポイントモジュレーターなどの成分の少なくとも2種または全3種の同時投与により作られる生のinvivo腫瘍特異的がんワクチンシステム |
| JP2016505245A (ja) * | 2012-11-21 | 2016-02-25 | ナショナル キャンサー センター | 安全性及び抗がん活性が増加された組換えアデノウイルス及びこの用途 |
| KR20190070890A (ko) * | 2017-12-13 | 2019-06-21 | 한양대학교 산학협력단 | 재조합 아데노바이러스 및 이를 포함하는 줄기세포 |
| JP2020011966A (ja) * | 2013-04-18 | 2020-01-23 | ティーアイエルティー・バイオセラピューティクス・オーワイTILT Biotherapeutics Oy | 増強された養子細胞療法 |
| US11497781B2 (en) | 2016-03-10 | 2022-11-15 | Cg Oncology, Inc. | Methods of treating bladder cancer by combination therapy comprising the oncolytic adenovirus CG0070 and an immune checkpoint inhibitor |
| US11596660B2 (en) | 2017-04-14 | 2023-03-07 | Cg Oncology, Inc. | Methods of treating bladder cancer |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070010016A1 (en) * | 2005-03-11 | 2007-01-11 | Mccelland Alan | Gene transfer with adenoviruses having modified fiber proteins |
| ATE510907T1 (de) * | 2007-03-14 | 2011-06-15 | Inst Catala D Oncologia | Adenovirus mit mutationen in der domäne des e3- 19k-proteins zur retention im endoplasmatischen retikulum und verwendung in der krebsbehandlung |
| WO2009111738A2 (en) | 2008-03-06 | 2009-09-11 | Mayo Foundation For Medical Education And Research | Single cycle replicating adenovirus vectors |
| WO2010120541A2 (en) | 2009-03-31 | 2010-10-21 | University Of Washington | Compositions and methods for modulating the activity of complement regulatory proteins on target cells |
| US9624476B2 (en) | 2011-08-23 | 2017-04-18 | National Institute Of Biomedical Innovation | Conditionally replicating adenovirus |
| EP2798069B1 (en) | 2011-12-15 | 2017-03-29 | Washington University | Porcine knob xenotype chimeric adenoviral vector for dendritic cell infection |
| JP2017514476A (ja) * | 2014-05-01 | 2017-06-08 | ユニバーシティ・オブ・ワシントン | アデノウイルスベクターを用いたインビボでの遺伝子操作 |
| US10617729B2 (en) * | 2014-12-24 | 2020-04-14 | The Uab Research Foundation | Multitargeting onocolytic adenovirus, methods of use, and methods of making |
| US20220111044A1 (en) * | 2019-01-29 | 2022-04-14 | Children's National Medical Center | Whole cell tumor vaccines and methods of use therof |
| US11149286B1 (en) | 2020-08-17 | 2021-10-19 | Mayo Foundation For Medical Education And Research | Adenovirus vectors and methods for using adenovirus vectors |
| EP4381082A1 (en) * | 2021-08-06 | 2024-06-12 | Theravax, Inc. | Adenoviral vector-based vaccine for emerging viruses |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US560843A (en) * | 1896-05-26 | Ningham | ||
| US5078996A (en) * | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
| US5098702A (en) * | 1986-04-09 | 1992-03-24 | Cetus Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
| US5904920A (en) * | 1991-10-04 | 1999-05-18 | Whitehead Institute For Biomedical Research | Regulation of systemic immune responses utilizing cytokines and antigens |
| US5637483A (en) * | 1991-10-04 | 1997-06-10 | Whitehead Institute For Biomedical Research | Irradiated tumor cell vaccine engineered to express GM-CSF |
| US5801029A (en) * | 1993-02-16 | 1998-09-01 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| US5543328A (en) * | 1993-08-13 | 1996-08-06 | Genetic Therapy, Inc. | Adenoviruses having modified fiber proteins |
| US5698443A (en) * | 1995-06-27 | 1997-12-16 | Calydon, Inc. | Tissue specific viral vectors |
| US6312699B1 (en) * | 1994-03-28 | 2001-11-06 | Uab Research Foundation | Ligands added to adenovirus fiber |
| US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| US5962311A (en) * | 1994-09-08 | 1999-10-05 | Genvec, Inc. | Short-shafted adenoviral fiber and its use |
| US5846782A (en) * | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| US5998205A (en) * | 1994-11-28 | 1999-12-07 | Genetic Therapy, Inc. | Vectors for tissue-specific replication |
| US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
| KR100470180B1 (ko) * | 1995-06-15 | 2005-02-04 | 크루셀 홀란드 비.브이. | 유전자 요법에 사용할 수 있는 인간의 재조합아데노바이러스 패키징 시스템 |
| US6033674A (en) * | 1995-12-28 | 2000-03-07 | Johns Hopkins University School Of Medicine | Method of treating cancer with a tumor cell line having modified cytokine expression |
| US6277368B1 (en) * | 1996-07-25 | 2001-08-21 | The Regents Of The University Of California | Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine |
| US5922315A (en) * | 1997-01-24 | 1999-07-13 | Genetic Therapy, Inc. | Adenoviruses having altered hexon proteins |
| US6432700B1 (en) * | 1997-03-03 | 2002-08-13 | Cell Genesys, Inc. | Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same |
| US6464973B1 (en) * | 1998-02-02 | 2002-10-15 | Johns Hopkins University, School Of Medicine | Universal GM-CSF expressing bystander human K562 cell line |
| US6900049B2 (en) * | 1998-09-10 | 2005-05-31 | Cell Genesys, Inc. | Adenovirus vectors containing cell status-specific response elements and methods of use thereof |
| AU767975B2 (en) * | 1998-09-11 | 2003-11-27 | Genvec, Inc. | Alternatively targeted adenovirus |
| EP1214098B1 (en) * | 1999-09-24 | 2006-11-22 | The Uab Research Foundation | Capsid-modified recombinant adenovirus and methods of use |
| US6692736B2 (en) * | 2000-03-24 | 2004-02-17 | Cell Genesys, Inc. | Cell-specific adenovirus vectors comprising an internal ribosome entry site |
| US7235233B2 (en) * | 2000-09-26 | 2007-06-26 | Crucell Holland B.V. | Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts |
| WO2002068627A2 (en) * | 2001-02-23 | 2002-09-06 | Novartis Ag | Vector constucts |
| IL152420A0 (en) * | 2001-02-23 | 2003-05-29 | Novartis Ag | Novel oncolytic adenoviral vectors |
| US20040002060A1 (en) * | 2002-01-24 | 2004-01-01 | Novartis Ag | Fiber shaft modifications for efficient targeting |
| EP1507593B1 (en) * | 2002-05-17 | 2007-10-17 | Gen-Probe Incorporated | Sample carrier having releasable locking mechanism |
| US7231839B2 (en) * | 2003-08-11 | 2007-06-19 | The Board Of Trustees Of The Leland Stanford Junior University | Electroosmotic micropumps with applications to fluid dispensing and field sampling |
| JP4561092B2 (ja) * | 2003-12-16 | 2010-10-13 | 日産自動車株式会社 | 車両用運転操作補助装置および車両用運転操作補助装置を備えた車両 |
-
2005
- 2005-08-11 US US11/201,384 patent/US20060062764A1/en not_active Abandoned
- 2005-08-25 WO PCT/US2005/030196 patent/WO2006026331A2/en not_active Ceased
- 2005-08-25 EP EP05791237A patent/EP1791968A4/en not_active Withdrawn
- 2005-08-25 CA CA002577470A patent/CA2577470A1/en not_active Abandoned
- 2005-08-25 JP JP2007530107A patent/JP2008510493A/ja not_active Withdrawn
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| JP2015523412A (ja) * | 2012-07-30 | 2015-08-13 | ワウ ヒン イェウング,アレックス | 腫瘍細胞、GM‐CSFのトランスジェニック発現を伴う腫瘍溶解性ウイルスベクター、および免疫チェックポイントモジュレーターなどの成分の少なくとも2種または全3種の同時投与により作られる生のinvivo腫瘍特異的がんワクチンシステム |
| JP2016505245A (ja) * | 2012-11-21 | 2016-02-25 | ナショナル キャンサー センター | 安全性及び抗がん活性が増加された組換えアデノウイルス及びこの用途 |
| US10077430B2 (en) | 2012-11-21 | 2018-09-18 | National Cancer Center | Recombinant adenovirus with increased safety and anticancer activities, and use thereof |
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| US11497781B2 (en) | 2016-03-10 | 2022-11-15 | Cg Oncology, Inc. | Methods of treating bladder cancer by combination therapy comprising the oncolytic adenovirus CG0070 and an immune checkpoint inhibitor |
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| JP2021506267A (ja) * | 2017-12-13 | 2021-02-22 | ジーンメディスン・カンパニー・リミテッド | 組換えアデノウイルスおよびこれを含む幹細胞 |
| KR102167934B1 (ko) | 2017-12-13 | 2020-10-20 | 진메디신 주식회사 | 재조합 아데노바이러스 및 이를 포함하는 줄기세포 |
| KR20190070890A (ko) * | 2017-12-13 | 2019-06-21 | 한양대학교 산학협력단 | 재조합 아데노바이러스 및 이를 포함하는 줄기세포 |
| JP7558808B2 (ja) | 2017-12-13 | 2024-10-01 | ジーンメディスン・カンパニー・リミテッド | 組換えアデノウイルスおよびこれを含む幹細胞 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2577470A1 (en) | 2006-03-09 |
| WO2006026331A3 (en) | 2006-08-17 |
| US20060062764A1 (en) | 2006-03-23 |
| EP1791968A4 (en) | 2009-05-13 |
| EP1791968A2 (en) | 2007-06-06 |
| WO2006026331A2 (en) | 2006-03-09 |
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