JP2008509969A - ヘルペスウイルス感染の治療のためのペプチド - Google Patents
ヘルペスウイルス感染の治療のためのペプチド Download PDFInfo
- Publication number
- JP2008509969A JP2008509969A JP2007526458A JP2007526458A JP2008509969A JP 2008509969 A JP2008509969 A JP 2008509969A JP 2007526458 A JP2007526458 A JP 2007526458A JP 2007526458 A JP2007526458 A JP 2007526458A JP 2008509969 A JP2008509969 A JP 2008509969A
- Authority
- JP
- Japan
- Prior art keywords
- use according
- hervip
- peptide
- infection
- hsv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/017—Hydrolysed proteins; Derivatives thereof from animals from blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Abstract
Description
細胞アッセイを用いて、単純ヘルペスウイルスの感染率を決定する。HSV−2の阻害剤は、このアッセイにおいて感染率を低下させる。
Claims (7)
- ウイルス性疾患の治療のための、アミノ酸配列
NH2−VCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH−COOH
を有するペプチドの使用。 - 請求項1に記載のペプチドの誘導体、変異体及び断片、特に、アミド化、アセチル化、硫酸化、リン酸、グリコシル化、酸化又はポリエチレングリコール修飾誘導体、特にアミノ酸の保存的な交換及び/又は欠失により得られた変異体及び断片、及び/又は該ペプチドのN末端及び/又はC末端において1から10までの付加アミノ酸を含有する異性体の、請求項1に記載の使用(前記誘導体、断片及び異性体は請求項1に記載の前記ペプチドと、少なくとも80%、特に90%の配列同一性を有し、且つ細胞感染アッセイにおいて、HSV−2に対する阻害活性を有する。)。
- 前記ウイルス性疾患がヘルペスである、請求項1又は2に記載の使用。
- 前記ウイルス性疾患が単純ヘルペスウイルスを伴う感染により引き起こされた、請求項1から3の少なくとも一項に記載の使用。
- 前記ウイルス性疾患が細菌の不定着化を引き起こさない、請求項1から4の少なくとも一項に記載の使用。
- 注入、軟膏、錠剤、スプレー、「持続放出」カプセル及び類似調製物のために調合された生薬製剤中での、及び/又は他の抗ウイルス治療剤との組み合わせによる、請求項1から5の少なくとも一項に記載の使用。
- 断片が、
NH2−VCVLAHHFGKEF−COOH、又は、
NH2−CVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH−COOHである、
請求項2から6の少なくとも一項に記載の使用。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60231304P | 2004-08-18 | 2004-08-18 | |
EP04019552 | 2004-08-18 | ||
US60/602,313 | 2004-08-18 | ||
EP04019552.1 | 2004-08-18 | ||
PCT/EP2005/054028 WO2006018431A2 (en) | 2004-08-18 | 2005-08-16 | Peptides for the treatment of herpes virus infections |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012186755A Division JP5568609B2 (ja) | 2004-08-18 | 2012-08-27 | ヘルペスウイルス感染の治療のためのペプチド |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008509969A true JP2008509969A (ja) | 2008-04-03 |
JP5101280B2 JP5101280B2 (ja) | 2012-12-19 |
Family
ID=34926208
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007526458A Expired - Fee Related JP5101280B2 (ja) | 2004-08-18 | 2005-08-16 | ヘルペスウイルス感染の治療のためのペプチド |
Country Status (7)
Country | Link |
---|---|
US (1) | US7741287B2 (ja) |
EP (1) | EP1778271B1 (ja) |
JP (1) | JP5101280B2 (ja) |
AT (1) | ATE411812T1 (ja) |
CA (1) | CA2558289C (ja) |
DK (1) | DK1778271T3 (ja) |
WO (1) | WO2006018431A2 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016516760A (ja) * | 2013-04-11 | 2016-06-09 | クリニック・ラ・プレリー | 新規のヘモグロビン由来ペプチドベースの医薬組成物 |
JP2016121081A (ja) * | 2014-12-24 | 2016-07-07 | 国立大学法人秋田大学 | 抗ウイルス剤、および抗菌剤 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602005010590D1 (de) * | 2004-08-18 | 2008-12-04 | Ipf Pharmaceuticals Gmbh | Peptide zur behandlung von infektionen mit dem herpes-virus |
IT1395137B1 (it) | 2009-08-05 | 2012-09-05 | Spider Biotech S R L | Nuovi peptidi antipatogeni |
ES2444299B1 (es) | 2012-08-23 | 2014-12-12 | Nutrición Técnica Deportiva, S.L. | Uso de un hidrolizado de caseina como agente antiherpético |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS649997A (en) * | 1987-07-02 | 1989-01-13 | Toray Industries | Serine protease inhibitor |
WO2001094386A2 (de) * | 2000-06-08 | 2001-12-13 | Ipf Pharmaceuticals Gmbh | Verfahren zur gewinnung und anwendung von antibiotisch wirksamen peptiden zur behandlung von infektionskrankheiten |
GB2382347B (en) * | 2001-10-26 | 2005-04-06 | Ezio Panzeri | Hemoglobin conjugates |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5922854A (en) * | 1991-06-14 | 1999-07-13 | Kumar; Ramesh | Purifying Human Hemogloblin from transgenic pig red cells and plasmids containing pig globin nucleic acids |
US6610654B2 (en) * | 1993-03-31 | 2003-08-26 | Wellstat Therapeutics Corporation | Inhibitor of stem cell proliferation and uses thereof |
JPH08510997A (ja) * | 1993-03-31 | 1996-11-19 | プロ−ニューロン,インコーポレイテッド | 幹細胞増殖インヒビターおよびその使用 |
US5861483A (en) * | 1996-04-03 | 1999-01-19 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
AU3904497A (en) * | 1996-08-02 | 1998-02-25 | Somatogen, Inc. | Methods of controlling beta dimer formation in hemoglobin |
EA002242B1 (ru) * | 1997-10-08 | 2002-02-28 | ТЕРАГЕМ, Инк. | Пептиды млекопитающих для лечения микробной инфекции |
-
2005
- 2005-08-16 DK DK05786951T patent/DK1778271T3/da active
- 2005-08-16 JP JP2007526458A patent/JP5101280B2/ja not_active Expired - Fee Related
- 2005-08-16 AT AT05786951T patent/ATE411812T1/de not_active IP Right Cessation
- 2005-08-16 WO PCT/EP2005/054028 patent/WO2006018431A2/en active Application Filing
- 2005-08-16 US US11/658,269 patent/US7741287B2/en active Active
- 2005-08-16 CA CA2558289A patent/CA2558289C/en not_active Expired - Fee Related
- 2005-08-16 EP EP05786951A patent/EP1778271B1/en not_active Not-in-force
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS649997A (en) * | 1987-07-02 | 1989-01-13 | Toray Industries | Serine protease inhibitor |
WO2001094386A2 (de) * | 2000-06-08 | 2001-12-13 | Ipf Pharmaceuticals Gmbh | Verfahren zur gewinnung und anwendung von antibiotisch wirksamen peptiden zur behandlung von infektionskrankheiten |
EP1481988A2 (de) * | 2000-06-08 | 2004-12-01 | IPF PharmaCeuticals GmbH | Verfahren zur Gewinnung und Anwendung von antibiotisch wirksamen Peptiden zur Behandlung von Infektionskrankheiten |
GB2382347B (en) * | 2001-10-26 | 2005-04-06 | Ezio Panzeri | Hemoglobin conjugates |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016516760A (ja) * | 2013-04-11 | 2016-06-09 | クリニック・ラ・プレリー | 新規のヘモグロビン由来ペプチドベースの医薬組成物 |
JP2016121081A (ja) * | 2014-12-24 | 2016-07-07 | 国立大学法人秋田大学 | 抗ウイルス剤、および抗菌剤 |
Also Published As
Publication number | Publication date |
---|---|
CA2558289A1 (en) | 2006-02-23 |
CA2558289C (en) | 2018-05-15 |
US7741287B2 (en) | 2010-06-22 |
WO2006018431A2 (en) | 2006-02-23 |
EP1778271B1 (en) | 2008-10-22 |
DK1778271T3 (da) | 2009-02-16 |
US20080312144A1 (en) | 2008-12-18 |
ATE411812T1 (de) | 2008-11-15 |
JP5101280B2 (ja) | 2012-12-19 |
WO2006018431A3 (en) | 2006-06-08 |
EP1778271A2 (en) | 2007-05-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2875826B1 (en) | Composition for preventing or treating sepsis | |
AU2022203288A1 (en) | Antimicrobial therapy | |
US7718618B2 (en) | Human cathelicidin antimicrobial peptides | |
AU2002328203C1 (en) | Antimicrobial and anti-inflammatory peptides | |
CA2456477A1 (en) | Antimicrobial cationic peptides and formulations thereof | |
US7776823B2 (en) | Human cathelicidin antimicrobial peptides | |
JP5101280B2 (ja) | ヘルペスウイルス感染の治療のためのペプチド | |
CA2915174C (en) | Tetrapeptides derived from human c-x-c chemokines useful for treatment of various skin conditions | |
EP3193906B1 (en) | Use of peptide inhibitors of il-36 proteolytic processing for the treatment and/or reduction of inflammation | |
EP2125878B1 (en) | Short bio-active peptides for cellular and immunological modulation | |
JP5568609B2 (ja) | ヘルペスウイルス感染の治療のためのペプチド | |
US10857201B2 (en) | NNIF and nNIF-related peptides and related methods | |
US7427595B1 (en) | Use of proepithelin to promote wound repair and reduce inflammation | |
CN112402592B (zh) | Spink7蛋白在制备促进过度炎症创面愈合的药物中的应用 | |
JP2017524000A (ja) | 腹膜炎の治療のための組成物 | |
EP3270950B1 (en) | Isolated peptides and fragments thereof from fibrinogen for use as drugs, particularly in skin inflammatory diseases | |
US5698519A (en) | Polypeptide specifically inhibiting cathepsin L | |
WO2002029082A1 (en) | Endothelial cell mitogen bioassay | |
US11324801B2 (en) | NNIF and nNIF-related peptides and related methods | |
KR20220164450A (ko) | Agkistrodon piscivorus piscivorus 또는 Naja melanoleuca로부터 유래된 신규한 펩타이드, 및 이를 포함하는 베체트병 또는 류마티스 관절염의 치료용 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080815 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120228 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120522 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120529 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120827 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120918 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120926 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20151005 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5101280 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |