JP2008509110A - Ｒｎａ依存性ｄｎａポリメラーゼで活性化されるプロドラッグ - Google Patents

Ｒｎａ依存性ｄｎａポリメラーゼで活性化されるプロドラッグ Download PDF

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Publication number
JP2008509110A
JP2008509110A JP2007524340A JP2007524340A JP2008509110A JP 2008509110 A JP2008509110 A JP 2008509110A JP 2007524340 A JP2007524340 A JP 2007524340A JP 2007524340 A JP2007524340 A JP 2007524340A JP 2008509110 A JP2008509110 A JP 2008509110A
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JP
Japan
Prior art keywords
compound
group
compound according
treatment
rna
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Pending
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JP2007524340A
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English (en)
Japanese (ja)
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JP2008509110A5 (enExample
Inventor
ベルティニ・イヴァノ
ルチナト・クラウディオ
クオットロネ・アレッサンドロ
カラマンテ・マッシモ
モルディニ・アレッサンドロ
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プロテラ ソシエタ ア レスポンサビリタ リミタータ
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Publication of JP2008509110A publication Critical patent/JP2008509110A/ja
Publication of JP2008509110A5 publication Critical patent/JP2008509110A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2007524340A 2004-08-03 2005-08-02 Ｒｎａ依存性ｄｎａポリメラーゼで活性化されるプロドラッグ Pending JP2008509110A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000173A ITFI20040173A1 (it) 2004-08-03 2004-08-03 Profarmaci attivati da dna polimerasi dipendenti da rna
PCT/EP2005/053765 WO2006013203A2 (en) 2004-08-03 2005-08-02 Prodrugs activated by rna-dependent dna-polymerases

Publications (2)

Publication Number Publication Date
JP2008509110A true JP2008509110A (ja) 2008-03-27
JP2008509110A5 JP2008509110A5 (enExample) 2008-09-04

Family

ID=35589591

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007524340A Pending JP2008509110A (ja) 2004-08-03 2005-08-02 Ｒｎａ依存性ｄｎａポリメラーゼで活性化されるプロドラッグ

Country Status (8)

Country Link
US (1) US8110676B2 (enExample)
EP (1) EP1778254A2 (enExample)
JP (1) JP2008509110A (enExample)
CN (1) CN101031308A (enExample)
AU (1) AU2005268775A1 (enExample)
CA (1) CA2575520A1 (enExample)
IT (1) ITFI20040173A1 (enExample)
WO (1) WO2006013203A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
CN102014919B (zh) * 2008-03-03 2015-02-25 托斯克公司 减少毒性的甲氨蝶呤佐剂及其使用方法
ES2874774T3 (es) 2011-12-22 2021-11-05 Geron Corp Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
US20190100553A1 (en) * 2016-04-12 2019-04-04 The Board Of Trustees Of The Leland Stanford Junior University Direct activity assays and compositions for nucleotide pool sanitizing enzymes
WO2023007019A1 (en) * 2021-07-30 2023-02-02 CureVac SE Cap analogs having an acyclic linker to the guanine derivative nucleobase

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61263996A (ja) * 1984-12-07 1986-11-21 保寧製薬株式会社 新規ヌクレオシド誘導体およびその製造法
JPH0920792A (ja) * 1995-07-11 1997-01-21 Soyaku Gijutsu Kenkyusho:Kk ヌクレオチドダイマー
WO2003072757A2 (en) * 2002-02-28 2003-09-04 Biota, Inc. Nucleotide mimics and their prodrugs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064782A2 (en) * 2003-01-16 2004-08-05 Hybridon, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61263996A (ja) * 1984-12-07 1986-11-21 保寧製薬株式会社 新規ヌクレオシド誘導体およびその製造法
JPH0920792A (ja) * 1995-07-11 1997-01-21 Soyaku Gijutsu Kenkyusho:Kk ヌクレオチドダイマー
WO2003072757A2 (en) * 2002-02-28 2003-09-04 Biota, Inc. Nucleotide mimics and their prodrugs

Also Published As

Publication number Publication date
US8110676B2 (en) 2012-02-07
ITFI20040173A1 (it) 2004-11-03
US20080300215A1 (en) 2008-12-04
WO2006013203A2 (en) 2006-02-09
CA2575520A1 (en) 2006-02-09
EP1778254A2 (en) 2007-05-02
WO2006013203A3 (en) 2006-07-27
AU2005268775A1 (en) 2006-02-09
CN101031308A (zh) 2007-09-05

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