JP2008509086A5 - - Google Patents
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- JP2008509086A5 JP2008509086A5 JP2007515288A JP2007515288A JP2008509086A5 JP 2008509086 A5 JP2008509086 A5 JP 2008509086A5 JP 2007515288 A JP2007515288 A JP 2007515288A JP 2007515288 A JP2007515288 A JP 2007515288A JP 2008509086 A5 JP2008509086 A5 JP 2008509086A5
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- Prior art keywords
- seq
- antibody
- ligand
- amino acid
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- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57389604P | 2004-05-25 | 2004-05-25 | |
| US60/573,896 | 2004-05-25 | ||
| PCT/US2005/018322 WO2005116077A2 (en) | 2004-05-25 | 2005-05-25 | LIGANDS BINDING THE COMPLEX OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (uPA) AND ITS RECEPTOR (uPAR) THAT INHIBIT DOWNSTREAM uPAR INTERACTIONS: IDENTIFICATION AND USE IN DIAGNOSIS OR THERAPY |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008509086A JP2008509086A (ja) | 2008-03-27 |
| JP2008509086A5 true JP2008509086A5 (cg-RX-API-DMAC10.html) | 2008-07-10 |
| JP4890449B2 JP4890449B2 (ja) | 2012-03-07 |
Family
ID=35451457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007515288A Expired - Lifetime JP4890449B2 (ja) | 2004-05-25 | 2005-05-25 | 下流ｕＰＡＲ相互作用を阻害するウロキナーゼ型プラスミノーゲン活性化因子（ｕＰＡ）とそのレセプター（ｕＰＡＲ）との複合体に結合するリガンド：診断または治療における同定および使用 |
Country Status (16)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007109742A2 (en) * | 2006-03-21 | 2007-09-27 | Weaver David T | Methods for humanizing antibodies and humanized antibodies made thereby |
| CN1919874B (zh) * | 2006-09-18 | 2010-09-08 | 中国人民解放军军事医学科学院生物工程研究所 | 一种抗尿激酶型纤溶酶激活剂受体的抗体样分子ATF-Fc融合蛋白及其用途 |
| WO2008073312A2 (en) * | 2006-12-08 | 2008-06-19 | Attenuon, Llc | Urokinase-type plasminogen activator receptor epitope, monoclonal antibodies derived therefrom and methods of use thereof |
| US8815519B2 (en) | 2006-12-22 | 2014-08-26 | Hvidovre Hospital | Method for predicting cancer and other diseases |
| EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| EP2730282A1 (en) * | 2007-11-08 | 2014-05-14 | The General Hospital Corporation | Methods and compositions for the treatment of proteinuric diseases |
| US20110212083A1 (en) | 2008-11-06 | 2011-09-01 | University Of Miami Office Of Technology Transfer | Role of soluble upar in the pathogenesis of proteinuric kidney disease |
| AU2010298036B2 (en) | 2009-09-25 | 2015-05-21 | Xoma Technology Ltd. | Screening methods |
| CA2821372A1 (en) | 2010-12-22 | 2012-06-28 | Ifom Fondazione Istituto Firc Di Oncologia Molecolare | Upar-antagonists and uses thereof |
| EP3252076B1 (en) | 2011-01-14 | 2019-09-04 | The Regents Of The University Of California | Diagnostic use of antibodies against ror-1 protein |
| WO2012125775A1 (en) | 2011-03-16 | 2012-09-20 | Sanofi | Uses of a dual v region antibody-like protein |
| WO2012154218A2 (en) | 2011-05-09 | 2012-11-15 | The University Of Miami | Reducing soluble urokinase receptor in the circulation |
| JP2014529581A (ja) | 2011-08-05 | 2014-11-13 | イフォム・フォンダツィオーネ・インスティトゥオ・フィルチ・ディ・オンコロジア・モレコラーレ | 構成的に活性なｕＰＡＲバリアントならびに阻害抗体の生成および単離へのそれの使用 |
| KR20230148263A (ko) * | 2013-03-15 | 2023-10-24 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 누트린-3a 및 펩티드에 의한 폐 섬유증의 저해 |
| CN105368859B (zh) * | 2015-11-25 | 2019-10-18 | 王任直 | 一种嵌合抗原受体hCD87-CAR及载有hCD87-CAR基因结构的慢病毒及质粒及其应用 |
| US10681506B1 (en) | 2018-04-19 | 2020-06-09 | Tango Tango, Inc. | System and method for push-to-talk over cellular integration with software defined radio |
| US10959062B1 (en) | 2018-04-19 | 2021-03-23 | Tango Tango, Inc. | System and method for push-to-talk over cellular integration with software defined radio |
| KR102958241B1 (ko) | 2018-09-10 | 2026-04-30 | 레인 테라퓨틱스, 인크. | Cav-1 단백질의 변형된 펩타이드 단편 및 섬유증의 치료에 있어서 이의 용도 |
| JP2022513317A (ja) * | 2018-09-28 | 2022-02-07 | ヨッヘン ライザー | ｓｕＰＡＲならびに急性腎傷害の予測および治療 |
| CA3158174A1 (en) | 2019-10-28 | 2021-05-06 | Monash University | Antibodies for binding plasmin |
| CA3182769A1 (en) * | 2020-06-15 | 2021-12-23 | Andrew P. Mazar | Precision radioimmunotherapeutic targeting of the urokinase plasminogen activator receptor (upar) for treatment of severe covid-19 disease |
| WO2022204267A1 (en) | 2021-03-24 | 2022-09-29 | Alkermes, Inc. | Upar antibodies and fusion proteins with the same |
| EP4341296A4 (en) * | 2021-05-21 | 2025-07-30 | Northstar Medical Tech Llc | RADIOPHARMACEUTICAL PRODUCT TARGETING THE UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR |
| CA3221342A1 (en) * | 2021-06-11 | 2022-12-15 | Scott W. Lowe | Antigen recognizing receptors targeting upar and uses thereof |
| US20250296999A1 (en) * | 2022-03-07 | 2025-09-25 | Rush University Medical Center | Novel Treatment of Diabetes and Kidney Disease by Inhibition of D2D3 a Proteolytic UPAR |
| CA3246325A1 (en) * | 2022-03-24 | 2023-09-28 | The United States Government As Represented By The Department Of Veterans Affairs | Urokinase-type plasminogen activator receptor-binding peptides and methods of use |
| EP4610269A1 (en) | 2024-02-29 | 2025-09-03 | 3B Pharmaceuticals GmbH | Urokinase plasminogen activator surface receptor (upar) ligands for diagnostic or therapeutic use |
| WO2025207781A1 (en) | 2024-03-26 | 2025-10-02 | Monopar Therapeutics Inc. | Antibody radioisotope constructs |
| WO2026019458A1 (en) | 2024-07-19 | 2026-01-22 | Monopar Therpeutics, Inc | Squaramide bi-functional chelators and associated radiopharmaceuticals and methods of use |
| CN121248786B (zh) * | 2025-12-08 | 2026-05-08 | 上海宏成药业有限公司 | 抗尿激酶纤溶酶原激活物受体抗体及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5532132A (en) * | 1993-09-28 | 1996-07-02 | President And Fellows Of Harvard University | Method for regulating formation of a complex of plasminogen activator, its receptor and inhibitor |
| DE10117381A1 (de) * | 2001-04-06 | 2002-10-10 | Wilex Biotechnology Gmbh | Herstellung polyklonaler, monospezifischer Antikörper gegen die uPAR-Varianten del4, del5 und del4+5 sowie deren Verwendung für diagnostische und therapeutische Zwecke |
| AU2003216512A1 (en) * | 2002-03-18 | 2003-10-08 | Dyax Corporation | Integrin ligand |
| WO2008073312A2 (en) * | 2006-12-08 | 2008-06-19 | Attenuon, Llc | Urokinase-type plasminogen activator receptor epitope, monoclonal antibodies derived therefrom and methods of use thereof |
-
2005
- 2005-05-25 PL PL05754219T patent/PL1765397T3/pl unknown
- 2005-05-25 ES ES05754219T patent/ES2398221T3/es not_active Expired - Lifetime
- 2005-05-25 EP EP05754219A patent/EP1765397B1/en not_active Expired - Lifetime
- 2005-05-25 ZA ZA200610578A patent/ZA200610578B/xx unknown
- 2005-05-25 US US11/597,689 patent/US8101726B2/en active Active
- 2005-05-25 PT PT57542193T patent/PT1765397E/pt unknown
- 2005-05-25 AU AU2005248400A patent/AU2005248400A1/en not_active Abandoned
- 2005-05-25 CN CNA2005800249140A patent/CN101022830A/zh active Pending
- 2005-05-25 MX MXPA06013709A patent/MXPA06013709A/es active IP Right Grant
- 2005-05-25 WO PCT/US2005/018322 patent/WO2005116077A2/en not_active Ceased
- 2005-05-25 DK DK05754219.3T patent/DK1765397T3/da active
- 2005-05-25 JP JP2007515288A patent/JP4890449B2/ja not_active Expired - Lifetime
- 2005-05-25 KR KR1020067027198A patent/KR20070047246A/ko not_active Withdrawn
- 2005-05-25 CA CA2568428A patent/CA2568428C/en not_active Expired - Lifetime
- 2005-05-25 RU RU2006145905/13A patent/RU2006145905A/ru not_active Application Discontinuation
-
2006
- 2006-11-23 IL IL179565A patent/IL179565A0/en unknown
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