JP2008508354A5 - - Google Patents

Info

Publication number

JP2008508354A5

JP2008508354A5 JP2007524780A JP2007524780A JP2008508354A5 JP 2008508354 A5 JP2008508354 A5 JP 2008508354A5 JP 2007524780 A JP2007524780 A JP 2007524780A JP 2007524780 A JP2007524780 A JP 2007524780A JP 2008508354 A5 JP2008508354 A5 JP 2008508354A5

Authority

JP

Japan

Prior art keywords

boswellic acid

keto

acetyl

composition according

acid

Prior art date

2004-10-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 12
• NBGQZFQREPIKMG-UHFFFAOYSA-N 3beta-hydroxy-beta-boswellic acid Natural products C1CC(O)C(C)(C(O)=O)C2CCC3(C)C4(C)CCC5(C)CCC(C)C(C)C5C4=CCC3C21C NBGQZFQREPIKMG-UHFFFAOYSA-N 0.000 claims 9
• NBGQZFQREPIKMG-PONOSELZSA-N Boswellic acid Chemical compound C1C[C@@H](O)[C@](C)(C(O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C NBGQZFQREPIKMG-PONOSELZSA-N 0.000 claims 9
• YJBVHJIKNLBFDX-MQURJEHKSA-N (3r,4r,4ar,6ar,6bs,8ar,11r,12s,12ar,14ar,14br)-3-acetyloxy-4,6a,6b,8a,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1h-picene-4-carboxylic acid Chemical compound C1C[C@@H](OC(C)=O)[C@](C)(C(O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C YJBVHJIKNLBFDX-MQURJEHKSA-N 0.000 claims 6
• HMMGKOVEOFBCAU-BCDBGHSCSA-N 3-Acetyl-11-keto-beta-boswellic acid Chemical compound C1C[C@@H](OC(C)=O)[C@](C)(C(O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C)[C@H](C)[C@H]5C4=CC(=O)[C@@H]3[C@]21C HMMGKOVEOFBCAU-BCDBGHSCSA-N 0.000 claims 5
• HMMGKOVEOFBCAU-UHFFFAOYSA-N AKBA Natural products C1CC(OC(C)=O)C(C)(C(O)=O)C2CCC3(C)C4(C)CCC5(C)CCC(C)C(C)C5C4=CC(=O)C3C21C HMMGKOVEOFBCAU-UHFFFAOYSA-N 0.000 claims 5
• LRESHPOWNLIPRR-WYBDTLHZSA-N acetyl-11-keto-beta-boswellic acid Natural products C[C@@H]1CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CC[C@@H](C(=O)C)[C@@](C)([C@@H]5CC[C@@]34C)C(=O)O)[C@@H]2[C@H]1C LRESHPOWNLIPRR-WYBDTLHZSA-N 0.000 claims 5
• YIMHGPSYDOGBPI-YZCVQEKWSA-N 11-keto-β-boswellic acid Chemical compound C1C[C@@H](O)[C@](C)(C(O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C)[C@H](C)[C@H]5C4=CC(=O)[C@@H]3[C@]21C YIMHGPSYDOGBPI-YZCVQEKWSA-N 0.000 claims 3
• RJFAYQIBOAGBLC-BYPYZUCNSA-N Selenium-L-methionine Chemical compound C[Se]CC[C@H](N)C(O)=O RJFAYQIBOAGBLC-BYPYZUCNSA-N 0.000 claims 3
• YIMHGPSYDOGBPI-UHFFFAOYSA-N beta-KBA Natural products C1CC(O)C(C)(C(O)=O)C2CCC3(C)C4(C)CCC5(C)CCC(C)C(C)C5C4=CC(=O)C3C21C YIMHGPSYDOGBPI-UHFFFAOYSA-N 0.000 claims 3
• 229940091258 selenium supplement Drugs 0.000 claims 3
• 240000007551 Boswellia serrata Species 0.000 claims 2
• 235000012035 Boswellia serrata Nutrition 0.000 claims 2
• BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 2
• RJFAYQIBOAGBLC-UHFFFAOYSA-N Selenomethionine Natural products C[Se]CCC(N)C(O)=O RJFAYQIBOAGBLC-UHFFFAOYSA-N 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 2
• 239000000039 congener Substances 0.000 claims 2
• 239000006071 cream Substances 0.000 claims 2
• 239000000499 gel Substances 0.000 claims 2
• 230000003463 hyperproliferative effect Effects 0.000 claims 2
• 239000006210 lotion Substances 0.000 claims 2
• 239000011347 resin Substances 0.000 claims 2
• 229920005989 resin Polymers 0.000 claims 2
• 229910052711 selenium Inorganic materials 0.000 claims 2
• 239000011669 selenium Substances 0.000 claims 2
• 229960002718 selenomethionine Drugs 0.000 claims 2
• 208000017520 skin disease Diseases 0.000 claims 2
• 102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 claims 1
• 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 claims 1
• 241000196324 Embryophyta Species 0.000 claims 1
• 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 claims 1
• 102100033174 Neutrophil elastase Human genes 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• XDSSPSLGNGIIHP-VKHMYHEASA-N Se-methyl-L-selenocysteine Chemical compound C[Se]C[C@H]([NH3+])C([O-])=O XDSSPSLGNGIIHP-VKHMYHEASA-N 0.000 claims 1
• 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
• 239000002775 capsule Substances 0.000 claims 1
• 229940125436 dual inhibitor Drugs 0.000 claims 1
• 239000000463 material Substances 0.000 claims 1
• 239000000843 powder Substances 0.000 claims 1
• 210000004761 scalp Anatomy 0.000 claims 1
• 238000011200 topical administration Methods 0.000 claims 1