WO2006022762A1 - Compositions and methods for the management of hyperproliferative dermatological conditions - Google Patents

Compositions and methods for the management of hyperproliferative dermatological conditions Download PDF

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Publication number
WO2006022762A1
WO2006022762A1 PCT/US2004/033846 US2004033846W WO2006022762A1 WO 2006022762 A1 WO2006022762 A1 WO 2006022762A1 US 2004033846 W US2004033846 W US 2004033846W WO 2006022762 A1 WO2006022762 A1 WO 2006022762A1
Authority
WO
WIPO (PCT)
Prior art keywords
beta
boswellic acid
boswellic
keto
acetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/033846
Other languages
English (en)
French (fr)
Other versions
WO2006022762B1 (en
Inventor
Muhammed Majeed
Subbalakshmi Prakash
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/710,778 external-priority patent/US7582314B2/en
Priority to ES04795060T priority Critical patent/ES2422893T3/es
Priority to CN2004800436759A priority patent/CN101132693B/zh
Priority to DK04795060.5T priority patent/DK1791423T3/da
Priority to AU2004322710A priority patent/AU2004322710B2/en
Priority to JP2007524780A priority patent/JP4820819B2/ja
Application filed by Individual filed Critical Individual
Priority to PL04795060T priority patent/PL1791423T3/pl
Priority to EP04795060.5A priority patent/EP1791423B1/en
Priority to NZ552027A priority patent/NZ552027A/en
Publication of WO2006022762A1 publication Critical patent/WO2006022762A1/en
Publication of WO2006022762B1 publication Critical patent/WO2006022762B1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • compositions and methods for the management of hyperproliferative are provided.
  • hyperproliferative skin conditions such as psoriasis
  • compositions described herein contain a
  • Psoriasis is a chronic skin disease marked by periodic flare-ups of sharply
  • keratinocytes in the epidermis forming patches or plaques with silvery
  • psoriasis is plaque psoriasis.
  • Psoriatic arthritis is a debilitating disorder
  • Boswellia serrata (Roxb.) Burseraceae is a large tree which grows in the /
  • gum contains a mixture of four boswellic acids.
  • Boswellic acids inhibit 5-lipoxygenase (Safayhi et al., 1992) the enzyme
  • Boswellic acids also inhibit the enzyme human leukocyte
  • HLE connective tissue break down
  • leukotriene B4 was found to increase by approximately 6.6-fold
  • HLE human leukocyte elastase
  • WO 96/19212 describes the use of boswellic acids in treating brain
  • EP 0552657 describes the use of pure boswellic acid, a physiologically
  • WO 00/57893 describes compositions containing Boswellia serrata extract
  • Boswellia serrata extract, boswellic acid or a derivative thereof is
  • selenium as selenocysteine
  • glutathione peroxidase glutathione peroxidase
  • Se-yeast containing about 70% selenomethionine
  • selenomethionine may be able to modulate the immunological
  • TNF-alpha Tumor necrosis factor-alpha
  • TNF-R1 soluble TNF-alpha receptor type 1
  • Patent application CN 1233482 describes the application of glossy
  • animal origin selected from cod liver oil, mink oil and tortoise oil containing
  • epidermal growth factor in a topical carrier and method of using the
  • Boswellic acids novel, specific, non-redox
  • psoriatic arthritis psoriatic lesions are accompanied by symptoms of
  • Psoriatic arthritis is characterized by stiff, tender, and inflamed
  • the current invention addresses hyperproliferative skin conditions with a
  • lipoxygenase and human leukocyte elastase is ingested orally, as well
  • HLA leukocyte antigen
  • the current invention is directed towards
  • treatment entails configuring the correct dosing regimen that would
  • Figure 1 shows the appearance of psoriatic lesions in patient 1 , patient 2,
  • Figure 2 shows the appearance of psoriatic lesions in patient 4, patient 5,
  • Figure 3 shows the appearance of psoriatic lesions in patient 7, patient 8,
  • Figure 4 shows the appearance of psoriatic lesions in patient 10, patient
  • compositions [0054]
  • Tab le 1 Active Ingredient Composition of the Oral dosage form
  • the formulation is prepared in the form of a capsule, tablet, power,
  • spansule or other dosage form for oral administration with commonly used
  • Boswellin (a trademark of Sabinsa Corporation, NJ, USA) is a
  • the active ingredient may be formulated as a cream, lotion, patch, gel or
  • Example 2 Treatment of psoriatic human subjects with the composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
PCT/US2004/033846 2004-08-02 2004-10-14 Compositions and methods for the management of hyperproliferative dermatological conditions Ceased WO2006022762A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
NZ552027A NZ552027A (en) 2004-08-02 2004-10-14 Compositions and methods for the management of hyperproliferative dermatological conditions
CN2004800436759A CN101132693B (zh) 2004-08-02 2004-10-14 用于控制过度增生性皮肤病的组合物以及方法
DK04795060.5T DK1791423T3 (da) 2004-08-02 2004-10-14 Sammensætninger og fremgangsmåder til behandling af hyperproliferative dermatologiske tilstande
AU2004322710A AU2004322710B2 (en) 2004-08-02 2004-10-14 Compositions and methods for the management of hyperproliferative dermatological conditions
JP2007524780A JP4820819B2 (ja) 2004-08-02 2004-10-14 過剰増殖性皮膚疾患を治療するための組成物および方法
ES04795060T ES2422893T3 (es) 2004-08-02 2004-10-14 Composiciones y procedimientos para el tratamiento de las afecciones dermatológicas hiperproliferativas
PL04795060T PL1791423T3 (pl) 2004-08-02 2004-10-14 Kompozycje i sposoby postępowania z hiperproliferacyjnymi zaburzeniami dermatologicznymi
EP04795060.5A EP1791423B1 (en) 2004-08-02 2004-10-14 Compositions and methods for the management of hyperproliferative dermatological conditions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/710,778 US7582314B2 (en) 2003-12-03 2004-08-02 Compositions and methods for the management of hyperproliferative dermatological conditions
US10/710,778 2004-08-02

Publications (2)

Publication Number Publication Date
WO2006022762A1 true WO2006022762A1 (en) 2006-03-02
WO2006022762B1 WO2006022762B1 (en) 2006-05-04

Family

ID=35967805

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/033846 Ceased WO2006022762A1 (en) 2004-08-02 2004-10-14 Compositions and methods for the management of hyperproliferative dermatological conditions

Country Status (12)

Country Link
EP (1) EP1791423B1 (enExample)
JP (1) JP4820819B2 (enExample)
CN (1) CN101132693B (enExample)
AU (1) AU2004322710B2 (enExample)
DK (1) DK1791423T3 (enExample)
ES (1) ES2422893T3 (enExample)
NZ (1) NZ552027A (enExample)
PL (1) PL1791423T3 (enExample)
PT (1) PT1791423E (enExample)
RU (1) RU2366412C2 (enExample)
WO (1) WO2006022762A1 (enExample)
ZA (1) ZA200700694B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITVR20080125A1 (it) * 2008-11-13 2010-05-14 Phytonature Sas Di Masini Dr Antoni O E C Nuova forma di preparazione ed utilizzo della boswellia serrata
US9975917B1 (en) 2017-09-20 2018-05-22 King Saud University Pentacyclic triterpenoidal derivatives
EP4295842A1 (en) 2022-06-24 2023-12-27 Faaborg Pharma - IP ApS A skin care composition

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0913499B1 (pt) * 2008-09-15 2020-03-17 Laila Nutraceuticals Composições anti-inflamatórias sinergísticas compreendendo extratos de boswellia serrata
WO2011099029A1 (en) * 2010-02-15 2011-08-18 Laila Nutraceuticals A novel boswellia low polar gum resin extract and its synergistic compositions
US20110218172A1 (en) * 2010-03-02 2011-09-08 Muhammed Majeed Composition for down-regulating pro-inflammatory markers
CN102670565A (zh) * 2011-03-14 2012-09-19 苏州博创园生物医药科技有限公司 一种含天然药物的透皮吸收贴片
CN102670690A (zh) * 2011-03-14 2012-09-19 苏州博创园生物医药科技有限公司 一种抗牛皮癣纯天然药物乳膏及其制备方法
CN103193853A (zh) * 2012-01-06 2013-07-10 苏州博创园生物医药科技有限公司 用于治疗银屑病的化合物、组合物及其制备方法
US9498423B2 (en) * 2012-05-07 2016-11-22 Sami Labs Limited Synergistic selenopeptide formulations for the protection of dermal papilla cells
US20200179305A1 (en) * 2016-04-19 2020-06-11 Azura Ophthalmics Ltd. Compositions for the Treatment of Hyperkeratosis Disorders
CN115279458A (zh) 2020-01-10 2022-11-01 阿祖拉眼科有限公司 组合物和敏感性说明

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3670084A (en) * 1969-06-20 1972-06-13 Leopoldo F Montes Method of treating psoriasis with cycloheximide
US5536506A (en) * 1995-02-24 1996-07-16 Sabinsa Corporation Use of piperine to increase the bioavailability of nutritional compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4201903B4 (de) * 1992-01-24 2004-04-15 Hermann P.T. Prof. Dr.Med. Ammon Pharmazeutische Verwendung von Boswelliasäuren
DE4445728A1 (de) * 1994-12-21 1996-06-27 Simmet Th Prof Dr Verwendung von Boswelliasäure zur Behandlung von Hirntumoren
RU2152218C1 (ru) * 1998-04-21 2000-07-10 Дальневосточный государственный медицинский университет Способ лечения псориаза
CN1064264C (zh) * 1998-04-28 2001-04-11 山东省滨州卫生学校 富硒灵芝在制备治疗银屑病的药物中的应用
US6399105B1 (en) * 1999-01-20 2002-06-04 Peter Donald Collin Sea cucumber carotenoid lipid fraction products and methods of use
WO2000066111A1 (en) * 1999-04-30 2000-11-09 Sabinsa Corporation Compositions of boswellic acids derived from boswellia serrata gum resin, for treating lymphoproliferative and autoimmune conditions
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
GB0230203D0 (en) * 2002-12-27 2003-02-05 Domantis Ltd Fc fusion
ATE449081T1 (de) * 2002-12-30 2009-12-15 Celgene Corp Fluoralkoxy-substituierte 1, 3-dihydro-isoindolyl-verbindungen und ihre pharmazeutischen verwendungen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3670084A (en) * 1969-06-20 1972-06-13 Leopoldo F Montes Method of treating psoriasis with cycloheximide
US5536506A (en) * 1995-02-24 1996-07-16 Sabinsa Corporation Use of piperine to increase the bioavailability of nutritional compounds

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITVR20080125A1 (it) * 2008-11-13 2010-05-14 Phytonature Sas Di Masini Dr Antoni O E C Nuova forma di preparazione ed utilizzo della boswellia serrata
US9975917B1 (en) 2017-09-20 2018-05-22 King Saud University Pentacyclic triterpenoidal derivatives
EP4295842A1 (en) 2022-06-24 2023-12-27 Faaborg Pharma - IP ApS A skin care composition
WO2023247796A1 (en) 2022-06-24 2023-12-28 Faaborg Pharma - Ip Aps A skin care composition

Also Published As

Publication number Publication date
AU2004322710A1 (en) 2006-03-02
EP1791423A4 (en) 2009-06-17
RU2366412C2 (ru) 2009-09-10
CN101132693B (zh) 2012-11-07
PT1791423E (pt) 2013-08-02
ES2422893T3 (es) 2013-09-16
JP4820819B2 (ja) 2011-11-24
JP2008508354A (ja) 2008-03-21
NZ552027A (en) 2009-10-30
CN101132693A (zh) 2008-02-27
RU2007102720A (ru) 2008-09-10
EP1791423A1 (en) 2007-06-06
ZA200700694B (en) 2007-11-28
DK1791423T3 (da) 2013-08-05
PL1791423T3 (pl) 2013-09-30
EP1791423B1 (en) 2013-05-01
WO2006022762B1 (en) 2006-05-04
AU2004322710B2 (en) 2011-03-31

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