JP2008505339A5 - - Google Patents
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- Publication number
- JP2008505339A5 JP2008505339A5 JP2007519869A JP2007519869A JP2008505339A5 JP 2008505339 A5 JP2008505339 A5 JP 2008505339A5 JP 2007519869 A JP2007519869 A JP 2007519869A JP 2007519869 A JP2007519869 A JP 2007519869A JP 2008505339 A5 JP2008505339 A5 JP 2008505339A5
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- JP
- Japan
- Prior art keywords
- mass
- charge ratio
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- fractional
- ions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000002500 ions Chemical class 0.000 claims 86
- 239000000126 substance Substances 0.000 claims 44
- 238000004949 mass spectrometry Methods 0.000 claims 29
- 239000012634 fragment Substances 0.000 claims 17
- 238000000034 method Methods 0.000 claims 15
- 238000001819 mass spectrum Methods 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 230000003595 spectral effect Effects 0.000 claims 6
- 239000012491 analyte Substances 0.000 claims 5
- 239000002207 metabolite Substances 0.000 claims 5
- 238000006243 chemical reaction Methods 0.000 claims 4
- 238000004587 chromatography analysis Methods 0.000 claims 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 3
- 238000004458 analytical method Methods 0.000 claims 3
- 238000001914 filtration Methods 0.000 claims 3
- 238000000926 separation method Methods 0.000 claims 3
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000002068 Glycopeptides Human genes 0.000 claims 2
- 108010015899 Glycopeptides Proteins 0.000 claims 2
- 102000003886 Glycoproteins Human genes 0.000 claims 2
- 108090000288 Glycoproteins Proteins 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 102000006382 Ribonucleases Human genes 0.000 claims 2
- 108010083644 Ribonucleases Proteins 0.000 claims 2
- 230000001133 acceleration Effects 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 150000001450 anions Chemical class 0.000 claims 2
- 229920001222 biopolymer Polymers 0.000 claims 2
- 238000005251 capillar electrophoresis Methods 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 235000014633 carbohydrates Nutrition 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 239000002299 complementary DNA Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000003795 desorption Methods 0.000 claims 2
- 238000000688 desorption electrospray ionisation Methods 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 238000001962 electrophoresis Methods 0.000 claims 2
- 238000010265 fast atom bombardment Methods 0.000 claims 2
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 238000004128 high performance liquid chromatography Methods 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 238000009616 inductively coupled plasma Methods 0.000 claims 2
- 238000001698 laser desorption ionisation Methods 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 108091005981 phosphorylated proteins Proteins 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 238000004366 reverse phase liquid chromatography Methods 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims 1
- 208000035699 Distal ileal obstruction syndrome Diseases 0.000 claims 1
- 238000004252 FT/ICR mass spectrometry Methods 0.000 claims 1
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 claims 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000008186 active pharmaceutical agent Substances 0.000 claims 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 1
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims 1
- 230000005540 biological transmission Effects 0.000 claims 1
- 238000000451 chemical ionisation Methods 0.000 claims 1
- 238000000766 differential mobility spectroscopy Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000000132 electrospray ionisation Methods 0.000 claims 1
- 230000007717 exclusion Effects 0.000 claims 1
- 238000013467 fragmentation Methods 0.000 claims 1
- 238000006062 fragmentation reaction Methods 0.000 claims 1
- 238000004817 gas chromatography Methods 0.000 claims 1
- 238000005040 ion trap Methods 0.000 claims 1
- 238000004811 liquid chromatography Methods 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 238000001844 multi-dimensional electrophoresis Methods 0.000 claims 1
- PXHVJJICTQNCMI-RNFDNDRNSA-N nickel-63 Chemical compound [63Ni] PXHVJJICTQNCMI-RNFDNDRNSA-N 0.000 claims 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 238000004150 penning trap Methods 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- 239000010703 silicon Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 238000004611 spectroscopical analysis Methods 0.000 claims 1
- 238000004808 supercritical fluid chromatography Methods 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58413904P | 2004-07-01 | 2004-07-01 | |
| US60/584,139 | 2004-07-01 | ||
| GB0415046.2 | 2004-07-05 | ||
| GBGB0415046.2A GB0415046D0 (en) | 2004-07-05 | 2004-07-05 | Mass spectrometer |
| PCT/GB2005/002610 WO2006003429A2 (en) | 2004-07-01 | 2005-07-01 | Mass spectrometer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008505339A JP2008505339A (ja) | 2008-02-21 |
| JP2008505339A5 true JP2008505339A5 (https=) | 2008-08-28 |
| JP4852541B2 JP4852541B2 (ja) | 2012-01-11 |
Family
ID=32843596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007519869A Expired - Fee Related JP4852541B2 (ja) | 2004-07-01 | 2005-07-01 | 質量分析方法及び質量分析計 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8063357B2 (https=) |
| EP (1) | EP1779406B1 (https=) |
| JP (1) | JP4852541B2 (https=) |
| CA (2) | CA2851908C (https=) |
| GB (2) | GB0415046D0 (https=) |
| WO (1) | WO2006003429A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020115056A1 (en) | 2000-12-26 | 2002-08-22 | Goodlett David R. | Rapid and quantitative proteome analysis and related methods |
| GB0305796D0 (en) | 2002-07-24 | 2003-04-16 | Micromass Ltd | Method of mass spectrometry and a mass spectrometer |
| GB0609253D0 (en) * | 2006-05-10 | 2006-06-21 | Micromass Ltd | Mass spectrometer |
| US20100312487A1 (en) * | 2006-11-15 | 2010-12-09 | Shimadzu Corporation | Mass analysis data analyzing method and apparatus thereof |
| DE102008023694B4 (de) * | 2008-05-15 | 2010-12-30 | Bruker Daltonik Gmbh | Fragmentierung von Analytionen durch Ionenstoß in HF-Ionenfallen |
| EP2667934B1 (en) | 2011-01-25 | 2020-05-27 | Apellis Holdings, LLC | Apparatus and methods for assisting breathing |
| GB201108082D0 (en) * | 2011-05-16 | 2011-06-29 | Micromass Ltd | Segmented planar calibration for correction of errors in time of flight mass spectrometers |
| CN103703360B (zh) * | 2011-08-03 | 2016-02-24 | 株式会社岛津制作所 | 质量分析数据解析方法以及装置 |
| GB2514836B (en) | 2013-06-07 | 2020-04-22 | Thermo Fisher Scient Bremen Gmbh | Isotopic Pattern Recognition |
| US9998863B2 (en) | 2013-08-19 | 2018-06-12 | Estimote Polska Sp. Z O. O. | System and method for providing content using beacon systems |
| CN105637550A (zh) | 2013-08-19 | 2016-06-01 | 埃斯蒂莫特公司 | 无线信标及方法 |
| JP6079587B2 (ja) * | 2013-11-27 | 2017-02-15 | 株式会社島津製作所 | 糖ペプチド解析装置 |
| CN105917220B (zh) * | 2014-01-16 | 2019-05-28 | 株式会社岛津制作所 | 质谱分析装置 |
| GB201407814D0 (en) * | 2014-05-02 | 2014-06-18 | Pilkington Group Ltd | Glazed solar collectors |
| WO2016145390A1 (en) | 2015-03-12 | 2016-09-15 | Mars, Incorporated | Ultra high resolution mass spectrometry and methods of using the same |
| US10136250B2 (en) | 2015-09-02 | 2018-11-20 | Estimote Polska Sp. Z O. O. | System and method for lower power data routing |
| US10523685B1 (en) | 2018-08-22 | 2019-12-31 | Estimote Polska Sp z o.o. | System and method for verifying device security |
| US10852441B2 (en) | 2018-08-24 | 2020-12-01 | Estimote Polska Sp z o.o. | Method and system for asset management |
| US11239068B2 (en) * | 2018-11-02 | 2022-02-01 | Agilent Technologies, Inc. | Inductively coupled plasma mass spectrometer with mass correction |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1193255A (en) * | 1966-05-27 | 1970-05-28 | Ass Elect Ind | Improvements relating to Mass Spectrometry |
| US4008388A (en) | 1974-05-16 | 1977-02-15 | Universal Monitor Corporation | Mass spectrometric system for rapid, automatic and specific identification and quantitation of compounds |
| US5072115A (en) | 1990-12-14 | 1991-12-10 | Finnigan Corporation | Interpretation of mass spectra of multiply charged ions of mixtures |
| US5453613A (en) | 1994-10-21 | 1995-09-26 | Hewlett Packard Company | Mass spectra interpretation system including spectra extraction |
| US6147348A (en) | 1997-04-11 | 2000-11-14 | University Of Florida | Method for performing a scan function on quadrupole ion trap mass spectrometers |
| US6147344A (en) | 1998-10-15 | 2000-11-14 | Neogenesis, Inc | Method for identifying compounds in a chemical mixture |
| US6289287B1 (en) | 1999-01-29 | 2001-09-11 | Agilent Technologies, Inc. | Identification of sample component using a mass sensor system |
| US6455321B1 (en) | 1999-01-30 | 2002-09-24 | Neo Gen Screening, Inc. | Method for interpreting tandem mass spectrometry data for clinical diagnosis |
| US6258605B1 (en) | 1999-03-26 | 2001-07-10 | Neo Gen Screening, Inc. | Clinical method for the genetic screening of newborns using tandem mass spectrometry |
| US7291767B2 (en) | 2000-07-20 | 2007-11-06 | The Dow Chemical Company | Nucleic acids compositions conferring dwarfing phenotype |
| WO2002037121A2 (en) * | 2000-10-25 | 2002-05-10 | Mds Proteomics, Inc. | Detection of modified amino acids by mass spectrometry |
| US6787761B2 (en) | 2000-11-27 | 2004-09-07 | Surromed, Inc. | Median filter for liquid chromatography-mass spectrometry data |
| WO2002057989A2 (en) | 2001-01-18 | 2002-07-25 | Basf Aktiengesellschaft | Method for metabolic profiling |
| DE10145904A1 (de) | 2001-09-18 | 2003-04-10 | Bruker Daltonik Gmbh | Verfahren zur Aufklärung des Metabolismus |
| US20040023295A1 (en) | 2001-11-21 | 2004-02-05 | Carol Hamilton | Methods and systems for analyzing complex biological systems |
| EP1456667B2 (en) | 2001-12-08 | 2010-01-20 | Micromass UK Limited | Method of mass spectrometry |
| GB2394545B (en) | 2001-12-08 | 2005-03-16 | Micromass Ltd | Method of mass spectrometry |
| US20050164325A1 (en) | 2003-09-24 | 2005-07-28 | Micromass Uk Limited | Method of mass spectrometry |
| GB0322356D0 (en) * | 2003-09-24 | 2003-10-22 | Micromass Ltd | Mass spectrometer |
| US7381568B2 (en) * | 2004-06-02 | 2008-06-03 | Bristol-Myers Squibb Company | Mass defect filter |
-
2004
- 2004-07-05 GB GBGB0415046.2A patent/GB0415046D0/en not_active Ceased
-
2005
- 2005-07-01 WO PCT/GB2005/002610 patent/WO2006003429A2/en not_active Ceased
- 2005-07-01 CA CA2851908A patent/CA2851908C/en not_active Expired - Fee Related
- 2005-07-01 GB GB0513577A patent/GB2417363B/en not_active Expired - Lifetime
- 2005-07-01 CA CA2570174A patent/CA2570174C/en not_active Expired - Fee Related
- 2005-07-01 EP EP05757459.2A patent/EP1779406B1/en not_active Expired - Lifetime
- 2005-07-01 JP JP2007519869A patent/JP4852541B2/ja not_active Expired - Fee Related
- 2005-07-01 US US11/571,338 patent/US8063357B2/en active Active
-
2011
- 2011-10-05 US US13/253,312 patent/US8841606B2/en active Active
-
2014
- 2014-09-22 US US14/492,216 patent/US9390897B2/en not_active Expired - Lifetime
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