JP2008502735A5 - - Google Patents
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- Publication number
- JP2008502735A5 JP2008502735A5 JP2007527776A JP2007527776A JP2008502735A5 JP 2008502735 A5 JP2008502735 A5 JP 2008502735A5 JP 2007527776 A JP2007527776 A JP 2007527776A JP 2007527776 A JP2007527776 A JP 2007527776A JP 2008502735 A5 JP2008502735 A5 JP 2008502735A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- agent
- composition
- group
- polyisoprenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000002562 thickening agent Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 12
- 229940121649 protein inhibitor Drugs 0.000 claims 11
- 239000012268 protein inhibitor Substances 0.000 claims 11
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 201000004624 Dermatitis Diseases 0.000 claims 4
- 239000004909 Moisturizer Substances 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- -1 cleanser Substances 0.000 claims 4
- 230000001333 moisturizer Effects 0.000 claims 4
- WUILNKCFCLNXOK-CFBAGHHKSA-N salirasib Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CSC1=CC=CC=C1C(O)=O WUILNKCFCLNXOK-CFBAGHHKSA-N 0.000 claims 4
- 230000000699 topical effect Effects 0.000 claims 4
- XTURYZYJYQRJDO-BNAHBJSTSA-N Acetyl-farnesyl-cysteine Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CSC[C@@H](C(O)=O)NC(C)=O XTURYZYJYQRJDO-BNAHBJSTSA-N 0.000 claims 3
- 206010052428 Wound Diseases 0.000 claims 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 239000003086 colorant Substances 0.000 claims 3
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000000516 sunscreening agent Substances 0.000 claims 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 2
- BAJXZZVHKJKIOD-UHFFFAOYSA-N 2-(3,7,11-trimethyldodeca-2,6,10-trienyl)pyridine-3-carbothioic s-acid Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCC1=NC=CC=C1C(O)=S BAJXZZVHKJKIOD-UHFFFAOYSA-N 0.000 claims 2
- PFRYVOHLCIMHDV-UHFFFAOYSA-N 2-(3,7,11-trimethyldodeca-2,6,10-trienylsulfanyl)butanedioic acid Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCSC(C(O)=O)CC(O)=O PFRYVOHLCIMHDV-UHFFFAOYSA-N 0.000 claims 2
- KJCWHCKFLZXSTM-UHFFFAOYSA-N 4-(3,7,11-trimethyldodeca-2,6,10-trienylsulfanyl)-2h-triazole Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCSC=1C=NNN=1 KJCWHCKFLZXSTM-UHFFFAOYSA-N 0.000 claims 2
- GDHCKFCHYLHINS-UHFFFAOYSA-O CC(C)=CCCC(C)=CCCC(C)=CC[S+]=C(C1=CC=CC=C1OC)O Chemical compound CC(C)=CCCC(C)=CCCC(C)=CC[S+]=C(C1=CC=CC=C1OC)O GDHCKFCHYLHINS-UHFFFAOYSA-O 0.000 claims 2
- 206010011985 Decubitus ulcer Diseases 0.000 claims 2
- 206010017533 Fungal infection Diseases 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- PKFBJSDMCRJYDC-GEZSXCAASA-N N-acetyl-s-geranylgeranyl-l-cysteine Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CSC[C@@H](C(O)=O)NC(C)=O PKFBJSDMCRJYDC-GEZSXCAASA-N 0.000 claims 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 2
- 150000003863 ammonium salts Chemical class 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 239000003429 antifungal agent Substances 0.000 claims 2
- 229940121375 antifungal agent Drugs 0.000 claims 2
- 208000010668 atopic eczema Diseases 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- 239000006071 cream Substances 0.000 claims 2
- 239000002781 deodorant agent Substances 0.000 claims 2
- 239000007933 dermal patch Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 239000003205 fragrance Substances 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 125000002686 geranylgeranyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 230000003648 hair appearance Effects 0.000 claims 2
- 230000036074 healthy skin Effects 0.000 claims 2
- 239000000017 hydrogel Substances 0.000 claims 2
- 239000002085 irritant Substances 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 239000006210 lotion Substances 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 239000002674 ointment Substances 0.000 claims 2
- 239000003002 pH adjusting agent Substances 0.000 claims 2
- 239000003961 penetration enhancing agent Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 claims 2
- 150000004492 retinoid derivatives Chemical class 0.000 claims 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 2
- 239000002453 shampoo Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- 239000002294 steroidal antiinflammatory agent Substances 0.000 claims 2
- 229960001727 tretinoin Drugs 0.000 claims 2
- YWGFJCHHZZUWCO-BCNIOPEESA-N (2r)-2-acetamido-3-[(2e)-3,7-dimethylocta-2,6-dienyl]sulfanylpropanoic acid Chemical compound CC(C)=CCC\C(C)=C\CSC[C@@H](C(O)=O)NC(C)=O YWGFJCHHZZUWCO-BCNIOPEESA-N 0.000 claims 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- SSTCXMSFOZSNRE-UHFFFAOYSA-N 2-(3,7,11-trimethyldodeca-2,6,10-trienylsulfanyl)ethanesulfonic acid Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCSCCS(O)(=O)=O SSTCXMSFOZSNRE-UHFFFAOYSA-N 0.000 claims 1
- GNWWFEVBHYESNK-XGGJEREUSA-N 2-[(2e,6e)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylacetic acid Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CSCC(O)=O GNWWFEVBHYESNK-XGGJEREUSA-N 0.000 claims 1
- HHXKLPLAKJMLAI-UHFFFAOYSA-N 2-chloro-5-(3,7,11-trimethyldodeca-2,6,10-trienylamino)benzoic acid Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCNC1=CC=C(Cl)C(C(O)=O)=C1 HHXKLPLAKJMLAI-UHFFFAOYSA-N 0.000 claims 1
- 206010002515 Animal bite Diseases 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 208000027496 Behcet disease Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 239000004342 Benzoyl peroxide Substances 0.000 claims 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims 1
- VQVZJIZRZOYHCN-UHFFFAOYSA-N CC(C)=CCCC(C)=CCCC(C)=CC[S+]=C(CCC([O-])=O)O Chemical compound CC(C)=CCCC(C)=CCCC(C)=CC[S+]=C(CCC([O-])=O)O VQVZJIZRZOYHCN-UHFFFAOYSA-N 0.000 claims 1
- 206010007882 Cellulitis Diseases 0.000 claims 1
- 208000001840 Dandruff Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 1
- 206010013786 Dry skin Diseases 0.000 claims 1
- 206010015150 Erythema Diseases 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- 206010016936 Folliculitis Diseases 0.000 claims 1
- 208000006877 Insect Bites and Stings Diseases 0.000 claims 1
- SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 claims 1
- 208000034693 Laceration Diseases 0.000 claims 1
- 206010027627 Miliaria Diseases 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 208000004210 Pressure Ulcer Diseases 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 241001303601 Rosacea Species 0.000 claims 1
- SYSLNQMKLROGCL-BCYUYYMPSA-N S-[(2E,6E)-farnesyl]-L-cysteine zwitterion Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CSC[C@H](N)C(O)=O SYSLNQMKLROGCL-BCYUYYMPSA-N 0.000 claims 1
- 206010040799 Skin atrophy Diseases 0.000 claims 1
- 206010041899 Stab wound Diseases 0.000 claims 1
- 208000025194 Sweat Gland Neoplasms Diseases 0.000 claims 1
- 206010042658 Sweat gland tumour Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
- 125000002009 alkene group Chemical group 0.000 claims 1
- 229930002945 all-trans-retinaldehyde Natural products 0.000 claims 1
- 229940061720 alpha hydroxy acid Drugs 0.000 claims 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 206010002022 amyloidosis Diseases 0.000 claims 1
- 230000001387 anti-histamine Effects 0.000 claims 1
- 230000001153 anti-wrinkle effect Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 235000006708 antioxidants Nutrition 0.000 claims 1
- 239000003904 antiprotozoal agent Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 235000019400 benzoyl peroxide Nutrition 0.000 claims 1
- 150000001277 beta hydroxy acids Chemical class 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003518 caustics Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 208000031513 cyst Diseases 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 150000002016 disaccharides Chemical class 0.000 claims 1
- 230000037336 dry skin Effects 0.000 claims 1
- 239000003974 emollient agent Substances 0.000 claims 1
- 231100000321 erythema Toxicity 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 208000014617 hemorrhoid Diseases 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 229960005280 isotretinoin Drugs 0.000 claims 1
- 239000003410 keratolytic agent Substances 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 239000003223 protective agent Substances 0.000 claims 1
- 235000020945 retinal Nutrition 0.000 claims 1
- 239000011604 retinal Substances 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- NCYCYZXNIZJOKI-OVSJKPMPSA-N retinal group Chemical group C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 claims 1
- 229930002330 retinoic acid Natural products 0.000 claims 1
- 235000020944 retinol Nutrition 0.000 claims 1
- 229960003471 retinol Drugs 0.000 claims 1
- 239000011607 retinol Substances 0.000 claims 1
- 235000019172 retinyl palmitate Nutrition 0.000 claims 1
- 239000011769 retinyl palmitate Substances 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 229960004889 salicylic acid Drugs 0.000 claims 1
- 150000004671 saturated fatty acids Chemical class 0.000 claims 1
- 239000003229 sclerosing agent Substances 0.000 claims 1
- 230000000475 sunscreen effect Effects 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 238000011477 surgical intervention Methods 0.000 claims 1
- 208000027371 sweat gland benign neoplasm Diseases 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 239000004408 titanium dioxide Substances 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 1
- 230000024883 vasodilation Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 235000019155 vitamin A Nutrition 0.000 claims 1
- 239000011719 vitamin A Substances 0.000 claims 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 claims 1
- 229940045997 vitamin a Drugs 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
- 239000011787 zinc oxide Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57909304P | 2004-06-12 | 2004-06-12 | |
| US60/579,093 | 2004-06-12 | ||
| US65292105P | 2005-02-14 | 2005-02-14 | |
| US60/652,921 | 2005-02-14 | ||
| PCT/US2005/020555 WO2005123103A1 (en) | 2004-06-12 | 2005-06-13 | Topical compositions and methods for epithelial-related conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008502735A JP2008502735A (ja) | 2008-01-31 |
| JP2008502735A5 true JP2008502735A5 (https=) | 2008-07-31 |
| JP4987715B2 JP4987715B2 (ja) | 2012-07-25 |
Family
ID=35509456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007527776A Expired - Fee Related JP4987715B2 (ja) | 2004-06-12 | 2005-06-13 | 上皮関連状態のための局所用組成物及び方法 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1765376B1 (https=) |
| JP (1) | JP4987715B2 (https=) |
| KR (1) | KR20070061516A (https=) |
| CN (1) | CN101039689B (https=) |
| AU (1) | AU2005254035B2 (https=) |
| BR (1) | BRPI0512021A (https=) |
| CA (1) | CA2579605C (https=) |
| DK (1) | DK1765376T3 (https=) |
| ES (1) | ES2420516T3 (https=) |
| MX (1) | MXPA06014514A (https=) |
| PT (1) | PT1765376E (https=) |
| RU (1) | RU2007101243A (https=) |
| WO (1) | WO2005123103A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8338648B2 (en) * | 2004-06-12 | 2012-12-25 | Signum Biosciences, Inc. | Topical compositions and methods for epithelial-related conditions |
| GB0525504D0 (en) | 2005-12-14 | 2006-01-25 | Bristol Myers Squibb Co | Antimicrobial composition |
| US20130115320A1 (en) | 2007-03-30 | 2013-05-09 | Dynova Laboratories, Inc. | Therapeutic agent for intranasal administration and method of making and using same |
| GB0823265D0 (en) * | 2008-12-20 | 2009-01-28 | Convatec Technologies Inc | Antimicrobial Composition |
| EP2389357A4 (en) * | 2009-01-20 | 2013-01-23 | Signum Biosciences Inc | INFLAMMATORY COMPLEXES |
| CA2683258C (en) * | 2009-10-20 | 2011-08-09 | Asa Bullion Investment Limited | Lotion for cleaning human anorectal area |
| CN102655745B (zh) | 2009-11-12 | 2016-01-06 | 西格纳姆生物科学公司 | 抗细菌剂用于治疗上皮相关病况的用途 |
| GB201020236D0 (en) | 2010-11-30 | 2011-01-12 | Convatec Technologies Inc | A composition for detecting biofilms on viable tissues |
| CN110075310A (zh) | 2011-12-20 | 2019-08-02 | 维奥姆治疗有限公司 | 用于治疗真菌感染的局部油组合物 |
| US20160243011A1 (en) * | 2012-09-14 | 2016-08-25 | Elizabeth Arden, Inc. | Formulations Comprising Idebenone, N-Acetyl-S-Farnesyl-L-Cysteine and Ergothioneine and Uses Thereof |
| JP2016507663A (ja) | 2012-12-20 | 2016-03-10 | コンバテック・テクノロジーズ・インコーポレイテッドＣｏｎｖａｔｅｃ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ | 化学修飾セルロース系繊維の加工 |
| GB201308770D0 (en) | 2013-05-15 | 2013-06-26 | Convatec Technologies Inc | Wound Dressing Comprising an Antimicrobial Composition |
| CN104739758A (zh) * | 2013-12-30 | 2015-07-01 | 天津高科生产力促进有限公司 | N-乙酰-l-半胱氨酸含漱液 |
| TWI687405B (zh) * | 2016-03-16 | 2020-03-11 | 慧穎應用生物科技有限公司 | 一種沉香樹籽萃取物、製備方法及其應用於抗過敏之用途 |
| EP3497080A4 (en) * | 2016-08-08 | 2020-07-29 | Signum Biosciences, Inc. | PHARMACEUTICAL FORMULATIONS AND THEIR USE |
| FR3104943B1 (fr) * | 2019-12-19 | 2022-05-13 | Oreal | Lipoaminoacides et leurs utilisations comme actif antipelliculaire |
| CN111773212A (zh) * | 2020-08-14 | 2020-10-16 | 云南中医药大学 | 一种瑞香素的应用 |
| CN111909069B (zh) * | 2020-08-25 | 2022-04-19 | 安徽启威生物科技有限公司 | 一种可降解的季铵盐化合物及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3849576A (en) * | 1964-01-29 | 1974-11-19 | Oreal | Process and cosmetic compositions for the treatment of skin and scalp |
| US5043268A (en) * | 1990-05-04 | 1991-08-27 | The Trustees Of Princeton University | Substrates and inhibitors for prenyl cysteine methyltransferase enzymes |
| US5202456A (en) * | 1991-04-15 | 1993-04-13 | The President And Fellows Of Harvard College | Compounds for inhibition of protein methylation |
| IL107587A (en) * | 1993-11-12 | 1998-08-16 | Univ Ramot | Farnesyl geranyl or geranyl-geranyl derivatives pharmaceutical compositions containing them and methods for their preparation |
| US6372793B1 (en) * | 1999-08-20 | 2002-04-16 | Florida Agricultural & Mechanical University | Method for treatment of a neurological disease characterized by impaired neuromodulator function |
| US20030228688A1 (en) * | 2002-05-31 | 2003-12-11 | Isis Pharmaceuticals Inc. | Antisense modulation of isoprenylcysteine carboxyl methyltransferase expression |
| EP1613585A4 (en) * | 2003-03-26 | 2008-07-23 | Purdue Research Foundation | COMPOUNDS AND METHOD FOR USE IN THE TREATMENT OF NEOPLASMS AND CANCER BASED ON INHIBITORS OF ISOPRENYLCYSTEIN METHYLTRANSFERASE |
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2005
- 2005-06-13 WO PCT/US2005/020555 patent/WO2005123103A1/en not_active Ceased
- 2005-06-13 CN CN2005800274693A patent/CN101039689B/zh not_active Expired - Fee Related
- 2005-06-13 CA CA2579605A patent/CA2579605C/en not_active Expired - Fee Related
- 2005-06-13 AU AU2005254035A patent/AU2005254035B2/en not_active Ceased
- 2005-06-13 PT PT57574659T patent/PT1765376E/pt unknown
- 2005-06-13 KR KR1020077000738A patent/KR20070061516A/ko not_active Withdrawn
- 2005-06-13 BR BRPI0512021-7A patent/BRPI0512021A/pt not_active IP Right Cessation
- 2005-06-13 EP EP05757465.9A patent/EP1765376B1/en not_active Expired - Lifetime
- 2005-06-13 DK DK05757465.9T patent/DK1765376T3/da active
- 2005-06-13 RU RU2007101243/15A patent/RU2007101243A/ru not_active Application Discontinuation
- 2005-06-13 MX MXPA06014514A patent/MXPA06014514A/es not_active Application Discontinuation
- 2005-06-13 ES ES05757465T patent/ES2420516T3/es not_active Expired - Lifetime
- 2005-06-13 JP JP2007527776A patent/JP4987715B2/ja not_active Expired - Fee Related
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