JP2008501656A5 - - Google Patents
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- Publication number
- JP2008501656A5 JP2008501656A5 JP2007513821A JP2007513821A JP2008501656A5 JP 2008501656 A5 JP2008501656 A5 JP 2008501656A5 JP 2007513821 A JP2007513821 A JP 2007513821A JP 2007513821 A JP2007513821 A JP 2007513821A JP 2008501656 A5 JP2008501656 A5 JP 2008501656A5
- Authority
- JP
- Japan
- Prior art keywords
- reuptake inhibitor
- monoamine neurotransmitter
- neurotransmitter reuptake
- inhibitor according
- amyloidosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003112 inhibitor Substances 0.000 claims 12
- 230000001561 neurotransmitter reuptake Effects 0.000 claims 11
- 206010002022 amyloidosis Diseases 0.000 claims 4
- 102000001708 Protein Isoforms Human genes 0.000 claims 3
- 108010029485 Protein Isoforms Proteins 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 230000007505 plaque formation Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- XLRPYZSEQKXZAA-OCAPTIKFSA-N tropane Chemical group C1CC[C@H]2CC[C@@H]1N2C XLRPYZSEQKXZAA-OCAPTIKFSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000031124 Dementia Alzheimer type Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 239000002858 neurotransmitter agent Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000007507 senile plaque formation Effects 0.000 claims 1
- 208000022288 senile plaque formation Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04013242 | 2004-06-04 | ||
| PCT/EP2005/005748 WO2005117874A1 (en) | 2004-06-04 | 2005-05-28 | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITOR FOR THE INHIBITION OF BETA-AMYLOID (Aß40 AND Aß42) -GENERATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008501656A JP2008501656A (ja) | 2008-01-24 |
| JP2008501656A5 true JP2008501656A5 (https=) | 2008-06-19 |
Family
ID=34925256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007513821A Abandoned JP2008501656A (ja) | 2004-06-04 | 2005-05-28 | β−アミロイド（Ａβ４０及びＡβ４２）生成阻害のためのモノアミン神経伝達物質再取り込み阻害剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20050277664A1 (https=) |
| EP (1) | EP1755602A1 (https=) |
| JP (1) | JP2008501656A (https=) |
| WO (1) | WO2005117874A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1675591B1 (en) * | 2003-10-16 | 2011-08-10 | NeuroSearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor |
| CA2553649A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
| EP1708707A1 (en) * | 2004-01-22 | 2006-10-11 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
| WO2007028769A1 (en) * | 2005-09-05 | 2007-03-15 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitor for neuroprotection |
| AU2006326853B2 (en) | 2005-12-22 | 2012-02-16 | Es Cell International Pte Ltd | Direct differentiation of cardiomyocytes from human embryonic stem cells |
| AR110122A1 (es) | 2016-11-08 | 2019-02-27 | Hoffmann La Roche | Fenoxitriazoles |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2957693A (en) * | 1956-12-03 | 1960-10-25 | Arthur C Ross | Electrical robot dueler |
| US4934937A (en) * | 1988-12-14 | 1990-06-19 | Tommy Judd | Combat training system and apparatus |
| US5320358A (en) * | 1993-04-27 | 1994-06-14 | Rpb, Inc. | Shooting game having programmable targets and course for use therewith |
| US5599187A (en) * | 1994-12-21 | 1997-02-04 | Mesiano; Dominick N. | Firearm use training device and method |
| US5676548A (en) * | 1995-11-21 | 1997-10-14 | Mcalpin; Jim L. | Apparatus for target practice |
| JP3238414B2 (ja) * | 1996-02-22 | 2001-12-17 | ニューロサーチ・アクティーゼルスカブ | トロパン―誘導体、その製造方法及びその使用方法 |
| JP2005508872A (ja) * | 2001-05-23 | 2005-04-07 | ニューロサーチ、アクティーゼルスカブ | トロパン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
| CA2515732A1 (en) * | 2003-02-12 | 2004-08-26 | Neurosearch A/S | Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP1675591B1 (en) * | 2003-10-16 | 2011-08-10 | NeuroSearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor |
| EP1708707A1 (en) * | 2004-01-22 | 2006-10-11 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
| CA2554616A1 (en) * | 2004-01-22 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and a dopamine agonist |
-
2005
- 2005-05-28 EP EP05754244A patent/EP1755602A1/en not_active Withdrawn
- 2005-05-28 JP JP2007513821A patent/JP2008501656A/ja not_active Abandoned
- 2005-05-28 WO PCT/EP2005/005748 patent/WO2005117874A1/en not_active Ceased
- 2005-06-03 US US11/144,481 patent/US20050277664A1/en not_active Abandoned