JP2008500828A5 - - Google Patents
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- Publication number
- JP2008500828A5 JP2008500828A5 JP2007514089A JP2007514089A JP2008500828A5 JP 2008500828 A5 JP2008500828 A5 JP 2008500828A5 JP 2007514089 A JP2007514089 A JP 2007514089A JP 2007514089 A JP2007514089 A JP 2007514089A JP 2008500828 A5 JP2008500828 A5 JP 2008500828A5
- Authority
- JP
- Japan
- Prior art keywords
- groups
- methyl
- compound
- group
- coor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 19
- -1 t- butyl Chemical group 0.000 claims 17
- 102000004459 Nitroreductase Human genes 0.000 claims 16
- 108020001162 nitroreductase Proteins 0.000 claims 16
- 239000000975 dye Substances 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 12
- 230000000694 effects Effects 0.000 claims 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000003153 chemical reaction reagent Substances 0.000 claims 9
- 230000014509 gene expression Effects 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 7
- 229910004013 NO 2 Inorganic materials 0.000 claims 6
- IHXWECHPYNPJRR-UHFFFAOYSA-N 3-hydroxycyclobut-2-en-1-one Chemical compound OC1=CC(=O)C1 IHXWECHPYNPJRR-UHFFFAOYSA-N 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 239000011593 sulfur Substances 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 230000003287 optical effect Effects 0.000 claims 3
- 238000012216 screening Methods 0.000 claims 2
- IMGNOSJOEJVQJM-UHFFFAOYSA-N (4e)-2-[(e)-[3,3-dimethyl-5-sulfo-1-(4-sulfobutyl)indol-2-ylidene]methyl]-4-[(1-methyl-6-nitroquinolin-1-ium-2-yl)methylidene]-3-oxocyclobuten-1-olate Chemical compound C1=CC2=CC([N+]([O-])=O)=CC=C2[N+](C)=C1C=C1C(=O)C(C=C2C(C3=CC(=CC=C3N2CCCCS(O)(=O)=O)S(O)(=O)=O)(C)C)=C1[O-] IMGNOSJOEJVQJM-UHFFFAOYSA-N 0.000 claims 1
- 229940125904 compound 1 Drugs 0.000 claims 1
- 229940125782 compound 2 Drugs 0.000 claims 1
- 229940126214 compound 3 Drugs 0.000 claims 1
- 229940125898 compound 5 Drugs 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000006502 nitrobenzyl group Chemical group 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 238000012634 optical imaging Methods 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0411993.9 | 2004-05-28 | ||
| GBGB0411993.9A GB0411993D0 (en) | 2004-05-28 | 2004-05-28 | Method and reagent for measuring nitroreductase enzyme activity |
| PCT/GB2005/002057 WO2005118839A1 (en) | 2004-05-28 | 2005-05-24 | Method and reagent for measuring nitroreductase enzyme activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008500828A JP2008500828A (ja) | 2008-01-17 |
| JP2008500828A5 true JP2008500828A5 (https=) | 2008-07-03 |
| JP4838239B2 JP4838239B2 (ja) | 2011-12-14 |
Family
ID=32671256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007514089A Expired - Fee Related JP4838239B2 (ja) | 2004-05-28 | 2005-05-24 | ニトロレダクターゼ酵素活性の測定法及び試薬 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7579140B2 (https=) |
| EP (1) | EP1749103B1 (https=) |
| JP (1) | JP4838239B2 (https=) |
| CN (1) | CN1993477A (https=) |
| AT (1) | ATE553215T1 (https=) |
| AU (1) | AU2005250209B2 (https=) |
| CA (2) | CA2778894C (https=) |
| GB (1) | GB0411993D0 (https=) |
| NZ (2) | NZ551506A (https=) |
| WO (1) | WO2005118839A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7767834B2 (en) | 2004-08-13 | 2010-08-03 | Elitech Holding B.V. | Phosphonylated fluorescent dyes and conjugates |
| EP1781675B1 (en) | 2004-08-13 | 2014-03-26 | Epoch Biosciences, Inc. | Phosphonate fluorescent dyes and conjugates |
| GB0505777D0 (en) * | 2005-03-22 | 2005-04-27 | Amersham Biosciences Uk Ltd | Enzyme detection method and reagent |
| GB0800938D0 (en) | 2008-01-18 | 2008-02-27 | Ge Healthcare Uk Ltd | Multiplex cell signalling assay |
| WO2010151592A1 (en) * | 2009-06-23 | 2010-12-29 | Bayer Healthcare Llc | System and apparatus for determining temperatures in a fluid analyte system |
| JP5535664B2 (ja) * | 2010-01-15 | 2014-07-02 | 株式会社Ａｄｅｋａ | 色調補正剤、スクアリリウム化合物及び光学フィルター |
| US8828678B2 (en) | 2010-11-16 | 2014-09-09 | Enzo Life Sciences, Inc. | Self-immolative probes for enzyme activity detection |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5039818A (en) * | 1986-02-27 | 1991-08-13 | Syntex (U.S.A.) Inc. | Squaraine dye |
| US5403686A (en) | 1993-09-27 | 1995-04-04 | Eastman Kodak Company | Electrophotographic element and imaging method exhibiting reduced incidence of laser interference patterns |
| JP2000508709A (ja) * | 1996-04-19 | 2000-07-11 | アマーシャム・ファルマシア・バイオテック・ユーケイ・リミテッド | スクアラート染料類および蛍光配列決定法におけるそれらの使用 |
| EP1196398A4 (en) | 1999-07-06 | 2002-11-06 | Surromed Inc | BRIDGED FLUORESCENT DYES, THEIR PRODUCTION AND USE IN DETECTION METHODS |
| GB0002261D0 (en) * | 2000-02-02 | 2000-03-22 | Amersham Pharm Biotech Uk Ltd | Fluorescent detection method & reagent |
| AU2003224912A1 (en) * | 2002-04-10 | 2003-10-27 | Igor Borovoy | Dyes and fluorescent compounds |
-
2004
- 2004-05-28 GB GBGB0411993.9A patent/GB0411993D0/en not_active Ceased
-
2005
- 2005-05-24 CA CA2778894A patent/CA2778894C/en not_active Expired - Fee Related
- 2005-05-24 EP EP05746539A patent/EP1749103B1/en not_active Expired - Lifetime
- 2005-05-24 CA CA2568754A patent/CA2568754C/en not_active Expired - Fee Related
- 2005-05-24 NZ NZ551506A patent/NZ551506A/en not_active IP Right Cessation
- 2005-05-24 JP JP2007514089A patent/JP4838239B2/ja not_active Expired - Fee Related
- 2005-05-24 US US11/569,682 patent/US7579140B2/en not_active Expired - Fee Related
- 2005-05-24 CN CNA200580025476XA patent/CN1993477A/zh active Pending
- 2005-05-24 AU AU2005250209A patent/AU2005250209B2/en not_active Ceased
- 2005-05-24 AT AT05746539T patent/ATE553215T1/de active
- 2005-05-24 NZ NZ583956A patent/NZ583956A/en not_active IP Right Cessation
- 2005-05-24 WO PCT/GB2005/002057 patent/WO2005118839A1/en not_active Ceased
-
2009
- 2009-07-10 US US12/500,730 patent/US8378120B2/en not_active Expired - Fee Related
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