AU2005250209B2 - Method and reagent for measuring nitroreductase enzyme activity - Google Patents

Method and reagent for measuring nitroreductase enzyme activity Download PDF

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Publication number
AU2005250209B2
AU2005250209B2 AU2005250209A AU2005250209A AU2005250209B2 AU 2005250209 B2 AU2005250209 B2 AU 2005250209B2 AU 2005250209 A AU2005250209 A AU 2005250209A AU 2005250209 A AU2005250209 A AU 2005250209A AU 2005250209 B2 AU2005250209 B2 AU 2005250209B2
Authority
AU
Australia
Prior art keywords
compound
group
methyl
nitroreductase
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005250209A
Other languages
English (en)
Other versions
AU2005250209A1 (en
Inventor
Rahman Ismail
Richard Martin West
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare UK Ltd
Original Assignee
GE Healthcare UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare UK Ltd filed Critical GE Healthcare UK Ltd
Publication of AU2005250209A1 publication Critical patent/AU2005250209A1/en
Application granted granted Critical
Publication of AU2005250209B2 publication Critical patent/AU2005250209B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/007—Squaraine dyes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2005250209A 2004-05-28 2005-05-24 Method and reagent for measuring nitroreductase enzyme activity Ceased AU2005250209B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0411993.9 2004-05-28
GBGB0411993.9A GB0411993D0 (en) 2004-05-28 2004-05-28 Method and reagent for measuring nitroreductase enzyme activity
PCT/GB2005/002057 WO2005118839A1 (en) 2004-05-28 2005-05-24 Method and reagent for measuring nitroreductase enzyme activity

Publications (2)

Publication Number Publication Date
AU2005250209A1 AU2005250209A1 (en) 2005-12-15
AU2005250209B2 true AU2005250209B2 (en) 2009-07-30

Family

ID=32671256

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005250209A Ceased AU2005250209B2 (en) 2004-05-28 2005-05-24 Method and reagent for measuring nitroreductase enzyme activity

Country Status (10)

Country Link
US (2) US7579140B2 (https=)
EP (1) EP1749103B1 (https=)
JP (1) JP4838239B2 (https=)
CN (1) CN1993477A (https=)
AT (1) ATE553215T1 (https=)
AU (1) AU2005250209B2 (https=)
CA (2) CA2778894C (https=)
GB (1) GB0411993D0 (https=)
NZ (2) NZ551506A (https=)
WO (1) WO2005118839A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767834B2 (en) 2004-08-13 2010-08-03 Elitech Holding B.V. Phosphonylated fluorescent dyes and conjugates
EP1781675B1 (en) 2004-08-13 2014-03-26 Epoch Biosciences, Inc. Phosphonate fluorescent dyes and conjugates
GB0505777D0 (en) * 2005-03-22 2005-04-27 Amersham Biosciences Uk Ltd Enzyme detection method and reagent
GB0800938D0 (en) 2008-01-18 2008-02-27 Ge Healthcare Uk Ltd Multiplex cell signalling assay
WO2010151592A1 (en) * 2009-06-23 2010-12-29 Bayer Healthcare Llc System and apparatus for determining temperatures in a fluid analyte system
JP5535664B2 (ja) * 2010-01-15 2014-07-02 株式会社Ａｄｅｋａ 色調補正剤、スクアリリウム化合物及び光学フィルター
US8828678B2 (en) 2010-11-16 2014-09-09 Enzo Life Sciences, Inc. Self-immolative probes for enzyme activity detection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030186348A1 (en) * 2000-02-02 2003-10-02 Nicholas Thomas Fluorescent detection method and reagent

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039818A (en) * 1986-02-27 1991-08-13 Syntex (U.S.A.) Inc. Squaraine dye
US5403686A (en) 1993-09-27 1995-04-04 Eastman Kodak Company Electrophotographic element and imaging method exhibiting reduced incidence of laser interference patterns
JP2000508709A (ja) * 1996-04-19 2000-07-11 アマーシャム・ファルマシア・バイオテック・ユーケイ・リミテッド スクアラート染料類および蛍光配列決定法におけるそれらの使用
EP1196398A4 (en) 1999-07-06 2002-11-06 Surromed Inc BRIDGED FLUORESCENT DYES, THEIR PRODUCTION AND USE IN DETECTION METHODS
AU2003224912A1 (en) * 2002-04-10 2003-10-27 Igor Borovoy Dyes and fluorescent compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030186348A1 (en) * 2000-02-02 2003-10-02 Nicholas Thomas Fluorescent detection method and reagent

Also Published As

Publication number Publication date
EP1749103B1 (en) 2012-04-11
ATE553215T1 (de) 2012-04-15
US20080317674A1 (en) 2008-12-25
NZ551506A (en) 2010-04-30
CA2568754C (en) 2012-08-21
WO2005118839A1 (en) 2005-12-15
US7579140B2 (en) 2009-08-25
GB0411993D0 (en) 2004-06-30
JP2008500828A (ja) 2008-01-17
EP1749103A1 (en) 2007-02-07
US20090325209A1 (en) 2009-12-31
CA2778894A1 (en) 2005-12-15
CN1993477A (zh) 2007-07-04
CA2778894C (en) 2013-12-31
US8378120B2 (en) 2013-02-19
AU2005250209A1 (en) 2005-12-15
NZ583956A (en) 2011-08-26
CA2568754A1 (en) 2005-12-15
JP4838239B2 (ja) 2011-12-14

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired