JP2008500316A5 - - Google Patents
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- Publication number
- JP2008500316A5 JP2008500316A5 JP2007514085A JP2007514085A JP2008500316A5 JP 2008500316 A5 JP2008500316 A5 JP 2008500316A5 JP 2007514085 A JP2007514085 A JP 2007514085A JP 2007514085 A JP2007514085 A JP 2007514085A JP 2008500316 A5 JP2008500316 A5 JP 2008500316A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- solution
- viii
- vii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 20
- 238000000034 method Methods 0.000 claims 14
- -1 cyano, methyl Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- SXDBWCPKPHAZSM-UHFFFAOYSA-M bromate Inorganic materials [O-]Br(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-M 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 5
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims 4
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 229910052783 alkali metal Inorganic materials 0.000 claims 3
- SXDBWCPKPHAZSM-UHFFFAOYSA-N bromic acid Chemical compound OBr(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-N 0.000 claims 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 3
- 229910052794 bromium Inorganic materials 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 2
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims 1
- 229940001584 sodium metabisulfite Drugs 0.000 claims 1
- 235000010262 sodium metabisulphite Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- XQMRLAJQDHQFQY-LBAQZLPGSA-N Cc1c[n](CC(C2)ON=C2c(cc2)ccc2-c(ccc(N(C[C@H](CNc2n[o]cc2)O2)C2=O)c2)c2F)nn1 Chemical compound Cc1c[n](CC(C2)ON=C2c(cc2)ccc2-c(ccc(N(C[C@H](CNc2n[o]cc2)O2)C2=O)c2)c2F)nn1 XQMRLAJQDHQFQY-LBAQZLPGSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0411596.0A GB0411596D0 (en) | 2004-05-25 | 2004-05-25 | Chemical process |
| PCT/GB2005/002042 WO2005116017A1 (en) | 2004-05-25 | 2005-05-24 | Process for the preparation of aryl substituted oxazolidinones as intermediates for antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008500316A JP2008500316A (ja) | 2008-01-10 |
| JP2008500316A5 true JP2008500316A5 (https=) | 2008-06-26 |
Family
ID=32670975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007514085A Pending JP2008500316A (ja) | 2004-05-25 | 2005-05-24 | 抗菌薬の中間体としてのアリール置換されたオキサゾリジノンの製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090105484A1 (https=) |
| EP (1) | EP1753751A1 (https=) |
| JP (1) | JP2008500316A (https=) |
| CN (1) | CN100537567C (https=) |
| GB (1) | GB0411596D0 (https=) |
| WO (1) | WO2005116017A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| WO2010042887A2 (en) | 2008-10-10 | 2010-04-15 | Trius Therapeutics | Methods for preparing oxazolidinones and compositions containing them |
| KR101918678B1 (ko) | 2009-02-03 | 2018-11-14 | 머크 샤프 앤드 돔 코포레이션 | Ｒ)-3-(4-(2-(2-메틸테트라졸-5-일)피리딘-5-일)-3-플루오로페닐)-5-히드록시메틸 옥사졸리딘-2-온 디히드로겐 포스페이트의 결정형 |
| US8580767B2 (en) | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002057207A1 (en) * | 2001-01-22 | 2002-07-25 | Council Of Scientific And Industrial Research | An eco-friendly method of preparation of high purity tetrabromobisphenol-a |
| US7396847B2 (en) * | 2001-09-11 | 2008-07-08 | Astrazeneca Ab | Oxazolidinone and/or isoxazoline as antibacterial agents |
| GB2396350A (en) * | 2001-10-25 | 2004-06-23 | Astrazeneca Ab | Aryl substituted oxazolidinones with antibacterial activity |
| JP2005524661A (ja) * | 2002-02-28 | 2005-08-18 | アストラゼネカ アクチボラグ | ３−シクリル−５−（窒素含有５員環）メチル−オキサゾリジノン誘導体と抗菌剤としてのその使用 |
| JP2003335762A (ja) * | 2002-05-20 | 2003-11-28 | Meiji Seika Kaisha Ltd | 新規ビフェニル誘導体 |
| TW200500360A (en) * | 2003-03-01 | 2005-01-01 | Astrazeneca Ab | Hydroxymethyl compounds |
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2004
- 2004-05-25 GB GBGB0411596.0A patent/GB0411596D0/en not_active Ceased
-
2005
- 2005-05-24 US US11/569,399 patent/US20090105484A1/en not_active Abandoned
- 2005-05-24 JP JP2007514085A patent/JP2008500316A/ja active Pending
- 2005-05-24 CN CNB2005800249846A patent/CN100537567C/zh not_active Expired - Fee Related
- 2005-05-24 EP EP05746863A patent/EP1753751A1/en not_active Withdrawn
- 2005-05-24 WO PCT/GB2005/002042 patent/WO2005116017A1/en not_active Ceased