JP2008500074A - 脳のニューロン活動をデカップリング及び／又は非同期にする方法及び装置 - Google Patents
脳のニューロン活動をデカップリング及び／又は非同期にする方法及び装置 Download PDFInfo
- Publication number
- JP2008500074A JP2008500074A JP2007513667A JP2007513667A JP2008500074A JP 2008500074 A JP2008500074 A JP 2008500074A JP 2007513667 A JP2007513667 A JP 2007513667A JP 2007513667 A JP2007513667 A JP 2007513667A JP 2008500074 A JP2008500074 A JP 2008500074A
- Authority
- JP
- Japan
- Prior art keywords
- control system
- stimulation
- stimulus
- signal
- neurons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000001537 neural effect Effects 0.000 title claims abstract description 136
- 210000004556 brain Anatomy 0.000 title claims abstract description 50
- 238000000034 method Methods 0.000 title claims description 77
- 210000002569 neuron Anatomy 0.000 claims abstract description 300
- 230000000638 stimulation Effects 0.000 claims abstract description 293
- 230000000694 effects Effects 0.000 claims abstract description 132
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 62
- 201000010099 disease Diseases 0.000 claims abstract description 60
- 230000002159 abnormal effect Effects 0.000 claims abstract description 59
- 238000005259 measurement Methods 0.000 claims description 69
- 238000012545 processing Methods 0.000 claims description 36
- 230000008878 coupling Effects 0.000 claims description 28
- 238000010168 coupling process Methods 0.000 claims description 28
- 238000005859 coupling reaction Methods 0.000 claims description 28
- 230000008569 process Effects 0.000 claims description 21
- 238000010304 firing Methods 0.000 claims description 20
- 238000004458 analytical method Methods 0.000 claims description 17
- 238000001914 filtration Methods 0.000 claims description 13
- 230000005856 abnormality Effects 0.000 claims description 11
- 208000018737 Parkinson disease Diseases 0.000 claims description 10
- 230000008859 change Effects 0.000 claims description 10
- 210000004126 nerve fiber Anatomy 0.000 claims description 10
- 210000003205 muscle Anatomy 0.000 claims description 9
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 8
- 201000006517 essential tremor Diseases 0.000 claims description 8
- 206010003591 Ataxia Diseases 0.000 claims description 7
- 230000005540 biological transmission Effects 0.000 claims description 7
- 206010015037 epilepsy Diseases 0.000 claims description 7
- 238000011156 evaluation Methods 0.000 claims description 7
- 230000001934 delay Effects 0.000 claims description 5
- 238000012886 linear function Methods 0.000 claims description 5
- 230000002596 correlated effect Effects 0.000 claims description 4
- 230000002547 anomalous effect Effects 0.000 claims description 2
- 230000009466 transformation Effects 0.000 claims description 2
- 238000000844 transformation Methods 0.000 claims description 2
- 230000001131 transforming effect Effects 0.000 claims 2
- 238000010292 electrical insulation Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 abstract description 23
- 230000001360 synchronised effect Effects 0.000 abstract description 22
- 230000003111 delayed effect Effects 0.000 abstract description 6
- 230000007177 brain activity Effects 0.000 abstract description 3
- 230000005821 brain abnormality Effects 0.000 abstract 1
- 230000006978 adaptation Effects 0.000 description 16
- 230000003287 optical effect Effects 0.000 description 16
- 230000033764 rhythmic process Effects 0.000 description 15
- 230000002459 sustained effect Effects 0.000 description 15
- 206010044565 Tremor Diseases 0.000 description 13
- 238000002513 implantation Methods 0.000 description 11
- 230000007246 mechanism Effects 0.000 description 11
- 230000001020 rhythmical effect Effects 0.000 description 11
- 238000001356 surgical procedure Methods 0.000 description 11
- 210000001519 tissue Anatomy 0.000 description 11
- 230000001276 controlling effect Effects 0.000 description 9
- 230000004936 stimulating effect Effects 0.000 description 9
- 230000008901 benefit Effects 0.000 description 7
- 238000004364 calculation method Methods 0.000 description 7
- 210000003484 anatomy Anatomy 0.000 description 6
- 210000004227 basal ganglia Anatomy 0.000 description 6
- 230000003993 interaction Effects 0.000 description 6
- 238000002955 isolation Methods 0.000 description 6
- 210000001103 thalamus Anatomy 0.000 description 6
- 230000006870 function Effects 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 230000000542 thalamic effect Effects 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 230000000926 neurological effect Effects 0.000 description 4
- 208000020016 psychiatric disease Diseases 0.000 description 4
- 230000003252 repetitive effect Effects 0.000 description 4
- 230000003595 spectral effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 210000005013 brain tissue Anatomy 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000013307 optical fiber Substances 0.000 description 3
- 230000000737 periodic effect Effects 0.000 description 3
- 230000000451 tissue damage Effects 0.000 description 3
- 231100000827 tissue damage Toxicity 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 208000009017 Athetosis Diseases 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000036982 action potential Effects 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 230000002146 bilateral effect Effects 0.000 description 2
- 208000034158 bleeding Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 210000003710 cerebral cortex Anatomy 0.000 description 2
- 210000004720 cerebrum Anatomy 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 230000001808 coupling effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
- 208000014617 hemorrhoid Diseases 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 210000000337 motor cortex Anatomy 0.000 description 2
- 201000006417 multiple sclerosis Diseases 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 201000000980 schizophrenia Diseases 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010003162 Arterial injury Diseases 0.000 description 1
- 206010008025 Cerebellar ataxia Diseases 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 206010008754 Choreoathetosis Diseases 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000006931 brain damage Effects 0.000 description 1
- 231100000874 brain damage Toxicity 0.000 description 1
- 208000029028 brain injury Diseases 0.000 description 1
- 210000001159 caudate nucleus Anatomy 0.000 description 1
- 210000001638 cerebellum Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000003109 clavicle Anatomy 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000009266 disease activity Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000002267 hypothalamic effect Effects 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000010363 phase shift Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 210000000976 primary motor cortex Anatomy 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 208000027765 speech disease Diseases 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000000946 synaptic effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36067—Movement disorders, e.g. tremor or Parkinson disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
- A61B5/0006—ECG or EEG signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
- A61B5/372—Analysis of electroencephalograms
- A61B5/374—Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
- A61B5/4082—Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7225—Details of analogue processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7253—Details of waveform analysis characterised by using transforms
- A61B5/726—Details of waveform analysis characterised by using transforms using Wavelet transforms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/06—Electrodes for high-frequency therapy
Landscapes
- Health & Medical Sciences (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Developmental Disabilities (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004025945A DE102004025945A1 (de) | 2004-05-27 | 2004-05-27 | Verfahren und Vorrichtung zur Entkopplung und/oder Desynchronisation neuronaler Hirnaktivität |
| PCT/DE2005/000780 WO2005115537A1 (de) | 2004-05-27 | 2005-04-28 | Verfahren und vorrichtung zur entkopplung und/oder desynchronisation neuronaler hirnaktivität |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008500074A true JP2008500074A (ja) | 2008-01-10 |
| JP2008500074A5 JP2008500074A5 (cg-RX-API-DMAC10.html) | 2011-02-17 |
Family
ID=34969225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007513667A Pending JP2008500074A (ja) | 2004-05-27 | 2005-04-28 | 脳のニューロン活動をデカップリング及び／又は非同期にする方法及び装置 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8000796B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1748819B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2008500074A (cg-RX-API-DMAC10.html) |
| CN (1) | CN1956751B (cg-RX-API-DMAC10.html) |
| CA (1) | CA2567392C (cg-RX-API-DMAC10.html) |
| DE (1) | DE102004025945A1 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2600579T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2005115537A1 (cg-RX-API-DMAC10.html) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140042711A (ko) * | 2012-09-28 | 2014-04-07 | 한양대학교 산학협력단 | 뇌심부 자극을 위한 능동적 자극 패턴 조절 기능을 갖는 적응형 뇌심부 자극 시스템 |
| JP2017535364A (ja) * | 2014-11-27 | 2017-11-30 | フォースチュングスヌートラム ユーリッヒ ゲーエムベーハー | 様々な刺激系列による効果的な非侵襲性神経刺激のためのデバイスおよび方法 |
| CN109069829A (zh) * | 2016-03-16 | 2018-12-21 | 于利奇研究中心有限公司 | 用于有效侵入式并且振幅受到调制的神经元刺激的设备 |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7346382B2 (en) | 2004-07-07 | 2008-03-18 | The Cleveland Clinic Foundation | Brain stimulation models, systems, devices, and methods |
| US11389661B2 (en) * | 2005-01-21 | 2022-07-19 | Michael Sasha John | Programming adjustment for brain network treatment |
| US9211408B2 (en) | 2005-04-13 | 2015-12-15 | The Cleveland Clinic Foundation | System and method for neuromodulation using composite patterns of stimulation or waveforms |
| US8112154B2 (en) * | 2005-04-13 | 2012-02-07 | The Cleveland Clinic Foundation | Systems and methods for neuromodulation using pre-recorded waveforms |
| US9339650B2 (en) | 2005-04-13 | 2016-05-17 | The Cleveland Clinic Foundation | Systems and methods for neuromodulation using pre-recorded waveforms |
| US7398213B1 (en) * | 2005-05-17 | 2008-07-08 | Exaudios Technologies | Method and system for diagnosing pathological phenomenon using a voice signal |
| US8280514B2 (en) | 2006-10-31 | 2012-10-02 | Advanced Neuromodulation Systems, Inc. | Identifying areas of the brain by examining the neuronal signals |
| AT10617U1 (de) * | 2007-04-20 | 2009-07-15 | Szeles Jozsef Constantin Dr | Gerät zur punktual-stimulation |
| JP5425795B2 (ja) * | 2007-10-29 | 2014-02-26 | ケース ウェスタン リザーブ ユニバーシティ | 初動緩和高周波数神経ブロック |
| US9220889B2 (en) | 2008-02-11 | 2015-12-29 | Intelect Medical, Inc. | Directional electrode devices with locating features |
| US8019440B2 (en) | 2008-02-12 | 2011-09-13 | Intelect Medical, Inc. | Directional lead assembly |
| US9310985B2 (en) | 2008-05-15 | 2016-04-12 | Boston Scientific Neuromodulation Corporation | System and method for determining target stimulation volumes |
| US9272153B2 (en) | 2008-05-15 | 2016-03-01 | Boston Scientific Neuromodulation Corporation | VOA generation system and method using a fiber specific analysis |
| US20110004114A1 (en) * | 2009-07-06 | 2011-01-06 | Farida Hanna Schenck (Campbell), | Cognitive information encoding conversion telecommunication system and conferencing method |
| CA2772330A1 (en) | 2009-08-27 | 2011-03-03 | The Cleveland Clinic Foundation | System and method to estimate region of tissue activation |
| WO2011068997A1 (en) | 2009-12-02 | 2011-06-09 | The Cleveland Clinic Foundation | Reversing cognitive-motor impairments in patients having a neuro-degenerative disease using a computational modeling approach to deep brain stimulation programming |
| WO2011159688A2 (en) | 2010-06-14 | 2011-12-22 | Boston Scientific Neuromodulation Corporation | Programming interface for spinal cord neuromodulation |
| US9669213B2 (en) * | 2011-01-24 | 2017-06-06 | David Tsai | Stimulation method for maintaining the responsiveness of electrically excitable cells to repeated electrical stimulation |
| DE102011010956A1 (de) * | 2011-02-10 | 2012-08-16 | Theodor Schuldes | Gerät zur Stimulation von Probanden |
| US9592389B2 (en) | 2011-05-27 | 2017-03-14 | Boston Scientific Neuromodulation Corporation | Visualization of relevant stimulation leadwire electrodes relative to selected stimulation information |
| WO2013023081A1 (en) | 2011-08-09 | 2013-02-14 | Boston Scientific Neuromodulation Corporation | Remote control for blind clinical trials of electrical stimulation |
| EP2879757B1 (en) | 2012-08-04 | 2019-06-26 | Boston Scientific Neuromodulation Corporation | Systems and methods for storing and transferring registration, atlas, and lead information between medical devices |
| EP2890454B1 (en) | 2012-08-28 | 2017-11-08 | Boston Scientific Neuromodulation Corporation | Point-and-click programming for deep brain stimulation using real-time monopolar review trendlines |
| US9792412B2 (en) | 2012-11-01 | 2017-10-17 | Boston Scientific Neuromodulation Corporation | Systems and methods for VOA model generation and use |
| CN103054574B (zh) * | 2013-01-06 | 2014-07-09 | 电子科技大学 | 基于多变量同步指数的频率识别方法 |
| CN114768089A (zh) | 2013-01-21 | 2022-07-22 | 卡拉健康公司 | 用于控制震颤的设备和方法 |
| US12453853B2 (en) | 2013-01-21 | 2025-10-28 | Cala Health, Inc. | Multi-modal stimulation for treating tremor |
| US9174053B2 (en) | 2013-03-08 | 2015-11-03 | Boston Scientific Neuromodulation Corporation | Neuromodulation using modulated pulse train |
| US11229789B2 (en) | 2013-05-30 | 2022-01-25 | Neurostim Oab, Inc. | Neuro activator with controller |
| EP3441109A1 (en) | 2013-05-30 | 2019-02-13 | Graham H. Creasey | Flexible dermal patch for a topical nerve stimulator system |
| US11083402B2 (en) | 2013-06-04 | 2021-08-10 | Medtronic, Inc. | Patient state determination based on one or more spectral characteristics of a bioelectrical brain signal |
| BR112016025203B1 (pt) | 2014-06-02 | 2022-09-06 | Cala Health, Inc | Sistema transcutâneo para tratar um paciente que sofre de tremor |
| US9959388B2 (en) | 2014-07-24 | 2018-05-01 | Boston Scientific Neuromodulation Corporation | Systems, devices, and methods for providing electrical stimulation therapy feedback |
| US10265528B2 (en) | 2014-07-30 | 2019-04-23 | Boston Scientific Neuromodulation Corporation | Systems and methods for electrical stimulation-related patient population volume analysis and use |
| US10272247B2 (en) | 2014-07-30 | 2019-04-30 | Boston Scientific Neuromodulation Corporation | Systems and methods for stimulation-related volume analysis, creation, and sharing with integrated surgical planning and stimulation programming |
| AU2015328575B2 (en) | 2014-09-22 | 2018-07-19 | Boston Scientific Neuromodulation Corporation | Devices and methods to use power spectrum or signal association for pain management |
| US9901737B2 (en) | 2014-09-22 | 2018-02-27 | Boston Scientific Neuromodulation Corporation | Systems and methods for providing therapy to a patient using intermittent electrical stimulation |
| US9925377B2 (en) | 2014-09-22 | 2018-03-27 | Boston Scientific Neuromodulation Corporation | Systems and methods for providing therapy using electrical stimulation to disrupt neuronal activity |
| US9833622B2 (en) | 2014-09-22 | 2017-12-05 | Boston Scientific Neuromodulation Corporation | Devices and methods using a pathological frequency in electrical stimulation for pain management |
| AU2015321473B2 (en) | 2014-09-22 | 2018-02-01 | Boston Scientific Neuromodulation Corporation | Systems and methods for providing therapy using electrical stimulation to disrupt neuronal activity |
| US9974959B2 (en) | 2014-10-07 | 2018-05-22 | Boston Scientific Neuromodulation Corporation | Systems, devices, and methods for electrical stimulation using feedback to adjust stimulation parameters |
| DE102014115997B4 (de) * | 2014-11-03 | 2016-12-22 | Forschungszentrum Jülich GmbH | Vorrichtung zur effektiven nicht-invasiven desynchronisierenden Neurostimulation |
| DE102014115994B4 (de) * | 2014-11-03 | 2016-12-22 | Forschungszentrum Jülich GmbH | Vorrichtung zur effektiven invasiven desynchronisierenden Neurostimulation |
| US11077301B2 (en) | 2015-02-21 | 2021-08-03 | NeurostimOAB, Inc. | Topical nerve stimulator and sensor for bladder control |
| AU2016268259B2 (en) | 2015-05-26 | 2019-01-31 | Boston Scientific Neuromodulation Corporation | Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation |
| US10780283B2 (en) | 2015-05-26 | 2020-09-22 | Boston Scientific Neuromodulation Corporation | Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation |
| EP3302690B1 (en) * | 2015-05-28 | 2019-09-25 | Boston Scientific Neuromodulation Corporation | Neuromodulation system using stochastically-modulated stimulation parameters |
| CA2988586A1 (en) | 2015-06-10 | 2016-12-15 | Cala Health, Inc. | Neuromodulation system for peripheral nerve stimulation with detachable therapy unit |
| ES2940303T3 (es) | 2015-06-29 | 2023-05-05 | Boston Scient Neuromodulation Corp | Sistemas de selección de parámetros de estimulación por uso de dianas y direccionamiento |
| US20160375248A1 (en) | 2015-06-29 | 2016-12-29 | Boston Scientific Neuromodulation Corporation | Systems and methods for selecting stimulation parameters based on stimulation target region, effects, or side effects |
| US20200093400A1 (en) | 2015-07-31 | 2020-03-26 | Cala Health, Inc. | Systems, devices, and method for the treatment of osteoarthritis |
| CN105138863B (zh) * | 2015-08-05 | 2017-02-15 | 陕西师范大学 | 具有耦合时滞的模块神经元网络簇同步的抑制方法 |
| WO2017053847A1 (en) | 2015-09-23 | 2017-03-30 | Cala Health, Inc. | Systems and methods for peripheral nerve stimulation in the finger or hand to treat hand tremors |
| US10413737B2 (en) | 2015-09-25 | 2019-09-17 | Boston Scientific Neuromodulation Corporation | Systems and methods for providing therapy using electrical stimulation to disrupt neuronal activity |
| US10071249B2 (en) | 2015-10-09 | 2018-09-11 | Boston Scientific Neuromodulation Corporation | System and methods for clinical effects mapping for directional stimulation leads |
| US11344722B2 (en) | 2016-01-21 | 2022-05-31 | Cala Health, Inc. | Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder |
| US10406368B2 (en) * | 2016-04-19 | 2019-09-10 | Boston Scientific Neuromodulation Corporation | Pulse generator system for promoting desynchronized firing of recruited neural populations |
| US10716942B2 (en) | 2016-04-25 | 2020-07-21 | Boston Scientific Neuromodulation Corporation | System and methods for directional steering of electrical stimulation |
| WO2017223430A1 (en) * | 2016-06-23 | 2017-12-28 | The General Hospital Corporation | Systems and methods for controlling brain activity |
| JP6905541B2 (ja) | 2016-06-24 | 2021-07-21 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 臨床効果の視覚分析のためのシステム及び方法 |
| AU2017293799B2 (en) | 2016-07-08 | 2022-10-20 | Cala Health, Inc. | Systems and methods for stimulating n nerves with exactly n electrodes and improved dry electrodes |
| CA3033662A1 (en) | 2016-08-25 | 2018-03-01 | Cala Health, Inc. | Systems and methods for treating cardiac dysfunction through peripheral nerve stimulation |
| US10350404B2 (en) | 2016-09-02 | 2019-07-16 | Boston Scientific Neuromodulation Corporation | Systems and methods for visualizing and directing stimulation of neural elements |
| US10780282B2 (en) | 2016-09-20 | 2020-09-22 | Boston Scientific Neuromodulation Corporation | Systems and methods for steering electrical stimulation of patient tissue and determining stimulation parameters |
| JP6828149B2 (ja) | 2016-10-14 | 2021-02-10 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 電気刺激システムに対する刺激パラメータ設定の閉ループ決定のためのシステム及び方法 |
| AU2017391436B2 (en) | 2017-01-03 | 2020-06-18 | Boston Scientific Neuromodulation Corporation | Systems and methods for selecting MRI-compatible stimulation parameters |
| WO2018132334A1 (en) | 2017-01-10 | 2018-07-19 | Boston Scientific Neuromodulation Corporation | Systems and methods for creating stimulation programs based on user-defined areas or volumes |
| US10625082B2 (en) | 2017-03-15 | 2020-04-21 | Boston Scientific Neuromodulation Corporation | Visualization of deep brain stimulation efficacy |
| EP3606604A4 (en) | 2017-04-03 | 2020-12-16 | Cala Health, Inc. | PERIPHERAL NEUROMODULATION SYSTEMS, METHODS AND DEVICES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH BLADDER HYPERACTIVITY |
| US11357986B2 (en) | 2017-04-03 | 2022-06-14 | Boston Scientific Neuromodulation Corporation | Systems and methods for estimating a volume of activation using a compressed database of threshold values |
| EP3651849B1 (en) | 2017-07-14 | 2023-05-31 | Boston Scientific Neuromodulation Corporation | Estimating clinical effects of electrical stimulation |
| US10960214B2 (en) | 2017-08-15 | 2021-03-30 | Boston Scientific Neuromodulation Corporation | Systems and methods for controlling electrical stimulation using multiple stimulation fields |
| EP3706856A4 (en) | 2017-11-07 | 2021-08-18 | Neurostim Oab, Inc. | NON-INVASIVE NERVOUS ACTIVATOR WITH ADAPTIVE CIRCUIT |
| WO2019099887A1 (en) | 2017-11-17 | 2019-05-23 | Boston Scientific Neuromodulation Corporation | Systems and methods for generating intermittent stimulation using electrical stimulation systems |
| WO2019143790A1 (en) | 2018-01-17 | 2019-07-25 | Cala Health, Inc. | Systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation |
| WO2019210202A1 (en) | 2018-04-27 | 2019-10-31 | Boston Scientific Neuromodulation Corporation | Multi-mode electrical stimulation systems and methods of making and using |
| US11285329B2 (en) | 2018-04-27 | 2022-03-29 | Boston Scientific Neuromodulation Corporation | Systems and methods for visualizing and programming electrical stimulation |
| WO2020049004A1 (en) * | 2018-09-03 | 2020-03-12 | Gretap Ag C/O Vtb Verwaltung, Treuhand Und Beratung Ag | Medical treatment device and method for stimulating neurons of a patient to suppress a pathologically synchronous activity of the neurons |
| US11458311B2 (en) | 2019-06-26 | 2022-10-04 | Neurostim Technologies Llc | Non-invasive nerve activator patch with adaptive circuit |
| US12251560B1 (en) | 2019-08-13 | 2025-03-18 | Cala Health, Inc. | Connection quality determination for wearable neurostimulation systems |
| US11890468B1 (en) | 2019-10-03 | 2024-02-06 | Cala Health, Inc. | Neurostimulation systems with event pattern detection and classification |
| EP4017580A4 (en) | 2019-12-16 | 2023-09-06 | Neurostim Technologies LLC | NON-INVASIVE NERVE ACTIVATOR WITH ENHANCED CHARGE DELIVERY |
| EP4291294A1 (en) | 2021-04-27 | 2023-12-20 | Boston Scientific Neuromodulation Corporation | Systems and methods for automated programming of electrical stimulation |
| US12403313B2 (en) | 2021-06-15 | 2025-09-02 | Boston Scientific Neuromodulation Corporation | Methods and systems for estimating neural activation by stimulation using a stimulation system |
| CN118251257A (zh) | 2021-12-09 | 2024-06-25 | 波士顿科学神经调制公司 | 用于使用刺激系统监测或评估运动障碍或其他生理参数的方法和系统 |
| US12471831B2 (en) | 2021-12-10 | 2025-11-18 | Boston Scientific Neuromodulation Corporation | Systems and methods for generating and using response maps for electrical stimulation |
| US12690801B2 (en) | 2021-12-10 | 2026-07-28 | Boston Scientific Neuromodulation Corporation | Methods and systems for determining and using an intensity index for electrical stimulation |
| CN114305429B (zh) * | 2022-01-10 | 2023-07-28 | 中国人民解放军军事科学院军事医学研究院 | 经颅直流电刺激信号与脑电信号同步的电极帽和测试方法 |
| WO2023167872A1 (en) | 2022-03-02 | 2023-09-07 | Boston Scientific Neuromodulation Corporation | Systems and methods for monitoring stimulation drift in an electrical stimulation system |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003077985A1 (de) * | 2002-03-14 | 2003-09-25 | Forschungszentrum Jülich GmbH | Vorrichtung zur behandlung von patienten mittels hirnstimulation |
| WO2004016165A1 (de) * | 2002-07-29 | 2004-02-26 | Forschungszentrum Jülich GmbH | Vorrichtung zur modulation neuronaler aktivität im gehirn mittels sensorischer stimulation und detektion hirnaktivität |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8406509D0 (en) * | 1984-03-13 | 1984-04-18 | Bio Medical Res Ltd | Electrical stimulation of muscle |
| US6480743B1 (en) * | 2000-04-05 | 2002-11-12 | Neuropace, Inc. | System and method for adaptive brain stimulation |
| US6944501B1 (en) * | 2000-04-05 | 2005-09-13 | Neurospace, Inc. | Neurostimulator involving stimulation strategies and process for using it |
| US5683422A (en) * | 1996-04-25 | 1997-11-04 | Medtronic, Inc. | Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation |
| US6459936B2 (en) * | 1997-10-27 | 2002-10-01 | Neuropace, Inc. | Methods for responsively treating neurological disorders |
| US6366813B1 (en) * | 1998-08-05 | 2002-04-02 | Dilorenzo Daniel J. | Apparatus and method for closed-loop intracranical stimulation for optimal control of neurological disease |
| US6466822B1 (en) * | 2000-04-05 | 2002-10-15 | Neuropace, Inc. | Multimodal neurostimulator and process of using it |
| US6529774B1 (en) * | 2000-11-09 | 2003-03-04 | Neuropace, Inc. | Extradural leads, neurostimulator assemblies, and processes of using them for somatosensory and brain stimulation |
| DE10211765B4 (de) * | 2002-03-14 | 2004-06-03 | Forschungszentrum Jülich GmbH | Vorrichtung zur Lokalisation des Zielpunktes von Elektroden zur Hirnstimulation, insbesondere zur Tiefenhirnstimulation |
| DE10318071A1 (de) * | 2003-04-17 | 2004-11-25 | Forschungszentrum Jülich GmbH | Vorrichtung zur Desynchronisation von neuronaler Hirnaktivität |
| DE10355652A1 (de) * | 2003-11-28 | 2005-06-30 | Forschungszentrum Jülich GmbH | Verfahren und Vorrichtung zur Desynchronisation neuronaler Hirnaktivität |
-
2004
- 2004-05-27 DE DE102004025945A patent/DE102004025945A1/de not_active Ceased
-
2005
- 2005-04-28 WO PCT/DE2005/000780 patent/WO2005115537A1/de not_active Ceased
- 2005-04-28 ES ES05745186.6T patent/ES2600579T3/es not_active Expired - Lifetime
- 2005-04-28 CA CA2567392A patent/CA2567392C/en not_active Expired - Fee Related
- 2005-04-28 CN CN2005800167850A patent/CN1956751B/zh not_active Expired - Fee Related
- 2005-04-28 EP EP05745186.6A patent/EP1748819B1/de not_active Expired - Lifetime
- 2005-04-28 JP JP2007513667A patent/JP2008500074A/ja active Pending
-
2006
- 2006-11-27 US US11/604,284 patent/US8000796B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003077985A1 (de) * | 2002-03-14 | 2003-09-25 | Forschungszentrum Jülich GmbH | Vorrichtung zur behandlung von patienten mittels hirnstimulation |
| WO2004016165A1 (de) * | 2002-07-29 | 2004-02-26 | Forschungszentrum Jülich GmbH | Vorrichtung zur modulation neuronaler aktivität im gehirn mittels sensorischer stimulation und detektion hirnaktivität |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140042711A (ko) * | 2012-09-28 | 2014-04-07 | 한양대학교 산학협력단 | 뇌심부 자극을 위한 능동적 자극 패턴 조절 기능을 갖는 적응형 뇌심부 자극 시스템 |
| KR101583044B1 (ko) | 2012-09-28 | 2016-01-07 | 한양대학교 산학협력단 | 뇌심부 자극을 위한 능동적 자극 패턴 조절 기능을 갖는 적응형 뇌심부 자극 시스템 |
| JP2017535364A (ja) * | 2014-11-27 | 2017-11-30 | フォースチュングスヌートラム ユーリッヒ ゲーエムベーハー | 様々な刺激系列による効果的な非侵襲性神経刺激のためのデバイスおよび方法 |
| CN109069829A (zh) * | 2016-03-16 | 2018-12-21 | 于利奇研究中心有限公司 | 用于有效侵入式并且振幅受到调制的神经元刺激的设备 |
| JP2019508138A (ja) * | 2016-03-16 | 2019-03-28 | フォースチュングスヌートラム ユーリッヒ ゲーエムベーハー | 効果的な侵襲性振幅変調神経刺激のための装置と方法 |
| CN109069829B (zh) * | 2016-03-16 | 2022-07-05 | 于利奇研究中心有限公司 | 用于有效侵入式并且振幅受到调制的神经元刺激的设备 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1956751A (zh) | 2007-05-02 |
| DE102004025945A1 (de) | 2005-12-29 |
| ES2600579T3 (es) | 2017-02-09 |
| WO2005115537A1 (de) | 2005-12-08 |
| EP1748819A1 (de) | 2007-02-07 |
| CA2567392C (en) | 2012-10-02 |
| US8000796B2 (en) | 2011-08-16 |
| US20070203532A1 (en) | 2007-08-30 |
| CN1956751B (zh) | 2012-08-22 |
| CA2567392A1 (en) | 2005-12-08 |
| EP1748819B1 (de) | 2016-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008500074A5 (cg-RX-API-DMAC10.html) | ||
| JP4855244B2 (ja) | 脳のニューロン活動を非同期にする装置 | |
| CA2567392C (en) | Method and device for decoupling and/or desynchronizing neural brain activity | |
| JP4489080B2 (ja) | 脳の神経活動を脱同期化するための方法及び装置 | |
| US6480743B1 (en) | System and method for adaptive brain stimulation | |
| EP1335668B1 (en) | Detecting neurological dysfunction | |
| CN104144728B (zh) | 校准侵入式、电的且去同步化的神经刺激的装置和方法 | |
| JP2006523474A5 (cg-RX-API-DMAC10.html) | ||
| US10350410B2 (en) | Device and method for effective non-invasive neurostimulation by means of varying stimulus sequences | |
| AU2006214074B2 (en) | System and method of prediction of response to neurological treatment using the electroencephalogram | |
| JP4757868B2 (ja) | 脳刺激によって患者を治療する装置 | |
| US12303694B2 (en) | Methods and systems for optimizing therapy using stimulation mimicking natural seizures | |
| US10722678B2 (en) | Device and method for effective non-invasive two-stage neurostimulation | |
| WO2004043536A1 (en) | System for adaptive brain stimulation | |
| JP2008500073A5 (cg-RX-API-DMAC10.html) | ||
| US11890473B2 (en) | System and method of pain relief based on frequency based analysis of temporal nociceptive signals | |
| JP2005528138A (ja) | 脳刺激、特に深部脳刺激のために電極を目標点に位置決めする装置 | |
| US11351379B2 (en) | Systems and methods for controlling synchrony in a plurality of brain regions | |
| JP2005526553A (ja) | 脳刺激によって患者を治療する装置 | |
| JP2005526553A5 (cg-RX-API-DMAC10.html) | ||
| Pulliam et al. | Designing Neuromodulation Devices for |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20091110 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100204 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20100518 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100928 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20101222 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20110329 |