JP2008273918A - Film drug product for repelling - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a film drug product for repelling that forms a film on the skin for preventing a mosquito from coming close, landing on the skin and biting even if it lands on the skin. <P>SOLUTION: Nitrocellulose is dissolved in a mixture of acetone and 3-methylbutyl acetate or isobutyl acetate and added with ethyl alcohol as a solubilizer to form a base. The base is added with castor oil and dimethyl silicone oil and as necessary a repelling component, a component for enhancing softness and strength, a moisturizer and the like. The base is applied to the skin and then forms a transparent or translucent film on the applied part of the skin with the solubilizer vaporized. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a repellent formulation against pests, particularly mosquitoes, and more particularly to a film repellent formulation that forms a thin film on the skin.

Conventional pest repellents generally administer natural or synthetic repellent ingredients directly to clothes and exposed skin in the form of external liquid preparations such as lotions and sprays. Ingredients with a repellent effect are included in microcapsules and attached to the fibers, and the fibers are used to make clothing for the purpose of repelling insects, or mixed into silicone rubber and shaped into a ring shape. At present, a ring is attached to the ankle (Patent Document 1).
In addition, as a skin external preparation which forms a film, as patent document 2 and patent document 3, what contains piroxylin, acetone, ethanol, and a medicinal component is proposed.
Furthermore, a composition for external use in which castor oil is added to a solution of nitrocellulose and ethanol is proposed in Patent Document 4, and it is disclosed in Patent Document 5 and Patent Document 6 that olive oil is contained in an external preparation used on the skin. Proposed.
JP 2004-51564 A JP 05-58914 A JP-A-47-39621 Japanese Patent Laid-Open No. 2003-514835 JP 2003-73263 A Japanese Patent Application No. 2006-160606

  Recently, with the global warming, the northern limit where mosquitoes in the tropics landed has risen, and the source of virus infection by mosquitoes is expanding. In particular, the West Nile virus, which has caused many sick people in recent years, has become a major problem. Viruses may have been brought into the country by wild birds imported as pets, or mosquitoes in infected areas may have been transported by plane or ship. When infected with West Nile virus, after a incubation period of 2 to 14 days, it suddenly develops a high fever exceeding 39 degrees, and symptoms such as headache and muscle pain appear with rash, and symptoms similar to those of new pneumonia are also seen. It is said that about 20% of infected people become ill, and 1% of them become seriously ill, causing encephalitis and death. Mosquitoes also carry diseases such as malaria, yellow fever, filariae, and dengue fever. There is a method of using an insecticide as a defense method to prevent biting against these harmful insects, especially mosquitoes, but it is actually impossible to use an insecticide in an unspecified number of places, In addition, insecticides have a great risk of harming health if they adhere to the human body or are aspirated by breathing.

  On the other hand, the method using repellents has many repellent ingredients that are naturally derived from plants and herbs, and since it is safe to sprinkle directly on the skin or inhale by inhalation, sprays, ointments, creams, It is used as an external preparation such as gel. In addition, a method has been adopted in which these ingredients are processed into fibers and tailored to clothes to protect against mosquitoes, or processed into silicon rings and fitted on the wrist to keep mosquitoes away. Mosquitoes have an excellent function of approaching by sensing the carbon dioxide generated by animal breathing with a sensor and descending when they feel the updraft produced by the animal's body temperature.

In particular, people with high body temperature, children, and people who drink alcohol tend to be stabbed on the same principle. The repellent rate of repellents against mosquitoes is 50-60% due to the open system, and it is impossible to escape from mosquitoes completely. In the case of preparations that apply or spray repellent to the skin, the repellent effect is improved, but it is actually possible to stab some mosquitoes that have stopped on the skin.
The present invention has been made in view of the above-described problems, and the problem is how to prevent mosquitoes from approaching, how to stop on the skin, and how to prevent mosquitoes from getting stuck even if they stop on the skin. The point is whether or not
In addition, although the above-mentioned patent documents 2 thru | or patent document 6 which form a film are what forms a film, they do not guard against a pest, such as a mosquito, in a human skin, and in particular, a repellent is not used. There is no technical idea to include.
Another problem of the present invention is that even when a film is formed on the skin by a conventional external preparation for forming a film, it does not feel uncomfortable during exercise and diminishes the unique odor of nitrocellulose. There is in point to do.

The present inventor is a simple new that has a reliable protective effect against safety and convenience against the biting of more pests (mosquitoes) without degrading the characteristics and repellent effects of herbal medicines and herbs. We considered various preparations and repeated experiments and trial productions. And the characteristics of the patch preparation, cream preparation, gel preparation, patch for treatment after spray bite and mosquito bite, which is representative of conventional repellent preparation (form before use of gel: semi-solid, close to liquid, A new gel dosage form having a composition utilizing the composition of spray: liquid, patch and patch after use: semi-solid) was tried. When the new gel preparation was applied to the skin, a semi-solid gel-form before use was thinly applied to the skin, and then a film close to the patch preparation was formed on the applied skin over time.
As a result of further research based on this fact, the present inventor was able to complete the present invention.

The film preparation according to the present invention solves the above-mentioned problems, and the invention according to claim 1 is characterized in that nitrocellulose is dissolved in a mixture of acetone, 3-methylbutyl acetate or isobutyl acetate, and ethyl alcohol is used as a solubilizer. Is added to the base, castor oil and dimethyl silicone oil are added to the base material, and after being applied to the skin, the dissolving agent is volatilized to form a transparent or translucent film on the skin at the application site. A film repellent preparation characterized by preventing biting.
The invention of claim 2 includes DEET, toluamide complex compound, insect repellent chrysanthemum extract, lemon eucalyptus, lemongrass, mint, citronella, black pine, clove, jasmine, sandalwood, peppermint as repellent ingredients dissolved in the base The film repellent preparation according to claim 1, further comprising at least one essential oil selected from lavender, eucalyptus, tea tree, geranium, lemon and cinnamon. In this case, if there are too many repellent components, film formation is impossible, so about 5% by weight or less is good, and 0.05% by weight or more may be mixed in order to keep insects such as mosquitoes away.

That is, in each of the above-mentioned inventions, nitrocellulose is dissolved in acetone, 3-methylbutyl acetate or isobutyl acetate, ethyl alcohol is added as a solubilizer, and an appropriate amount (effective amount) of a repellent component is added, and further as an auxiliary component. Castor oil and dimethyl silicone oil are blended into a preparation. After application to the skin, the solvent is volatilized, and the part to be applied is formed immediately on the skin where the transparent or translucent film is applied. Shielding, suppressing (controlling) the volatilization of repellent components, and demonstrates the long-lasting repellent effect. Further, by shielding the skin with the formed film, mosquitoes remaining on the skin without showing repellent action are prevented from being pierced with a needle. That is, a film corresponding to the defense shield is formed on the skin.
By preventing direct contact between moisture and the part where the repellent component is applied, it prevents the repellent component applied by hand washing etc. from flowing out from the skin, and also prevents the loss of the repellent component due to contact with clothes, etc. This will increase the sustainability of the repellent effect. Since the formed film is semi-ODT (semi-sealed) and has air permeability, no side effects (rash, redness, blistering, etc.) of the pasting site characteristic of conventional patch preparations are observed.
Further, since it is non-aqueous, the stability of the contained components is high, and there is no need to use a preservative or surfactant that has a risk of adversely affecting the skin, which is typical of general external preparations.

According to the film repellent preparation of the present invention, nitrocellulose is dissolved in a mixture of acetone, 3-methylbutyl acetate or isobutyl acetate, and ethyl alcohol is further added as a solubilizer to make a base. In addition, castor oil and dimethyl silicone oil are blended as auxiliary components, and after application to the skin, the solvent evaporates and forms a transparent or translucent film on the skin to seal the application site. Protects and enhances the transpiration repellent effect and persistence of the contained repellent components, prevents the mosquitoes from flying and stopping, and prevents mosquitoes that have not shown repellent action from stopping and biting into the skin. In the worst case, the film formed even if stabbed can prevent the occurrence of inflammation caused by scratching the affected area due to itching. Furthermore, since the film itself contains a repellent component, it stimulates the antenna of the mosquito and exhibits a contact repellent effect.
In addition, even a base that does not contain repellents alone protects the skin itself by forming a film on the skin where the plaster is thinly applied, and protects the skin from physical irritation such as abrasion caused by clothes or plants. . That is, it has the effect | action which can also become a tough 2nd artificial stratum corneum.
Furthermore, a film can be formed only with a film-forming base material such as nitrocellulose, but dimethyl silicone oil and castor oil are blended as soft auxiliary ingredients, and the skin where human skins such as human limbs are stretched can be easily peeled off. It will not fall or crack. In particular, when dimethyl silicone oil is blended, flexibility and sealing performance are dramatically improved.

Hereinafter, preferred examples of the film repellent preparation of the present invention will be described.
[Example 1]
A preferred example 1 of the film repellent preparation for forming a film on the skin of the present invention will be described. First, the blending ratio of this example 1 is shown in the following [Table 1].
Component ratio of Example 1 [Table 1] [Composition ratio:% by weight]
Nitrocellulose ... 6.0
Ethyl alcohol ... 74.0
3-methylbutyl acetate ... 5.0
Acetone 10.0
Dimethyl silicone oil ... 4.0
Castor oil ... 1.0

[Preparation method]
The film preparation of Example 1 is prepared by the following procedure so as to achieve the above composition ratio. First, 2 to 10% by weight, preferably 6.0% by weight of nitrocellulose is dissolved in 3 to 8% by weight, preferably 5.0% by weight of 3-methylbutyl acetate, and then 12 to 8% by weight of acetone. %, Preferably 10.0% by weight, and well stirred at a liquid temperature of 30 ° C. Next, 80-60% by weight of ethyl alcohol, preferably 74.0% by weight, was added to this solution and stirred well, and then dimethyl silicone oil ((Shin-Etsu Chemical Co., Ltd .: Silicone KF-96-1000CS), Product name "Dimethicone" viscosity 1000 (25 ° C mm ² / S), specific gravity 0.970, refractive index 10403, volatile matter 0.5 or less (150 ° C / 24h%), pour point -50 ° C or less, flash point 315 ° C or more) 1 -5% by weight, preferably 4.0% by weight (1% by weight or more increases the flexibility of the film, but too much makes the film weaker), and this weight% is added little by little with stirring. Furthermore, similarly, castor oil is added in an amount of 0.3 to 3% by weight, preferably 1.0% by weight (1% by weight or more increases the flexibility of the film, but if too much, the film becomes weaker). A small amount is added to the mixture, and the mixture is stirred and kneaded for 3 hours.
In this embodiment, nitrocellulose is used as a film forming material, 3-methylbutyl acetate and acetone are used as a film forming and dissolving agent, and ethyl alcohol is mixed as a pure dissolving agent to form a base material. Furthermore, castor oil and dimethyl silicone oil, which are oils and fats, which are liquid softeners, are applied to the base material to improve the flexibility and sealing properties of the film, thereby enhancing the fit of the skin. Improves skin strength against stinging.
Here, the reason why 3-methylbutyl acetate is added is to enhance the solubility of the nitrocellulose and to bind the molecules of the nitrocellulose when the volatile components are volatilized to assist film formation. The addition of dimethyl silicone oil increases the flexibility of the formed film and at the same time increases the affinity (adhesion) to the skin. These functions are dramatically improved compared to castor oil alone. This is thought to be because dimethylsilicone oil replenishes the space for intermolecular bonding of nitrocellulose, that is, acts as a cell fluid (moisturizing component) that fills cells.

[Example 2]
Next, preferred example 2 of the film repellent preparation for forming a film on the skin of the present invention will be described. First, the blending ratio of this example 2 is shown in the following [Table 2].
Component ratio of Example 2 [Table 2] [Composition ratio:% by weight] Example 2
Nitrocellulose ... 6.0
Ethyl alcohol 67.2
3-methylbutyl acetate ... 5.0
Acetone ... 10.0
Lemon Eucalyptus ... 0.3
DEET ... 5.0
Chitin and chitosan ... 1.5
Sesame oil ... 3.0
Dimethyl silicone oil ... 1.0
Castor oil ... 1.0

[Preparation method]
The film preparation of this example is prepared by the following procedure so that the composition ratio is as described above. First, 2 to 10% by weight, preferably 6.0% by weight of nitrocellulose is dissolved in 3 to 8% by weight, preferably 5.0% by weight of 3-methylbutyl acetate, and then acetone is added to 12 to 8%. Add wt%, preferably 10.0 wt% and stir well at a liquid temperature of 30 ° C.
Next, 80-60% by weight of ethyl alcohol, preferably 67.2% by weight, is added to the solution and stirred well, followed by lemon eucalyptus, DEET, dimethyl silicone oil, sesame oil, castor oil, and finally chitin / chitosan. The mixture is added in small portions under sequential stirring, stirred and kneaded for 3 hours, and then allowed to stand at room temperature for 24 hours for production.
That is, the above nitrocellulose is a film-forming material, and 3-methylbutyl acetate, acetone, and ethyl alcohol are volatile solvents (also related to film-forming components (base materials)), and after 30 seconds to 1 minute after application, they volatilize. In addition, a film is formed on the surface of the preparation.
Here, the reason why 3-methylbutyl acetate and dimethyl silicone oil are added is the same as in Example 1.
Example 2 differs from Example 1 in that a repellent component against pests such as mosquitoes is included, but in the composition of Example 2 above, the repellent component is usually DEET (diethyl) used as an insect repellent. Toluamide) is added in an amount of 5.0 to 15.0% by weight, preferably 5.0% by weight, and 0.6 to 0.1% by weight, preferably 0.3% by weight, of Lemon Eucalyptus.
In addition, sesame oil 6.0 is used as a material (strength improver, softener, sealant) for adjusting the coefficient of friction of the film, which is a film to be formed, and enhancing the strength, flexibility, and sealability of the film. -1.0 wt%, preferably 3.0 wt% is added with stirring, dimethyl silicone oil (same as in Example 1) is added with 1-6 wt%, preferably 1.0 wt%, and further, 4.0% to 0.5%, preferably 1.0% by weight of castor oil is added with stirring.
In addition to castor oil, sesame oil, and dimethyl silicone oil in the above examples, these strength improvers, softeners, and sealants include horse oil, sesame oil, castor oil, acetylated hyaluronic acid, beeswax, carnauba wax, lanolin. Natural oils such as perilla oil, perilla oil, olive oil, hinoki oil and castor oil can be used.
Further, as a film-forming auxiliary agent for improving biocompatibility such as familiarity with skin and moisture retention and reinforcing the film, it is 3.0 to 0.5% by weight of chitin / chitosan, preferably 1.5% by weight. Is added with stirring.

[Mosquito repellent test 1]
The effect | action and effect of the film repellent formulation of Example 1 and Example 2 which were manufactured with said composition and the adjustment method were verified on the following conditions.
(1) Subject:
Film repellent formulations of Examples 1 and 2 (the above film repellent formulations: hereinafter referred to as “Example 1” and “Example 2”)
Comparative Example 1: Ordinary commercially available repellent spray preparation (C company repellent herb-containing spray preparation: hereinafter referred to as “Comparative Example 1”), however, the subjects are different as in (2) below.
(2) Subjects: Adult volunteer group 2 (Group A, Group B) x 5 (10)
(Males 48-60)

(3) Test method:
Example 2 was applied to the entire left hand and left foot of 5 volunteers (Group A), and Comparative Example 1 (Group A) was applied to the right hand and right foot of the same person. Example 1 was applied to the entire left hand and left foot of (Group B), and Comparative Example 1 (Group B) was similarly applied to the right hand and right foot of the same person.
Ten minutes after application, a field test was conducted in a mountainous area in which the mosquitoes live (at the foot of Mt. Shiratori Akiba in Higashi-Kagawa City, Kagawa Prefecture) for 1 hour from 6pm to 7pm. The number of flying mosquitoes (the number of times they stopped on the skin) and the number of places where the skin was actually stabbed were measured, and the respective cumulative numbers of 10 cases (subjects 1 to 5, 1a to 5a) were obtained.

(4) Test results The test results of [Mosquito repellent test 1] will be described with reference to (Table 3) of FIG. 1 and the graph of FIG.
In Example 1 (Group B), the number of mosquitoes was 4 in the left hand and 5 in the left foot, but the number of stabs was 0 in both hands and feet. In Example 2 (Group A), the number of mosquitoes was 2 on the left hand and 2 on the left foot, but the number of stabs was 0 on both hands and feet.
On the other hand, in Comparative Example 1 of Group A, the number of mosquitoes was 10 right-handed and 11 right-footed, and the number of bites was the same as the number of flying, 10 times for the right hand and 11 times for the right foot. In Comparative Example 1 of Group B, the number of mosquitoes was 12 right hand and 13 right foot, and the number of bites was 11 right hand and 13 right foot, almost the same as the number of flying mosquitoes.
From the above results, in Example 2, the number of flying mosquitoes was as low as 1/5 compared to Comparative Example 1 (Group A). In Example 1, the number of flying mosquitoes was slightly larger than in Example 2, but Comparative Example 1 Compared to (Group B), the number of mosquitoes flying is only 1/3, and the actual number of bites is 0 in both Example 1 and Example 2. However, a far superior repellent effect and anti-stab effect were confirmed.

[Mosquito repellent test 2]
The film repellent preparation of Example 1 and Example 2 produced by the above-described composition and preparation method and Example 3 were further prepared and [mosquito repellent test 2] was performed.
[Example 3]
Component ratio of Example 3 [Table 4] [Composition ratio:% by weight]
Nitrocellulose ... 8.0
Polyvinyl alcohol ... 1.0
Ethyl alcohol ... 71.2
Isobutyl acetate ... 5.0
Acetone ... 10.0
Insect chrysanthemum extract ... 0.5
Jasmine …… 0.3
Chitin and chitosan ... 1.0
Dimethyl silicone oil ... 2.0
Castor oil ... 1.0

[Adjustment method]
The film preparation of Example 3 is adjusted by the following procedure so as to achieve the above composition ratio.
First, in substantially the same manner as in Example 2, 2 to 10% by weight of nitrocellulose, preferably 8.0% by weight, and 0.5 to 2% by weight of polyvinyl alcohol, preferably 1.0% by weight of isobutyl acetate. After dissolving under stirring, acetone is further added and stirred well at a liquid temperature of about 30 ° C. Next, 71.2% by weight of ethyl alcohol is added to this stirring liquid and stirred for about 30 minutes, and then an insecticidal chrysanthemum extract and jasmine are added little by little under sequential stirring, and the final ingredient is added and stirred for 3 hours. Thereafter, it is allowed to stand at room temperature for 24 hours for production.
That is, the above-mentioned nitrocellulose and polyvinyl alcohol are film forming materials, and isobutyl acetate, acetone and ethyl alcohol are volatilized solvents and volatilize in about 1 to 2 minutes after application, and a film is formed on the surface of the preparation. To.
Here, isobutyl acetate is added in order to increase the solubility of nitrocellulose as in the case of 3-methylbutyl acetate, and at the same time to bond the molecules of nitrocellulose when volatile components are volatilized to assist film formation. is there. The addition of dimethyl silicone oil increases the flexibility of the film formed in the same manner as in Example 1 and at the same time increases the affinity (adhesion) to the skin.
As a repellent component in Example 3 of the above composition, 0.8 to 0.05% by weight, preferably 0.5% by weight, of an insect repellent extract commonly used as an insect repellent, and 0.6 to 0.5% of jasmine. 1 wt%, preferably 0.3 wt% is added with stirring.
For the purpose of enhancing the strength, flexibility and sealing property of the film during film formation, 1 to 6% by weight, preferably 2.0% by weight of dimethyl silicone oil (same as in Example 1) is added with stirring. Then, 4.0 to 0.5% by weight of castor oil, preferably 1.0% by weight, is added with stirring. Furthermore, as a film-forming auxiliary agent for improving biocompatibility such as familiarity with skin and moisture retention and reinforcing the film, 3.0 to 0.5% by weight of chitin / chitosan, preferably 1.0% by weight. Is added with stirring.

The repellent effect on the mosquitoes of the film repellent preparation of Example 1, Example 2, and Example 3 added above was verified under the following conditions.
(1) Subject: film repellent formulation (formulations of Examples 1, 2 and 3 above)
Control product: Comparative example 2 of a commercially available repellent spray formulation (normally commercially available repellent spray formulation: spray formulation containing lemon eucalyptus manufactured by Company C), and Comparative Example 3 with no treatment

(2) Test method:
Example 1, Example 2 and Example 3 were applied to the entire back surface of a female hairless mouse, and after a few minutes the film formation was confirmed, and then placed in a stainless steel fixed gauge (14 × 40 × 10 cm). . Similarly, Comparative Example 2 was sprayed on the front of the back of a hairless mouse and then placed in the same gauge. After the hairless mouse has stabilized, 30 test worms (anaesthetized with diethyl ether and preselected for female adults) are placed in a gauge that has been released, and the number of blood sucked after 1 to 6 hours. Counting was carried out to determine the blood absorption rate of each preparation (test insects sucked / total test insects × 100). As Comparative Example 3, hairless mice without treatment with repellent components were also tested and observed in the same gauge.

(3) Test results:
The test result of [mosquito repellent test 2] will be described with reference to (Table 5) in FIG.
In the hairless mouse of Comparative Example 3 of the non-treated control, the number of blood sucking increased with time at 10 places after 1 hour, 12 places after 2 hours, 18 places after 3 hours, and 28 places after 6 hours. The blood suction rate was 93.360%. Comparative Example 2 also increased over time to 3 places after 1 hour, 7 places after 2 hours, 10 places after 3 hours, and 23 places after 6 hours, but slightly less than Comparative Example 3 with no treatment. After 18 hours, it was 33.3%, but after 6 hours, the blood absorption rate was 76.6, and increased rapidly when the repelling effect diminished. On the other hand, in Example 1, Example 2, and Example 3, there was no stab at all during the test period of 3 hours, and the blood absorption rate was 0%.
Thus, the effect of conventional commercially available repellents fades out in about 1 hour, and after 6 hours, it becomes as thin as no treatment, but the film repellent formulations of Examples 1 to 3 of the present invention Protects against mosquito attacks by forming a film on the skin and protects it from mosquito attacks. The protective and repellent effects are maintained for a long time, and these effects last for more than 6 hours. Can be maintained.

Here, in order to verify the film formation state and flexibility in the film repellent formulations of Example 2 and Example 3, as shown in the following [Table 6], 3-methylbutyl acetate and isobutyl acetate were included as film forming agents. Samples of Comparative Example 4 having no dimethyl silicone oil and Comparative Example 5 having no dimethyl silicone oil were prepared and compared.
[Comparative Example 4] and [Comparative Example 5]
Component ratio of Comparative Example 4 and Comparative Example 5
[Table 6] [Composition ratio:% by weight] Comparative Example 4 Comparative Example 5
Nitrocellulose ... 6.0 6.0
Ethyl alcohol 72.2 68.2
3-methylbutyl acetate ... 0.0 5.0
Acetone ... 10.0 10.0
Lemon Eucalyptus ... 0.3 0.3
DEET ... 5.0 5.0
Chitin ・ chitosan ・ ・ ・ 1.5 1.5
Sesame oil ... 3.0 3.0
Dimethyl silicone oil 1.0.0.0
Castor oil ... 1.0 1.0

[Method for Preparing Comparative Examples 4 and 5]
In Comparative Example 4, acetone and ethyl alcohol were added to nitrocellulose and stirred well at a liquid temperature of 30 ° C. so that the above composition ratio was obtained, and then lemon eucalyptus, DEET, dimethyl silicone oil, sesame oil, castor oil, chitin / chitosan Are added little by little under sequential stirring, and are prepared in the same manner as Formulation 1 below.
Similarly, in Comparative Example 5, 3-methylbutyl acetate and acetone are added to nitrocellulose and stirred well at a liquid temperature of 30 ° C. Next, after adding ethyl alcohol to this solution and stirring well, lemon eucalyptus, DEET, sesame oil, castor oil, and chitin / chitosan are added in small portions successively with stirring and prepared in the same manner as in Comparative Example 4 above.

[Film formation test]
The film formation state and flexibility of the film repellent formulations of Examples 2 and 3 above and Comparative Examples 4 and 5 above were verified under the following conditions.
(1) Subject Example 2, Example 3, Comparative Example 4, Comparative Example 5,
(2) Test method Example 2, Example 3, Comparative Example 4, and Comparative Example 5 were each uniformly applied to a 3 cm area of 2 cm × 2 cm using a cotton swab on a slide glass. . The formation state of the film after 1 to 3 minutes at room temperature was visually confirmed. In order to confirm that a film (film) was physically formed, the slide glass on which the film was formed was immersed in physiological saline, and after 1 hour, peeling of the film was confirmed using tweezers.
Separately from the above slide glass, the subject is applied to the back of the hand of 3 adult male volunteers (3 people) in the same area as above, and the formation of the film after 1-5 minutes is visually observed. Confirmed. Next, the hand was immersed in the water in the basket, and the formation of a film on the back of the hand was visually confirmed.

(3) Test results The above test results are shown in [Table 7]. The film repellent preparations of Examples 2 and 3 confirmed the formation of a clear film 1 minute after application. Formation of the film was confirmed by peeling the film of about 30 to 50 μm with physiological saline.
On the other hand, the sample of Comparative Example 4 (removal of methyl butyl acetate was not sure) although it appeared to be a film on the slide glass, but it was not certain, but it was a white powder that seems to be nitrocellulose and chitin / chitosan after evaporation of the solvent. Residual material was confirmed. Similar results were confirmed on human skin (back of hand).
In the film repellent preparation of Comparative Example 5 (dimethylsilicone oil formulation removal), the formation of the film was insufficient after 1 minute of application, but the film was formed after 2 minutes of application, and then applied to physiological saline. Formation of the coating was confirmed by peeling of the film from the slide glass upon immersion. The formation of a film was also confirmed on human skin (back of hand).

[Flexibility test of formed film]
Of the film repellent preparations of Example 2, Example 3, Comparative Example 4, and Comparative Example 5 above, Example 2, Example 3, and Comparative Example 5 except for Comparative Example 4 in which film formation was observed in the above test. With respect to the preparation, the flexibility of the formed film was verified under the following conditions.
(1) Subject Example 2, Example 3, Comparative Example 5,
(2) Test method Three samples of each of the samples formed on the slide glass in the above-mentioned film formation test were set in a thermostatic bath set to 40 ° C., and the state of the film (degree of cracking) after setting 1 to 5 hours Were visually inspected. In addition, the film formed on the back of the human hand was dried with hot air from a distance of about 30 cm at an intermediate temperature of a dryer (1200 w), and the state of the film after 1 to 5 minutes was visually inspected.

(3) Test results Tables 8 and 9 show the test results obtained by the above test methods.
[Results of flexibility test 1]
As shown in the table of the result 1 of the flexibility test in [Table 8], in the flexibility test for the coatings (Example 2, Example 3, and Comparative Example 5) formed on the slide glass, Example 2, In the film repellent preparation of Example 3, no cracks could be confirmed in the coating in 1 to 5 hours after setting the thermostat. On the other hand, in the film repellent preparation of Comparative Example 5, a slight crack was confirmed in 1 hour after setting, and thereafter the crack progressed with time, and in 5 hours after setting of the final judgment, a strong crack and a film breaking phenomenon Was recognized.

[Result of flexibility test 2]
Next, as shown in the table of the result 2 of the flexibility test in [Table 9], in the flexibility test under severe conditions (dryer drying) for the film formed on the skin of the back of a human hand, Example 2, The film repellent formulation of Example 3 was confirmed to have a slight crack after 3 minutes in Comparative Example 5 film repellent formulation, compared to the fact that no cracks in the formed coating were observed after 5 minutes of dryer treatment. Five minutes after the final judgment, moderate crack growth was observed.
From the above results, it was considered that 3-methylbutyl acetate or isobutyl acetate, which is a component in the formulation of film repellent preparation, is greatly involved in the solubility of nitrocellulose, which is the main component of the film, and the film formation after solvent evaporation. Moreover, it was confirmed that dimethyl silicone oil is an essential component for obtaining the flexibility (skin following ability) of the formed film.

As described above, each example of the film repellent preparation for forming a film on the skin of the present invention covers the site by forming a transparent or translucent film on the skin. Protects and enhances the transpiration repellent effect and persistence of contained repellent components, prevents mosquitoes from coming and stopping, and also prevents mosquitoes that have not shown repellent action from stopping and biting into the skin. In the worst case, the film formed even if stabbed can prevent the occurrence of inflammation caused by scratching the affected area due to itching. Furthermore, since the film itself contains a repellent component, it stimulates the antenna of the mosquito and exhibits a contact repellent effect.
In addition, even a base that does not contain repellents alone protects the skin itself by forming a film on the skin where the plaster is thinly applied, and protects the skin from physical irritation such as abrasion caused by clothes or plants. . That is, it has the effect | action which can also become a tough 2nd artificial stratum corneum.
As a secondary action, it is possible to protect the skin from chemical irritation and bacterial infection and maintain the shielding effect and the moisturizing effect for a long time.
Needless to say, the present invention is not limited to the above-described embodiments as long as the features of the present invention are not impaired.

It is [Table 3] of the effect test of the mosquito repellent test 1 with respect to Example 1, 2 and Comparative Example 1 of this invention. It is the figure which made [Table 3] of FIG. 1 a graph. It is [Table 5] of the effect test of the mosquito repellent test 2 with respect to Examples 1 to 3 and Comparative Examples 2 and 3 of the present invention. It is [Table 7] of the result of the film formation test of Examples 2 and 3 of the present invention, and Comparative Examples 4 and 5. It is [Table 8] of the result 1 of the softness | flexibility test of Example 2, 3 of this invention and the comparative example 5. FIG. It is [Table 9] of the result 2 of the softness | flexibility test of Example 2, 3 of this invention and the comparative example 5. FIG.

Claims (2)

  Nitrocellulose is dissolved in a mixture of acetone, 3-methylbutyl acetate or isobutyl acetate, and ethyl alcohol is added as a solubilizer to make the base, castor oil and dimethyl silicone oil are contained in the base material, and applied to the skin. A film repellent preparation characterized in that after the dissolution agent is volatilized, a transparent or translucent film is formed on the skin at the application site to prevent insect bites.   As a repellent component that dissolves in the base, DEET, toluamide compound compound, insect repellent extract, and lemon eucalyptus, lemongrass, mint, citronella, black pine, clove, jasmine, sandalwood, peppermint, lavender, eucalyptus, tea tree, The film repellent preparation according to claim 1, further comprising at least one essential oil selected from geranium, lemon and cinnamon.

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