JP2008013492A - Preservative for cosmetic, cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a preservative for cosmetics, which can easily and effectively sterilize sepsis-causing bacteria existing in environments where cosmetics such as basic cosmetics, perfumes, lipsticks and shampoos are used. <P>SOLUTION: This preservative for the cosmetics comprises a silver colloid solution produced by adding finely micronized silver in a liquid. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a preservative for cosmetics capable of preventing the so-called cosmetics such as cosmetic basic cosmetics, perfumes, lipsticks and shampoos from decaying and deteriorating within a certain period of time, and in particular, it can exert a bactericidal effect by a metal-based material. Relates to preservatives.

  In so-called cosmetics such as basic cosmetics, perfumes, lipsticks, and shampoos, preservatives are used to prevent spoilage within a certain period and to maintain stable quality.

  Most of the preservatives currently used are organic preservatives produced by petrochemical products such as parabens (paraoxybenzoates) and phenoxyethanol. This antiseptic can sterilize various bacteria and molds, thereby preventing spoilage and the accompanying bad odor. In order to sterilize a wide variety of fungi, a preservative is used at a high concentration in order to enhance the sterilizing power, or a plurality of types of drugs are used in combination.

  However, in organic preservatives, if the sterilizing power is increased by increasing the concentration or combining the chemicals, there is a problem in that the user's body or usage environment may be affected. Therefore, when it is used in cosmetics, it is necessary to consider the effect on the skin, so that it is difficult to provide sufficient sterilizing power, and the quality of the cosmetics deteriorates over time.

  The present invention has been made in view of the above problems, and an object of the present invention is to provide a preservative that can be used with peace of mind and a cosmetic using the preservative for the purpose of preventing the corruption of cosmetics.

  As a result of intensive studies, the present inventors have focused on metal-based preservatives. This is because a metal-based disinfectant based on a physical reaction seems to be more advantageous than an organic system based on an organic chemical reaction in order to disinfect a wide variety of fungi. Metal-based materials may be those using copper, tin, zinc, silver, etc. Especially, among these, the knowledge that silver is safe and effective is obtained. It was. That is, the above object is achieved by the following means.

  (1) A preservative for cosmetics, comprising a colloidal silver solution produced by mixing finely divided silver into a liquid.

  (2) The above-mentioned silver colloid-L-histidine complex solution having a stable silver colloid-L-histidine complex mixed with L-histidine, which is one of amino acids, in the silver colloid solution. 1) The cosmetic preservative as described.

  (3) The preservative for cosmetics according to the above (1) or (2), wherein the concentration of the finely divided silver is adjusted to a predetermined concentration capable of preventing the cosmetic from being spoiled within a certain period of time. .

  (4) The environment in the silver colloid solution is maintained in a reduced state, and a reducing agent that prevents oxidation of the silver is further mixed in. (1), (2) or (3) Preservative for cosmetics.

  (5) A cosmetic comprising the cosmetic preservative according to any one of (1) to (4) above.

  The present inventors tried to apply finely divided silver as a preservative for cosmetics, as it has little effect on the skin and does not cause bad odor. Specifically, as in the above-mentioned means (1), as a preservative for cosmetics, a silver colloid solution formed by mixing finely divided silver into a liquid is used to achieve the object. As a result, when used in cosmetics, a sufficient antiseptic effect can be obtained, and adverse effects on the user's body and use environment can be suppressed.

  Since silver is expensive, it is necessary to finely disperse and use silver. However, even if silver is subdivided into nano-sized particles, there are cases where it cannot be stably dispersed in a solution. Therefore, according to the above means (2), by mixing L-histidine, which is one of the amino acids, finely divided silver is stably dispersed, and the efficiency of nano-sized silver particles and bacteria under low concentration conditions. Contact can be ensured. This is because L-histidine provides a place for forming a stable silver colloid complex and ensuring efficient contact between nanosized silver particles and bacteria. As a result, it is possible to enhance the antiseptic function by efficiently supplementing bacteria, and the amino acid is dispersed, so that it is extremely safe for humans.

  In this case, as in the above means (3), the concentration of silver is adjusted to a concentration that can prevent the decay of cosmetics. In order to maintain the antiseptic effect, it is preferable to suppress the oxidation of silver by mixing a reducing agent as in the above means (4).

  In addition, if the cosmetics such as basic cosmetics, perfumes, lipsticks, shampoos, etc. are produced using these cosmetic preservatives as in the means (5), the decay and deterioration within a certain period are suppressed, and the quality is stabilized. It can be made. Moreover, it can avoid easily and effectively having a bad influence on a user's body and environment.

  According to the preservative for cosmetics of the present invention, it is possible to prevent the cosmetic from being spoiled and deteriorated within a certain period by a stable bactericidal effect, and to maintain a stable quality. By blending this preservative for cosmetics into basic cosmetics, perfumes, lipsticks, shampoos, etc., it is possible to obtain cosmetics with extremely high quality safety and little adverse effects on the body.

    Hereinafter, embodiments of the present invention will be described in detail.

  The cosmetic preservative according to the first embodiment of the present invention comprises a colloidal silver solution produced by mixing silver finely divided to a set particle size or less into a liquid. Silver is finely divided into particles of, for example, a particle size of 10 nm (nanometers) or less, preferably 4 nm or less by a technique such as electrolysis or mechanical dispersion using zirconium. The lower limit of the silver particle size is not particularly limited, but for example, it is realistic to set it to 1 nm or more. As the dispersion medium, pure water with reduced negative ions is used. The silver concentration in the colloidal silver solution is adjusted so as to be a predetermined concentration (for example, 2 to 10 ppm) capable of preventing the cosmetic from being spoiled within a certain period. Further, a reducing agent is mixed in this silver colloid solution. As the reducing agent, for example, it is desirable to use at least one of vitamin C (ascorbic acid), vitamin E, β-carotene, and citric acid.

  Cosmetic preservatives containing this colloidal silver solution are incorporated into so-called cosmetics such as basic cosmetics, perfumes, lipsticks, shampoos, etc. to prevent the cosmetics from decaying or deteriorating within a certain period of time, and maintaining stable quality. Make it possible.

  Next, the cosmetic preservative according to the second embodiment of the present invention is one of amino acids for a silver colloid solution produced by mixing silver finely divided to a set particle size or less into a liquid. It consists of a silver colloid-L-histidine complex solution produced by mixing L-histidine. The silver concentration in the silver colloid solution is prepared to be a predetermined concentration (for example, 10 ppm). Furthermore, L-histidine of a predetermined concentration (for example, 1 mM) is mixed with this silver colloid solution. As in the first embodiment, a reducing agent is also mixed into the silver colloid-L-histidine complex solution. As the reducing agent, for example, at least one of vitamin C (ascorbic acid), vitamin E, β-carotene, and citric acid is used.

  In the produced silver colloid-L-histidine complex solution, the silver of fine particles is retained by the amino group of L-histidine, so that this silver can be stably present in the liquid. As described above, in the silver colloid-L-histidine complex solution with L-histidine, the silver silver ions formed into fine particles can maintain an environment in which bacteria are easily contacted to increase the chance of contact, and more efficiently. Can exhibit a bactericidal effect.

  Next, with reference to FIG. 1, the production method of the cosmetic preservative 1A shown in the first embodiment and the cosmetic preservative 1B shown in the second embodiment will be described. The cosmetic preservative 1A of the first embodiment is composed of a silver colloid solution 2, and the cosmetic preservative 1B of the second embodiment is composed of a silver colloid-L-histidine complex solution 3.

  The silver colloid solution 2 is produced by using finely divided silver 4 as a dispersoid and a liquid 5 as a dispersion medium to disperse the silver 4 in the liquid 5 and adjust it to a predetermined concentration. The silver 4 is finely divided in advance into a particle size of not more than a set particle size, for example, 10 nm (nanometer) or less, desirably 4 nm or less, by a technique such as electrolysis or mechanical dispersion using zirconium.

  The concentration of silver 4 with respect to liquid 5 is adjusted to be, for example, 0.5 to 100 ppm, desirably 1 to 10 ppm, and more desirably 2 to 5 ppm. Thereby, infectious bacteria that cause rot can be sterilized.

  The finely divided silver 4 is suspended and dispersed in the liquid 5 by the electric charge present on each fine particle, so that a silver colloid solution 2 is generated. As the liquid 5 in which the finely divided silver 4 is dispersed, for example, it is preferable to use pure water in which negative ions that react with silver ions are reduced, and it is possible to prevent a decrease in silver ions.

  The silver colloid-L-histidine complex solution 3 is produced by mixing L-histidine 6 with the silver colloid solution 2. The concentration of L-histidine 6 is set to a predetermined concentration (for example, 0.1 to 1 mM). The concentration of L-histidine 6 is preferably about 10 times the concentration of silver 4 or more.

  A reducing agent 7 is mixed in the silver colloid solution 2 and the silver colloid-L-histidine complex solution 3 generated in such a process. The reducing agent 7 maintains the in-liquid environment of the silver colloid solution 2 and the silver colloid-L-histidine complex solution 3 in a reduced state to prevent the oxidation of silver 4, vitamin C (ascorbic acid), vitamin At least one of E, β-carotene, and citric acid is used. The concentration of the reducing agent is set to 0.1 to 10 mM, for example.

  According to the cosmetic preservative 1A of the first embodiment described above, since the bactericidal effect is efficiently obtained by the silver colloid, it becomes possible to prevent the cosmetic from being spoiled. Further, according to the cosmetic preservative 1B of the second embodiment, a stable silver colloid complex is formed by L-histidine, and the nano-sized silver particles and bacteria are efficiently brought into contact with each other, thereby further enhancing the bactericidal effect. It is possible to increase. In addition, since these cosmetic preservatives 1A and 1B contain a reducing agent that has little effect on the human body or is beneficial to the human body, while preventing the oxidation of silver and maintaining the antiseptic effect for a long period of time, It is possible to reduce adverse effects on the human body.

  According to the procedure shown in the first embodiment, a cosmetic preservative 1A of Example 1 made of a silver colloid solution was produced, and antibacterial tests were conducted against typical spoilage bacteria such as Escherichia coli, Pseudomonas aeruginosa, and general bacteria. . As the composition of the preservative 1A for cosmetics, fine silver particles having a Sil barrier 600 (manufactured by Asahi Shokai Co., Ltd., particle size 40-100 nano size) were used, and pure water was used as a dispersion medium. The silver concentration was set to 10 ppm. Further, ascorbic acid was mixed as a reducing agent at a concentration of 1 mM. In order to measure antibacterial activity, for each of Escherichia coli, Pseudomonas aeruginosa, and general bacteria that have a predetermined number of initial bacterial cells, 1A of cosmetic preservative is mixed in each bacterial growth medium. Then, the cells were brought into contact for 24 hours, and then the number of colonies on the dedicated medium of each bacterium was measured to determine the number of microbial cells, and evaluation was performed based on the variation of the number. On the other hand, as <Comparative Example 1>, the number of cells in the case where the preservative was not brought into contact on the dedicated medium similar to Example 1 was measured. The result is shown in FIG.

  As is apparent from FIG. 2, the cosmetic preservative 1A of Example 1 not only suppresses the increase in the number of cells of typical spoilage bacteria, E. coli, Pseudomonas aeruginosa, and general bacteria, It became clear that the bactericidal effect was almost complete (beyond the measurement limit) after time. On the other hand, in the comparative example 1, the number of each viable bacteria increased significantly. From this, it was found that this preservative for cosmetics 1A can easily and effectively sterilize spoilage fungi existing in the use environment such as cosmetics.

  Next, according to the procedure shown in the second embodiment, the antiseptic 1B for cosmetics of Example 2 consisting of a silver colloid-L-histidine complex solution is produced, and Escherichia coli, Pseudomonas aeruginosa, and Antibacterial tests against general bacteria were performed. In addition, as a composition of the cosmetic preservative 1B, fine silver particles having a Syl barrier 600 (manufactured by Asahi Shokai Co., Ltd., particle size 40-100 nano size) were used, and pure water was used as a dispersion medium. The silver concentration was set to 10 ppm. The concentration of L-histidine to be mixed was set to 100 ppm. Further, ascorbic acid was mixed as a reducing agent at a concentration of 1 mM. The antibacterial activity was measured in the same manner as in Example 1. On the other hand, as <Comparative Example 2>, the antibacterial activity was measured when the preservative was not brought into contact with the dedicated medium as in Example 2. The result is shown in FIG.

  As is apparent from FIG. 3, the cosmetic preservative 1B of Example 2 not only suppresses the increase in the number of cells of typical spoilage bacteria, E. coli, Pseudomonas aeruginosa, and general bacteria, but also 24 It became clear that after time, almost complete bactericidal effect was exhibited. On the other hand, in the comparative example 2, the number of each viable bacteria increased significantly. Therefore, it turned out that the antiseptic | preservative 1B for cosmetics can perform easily and effectively disinfection of the rot fungi which exist in use environments, such as cosmetics.

  Next, a cosmetic emulsion was produced using the same cosmetic preservative 1B as in Example 2. The silver contained in the emulsion was set to have a concentration of 5 ppm. The detailed composition of this cosmetic is shown in FIG. As shown here, it was found that this cosmetic preservative 1B can be blended into the emulsion without any problems.

  Next, a facial cleansing foam was produced using the same cosmetic preservative 1B as in Example 2. The silver contained in the prior application form was set to have a concentration of 5 ppm. The detailed composition of this cosmetic is shown in FIG. As shown here, it was found that this cosmetic preservative 1B can be blended into a facial cleansing foam without any problems.

  A spoilage test was performed on the emulsion prepared in Example 3. Specifically, the emulsion was exposed to the air at room temperature for 7 days in an uncovered state, and the number of general bacteria was measured. On the other hand, as <Comparative Example 3>, a similar rot test was also conducted on an emulsion similarly prepared with a composition containing no preservative. The result is shown in FIG. As is apparent from the results, in the emulsion of Example 5, the number of general bacteria was below the measurement limit. On the other hand, in the emulsion of Comparative Example 3, the viable count of 3,800 general bacteria per gram was observed. This indicates that the preservative contained in the emulsion of Example 5 suppresses the infection of the bacteria present in the environment to the cosmetic product and has a preservative effect on the cosmetic product.

  Next, as Example 6, 34,000 general bacteria per gram was added to the emulsion prepared in Example 3 and allowed to stand at room temperature for 24 hours, and the increase or decrease in the number of general bacteria was measured. In addition, as <Comparative Example 4>, 34,000 general bacteria were added per 1 g of an emulsion similarly prepared with a composition containing no preservative, and the same rot test was conducted. The result is shown in FIG. According to this result, the emulsion of Example 6 was found to have a bactericidal effect on the added bacteria, and the number of growing general bacteria was kept below the measurement limit. On the other hand, in the emulsion of Comparative Example 4, 900,000 viable bacteria were observed per 1 g.

  From the results shown in FIGS. 6 and 7, even if the bacteria present in the environment are infected with cosmetics (in this case, emulsion), the preservative exhibits a bactericidal effect on the cosmetics in this example, It became clear that it had an antiseptic effect.

  The present invention can be used for various types of cosmetics including basic cosmetics, perfumes, lipsticks, and shampoos. In particular, the preservative for cosmetics of the present invention is extremely safe and can prevent the cosmetics from being spoiled and deteriorated within a certain period.

The process figure which shows the production | generation process of the antiseptic | preservative for cosmetics which concerns on 1st and 2nd embodiment of this invention. The table | surface which shows the measurement result of the antimicrobial activity of the antiseptic | preservative for cosmetics based on Example 1. FIG. The table | surface which shows the measurement result of the antimicrobial activity of the antiseptic | preservative for cosmetics based on Example 2. FIG. The table | surface which shows the detailed composition of the emulsion manufactured using the antiseptic | preservative for cosmetics of Example 2 as Example 3. FIG. The table | surface figure which shows the detailed composition of the face-washing foam manufactured using the antiseptic | preservative for cosmetics of Example 2 as Example 4. FIG. The table | surface which shows the result of having performed the spoilage test of the emulsion of Example 3 as Example 5. FIG. As Example 6, the table | surface figure which shows the result of having conducted the other rot test of the emulsion of Example 3. FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Preservative for cosmetics 2 Silver colloid solution 3 Silver colloid-L-histidine complex solution 4 Silver 5 Liquid 6 L-histidine 7 Reducing agent

Claims (5)

  A cosmetic preservative comprising a colloidal silver solution produced by mixing finely divided silver into a liquid.   2. The silver colloid-L-histidine complex solution having a stable silver colloid-L-histidine complex mixed with L-histidine, which is one of amino acids, in the silver colloid solution. Preservative for cosmetics.   The preservative for cosmetics according to claim 1 or 2, wherein the concentration of the finely divided silver is adjusted to a predetermined concentration capable of preventing the cosmetic from being spoiled within a certain period.   The preservative for cosmetics according to claim 1, 2 or 3, further comprising a reducing agent for maintaining the environment in the colloidal silver solution in a reduced state and preventing oxidation of the silver.   A cosmetic comprising the preservative for cosmetics according to any one of claims 1 to 4.

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